Humoral and Cellular Responses to COVID-19 Vaccines in SARS-CoV-2 Infection-Naïve and -Recovered Korean IndividualsArticle Published on 2022-02-182022-10-28 Journal: Vaccines [Category] COVID-19, [키워드] antibody Antibody Response BNT162b2 Complete convalescent COVID-19 COVID-19 vaccination COVID-19 vaccine dose ELISA ELISPOT evaluated IFN-γ ELISPOT immune response increase in individual individuals Korean mRNA-1273 mRNA-1273 vaccine much lower no significant difference pseudotyped pVNT50 regimen regimens required response S1 IgG SARS-CoV-2 SARS-COV-2 infection significantly higher single dose the mean the vaccine Vaccination strategy Vaccine vaccinee virus-neutralizing antibody were measured [DOI] 10.3390/vaccines10020332 PMC 바로가기 [Article Type] Article
T Cell Response following Anti-COVID-19 BNT162b2 Vaccination Is Maintained against the SARS-CoV-2 Omicron B.1.1.529 Variant of ConcernBrief Report Published on 2022-02-082022-10-28 Journal: Viruses [Category] COVID-19, COVID19(2023년), Fulltext, MERS, SARS, [키워드] addition Administered affected antigenic drift B.1.1.529 BNT162b2 carried Cell cells collected comparable concern COVID-19 COVID-19 pandemic dominant Efficacy eight ELISPOT examined fluorescent FluoroSpot form healthy volunteer IL-10 IL-4 Immunity individuals Maintained manifested mononuclear cell omicron overlapping PBMC peptide Peripheral blood progression Protective protective immunity reactivity reduced representing response SARS-CoV-2 SARS-CoV-2 virus variants secreting severe disease manifestations significantly Spike protein stimulated T cell T cell response T cell responses tested Th1 response the SARS-CoV-2 vaccination Vaccines variant variants of concern VoC wild-type Wuhan-1 [DOI] 10.3390/v14020347 PMC 바로가기 [Article Type] Brief Report
Children and Adults With Mild COVID-19: Dynamics of the Memory T Cell Response up to 10 Months경증 COVID-19가 있는 어린이 및 성인: 최대 10개월까지 기억 T 세포 반응의 역동성Clinical Trial Published on 2022-02-072022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, 임상, 치료기술, 치료법, [키워드] activated Activation acute respiratory syndrome acute respiratory syndrome coronavirus Adaptive immunity Adults Analysis Antibody Response Antigen CD4 Cell cellular children Concentration concentrations contribute controls Coronavirus-2 correlated Course COVID-19 Cytokines detectable determine develop Dynamics effective effector memory ELISPOT exposure to frequencies heat heat-inactivated IFN-γ IFN-γ ELISPOT IgG immune memory infected children infections Longitudinal assessment marker memory T memory T cell Mild mild SARS-CoV-2 infection mild symptoms Mild-to-moderate moderate moderate symptoms Month Nucleocapsid proteins overlapping PBMC PBMCs peptide peptides performed Peripheral blood peripheral blood samples recall reduced Reinfection respiratory response Result SARS-CoV-2 SARS-CoV-2 antigens SARS-COV-2 infection SARS-CoV-2-specific T cell SARS-CoV-2-specific T cells serum antibody severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus-2 significantly Stimulation symptom onset Symptoms T cell T cell immunity T cell response T cells Th1 phenotype [DOI] 10.3389/fimmu.2022.817876 PMC 바로가기 [Article Type] Clinical Trial
Immune responses following the first dose of the Sputnik V (Gam-COVID-Vac)Sputnik V의 첫 번째 용량 (Gam-Covid-Vac) 이후의 면역 반응Comparative Study Published on 2022-02-022022-09-01 Journal: Scientific Reports [Category] COVID19(2023년), MERS, SARS, 바이오마커, 진단, [키워드] ACE2 receptor Adaptive immunity administration antibodies antibody Antimicrobial responses AZD1222 B.1.1.7 B.1.351 B.1.617.2 CD107a Cell ELISPOT ELISpot responses Ex vivo expressing first dose Frequency Gam-COVID-Vac IFNγ immunogenic immunogenicity immunology in some Infection Infectious diseases investigated Lymphocytes memory B memory B cell Microbiology Molecular medicine naïve individuals natural infection Receptor binding domain response responses second dose seroconversion rate seroconverted significantly higher significantly lower single dose T cell T cells titre Vaccine Vaccines [DOI] 10.1038/s41598-022-05788-6 PMC 바로가기 [Article Type] Comparative Study
Development of an in-house SARS-CoV-2 interferon-gamma ELISpot and plate reader-free spot detection method자체 SARS-CoV-2 인터페론 감마 ELISpot 및 플레이트 리더 프리 스팟 검출 방법 개발Article Published on 2022-02-012022-09-11 Journal: Journal of virological methods [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Analysis Antigen antigens automated Concentration convalescent coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 disease COVID-19 disease severity COVID-19 pandemic demonstrated detect development diagnostic effective elicited ELISPOT enzyme enzyme-linked immunospot IFN-γ Immunity Infection Interferon-gamma mononuclear cell mononuclear cells multiple antigen Neutralising Antibodies peptide Peripheral blood Peripheral blood mononuclear cells plate reader quantified reliability Research respiratory response SARS-CoV-2 SARS-CoV-2-specific T cells severe acute respiratory syndrome Coronavirus stimulate T cell T cell response T cell responses T cells vaccination Volunteer volunteers [DOI] 10.1016/j.jviromet.2021.114398 PMC 바로가기 [Article Type] Article
Covid-19 in patients with chronic lymphocytic leukemia: clinical outcome and B- and T-cell immunity during 13 months in consecutive patients만성 림프구성 백혈병 환자의 코로나19: 연속 환자에서 13개월 동안 임상 결과 및 B 세포 및 T 세포 면역Article Published on 2022-02-012022-09-11 Journal: Leukemia [Category] COVID19(2023년), MERS, SARS, 유전자 메커니즘, 진단, 치료기술, [키워드] Admission admitted to ICU age Analysis anti-SARS-CoV-2 antibodies anti-SARS-CoV-2 antibody antibody BMI Clinical outcome CLL CLL patient CLL patients consecutive patient death detectable eight ELISPOT Gender Hospitalization hospitalizations Hospitalized ICU admission Immunity immunological indolent median age MOST Multivariate analysis Neutralizing antibodies neutralizing antibody occurred outcome pandemic Patient patients reduced remained risk factor robust Saliva Seroconversion severe COVID-19 subgroup subgroups T cell T-cell T-cell immunity T-cells therapy [DOI] 10.1038/s41375-021-01424-w PMC 바로가기 [Article Type] Article
SARS-CoV-2 memory B and T cell profiles in mild COVID-19 convalescent patients경증 COVID-19 회복기 환자의 SARS-CoV-2 기억 B 및 T 세포 프로필Article Published on 2022-02-012022-09-11 Journal: International Journal of Infectious Diseases [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 adaptive adaptive cellular immunity Analysis Anti-spike anti-Spike IgG cellular immunity convalescent Convalescents coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 convalescent patient cross-sectional declined demonstrated determined by disease onset ELISA ELISPOT evaluated first visit Frequency Humoral immunity IFN-γ IgG IL2 Immunity interferon gamma interleukin interleukin 2 long-lasting longitudinal longitudinal analysis longitudinal study magnitude MBC median memory B memory B cell memory B cells memory T cell memory T cells Mild Patient peptide peptide pools performed post infection profile RBD Receptor binding domain respiratory response SARS-CoV-2 SARS-CoV-2 anti-spike IgG SARS-COV-2 infection severe acute respiratory syndrome Coronavirus Significant T cell T cells was determined [DOI] 10.1016/j.ijid.2021.12.309 PMC 바로가기 [Article Type] Article
Evaluation of the Immune Response Induced by CoronaVac 28-Day Schedule Vaccination in a Healthy Population Group건강한 인구집단에서 CoronaVac 28일 일정 예방접종으로 유도된 면역 반응 평가Immunology Published on 2022-01-312022-09-11 Journal: Frontiers in Immunology [Category] 바이오마커, 진단, [키워드] administration Analysis anti-spike antibodies anti-spike antibody Cell cellular Cellular immune response cellular immune responses CoronaVac COVID-19 Effectiveness ELISPOT evaluate granzyme granzyme B group herd immunity Hospitalization humoral immune response IFN-gamma immune memory immune response immune responses immunization Immunological memory increase in induce induced life memory Negative PCR Neutralizing Neutralizing antibodies Population recruited response robust SARS-CoV-2 SARS-CoV-2 spike protein schedule Science Sinovac Spike protein vaccination schedule Vaccine Volunteer [DOI] 10.3389/fimmu.2021.766278 PMC 바로가기 [Article Type] Immunology
Immunogenicity of ChAdOx1 nCoV-19 Booster Vaccination Following Two CoronaVac Shots in Healthcare WorkersArticle Published on 2022-01-302022-10-28 Journal: Vaccines [Category] COVID-19, [키워드] Administered All participant Analysis anti-Spike IgG B cell baseline blood sample booster booster dose Cellular immune response cellular immunity ChAdOx1 ChAdOx1 nCoV-19 CoronaVac COVID-19 COVID-19 pandemic Decline dose early phase ELISA ELISPOT evaluate function healthcare healthcare worker humoral Humoral immunity IgG Immunity immunogenicity indicated neutralizing antibody PROTECT provided random SARS-CoV-2 significantly higher stratified T cell third dose Twenty participant vaccination Vaccine Vaccines were measured worker [DOI] 10.3390/vaccines10020217 PMC 바로가기 [Article Type] Article
Antigen Specific Humoral and Cellular Immunity Following SARS-CoV-2 Vaccination in ANCA-Associated Vasculitis Patients Receiving B-Cell Depleting TherapyB 세포 고갈 요법을 받는 ANCA 관련 혈관염 환자에서 SARS-CoV-2 백신 접종 후 항원 특이적 체액 및 세포 면역Immunology Published on 2022-01-282022-09-11 Journal: Frontiers in Immunology [Category] 진단, 치료법, [키워드] ANCA-associated vasculitis anti-CD20 anti-CD20 therapy anti-SARS-CoV-2 Anti-spike antibody assays B-cell B-cells cellular Cellular immune response characterized control subjects controls COVID-19 vaccination elicit ELISPOT enzyme-linked immunosorbent humoral humoral immune response Humoral response immune responses immunoassays interferon lack mounted Patient patients peptide peptide pool positive Protective protective effect receiving Receptor binding domain recovered patient Research response rituximab robust S glycoprotein SARS-CoV-2 SARS-CoV-2 vaccination Specific Specific T-cell response subject subjects subunit T-cell immunity T-cell Response T-cell responses targeted therapy vaccination Vaccine vaccine response Vasculitis were measured [DOI] 10.3389/fimmu.2022.834981 PMC 바로가기 [Article Type] Immunology