Transparency, health equity, and strategies in state-based protocols for remdesivir allocation and useResearch Article Published on 2021-10-182022-10-28 Journal: PLoS ONE [Category] COVID-19, MERS, SARS, [키워드] absence agency applied approach authorization Clinical use coronavirus disease Critical develop District eligible patient Emergency equity EUA explicit Government Guidance Health identify Inclusion medication objective pandemic Pandemics protocol Public question raised recommendation Remdesivir Result state state health department study period Transparency Treatment website [DOI] 10.1371/journal.pone.0257648 PMC 바로가기 [Article Type] Research Article
An investigation into the beneficial effects of high-dose interferon beta 1-a, compared to low-dose interferon beta 1-a in severe COVID-19: The COVIFERON II randomized controlled trial중증 COVID-19에서 고용량 인터페론 베타 1-a가 저용량 인터페론 베타 1-a에 비해 유익한 효과에 대한 조사: COVIFERON II 무작위 대조 시험Clinical Trial Published on 2021-10-012022-09-11 Journal: International immunopharmacology [Category] 임상, 치료제, [키워드] assigned clinical Clinical improvement clinical trial control group coronavirus disease Coronavirus disease 2019 COVID COVID-19 Effect Effectiveness eligible patient Eligible patients High-dose hospitalized patient hospitalized patients IFN-β IMPROVE improvement injection interferon interferon beta Interferon-beta Interferon-β 1a Intervention intervention group Kaletra Lopinavir Lopinavir/ritonavir low dose low-dose median time moderate moderate to severe Mortality mortality rate mortality rates Patient patients with COVID-19 public health randomization Randomized Randomized controlled trial Randomly receive Recigen reduction Registered Ritonavir SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 infections severe COVID-19 significant effect Subcutaneous subcutaneous injections The COVIFERON therapeutic time treat treated Trial TTCI TTIC twice a day [DOI] 10.1016/j.intimp.2021.107916 PMC 바로가기 [Article Type] Clinical Trial
Use of an antiviral mouthwash as a barrier measure in the SARS-CoV-2 transmission in adults with asymptomatic to mild COVID-19: a multicentre, randomized, double-blind controlled trial무증상에서 경증의 COVID-19가 있는 성인의 SARS-CoV-2 전파에 대한 차단 수단으로 항바이러스 구강 세정제 사용: 다기관, 무작위, 이중 맹검 대조 시험Randomized Controlled Trial Published on 2021-10-012022-09-11 Journal: Clinical microbiology and infection : the official [Category] SARS, 임상, 치료기술, 치료제, [키워드] 1:1 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 antiviral mouthwash appear assigned asymptomatic to mild benefit Citrox Controlled trial coronavirus coronavirus disease Coronavirus disease 2019 Course COVID-19 cyclodextrin decrease demonstrated detect determine disease dose double-blind effective eligible patient first dose greater initial intention-to-treat analysis IQR log median median value Mouthwash multicentre PCR-positive patient per-protocol analysis performed Placebo placebo group Quantitative RT-PCR Randomized Randomized controlled trial Randomly recruited reduce reducing Saliva salivary SARS-CoV-2 SARS-CoV-2 viral load second dose severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 significantly more Support Symptom the placebo group the SARS-CoV-2 Transmission treat Trial Viral load was performed was used β-cyclodextrin. [DOI] 10.1016/j.cmi.2021.05.028 PMC 바로가기 [Article Type] Randomized Controlled Trial
Assessment of an intervention to optimise antenatal management of women admitted with preterm labour and intact membranes using amniocentesis-based predictive risk models: study protocol for a randomised controlled trial (OPTIM-PTL Study)양수천자 기반 예측 위험 모델을 사용하여 조산 및 온전한 막으로 입원한 여성의 산전 관리를 최적화하기 위한 중재 평가: 무작위 대조 시험을 위한 연구 프로토콜(OPTIM-PTL 연구)Article Published on 2021-09-282022-09-11 Journal: BMJ Open [Category] SARS, 임상, [키워드] 24 hour 24 hours added age All participant All participants Amniocentesis amniotic Amniotic cavity Analysis Antenatal Antibiotic therapy Antibiotics approval approved assessment authority Care chorioamnionitis clinical clinical trial conducted control group Corticosteroid Corticosteroids Cost analysis database Device doses doses of corticosteroids dropout rate drug eligible patient Ethics ethics committee EudraCT European European Union Drug Regulating Authorities Clinical Trials database evaluated fetal fetal medicine finding gestational age high risk highest hospital discharge Hospital stay identification identification number institutional protocols Intervention intervention arm Invasion majority management maternal medicine Medical devices medication Medicine Medicines membrane microbial multicentre observé Occurrence overtreatment peer-reviewed power power of 80% Predictive Pregnancy Primary outcome randomisation randomised randomised controlled trial receiving reducing reduction reduction in Registered Regulating required risk secondary outcome Secondary outcomes Spanish stratified Study protocol Trial two-sided type I type I error Ultrasonography union while women written Informed Consent [DOI] 10.1136/bmjopen-2021-054711 PMC 바로가기 [Article Type] Article
Influenza vaccine uptake among at-risk adults (aged 16–64 years) in the UK: a retrospective database analysisResearch Published on 2021-09-242022-10-28 Journal: BMC Public Health [Category] Coronavirus, SARS, [키워드] ambition Analysis At-risk clinical benefit clinical risk Complication complications conducted Coverage COVID-19 database defined eligible patient England group groups Healthcare professional high risk highest increased risk individual Influenza influenza vaccination influenza vaccine International Ireland lowest measure National obesity Patient patients patients with diabete pregnant women professional Public Health England receiving recommendations Result retrospective Retrospective analysis targets uptake vaccination vaccination coverage rate Vaccine Variation [DOI] 10.1186/s12889-021-11736-2 PMC 바로가기 [Article Type] Research
Safety and preliminary efficacy of sequential multiple ascending doses of solnatide to treat pulmonary permeability edema in patients with moderate-to-severe ARDS—a randomized, placebo-controlled, double-blind trial중등도에서 중증 ARDS 환자의 폐 투과성 부종을 치료하기 위해 순차적으로 다중 상승하는 solnatide의 안전성 및 예비 효능 - 무작위, 위약 대조, 이중 맹검 시험Randomized Controlled Trial Published on 2021-09-202022-09-10 Journal: Trials [Category] SARS, 비임상, 임상, [키워드] acquisition acute respiratory distress syndrome administer alveolar animal model animal models ARDS ARDS patients breath clinical Clinical diagnosis clinical trial collected comatose complex Course Critical care data safety monitoring board decarboxylation diffusion distress dose double-blind double-blind trial edema Efficacy eligible patient Eligible patients Endpoint etiologies EU Clinical Trials EudraCT Extravascular lung water follow-up period for inclusion healthy Human Inclusion Informed consent Inhaled Intervention leads mechanical ventilation moderate moderate to severe monitoring board multiple ascending dose Oxygenation parallel group Particular pathway Patient patient safety peptide phase Phase I clinical trial Placebo placebo-controlled protocol Pulmonary edema pulmonary permeability Randomized receiving reduce Registered respiratory distress Respiratory distress syndrome Safe Safety sedated severe ARDS shown sick Solnatide syndrome treat Trial Trial registration [DOI] 10.1186/s13063-021-05588-9 PMC 바로가기 [Article Type] Randomized Controlled Trial
Elaboration of a Radiomics Strategy for the Prediction of the Re-positive Cases in the Discharged Patients With COVID-19Medicine Published on 2021-09-162022-10-31 Journal: Frontiers in Medicine [Category] COVID-19, [키워드] Accuracy Administered Admission Algorithm average age Chest CT China Chongqing clinical factor clinical feature collected Computed tomography COVID-19 COVID-19 case COVID-19 patient Critical database determine discharge discharged eligible patient enrolled Enrollment feature female IMPROVE Isolation male material Nasopharyngeal swab Patient Precision prediction Predictive protocols Radiomics re-positive cases recovered COVID-19 patient recursive feature elimination required RT-PCR test SARS-CoV-2 test selected shown significant differences Strategy student subset Support t -test the SARS-CoV-2 Three Gorge were used [DOI] 10.3389/fmed.2021.730441 PMC 바로가기 [Article Type] Medicine
Weekly 17 alpha-hydroxyprogesterone caproate to prevent preterm birth among women living with HIV: a randomised, double-blind, placebo-controlled trial주간 17 Alpha-HydroxyProgesterone CABROATE HIV를 가진 여성들 사이에서 조산을 예방하기위한 : 무작위, 이중 맹검, 위약 대조 시험Articles Published on 2021-09-092022-09-06 Journal: The Lancet. HIV [Category] Communicable Disease, [키워드] 1:1 17P 95% CI adherence adverse event adverse events age Anomaly antenatal care Antiretroviral therapy assessments assigned available data baseline characteristics both groups Cervical cerclage Characteristics Complete Composite criteria District double-blind drug during pregnancy early delivery Eligible participants eligible patient Eligible patients enrolled event Evidence evidence of except for exclusion criteria fetal Final finding Follow-up for inclusion foundation funding gestation gestational age group groups HIV infection HIV-1 infection in both groups in some increased risk injection Intention intention to treat intramuscular investigated less Melinda Gate Melinda Gates membrane miscarriage occurred Older participant Participants Patient Placebo placebo-controlled trial Pregnancy pregnant women Preterm birth Prevent Primary outcome proportion provided random assignment randomisation randomised Randomly receive receiving reduce Registered Relative risk reported risk risk difference Safe Serious Adverse Event Serious Adverse Events shown Stillbirth study drug Support Teaching treatment group treatment groups Trial university uterine Weekly were excluded with HIV women written Informed Consent [DOI] 10.1016/S2352-3018(21)00150-8 PMC 바로가기 [Article Type] Articles
Efficacy and safety of intramuscular administration of allogeneic adipose tissue derived and expanded mesenchymal stromal cells in diabetic patients with critical limb ischemia with no possibility of revascularization: study protocol for a randomized controlled double-blind phase II clinical trial (The NOMA Trial)혈관재생 가능성이 없는 위독한 사지 허혈이 있는 당뇨병 환자에서 동종 지방 조직 유래 및 확장 중간엽 기질 세포의 근육내 투여의 효능 및 안전성: 무작위 대조 이중 맹검 2상 임상 시험을 위한 연구 프로토콜(The NOMA Trial)Study Protocol Published on 2021-09-062022-09-10 Journal: Trials [Category] SARS, 비임상, 임상, [키워드] adipose Adipose tissue Adipose-derived mesenchymal stromal cells Administered administration Advanced therapy medicinal products adverse event adverse events Allogeneic Angiogenesis animal model animal models antiplatelet assigned breath Cell Cell therapy chronic clinical development Clinical practice clinical trial control group Critical Critical limb ischemia current data set demonstrated develop diabetes Diabetes Mellitus diabetic patient dose double-blind Efficacy eligible patient evaluate evaluated feasibility Health Organization health problem humans IMPROVE induce intramuscular Ischemia life limb lower limb Mesenchymal stromal cells multicenter outcome parameters Patient Phase II clinical trial placebo-controlled trial Primary outcome protocol public health Quality of life Randomized Randomly Registration Research revascularization secondary Secondary outcomes shown statins step stromal cell stromal cells study period Study protocol Tertiary the disease therapeutic therapeutic option therapeutic options therapy tissue tissue perfusion Treatment treatment group Trial registration type 2 diabete Type 2 diabetes mellitus World Health Organization [DOI] 10.1186/s13063-021-05430-2 PMC 바로가기 [Article Type] Study Protocol
Aspirin Is Related to Worse Clinical Outcomes of COVID-19Observational Study Published on 2021-09-042022-10-04 Journal: Medicina [Category] SARS, 임상, [키워드] adverse effect applied Aspirin association baseline characteristics clinical coronavirus disease COVID-19 COVID-19 patients COVID-19 test COVID-19 testing death death rate Diagnosis eligible eligible patient evaluated higher risk insurance intensive care investigated Korean material mechanical ventilation mechanism not significantly different objective Observational cohort study outcome Oxygen therapy Pain Patient Primary outcome propensity score matching reduce retrospective secondary outcome South Korea System was related [DOI] 10.3390/medicina57090931 PMC 바로가기 [Article Type] Observational Study