Ablation of CD8+ T cell recognition of an immunodominant epitope in SARS-CoV-2 Omicron variants BA.1, BA.2 and BA.3Article Published on 2022-10-272022-11-15 Journal: Nature Communications [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] Ablation addition affected Antigen CD8 CD8+ T cell changes in convalescent COVID-19 demonstrated epitope genetics Immunity immunodominant less leukocyte neutralization observation omicron raised recognize reduction in SARS-CoV-2 sequence suggested T cell T cell response T cell responses T cells the SARS-CoV-2 vaccinated individuals Vaccine-induced immunity variant [DOI] 10.1038/s41467-022-34180-1 PMC 바로가기
Towards the development of an epitope-focused vaccine for SARS-CoV-2Article Published on 2022-10-262022-11-15 Journal: Vaccine [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] antibodies BALB/c mice CD8+ T cell COVID-19 deficiency disease DNA effective effort epitope expression hamster hamsters IFN-γ immunogenic immunogenicity data in vitro Inclusion mice Mortality pandemic coronavirus peptide peptides platform predicted prevalent Protein Proteins RBD peptide regions reported RNA Safe SARS-CoV-2 SARS-CoV-2 virus sequence specific IgG antibody spread of COVID-19 starting point subcutaneous administration Support tested the Spike Vaccine Vaccine development Vaccines variant variants of concern Viral vector virus [DOI] 10.1016/j.vaccine.2022.09.059 PMC 바로가기
Novel Regioselective Approach to Cyclize Phage-Displayed Peptides in Combination with Epitope-Directed Selection to Identify a Potent Neutralizing Macrocyclic Peptide for SARS-CoV-2Article Published on 2022-10-212022-11-15 Journal: ACS chemical biology [Category] COVID19(2023년), SARS, 치료기술, 치료제, [키워드] ACE2 acute respiratory syndrome angiotensin-converting enzyme 2 antivirals Combination cysteine cysteines effective epitope human host inhibit Interaction iterative methodology N-terminal novel peptide peptides potent Protein RBD reaction receptor Receptor binding domain SARS-CoV-2 Selection spike the SARS-CoV-2 the Spike Vero E6 cell virus were used [DOI] 10.1021/acschembio.2c00565 PMC 바로가기
Cellular interferon-gamma and interleukin-2 responses to SARS-CoV-2 structural proteins are broader and higher in those vaccinated after SARS-CoV-2 infection compared to vaccinees without prior SARS-CoV-2 infectionArticle Published on 2022-10-172022-11-15 Journal: PLoS ONE [Category] COVID19(2023년), SARS, 진단, [키워드] assays BNT162b2 BNT162b2 vaccine class correlated demonstrated develop dose doses epitope exhibited Frequency greater healthcare worker healthy IFN-γ IgG response IL-2 IL2 Immunity individual infected with SARS-CoV-2 Infection Interferon-gamma interleukin-2 magnitude Moderna mRNA-1273 vaccine mononuclear cell mRNA-1273 N and M nine participant Participants PCR testing peptide Peripheral blood Pfizer-BioNTech positive Post-infection Proteins proteome repeated responders response responses against robust S glycoprotein S1 and S2 S2 subunit SARS-CoV-2 SARS-COV-2 infection structural protein subunit subunits T cell response T-cell Response the SARS-CoV-2 uninfected vaccination vaccinee was determined were expressed with COVID-19 [DOI] 10.1371/journal.pone.0276241 PMC 바로가기
Systems Bioinformatics Reveals Possible Relationship between COVID-19 and the Development of Neurological Diseases and Neuropsychiatric DisordersArticle Published on 2022-10-162022-11-16 Journal: Viruses [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] Acidic acute respiratory syndrome Analysis app Autoimmunity bioinformatics biological processe Combination contribute coronavirus COVID-19 development disease disease-associated disorder disorders dysregulation epitope Epitopes genetic risk factor GFAp Host identify incidence include increased risk indicated Infection linear MAPT microtubule-associated protein modulated molecular molecular mimicry motif Multiple Myasthenia network biology neurodegenerative Neurodegenerative diseases neurological Neurological disease Neurological diseases Neurological disorder Neuropsychiatric neuropsychiatric disorders PPI precursor Protein protein-protein interaction Proteins receptors recognize relationship SARS-CoV-2 SARS-CoV-2 epitope SARS-COV-2 infection sclerosis sequence similarity System systems bioinformatics. [DOI] 10.3390/v14102270 PMC 바로가기
A comparative study of spike protein of SARS-CoV-2 and its variant Omicron (B.1.1.529) on some immune characteristicsArticle Published on 2022-10-122022-11-15 Journal: Scientific Reports [Category] COVID19(2023년), SARS, 변종, 치료제, [키워드] abrogated activate activated affected antibody Antigen antigenic Antiviral B.1.1.529 binding ability Breakthrough infection comparable complement domain Effects epitope immune characteristics indicated induce inflammatory reaction macrophages molecular Mutation NF-κB nuclear omicron pathogen-associated molecular pathogenicity pro-inflammatory pro-inflammatory cytokine raise receptor S-protein SARS-CoV-2 Spike protein TAK-242 the vaccine Transmissibility trimer variant wild type [DOI] 10.1038/s41598-022-21690-7 PMC 바로가기
Dynamic SARS-CoV-2 emergence algorithm for rationally-designed logical next-generation vaccinesArticle Published on 2022-10-102022-11-15 Journal: Communications Biology [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] Algorithm amino acid substitution change Clinical efficacy clinical sample correlation D614G decrease determine dynamic Efficacy Endemic epitope Epitopes Evolution Evolution of SARS-CoV-2 immune immunogenic indicated lineages mAb monitoring monoclonal antibodies Mutation mutations Pearson positive positive correlation predicted Predictive Prevalence prevalent resulting SARS-CoV-2 SARS-CoV-2 evolution SARS-CoV-2 genome spike mutation Spike protein Spread Substitution Vaccine Vaccine design variant virus [DOI] 10.1038/s42003-022-04030-3 PMC 바로가기
Severe COVID-19 induces autoantibodies against angiotensin II that correlate with blood pressure dysregulation and disease severityArticle Published on 2022-10-072022-11-15 Journal: Science Advances [Category] COVID19(2023년), SARS, 진단, [키워드] ACE2 acute respiratory syndrome angiotensin-converting enzyme 2 antibody autoantibody Blood blood pressure coronavirus COVID-19 develop disease severity distress domain dysregulation epitope hospitalized patient immune reaction impair induce life-threatening main entry receptor Oxygenation peptide proportion Protein RBD regulate Regulation SARS-CoV-2 spike the SARS-CoV-2 thought thrombosis with COVID-19 [DOI] 10.1126/sciadv.abn3777 PMC 바로가기
Differential patterns of cross-reactive antibody response against SARS-CoV-2 spike protein detected for chronically ill and healthy COVID-19 naïve individualsArticle Published on 2022-10-072022-11-15 Journal: Scientific Reports [Category] COVID19(2023년), SARS, 변종, 진단, 치료기술, 치료제, [키워드] Affect Alter antibody Antibody Response Antigen antigen exposure antigenic B.1.1.529 boost chronic conditions chronic infection clinical history Cohort COVID-19 COVID-19 pandemic cross-reactive cross-reactive antibody cross-reactivity defined described detectable Diseases epitope glycoprotein healthy high mutation rate highly antigenic immune response immunogenic individual mechanism mutations naïve individual neurological omicron overlapped Pathogens resolved SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 S1 SARS-CoV-2 spike protein serum antibody severe COVID-19 specificity Spike protein Subsequent infection target the antibody response understanding vaccination variants of SARS-CoV-2 Viral antigen virus viruses [DOI] 10.1038/s41598-022-20849-6 PMC 바로가기
Structural insights for neutralization of Omicron variants BA.1, BA.2, BA.4, and BA.5 by a broadly neutralizing SARS-CoV-2 antibodyArticle Published on 2022-10-072022-11-15 Journal: Science Advances [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] Beta complex conserved Delta early stage epitope Gamma Human monoclonal antibody implication India individual Intervention mAb mAbs motif neutralization neutralization activity neutralized Neutralizing omicron pandemic RBD Receptor binding domain SARS-CoV-2 SARS-CoV-2 antibody SARS-CoV-2 variant single B cell spike trimer target therapeutic Vaccine variant viral isolate Wuhan strain [DOI] 10.1126/sciadv.add2032 PMC 바로가기