Characteristics and outcomes of vaccinated and nonvaccinated patients hospitalized in a single Italian hub for COVID-19 during the Delta and Omicron waves in Northern ItalyResearch article Published on 2022-09-012022-10-05 Journal: International Journal of Infectious Diseases [Category] COVID19(2023년), SARS, 변종, [키워드] admitted to ICU analyzed appear caused Characteristics COVID COVID-19 Delta delta variant Delta wave died Effectiveness faster healthcare worker hospitalized patient ICU Immunity incidence individual infections intensive care Italian Italy less medical condition objective omicron Omicron variant outcome Patient patients hospitalized postvaccination prevaccination Result SARS-COV-2 infection severe COVID-19 significantly higher Vaccinated variant with COVID-19 [DOI] 10.1016/j.ijid.2022.06.028 [Article Type] Research article
Durability of Immune Response After COVID-19 Booster Vaccination and Association With COVID-19 Omicron InfectionArticle Published on 2022-09-012022-11-15 Journal: JAMA Network Open [Category] SARS, 변종, 진단, [키워드] 95% CI age antibody antibody kinetics Antibody titer antibody waning association avidity BNT162b2 BNT162b2 vaccine booster dose COVID-19 delta variant demonstrated dose effective Effectiveness faster Follow-up geometric mean titer greater Health care worker Humoral response IgG IgG level immune response incidence Infection longitudinal cohort study microneutralization mononuclear cell mononuclear cells neutralization neutralizing antibody Older omicron outcome participant Peripheral blood Primary outcome response SARS-CoV-2 second dose secondary outcome sera Strains susceptibility T cell T cell activation tested Transmission Vaccine vaccine dose vaccine doses variant variant of SARS-CoV-2 variants of concern were assessed were used wild type women [DOI] 10.1001/jamanetworkopen.2022.31778 PMC 바로가기
A metropolitan-scale, three-dimensional agent-based model to assess the effectiveness of the COVID-19 Omicron wave interventions in a hyperdense city: a case study of Hong KongArticle Published on 2022-09-012022-11-16 Journal: International Journal of Infectious Diseases [Category] 변종, [키워드] agent-based model China COVID-19 Diseases effective Effectiveness examined faster flexible Hong Kong implementation Intervention lockdown omicron Omicron variant Prevent Spread Testing Three-dimensional (3D) Universal Zero-COVID. [DOI] 10.1016/j.ijid.2022.06.042 PMC 바로가기
Impact of Fast SARS-CoV-2 Molecular Point-Of-Care Testing on Patients’ Length of Stay in an Emergency DepartmentArticle Published on 2022-08-312022-11-15 Journal: Microbiology Spectrum [Category] COVID19(2023년), SARS, 치료기술, [키워드] Admission Analysis Anosmia/ageusia benefit Cepheid COVID-19 COVID-19 infection status COVID-19 pandemic Department diagnosis of SARS-CoV-2 Emergency evaluated Factor faster France highlight hypertension Impact implementation Isolation Laboratory Length Length of stay less LOS median molecular molecular detection Paris participated Patient patients per day POCT point of care point-of-care Rapid reduced remained RP2 SARS-CoV-2 SARS-CoV-2 genome significantly significantly higher tested Testing Univariate analysis worsened [DOI] 10.1128/spectrum.00636-22 PMC 바로가기
Multiplex Target-Redundant RT-LAMP for Robust Detection of SARS-CoV-2 Using Fluorescent Universal Displacement ProbesArticle Published on 2022-08-312022-11-15 Journal: Microbiology Spectrum [Category] COVID19(2023년), SARS, 변종, 진단, 치료기술, 치료제, [키워드] aggregate amplification analyzed Complete Control coronavirus Course Coverage COVID-19 diagnosis COVID-19 pandemic Delta detect detection diagnostic diagnostic tests diagnostics displacement disrupt Eta evade Evidence false-negative faster fluorescence detection fluorescent Gamma greater instance internal Laboratory Laboratory test lack Lineage loop Mediated methodology molecular molecular methods Multiplex assay Mutation over pandemic point of care positive Prevalence primer probe reduce remained resource robust RT-LAMP SARS-CoV-2 sensitivity sequence specificity Spread stability susceptible temperature the disease Universal variant viral lineage Viral RNA virus virus genome viruses Wuhan-Hu-1 isolate [DOI] 10.1128/spectrum.01583-21 PMC 바로가기
Development and application of LAMP assays for the detection of enteric adenoviruses in fecesArticle Published on 2022-08-312022-11-15 Journal: Microbiology Spectrum [Category] COVID19(2023년), SARS, 진단, 치료기술, [키워드] acute gastroenteritis Adenovirus amplification Asymptomatic carried children clinical sample colorimetric detection Combination comparable Comparative Complete detect Detection limit development diagnostic diagnostic capability diagnostics DNA DNA extraction electrophoretic separation equipment false-positive result faster fluorescent Fluorescent probe gastroenteritis gold standard Hepatitis human adenoviruses 40 and 41 identify Infection infections intestinal isothermal Laboratory LAMP Loop-mediated isothermal amplification many cases microorganisms molecular molecular diagnostics nucleic acid extraction Nucleic acid material outcomes pathogen pathogen detection Patient PCR reduce reported resources SARS-CoV-2 sensitivity sensitivity of PCR Severe case severity specificity threshold viral loads virus [DOI] 10.1128/spectrum.00516-22 PMC 바로가기
Protective Immunity of COVID-19 Vaccination with ChAdOx1 nCoV-19 Following Previous SARS-CoV-2 Infection: A Humoral and Cellular InvestigationArticle Published on 2022-08-302022-11-15 Journal: Viruses [Category] SARS, 진단, [키워드] activated acute respiratory syndrome antibody Antibody Response caused CD4+ naïve Cell cellular Cellular and humoral immunity cellular response ChAdOx1 ChAdOx1 nCoV-19 Cohort COVID-19 COVID-19 group D-dimer level DAV death effective faster humoral Humoral immunity Hybrid immunity IFN-γ IgG immune response Immunity increase in individual individuals induce infected individual interferon-γ investigated investigation Lymphocytes memory memory B cells naïve neutralizing antibody positive correlation SARS-CoV-2 SARS-CoV-2 vaccine secretion significant difference Support triggered vaccinated individual vaccination Vaccine with COVID-19 [DOI] 10.3390/v14091916 PMC 바로가기
Remdesivir Plus Dexamethasone Versus Dexamethasone Alone for the Treatment of Coronavirus Disease 2019 (COVID-19) Patients Requiring Supplemental O2 Therapy: A Prospective Controlled Nonrandomized Study코로나바이러스 질병 2019(COVID-19) 환자 치료를 위한 렘데시비르 플러스 덱사메타손 대 덱사메타손 단독 요법: 보충 O2 요법이 필요한 환자: 전향적 통제된 비무작위 연구Controlled Clinical Trial Published on 2022-08-242022-09-11 Journal: Clinical Infectious Diseases: An Official Publicat [Category] SARS, 임상, 치료제, [키워드] 30-Day mortality Antiviral baseline calculated clinical outcomes cohorts Combination Controlled coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient CRP D-dimer Dexamethasone drug effective Endpoint enrolled evaluate evaluated faster fibrinogen FiO2 group groups Hospitalization IMPROVE independent Inflammatory inflammatory markers Kaplan-Meier Kaplan-Meier curve Kaplan-Meier curves laboratory characteristics log-rank test median Mortality neutrophil neutrophil/lymphocyte ratio no differences occurred primary endpoint primary endpoints Prospective reducing mortality reduction in reduction in mortality Remdesivir Respiratory failure Respiratory function Sample size SARS-CoV-2 clearance secondary Secondary endpoints shown significant difference significant differences survival the log-rank test therapy treat Treatment viral clearance were used [DOI] 10.1093/cid/ciac014 PMC 바로가기 [Article Type] Controlled Clinical Trial
Antiviral and clinical activity of bamlanivimab in a randomized trial of non-hospitalized adults with COVID-19COVID-19로 입원하지 않은 성인을 대상으로 한 무작위 시험에서 밤라니비맙의 항바이러스 및 임상 활성Randomized Controlled Trial Published on 2022-08-222022-09-11 Journal: Nature Communications [Category] SARS, 바이오마커, 변종, 임상, 진단, 치료기술, 치료법, 치료제, [키워드] 1:1 adverse events Antiviral bamlanivimab clinical activity Clinical efficacy COVID-19 symptom COVID-19 symptoms COVID-19 therapeutics evaluated Evidence evidence of faster Inflammatory marker inflammatory markers median modeling monoclonal antibodies monoclonal antibody nasopharyngeal nasopharyngeal viral no differences Placebo Primary outcomes proportion provide Randomized Randomized controlled trial randomized trial reductions in risk risk ratio Safety SARS-CoV-2 RNA Symptom symptom duration undetectable variants of SARS-CoV-2 Viral with COVID-19 [DOI] 10.1038/s41467-022-32551-2 PMC 바로가기 [Article Type] Randomized Controlled Trial
Advancement and Challenges of Biosensing Using Field Effect Transistors전계효과 트랜지스터를 이용한 바이오센싱의 발전과 과제Review Published on 2022-08-172022-09-11 Journal: Biosensors [Category] SARS, 치료기술, [키워드] accompanied advancement approaches biosensors carried challenge coronavirus coronavirus disease COVID-19 pandemic Debye Debye length degrade Detection sensitivity Device direction domain Effect effective faster field field effect transistors field-effect transistor functional functionalization mechanism Microarray Modification modifications pace Pathogens provided raised SARS-CoV-2 spike protein Screening sensitivity specificity Spike protein surface area the SARS-CoV-2 transistor Transport [DOI] 10.3390/bios12080647 PMC 바로가기 [Article Type] Review