Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of nsp14/nsp10 exoribonucleaseBiochemical Techniques & Resources Published on 2021-07-162022-10-28 Journal: Biochemical Journal [Category] COVID-19, Fulltext, SARS, [키워드] Antiviral compound Antiviral treatment antiviral treatments antivirals approach approved biochemical assay cofactor Compound contributing to coronavirus COVID-19 effective enzymatic activity identify identifying in vitro inhibit inhibitor inhibitors non-structural protein nsp14 nsp14 exoribonuclease pandemic patulin proliferation purified Remdesivir replication of SARS-CoV-2 Research SARS-CoV-2 screened small molecule inhibitor Spread target therapeutic viral genome replication [DOI] 10.1042/BCJ20210198 PMC 바로가기 [Article Type] Biochemical Techniques & Resources
Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of nsp12/7/8 RNA-dependent RNA polymeraseBiochemical Techniques & Resources Published on 2021-07-162022-10-28 Journal: Biochemical Journal [Category] COVID-19, Fulltext, SARS, [키워드] acute respiratory syndrome Antiviral compound antiviral efficacy approach approved biochemically catalytic complex complexes Compound coronavirus coronavirus disease CoV COVID-19 drug effective enzymatic activity expressed global pandemic growth homologue host cells human cells identify identifying in viral in vitro inhibitor inhibitors lack MONITOR Nsp12 pandemic pharmacological public health purified RdRP Replication repurposing Research RNA virus RNA-dependent RNA polymerase RTC safety profile SARS-CoV-2 SARS-CoV-2 RdRp sequence single-stranded positive-sense small molecule inhibitor Suramin target [DOI] 10.1042/BCJ20210200 PMC 바로가기 [Article Type] Biochemical Techniques & Resources
High-Throughput Screening and Quantum Mechanics for Identifying Potent Inhibitors Against Mac1 Domain of SARS-CoV-2 Nsp3SARS-CoV-2 Nsp3의 Mac1 도메인에 대한 강력한 억제제를 식별하기 위한 고성능 스크리닝 및 양자 역학Article Published on 2021-07-012022-09-11 Journal: IEEE/ACM transactions on computational biology and [Category] SARS, 치료제, [키워드] acceptor ADP-ribose ADP-ribosylation Against Antiviral antiviral activity binding binding pocket compounds conserved coronavirus CoV database docking domain Donor drug target electron donor ENCODE enzymatic activity enzyme host response identifying inhibitor inhibitors Interaction Mac1 Mechanics molecular dynamics mono nonstructural protein 3 Nsp3 other coronaviruses pathogenicity phosphate potent protein 3 provide quantum regions Regulatory residue ribose SARS-CoV-2 Screening substrate Tight binding unique viral infections virulence virulence factor Zinc [DOI] 10.1109/TCBB.2020.3037136 PMC 바로가기 [Article Type] Article
Emerging Evidence for Pleiotropism of EosinophilsReview Published on 2021-06-302022-10-29 Journal: International Journal of Molecular Sciences [Category] COVID-19, MERS, SARS, [키워드] acute respiratory syndrome allergies Asthma Bacteria biologic treatment Blood Bone marrow complex coronavirus SARS-CoV-2 described detrimental Developing disease disorder effective response effector enzymatic activity eosinophil eosinophil extracellular traps eosinophils esophagitis example Exosome extracellular DNA Factors function gastrointestinal tract GM-CSF granulocyte homeostasis human physiology IL-5 immune immune defense immune responses Immunity involved liver lung Macrophage mammary mechanism monoclonal antibody organ organs parasites Pathologies pathophysiologic pleiotropic Pleiotropism regulatory cell respond Skeletal muscle specific treatment sub-phenotypes surface receptors sustained these cell tissue homeostasis Treatment viral pathogen [DOI] 10.3390/ijms22137075 PMC 바로가기 [Article Type] Review
De novo ssRNA Aptamers against the SARS-CoV-2 Main Protease: In Silico Design and Molecular Dynamics SimulationSARS-CoV-2 주요 프로테아제에 대한 새로운 ssRNA 앱타머: In Silico 설계 및 분자 역학 시뮬레이션Article Published on 2021-06-262022-09-10 Journal: International Journal of Molecular Sciences [Category] MERS, SARS, 신약개발, 진단, 치료법, [키워드] 3D structure Algorithm approaches aptamer aptamer-protein free energy calculation aptamer-protein interaction aptamers virtual screening best binding free energy conformation coronavirus Coronavirus replication COVID-19 COVID-19 disease Dynamics enzymatic activity enzyme free energy Genetic Genetic algorithm highest inhibit SARS-CoV-2 initial Interaction M pro molecular Perspective prediction of 3D RNA aptamer structure protease Protein RNA SARS-CoV-2 sequence Simulation single strand RNA aptamer ssRNA the SARS-CoV-2 the strongest therapeutic drug was selected [DOI] 10.3390/ijms22136874 PMC 바로가기 [Article Type] Article
A metal ion orients SARS-CoV-2 mRNA to ensure accurate 2′- O methylation of its first nucleotideArticle Published on 2021-06-022022-10-04 Journal: Nature Communications [Category] SARS, 변종, 치료제, [키워드] binding complex conformational change convert enzymatic activity enzyme evade help host cell host cells identify immune Methylation modify mRNA Multienzyme complexes nucleotide observé outbreak representing RNA SARS-CoV SARS-CoV-2 Structure Surveillance transcribed twisting unique variant of SARS-CoV-2 virus X-ray crystallography [DOI] 10.1038/s41467-021-23594-y PMC 바로가기 [Article Type] Article
Persistently Increased Systemic ACE2 Activity Is Associated With an Increased Inflammatory Response in Smokers With COVID-19Physiology Published on 2021-05-282022-10-31 Journal: Frontiers in Physiology [Category] COVID-19, [키워드] ACE2 activity Affect analyzed angiotensin cardiopulmonary diseases changes in conducted controls CoV COVID-19 COVID-19 infection COVID-19 pathogenesis COVID-19 patient COVID-19 patients cytokine levels demonstrated determine enzymatic activity enzyme activity Eotaxin furin healthy healthy controls IL-9 Immunity increase in Increased Infection infectious agent Inflammation Inflammatory cytokine involved lipid mediator Lung injury MCP-1 Multiplex assay outcome Pathogenesis pathogenesis of COVID-19 Patient patients patients with COVID-19 peptide positive progression Proteins pulmonary disease response serum serum sample serum samples significantly significantly increased smoker Smokers smoking subject susceptible systemic systemic inflammatory marker systemic level Tobacco weakened [DOI] 10.3389/fphys.2021.653045 PMC 바로가기 [Article Type] Physiology
Unconventional viral gene expression mechanisms as therapeutic targets Reviews Published on 2021-05-192022-10-05 Journal: Nature [Category] 치료제, [키워드] antiviral therapies coding Efficiency effort enzymatic activity enzyme Factor Genome Host Human genome mechanism Perspective protein expression provide regulatory sequences review targeting therapeutic target Transcription translation translational unique viral gene expression virus viruses [DOI] 10.1038/s41586-021-03511-5 [Article Type] Reviews
Analysis of the Evolution of Pandemic Influenza A(H1N1) Virus Neuraminidase Reveals Entanglement of Different Phenotypic CharacteristicsResearch Article Published on 2021-05-112023-06-08 Journal: mBio [Category] Fulltext, 신종인플루엔자, [키워드] antigenicity enzymatic activity influenza A virus neuraminidase [DOI] 10.1128/mBio.00287-21 PMC 바로가기 [Article Type] Research Article
The dimer-monomer equilibrium of SARS-CoV-2 main protease is affected by small molecule inhibitorsSARS-CoV-2 주요 프로테아제의 이량체-단량체 평형은 소분자 억제제에 의해 영향을 받습니다Article Published on 2021-04-292022-09-10 Journal: Scientific Reports [Category] MERS, SARS, 유전자 메커니즘, 치료제, [키워드] Affect affected angle antiviral drug Biophysics cleave Computational biology and bioinformatics coronavirus coronavirus SARS-CoV-2 COVID-19 pandemic Dissociation constant Drug discovery enzymatic activity etiological agent feature functional homodimer information inhibitor knowledge leads M pro maturation Molecular biology molecular mechanism opposite polyproteins protease protein concentration residue SARS-CoV-2 SARS-CoV-2 main protease selected small molecule small molecule inhibitor Small molecules solution temperature therapeutic intervention thermodynamic Thermodynamics Virtual screening X-ray [DOI] 10.1038/s41598-021-88630-9 PMC 바로가기 [Article Type] Article