Exploring the Binding Mechanism of PF-07321332 SARS-CoV-2 Protease Inhibitor through Molecular Dynamics and Binding Free Energy Simulations분자 역학 및 결합 자유 에너지 시뮬레이션을 통한 PF-07321332 SARS-CoV-2 프로테아제 억제제의 결합 메커니즘 탐색Article Published on 2021-08-242022-09-10 Journal: International Journal of Molecular Sciences [Category] SARS, 치료제, [키워드] α-ketoamide 3CL pro 3CL Protease affinity Analysis Antiviral binding binding affinity binding energy binding mechanism calculated catalytic dyad caused chymotrypsin complexes Compound coronavirus coronavirus disease COVID-19 Cys145 demonstrated disrupt docking Dynamics energy Free global public health His41 Interaction Ligand Lopinavir LOPINAVIR AND RITONAVIR low potency main protease MD simulation molecular Novel coronavirus novel coronavirus disease optimization PF-07321332 protease remained residue respiratory Respiratory Coronavirus Ritonavir SARS-CoV-2 SARS-CoV-2 protease severe acute respiratory coronavirus severe acute respiratory coronavirus 2 Simulation trajectory [DOI] 10.3390/ijms22179124 PMC 바로가기 [Article Type] Article
Using Privacy Respecting Sound Analysis to Improve Bluetooth Based Proximity Detection for COVID-19 Exposure Tracing and Social Distancing개인 정보 존중 사운드 분석을 사용하여 COVID-19 노출 추적 및 사회적 거리두기에 대한 Bluetooth 기반 근접 감지 개선Article Published on 2021-08-202022-09-10 Journal: Sensors (Basel, Switzerland) [Category] MERS, SARS, 치료기술, [키워드] adaptive ambient Analysis approach approaches Bluetooth can be used Characteristics complement complexity Contact tracing COVID-19 Critical detection determined by directions distance dominant energy evaluated experiment exposure feature fused future work high accuracy highlighting IMPROVE Indicator information intensity limitation mobile device privacy proximity detection radio Radio Frequency Received receiver signal sound sound intensity sound similarity strength tracing transmitter turn Variation weighted voting [DOI] 10.3390/s21165604 PMC 바로가기 [Article Type] Article
Protein and Energy Intake Assessment and Their Association With In-Hospital Mortality in Critically Ill COVID-19 Patients: A Prospective Cohort StudyNutrition Published on 2021-08-192022-10-31 Journal: Frontiers in Nutrition [Category] COVID-19, [키워드] 95% CI actual acute phase adjusted alleviate APACHE II assessment association Comorbidity Course COVID-19 COVID-19 patients Critically ill Critically ill patient Day disease severity energy Energy intake ICU ICU admission Ill in-hospital mortality indicated intake lower risk Mortality non-survivor Non-survivors nutritional intake Patient patients patients with COVID-19 Prospective prospective observational cohort Protein reached recommendation significantly statistically significant difference subset survival survivor the patient with COVID-19 [DOI] 10.3389/fnut.2021.708271 PMC 바로가기 [Article Type] Nutrition
Promising inhibitors of main protease of novel corona virus to prevent the spread of COVID-19 using docking and molecular dynamics simulation도킹 및 분자 역학 시뮬레이션을 사용하여 COVID-19의 확산을 방지하기 위해 새로운 코로나 바이러스의 주요 프로테아제의 유망한 억제제Article Published on 2021-08-012022-08-31 Journal: Journal of biomolecular structure & dynamics [Category] MERS, SARS, 치료제, [키워드] 2019-nCoV Antiviral best binding energy caused change China complexes Compound compounds coronavirus coronavirus disease coronavirus disease-2019 COVID-19 determine docking Efficiency energy health emergency Human in silico Approach Infection Infectious disease inhibit inhibitor inhibitors lead matter MD simulations MM-GBSA molecular dynamics Molecular dynamics simulation molecular dynamics simulations novel corona virus Novel coronavirus pandemic parameter performed Prevent protease room temperature SARS-CoV-2 SARS-COV-2 infection screened Spread spread of COVID-19 temperature thermodynamic Till Viral viral replication virus was determined WHO Wuhan Zinc ZINC database [DOI] 10.1080/07391102.2020.1779131 PMC 바로가기 [Article Type] Article
The evolution of genetic counseling graduate education in New York City during the COVID-19 pandemic: In the eye of the stormCOVID-19 전염병 동안 뉴욕시에서 유전 상담 대학원 교육의 진화: 폭풍의 눈 속에서Article Published on 2021-08-012022-09-11 Journal: Journal of genetic counseling [Category] 유전자 메커니즘, [키워드] Admission change changes in counseling Course COVID-19 COVID-19 pandemic curriculum desire education energy Enrollment event Evolution flexibility flexible Genetic Genetic counseling globe Health profession identify implication improvement iterative life New York City outcome measures pandemic practitioner-based enquiry profession Program evaluation reactivity recruitment reduced relative required retention returned summer telehealth United State United States [DOI] 10.1002/jgc4.1461 PMC 바로가기 [Article Type] Article
Energy requirements of long-term ventilated COVID-19 patients with resolved SARS-CoV-2 infectionObservational Study Published on 2021-08-012022-10-05 Journal: Clinical nutrition ESPEN [Category] SARS, 임상, [키워드] accompanied acute respiratory distress acute respiratory syndrome applicability average Bland-Altman plot calculated caused Clinical data coronavirus Coronavirus disease 2019 COVID-19 COVID-19 patient Critical care critically ill patients energy Energy expenditure Energy requirement evaluate evaluated examined gold standard Guidance hospitalized patients ICU independent Indirect calorimetry individual Infection intensive care intensive care units Invasive mechanical ventilation longitudinal management mechanically ventilated morbidity and mortality multi-organ failure Negative PCR Patient per day performed Predictive Predictive equations Resolution resolved resting retrieved retrospective SARS-CoV-2 SARS-COV-2 infection significantly significantly increased single-center study syndrome therapy Treatment Variation Ventilated were used [DOI] 10.1016/j.clnesp.2021.06.016 PMC 바로가기 [Article Type] Observational Study
Receptor Interactions of Angiotensin II and Angiotensin Receptor Blockers—Relevance to COVID-19Article Published on 2021-07-032022-10-28 Journal: Biomolecules [Category] COVID-19, [키워드] absence ACE2 Activation analogue Ang II angiotensin Angiotensin II angiotensin receptor blocker applied ARB ARBs Arg Artery AT1 AT1R binding blocker candesartan carried charge relay system clinical study COVID-19 COVID19 CRS cumulative cytokine determine disease dose Effect energy EXP3174 explain hypertensive patient implicated infected with SARS-CoV-2 negative charge protective effect provided recent receptor reducing SARS-CoV-2 sartans shown therapy Treatment vasoconstriction [DOI] 10.3390/biom11070979 PMC 바로가기 [Article Type] Article
Comparison of seven commercial SARS-CoV-2 rapid point-of-care antigen tests: a single-centre laboratory evaluation study7 개의 상업용 SARS-COV-2 빠른 시점 항원 테스트 비교 : 단일 센터 실험실 평가 연구Articles Published on 2021-07-012022-09-06 Journal: The Lancet. Microbe [Category] Communicable Disease, MERS, SARS, 치료기술, [키워드] 95% CI Abbott Abbott Panbio COVID-19 Ag Rapid Test accelerate Affair AgPOCT AgPOCTs analytical sensitivity Antigen Antigen point-of-care test assays Biocredit COVID-19 Ag Care cassette Cell culture clinical sample clinical samples Concentration coronavirus Coronaviruses COVID-19 COVID-19 Ag Respi-Strip cross-reactivity cumulative Cumulative specificities Cumulative specificity Decision making Endemic endemic human coronavirus energy evaluated False-positive results finding FIVE foundation funding generate HCoV HCoV-HKU1 supernatant HCoV‑229E HCoV‑HKU1 HCoV‑NL63 HCoV‑OC43 Healgen Healgen assay Healgen Coronavirus Ag Rapid Test Cassette Health Health care healthy volunteer healthy volunteers Horizon Infection infectious Laboratory limit of detection Melinda Gate Melinda Gates MERS MERS-CoV Ministry of Health Most patients nal von minden nal von minden NADAL COVID-19 Ag Test outlier overlap PanBio Pathogens Patient patients point-of-care positive public health quantified R-Biopharm ranged Rapid Rapid test RapiGEN RapiGEN BIOCREDIT COVID-19 Ag real-time RT-PCR recombinant SARS-CoV-2 nucleoprotein Research respiratory respiratory pathogen Respiratory pathogens Respiratory samples RIDA Roche Roche-SD Biosensor Roche-SD Biosensor SARS-CoV Rapid Antigen Test RT-PCR SARS-CoV SARS-CoV-2 SARS-CoV-2 antigen SARS-CoV-2 testing SARS-CoV-2 viral load SARS-CoV-2 viral loads sensitivity Seven specificity stored respiratory sample stored respiratory samples Swab Symptoms Test test results tissue culture tissue culture supernatant tissue culture supernatants utility Viral Viral concentration Viral load viral loads virus concentration [DOI] 10.1016/S2666-5247(21)00056-2 PMC 바로가기 [Article Type] Articles
Changes in Domestic Energy and Water Usage during the UK COVID-19 Lockdown Using High-Resolution Temporal DataArticle Published on 2021-06-252022-10-30 Journal: International Journal of Environmental Research an [Category] Coronavirus, MERS, SARS, [키워드] change changes in Compliance COVID-19 COVID-19 outbreak electricity usage energy gas usage Government Guidance implication lockdown lockdowns no difference pandemic provided public health sensors Temporal Temporal resolution Usage utility water water usage [DOI] 10.3390/ijerph18136818 PMC 바로가기 [Article Type] Article
Changes in the global impact of COVID-19 on nuclear medicine departments during 2020: an international follow-up surveyOriginal Article Published on 2021-06-192022-10-31 Journal: European Journal of Nuclear Medicine and Molecular [Category] COVID-19, MERS, SARS, [키워드] analysed carried change collected data conducted COVID-19 determine diagnostic distributions energy Follow-up global impact greater heterogeneous International less material nuclear nuclear medicine pandemic pet platform questionnaire recorded Region Regional remained response Result secure significant decrease significantly supplementary material survey therapeutic Volume was collected [DOI] 10.1007/s00259-021-05444-7 PMC 바로가기 [Article Type] Original Article