The p38/HOG stress-activated protein kinase network couples growth to division in Candida albicansp38/HOG 스트레스 활성화 단백질 키나제 네트워크는 칸디다 알비칸스의 성장과 분열을 연결합니다Research Article Published on 2019-03-282022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] Analysis basal Candida Candida albican Candida albicans Cell cell cycle cell division cell growth cell proliferation commitment complex conserved Control Critical developmental division environmental cues eukaryotic eukaryotic cell eukaryotic cells G1 Phase G1/S transition Gene Expression Genetic growth homeostasis identify inhibit inhibited kinases knowledge MAPK mutant mutants nexus overlapped pathogenic yeast performed plasticity Point problem promoter promoters Protein protein kinase protein kinases Quantitative Regulation regulatory pathway respond restriction ribosome biogenesis Saccharomyces cerevisiae threshold Transcription transcription factor transcription factors transcriptional regulator transcriptional regulators yeast [DOI] 10.1371/journal.pgen.1008052 PMC 바로가기 [Article Type] Research Article
Interplay between coronavirus, a cytoplasmic RNA virus, and nonsense-mediated mRNA decay pathway530 Published on 2018-10-232022-10-29 Journal: Proceedings of the National Academy of Sciences of [Category] Coronavirus, [키워드] 3′ untranslated region acute respiratory syndrome cellular mRNA codon coronavirus CoV CoV replication CoVs cytoplasmic cytoplasmic RNA virus Degradation detect disease effective Efficiency enveloped RNA virus eukaryotic Evidence feature Features Genome highlight Host Human Infection inhibition of NMD inhibitory interfere long 3′ UTR mechanisms Middle East modulate mRNA mRNAs murine hepatitis virus N protein nonsense-mediated mRNA decay ORF pathogen pathway positive-sense single-stranded RNA Protein regulate Replication resulting RNA RNA virus Significance stability Surveillance syndrome target variety viral gene expression viral mRNA viral mRNAs Viral protein viral replication [DOI] 10.1073/pnas.1811675115 PMC 바로가기 [Article Type] 530
Sequence features governing aggregation or degradation of prion-like proteins프리온 유사 단백질의 응집 또는 분해를 제어하는 서열 특징Research Article Published on 2018-07-132022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] aggregate aggregates aggregation aliphatic Alzheimer’s disease Amino acid amino acid sequence amino acids Amyotrophic lateral sclerosis aromatic residue aromatic residues asparagine cellular classical clearance complex interplay control systems correlated Degradation Diseases domain domains dose-dependent elicited enhanced eukaryotic evade Factor Factors feature Features Frequency Genetic genetic screen Glutamine glycine highlight hnRNPA1 human protein human proteins increase in intrinsic Lateral Sclerosis lead neurodegenerative disorder neurodegenerative disorders occur Prevent promote promoted Protein protein quality control Proteins Quality control recognize recognizing residue second sequence stimulate subset suppressed to define variety while yeast [DOI] 10.1371/journal.pgen.1007517 PMC 바로가기 [Article Type] Research Article
PRM1 and KAR5 function in cell-cell fusion and karyogamy to drive distinct bisexual and unisexual cycles in the Cryptococcus pathogenic species complexPRM1 및 KAR5는 세포-세포 융합 및 핵종에서 기능하여 Cryptococcus 병원성 종 복합체에서 뚜렷한 양성 및 단성 주기를 유도합니다Research Article Published on 2017-11-272022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] absence adaptation bisexual reproduction Cell Cell fusion cell-cell fusion cellular processe characterization characterized complex conserved Critical Cryptococcus Cryptococcus neoforman Cryptococcus neoformans de novo demonstrated diploid eukaryotic eukaryotic systems events Evolution forms fungal fungal pathogens fungi fusion protein generate Genetic genotypic hyphae hyphal independent individual involved isolate karyogamy mating type mechanism Morphological nuclear nuclear fusion nuclear membrane observation occur offset opposite organism ortholog orthologs pathogen pathogenic Pathogens pathway phenotypic diversity plants plasma membrane PRM1 produced regulate selfing sexual cycles sexual reproduction Sexuality similarities similarity Stage trajectory undergo yeast [DOI] 10.1371/journal.pgen.1007113 PMC 바로가기 [Article Type] Research Article
Crystal structure of Middle East respiratory syndrome coronavirus helicaseResearch Article Published on 2017-06-262022-10-29 Journal: PLoS Pathogens [Category] Coronavirus, [키워드] acute respiratory syndrome Analysis arterivirus C-terminal caused component conserved coronavirus CoV crystal structure domain domains drug design effective eukaryotic Fatality rate full-length Helicase information Interaction membrane MERS-CoV Middle East N-terminal nidoviruses nonstructural protein nsp13 Nsps Pandemics Protein Proteins public health remained replication-transcription complex respiratory syndrome coronavirus SARS-CoV SF1 targets Vaccine viral RNA synthesis while [DOI] 10.1371/journal.ppat.1006474 PMC 바로가기 [Article Type] Research Article
Pheromone independent unisexual development in Cryptococcus neoformansCryptococcus neoformans의 페로몬 독립 성 발달Research Article Published on 2017-05-032022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] activator allele Analysis Bifurcation bisexual reproduction calcineurin cellular cellular differentiation Complete completion component condition conditions contributed Cryptococcus Cryptococcus neoforman Cryptococcus neoformans differentiation processe distribution dominant door ENhance eukaryotic expression favor fungus generate genetic control genetic study higher eukaryotes hyphal inactivation independent independent of inefficient inhibitory insertional mutagenesis isolate Laboratory Like mating type mating types meiosis microbe mode opens pathway pheromone Population predicted Prevalence progeny promote Protein repressor required robust sexual development sexual reproduction skewed skewed distribution specific proteins suppresse tested transcription factor Transcriptome undergo Znf2 [DOI] 10.1371/journal.pgen.1006772 PMC 바로가기 [Article Type] Research Article
Comparative Proteome Analysis of Porcine Jejunum Tissues in Response to a Virulent Strain of Porcine Epidemic Diarrhea Virus and Its Attenuated StrainArticle Published on 2016-11-292022-10-28 Journal: Viruses [Category] Coronavirus, [키워드] Analysis Attenuated carried change Comparative diarrhea epidemic diarrhea eukaryotic expressed groups Heat shock heterogeneous immune system Infection inoculated Interaction interferon-stimulated gene involved ISGs iTRAQ Jejunum labeling Laboratory mechanism Mortality nuclear organ Pathogenesis pathogenicity PEDV Porcine epidemic diarrhea virus predominant produced Protein proteomic quantitation quantitative proteome analysis response responses responsible ribonucleoprotein Signal transduction strain Strains Stress tissue up-regulated virulent virus [DOI] 10.3390/v8120323 PMC 바로가기 [Article Type] Article
Characterization of the Role of Hexamer AGUAAA and Poly(A) Tail in Coronavirus PolyadenylationResearch Article Published on 2016-10-192022-10-28 Journal: PLoS ONE [Category] Coronavirus, MERS, [키워드] Analysis characterization Coronaviral coronavirus demonstrated element eukaryotic Evidence Factor Genetic Genome Infection initial length involved mRNA Mutagenesis nucleotides Polyadenylation regulated Regulation responsible role tail Variation [DOI] 10.1371/journal.pone.0165077 PMC 바로가기 [Article Type] Research Article
Amplification of TLO Mediator Subunit Genes Facilitate Filamentous Growth in Candida Spp .TLO 중재자 소단위 유전자의 증폭은 칸디다 종에서 필라멘트 성장을 촉진합니다.Research Article Published on 2016-10-142022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] Activation amplification amplitude ascomycete ascomycetes binding domain bloodstream infection Bloodstream infections Candida Candida albican Candida albicans candidiasis cause cell physiology complex death DNA domain Engineering ENhance environmental cues eukaryotic exhibit facilitated Filamentous fungal fungi gene family Genome genomes genomic growth hallmark individual Infection infections Interaction less mediator mortality rate multitude murine mutant Nuclear localization nuclear localization signal nucleus ortholog overexpressed overexpression pathogenicity phenotype Phenotypes phenotypic plasticity Protein provide reduced regulate subunit Support systemic Candidiasis systemic infection target targets The United States Transcription transcription factor transcription factors transcriptional transcriptional activation unique United States virulence [DOI] 10.1371/journal.pgen.1006373 PMC 바로가기 [Article Type] Research Article
Biogenesis and architecture of arterivirus replication organellesArticle Published on 2016-04-092022-11-01 Journal: Virus research [Category] Coronavirus, [키워드] analysed arteritis arterivirus biogenesis cell line comparable coronavirus Coronaviruses Correlative light-electron microscopy described electron tomography endoplasmic reticulum membranes equine eukaryotic Express expressed expression groups hepatitis C virus homogenous host cell membrane induce infected cells Infection knowledge membrane curvature Membrane remodelling modulating Nidovirale Nidovirales nidoviruses NSP2 Nsp3 organelle picornavirus polyprotein Protein question Regulatory Replication replication complex replication structures RNA RNA synthesis Structure subset Support thought Three-dimensional electron microscopy Topology transmembrane protein Vesicle viral infection viral RNA synthesis virus viruses [DOI] 10.1016/j.virusres.2016.04.001 PMC 바로가기 [Article Type] Article