effector – Page 5 – Communicable Diseases Research

Broncho-alveolar inflammation in COVID-19 patients: a correlation with clinical outcome

Research Article

Published on 2020-11-162022-10-28
Journal: BMC Pulmonary Medicine [Category] COVID-19, Fulltext, SARS,

Dynamics of NK, CD8 and Tfh cell mediated the production of cytokines and antiviral antibodies in Chinese patients with moderate COVID‐19

NK, CD8 및 Tfh 세포의 역학은 중등도 COVID-19 환자에서 사이토카인 및 항바이러스 항체 생성을 매개합니다

Original Article

Published on 2020-11-032022-09-12
Journal: Journal of Cellular and Molecular Medicine [Category] MERS, SARS, 진단,

[키워드] abnormal increase acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 analysed antibody antiviral antibody B‐cell benefit caused CD226 CD4 CD8 Cell cell count cellular change Chinese patient contribute control patient control patients convalescent convalescent patient coronavirus coronavirus disease Coronavirus disease 2019 COVID‐19 COVID‐19 cytokine cytokine level cytokine levels Cytokines decrease demonstrated Dynamics effector effector memory electrochemiluminescence immunoassay enrolled expression flow cytometry iCoS immune responses increase in Inflammatory cytokine Inflammatory cytokines inhibitory innate immune response lymphocyte maintenance memory moderate NK NK cell NK cells Patient patients with moderate peripheral lymphocyte Pneumonia Prevent recent respiratory RT‐PCR SARS‐CoV‐2 SARS‐CoV‐2‐specific antibodies SARS‐CoV‐2‐specific antibody severe acute respiratory syndrome Coronavirus Severe case severe cases significantly higher significantly increased subset T cell T cells T‐cell Tfh TIM‐3
[DOI] 10.1111/jcmm.16044 PMC 바로가기 [Article Type] Original Article

Complement C3 vs C5 inhibition in severe COVID-19: Early clinical findings reveal differential biological efficacy

Research article

Published on 2020-11-012022-10-05
Journal: Clinical immunology (Orlando, Fla.) [Category] SARS, 바이오마커,

[키워드] abrogate Activation acute respiratory distress AMY-101 anti-inflammatory response ARDS Biomarkers blockade C-reactive protein C3 inhibition C3a C5 blockade C5a candidate drug clinical evidence Clinical finding Cohort complement consequence COVID-19 COVID-19 hyper-inflammation COVID-19 patient COVID-19 therapeutics detrimental drug candidate Drug efficacy eculizumab effector Efficacy elicit exploratory study faster hyper-inflammation IL-6 levels immunopathology immunothrombosis implicated independent indicate inhibitor inhibitory Intervention LDH Lung function lymphocyte monoclonal antibody multi-organ failure NET neutrophil counts Neutrophil extracellular trap offer outcome pathogenic pathway reflected robust SARS-COV-2 infection SC5b-9 serum severe COVID-19 patients Support syndrome therapeutic Thromboinflammation thrombotic trials upstream
[DOI] 10.1016/j.clim.2020.108598 [Article Type] Research article

SARS-CoV-2 Is Restricted by Zinc Finger Antiviral Protein despite Preadaptation to the Low-CpG Environment in Humans

Research Article

Published on 2020-10-162022-10-29
Journal: mBio [Category] COVID-19, MERS, SARS,

[키워드] acute respiratory syndrome Analysis Antiviral bat bat coronaviruses cofactor Comprehensive conserved coronavirus coronavirus disease COVID-19 CpG CpG suppression defined dinucleotide effective effector Efficiency Environment evaluated Evidence Evolution experiment expressed expression expression levels finger genomic greater Host Human human coronaviruses human lung cells humans I, II IFN IFN-α IFN-γ IFNs immune in viral inhibit SARS-CoV-2 inhibited innate response interferon isoform KHNYN lowest orthologue orthologues pandemic pathogen promote Protein recent reduced restrict Restricted RNA sequences SARS-CoV-2 SARS-CoV-2 replication SARS-CoV-2 RNA sequence significantly suppressed target the SARS-CoV-2 genome therapy Treatment TRIM25 Type viral pathogen ZAP Zinc zoonosis
[DOI] 10.1128/mBio.01930-20 PMC 바로가기 [Article Type] Research Article

Inflammation as a Driver of Prostate Cancer Metastasis and Therapeutic Resistance

Review

Published on 2020-10-152022-10-31
Journal: Cancers [Category] COVID-19,

[키워드] advanced disease Angiogenesis anoikis Aspirin association Bacterial Biomarker biomarker signature Cancer controls Critical cytokine disease Disease progression drug effective effector elevated EMT phenotype Evidence expression facilitate functional Genetic variation growth high mortality rate IL-6 Inflammation Inflammatory Inflammatory cytokine inhibitors lethal disease low dose macrophages malignancy men Metastasis metastatic disease Mortality mutagenic Occurrence Patient patients phenotypic Predictive primary tumor progression promote Prostate Prostate cancer reduce reduction in resistance resulting risk risk reduction simple Support survival survival signaling systemic impact TGF-β therapeutic therapy Treatment treatment resistance tumor microenvironment tumor relapse vascularity viral infections
[DOI] 10.3390/cancers12102984 PMC 바로가기 [Article Type] Review

Antiviral Activity of Type I, II, and III Interferons Counterbalances ACE2 Inducibility and Restricts SARS-CoV-2

Observation

Published on 2020-09-102022-10-29
Journal: mBio [Category] COVID-19, SARS,

[키워드] ACE2 ACE2 mRNA ACE2 protein activity acute respiratory syndrome angiotensin-converting enzyme 2 Antiviral antiviral action antiviral activity antiviral drug antiviral gene approved benefit bronchial epithelial cells canonical Cell cell line clinical trial clinically coronavirus coronavirus disease counterbalance COVID-19 COVID-19 therapeutics Critical cytokine deaths dose-dependent manner Ebola virus Effect effector elevated ENhance entry receptor exacerbate exhibited expression help hepatitis C virus highlight HIV Host human lung I, II IFN IFN treatment IFN-β IFN-γ IFN-λ IFN-λ1 IFNs immune Immunotherapy Infection inhibited Innate immune defense interferon interferons investigated ISG ISG response ISGs limit mechanism mRNA pandemic produced raising receptor receptors repurposing Respiratory Coronavirus SARS-CoV-2 SARS-CoV-2 replication Severe infection Side effects surface protein the SARS-CoV-2 therapy Threats transcript treat Type type I upregulated upregulating virus entry virus replication viruses
[DOI] 10.1128/mBio.01928-20 PMC 바로가기 [Article Type] Observation

A unique bacterial tactic to circumvent the cell death crosstalk induced by blockade of caspase‐8

세포 사멸 교차 대화를 회피하기 위한 독특한 세균 전술, 카스파제-8 차단에 의해 유도됨

Article

Published on 2020-07-132024-07-30
Journal: The EMBO Journal [Category] 세균성이질,

[키워드] Apoptosis Autophagy & Cell Death effector Microbiology, Virology & Host Pathogen Interaction necroptosis Shigella
[DOI] 10.15252/embj.2020104469 PMC 바로가기 [Article Type] Article

The Potential Effect of Novel Coronavirus SARS-CoV-2 on NK Cells; A Perspective on Potential Therapeutic Interventions

Immunology

Published on 2020-07-102022-11-01
Journal: Frontiers in Immunology [Category] COVID-19, MERS, SARS,

Porcine Epidemic Diarrhea Virus and the Host Innate Immune Response

Review

Published on 2020-05-112022-10-28
Journal: Pathogens [Category] COVID-19,

Salmonella Enteritidis Effector AvrA Suppresses Autophagy by Reducing Beclin-1 Protein

살모넬라 엔테리티디스 효과 인자 AvrA는 Beclin-1 단백질을 감소시켜 자가포식을 억제한다.

Original Research

Published on 2020-04-172024-07-29
Journal: Frontiers in immunology [Category] 살모넬라증,

[키워드] autophagy effector Infection organoids Paneth cells
[DOI] 10.3389/fimmu.2020.00686 PMC 바로가기 [Article Type] Original Research