Automated diagnosis of COVID stages from lung CT images using statistical features in 2-dimensional flexible analytic wavelet transformResearch article Published on 2022-07-012022-10-05 Journal: Biocybernetics and Biomedical Engineering [Category] 치료기술, [키워드] Accuracy Algorithm applied approach assist chest imaging chest X-ray Computed tomography contagious COVID COVID-19 COVID-19 epidemic CT scan demonstrated detect diagnosed Diagnosis early stage FAWT based image decomposition feature Feature extraction Features flexible help identify illnesses image classification lung Lung CT machine learning Medical imaging outcomes PCA physical principal component analysis problems progression Respiratory system robust sensitivity specificity Spread Stage statistical student two-dimensional venous virus X-ray [DOI] 10.1016/j.bbe.2022.06.005 [Article Type] Research article
Highly Sensitive Flexible SERS-Based Sensing Platform for Detection of COVID-19COVID-19 감지를 위한 고감도 유연한 SERS 기반 감지 플랫폼Article Published on 2022-06-282022-09-11 Journal: Biosensors [Category] MERS, 바이오마커, 진단, 치료기술, [키워드] addition analytical technique Biomarker Biomarkers coronavirus COVID-19 COVID-19 virus Critical detect detection disease Disease diagnosis fingerprint flexibility flexible flexible SERS substrates help individual Infection Novel coronavirus omicron Prevent provide Raman spectroscopy Research researcher Reviewing sensitive sensitivity Spread substrate substrates Subtypes Surveillance therapy triggered Ultrasensitive detection unique virus viruses [DOI] 10.3390/bios12070466 PMC 바로가기 [Article Type] Article
SpySwitch enables pH- or heat-responsive capture and release for plug-and-display nanoassemblySpySwitch는 플러그 앤 디스플레이 나노 어셈블리를 위한 pH 또는 열 반응성 캡처 및 릴리스를 지원합니다.Article Published on 2022-06-282022-09-12 Journal: Nature Communications [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] antibodies Bacterial binding site Culture determine ENhance EY6A Final flexible generate histidine mammalian moderate Neutral New coronavirus pandemic Protein Proteins purification Receptor-binding domain Resilience Sarbecoviruses SARS-CoV-2 tested Threats Vaccine development [DOI] 10.1038/s41467-022-31193-8 PMC 바로가기 [Article Type] Article
Superimmunity by pan-sarbecovirus nanobodies범사르베코바이러스 나노바디에 의한 초면역Article Published on 2022-06-282022-09-11 Journal: Cell Reports [Category] COVID19(2023년), MERS, SARS, 변종, 유전자 메커니즘, 진단, [키워드] activities against SARS-CoV best booster breadth broadly neutralizing nanobody camelid clade conserved correlated CP: Immunology distance domain effective epitope Epitopes Evolution facilitate FIVE flat flexible Immunity immunized immunology Infection inhalable bispecific nanobody PiN-31 mechanism median milliliter nanobody neutralization potency Neutralizing observé omicron pan-sarbecovirus neutralization proteomics RBD RBD surface Receptor binding residues sarbecovirus SARS-CoV-2 SARS-CoV-2 antibodies SARS-CoV-2 antibody SARS-CoV-2 spike SARS-CoV-2 variants super immunity. the SARS-CoV-2 V(H)H antibody [DOI] 10.1016/j.celrep.2022.111004 PMC 바로가기 [Article Type] Article
COVIDHunter: COVID-19 Pandemic Wave Prediction and Mitigation via Seasonality Aware ModelingCOVIDHunter: 계절성 인식 모델링을 통한 COVID-19 팬데믹 웨이브 예측 및 완화Article Published on 2022-06-172022-09-11 Journal: Frontiers in Public Health [Category] 변종, [키워드] applied average case study caused Climate condition country COVID-19 COVID-19 outbreak COVID-19 outbreak simulation COVID-19 patient COVID-19 test death deaths disease spread Early detection effective environmental condition epidemiological epidemiological modeling estimate evaluate Factors flexible geographical region Healthcare system hospitalizations Humidity implementation Infection Isolation measure Measures Mitigation modeling modify MONITOR outbreak outbreak prevention and control performed predict prediction Prevention and control provide seasonal epidemic seasonality source code Spread spread of COVID-19 strength Switzerland temperature the disease vaccination vaccination rate variants of concern Wave [DOI] 10.3389/fpubh.2022.877621 PMC 바로가기 [Article Type] Article
Atomic-Resolution Structure of SARS-CoV-2 Nucleocapsid Protein N-Terminal DomainSARS-CoV-2 뉴클레오캡시드 단백질 N-말단 도메인의 원자 분해능 구조Article Published on 2022-06-152022-09-11 Journal: Journal of the American Chemical Society [Category] COVID19(2023년), SARS, 치료기술, 치료법, 치료제, [키워드] addition approach atomic bind binding experiment flexible genome organization genomic RNA Guidance in viral Infection information inhibitor means N- and C-termini N-terminal domain NMR NTD nucleocapsid offer pathogenicity Protein provide Region Replication RNA SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 virus structural protein structural proteins Structure the SARS-CoV-2 the SARS-CoV-2 virus therapeutic intervention therapeutic interventions Vaccine development X-ray diffraction [DOI] 10.1021/jacs.2c03320 PMC 바로가기 [Article Type] Article
Going Retro, Going Viral: Experiences and Lessons in Drug Discovery from COVID-19레트로화, 바이럴화: COVID-19 약물 발견의 경험과 교훈Article Published on 2022-06-142022-09-11 Journal: Molecules [Category] Coronavirus, COVID19(2023년), SARS, 신약개발, 치료제, [키워드] active site Antibiotics binding binding site Cell culture Clinical use computational studies Computational study COVID-19 COVID-19 pandemic develop docking drug Drug discovery drug target effective effort enzyme experience fidaxomicin flexible implication improvement in silico in vitro inhibit inhibitors lesson Ligand ligands Mutagenesis NiRAN nucleotide nucleotide analogs pace pathogen Pathogens predicted protein complex protein complexes RdRP researcher rifabutin rifamycins. RNA synthesis RNA-dependent RNA polymerase SARS-CoV-2 SARS-CoV-2 RdRp severity silico studies speed Spread throughput viral replication Virtual screening [DOI] 10.3390/molecules27123815 PMC 바로가기 [Article Type] Article
COVID-19 hospitalizations forecasts using internet search data인터넷 검색 데이터를 이용한 코로나19 입원 예측Article Published on 2022-06-112022-09-11 Journal: Scientific Reports [Category] 변종, 치료기술, [키워드] Admission ARGO assist association collected COVID-19 COVID-19 hospitalization Critical Decision making flexible globe Google Google search healthcare Hospital admission Hospitalization Infectious disease Influenza information LASSO Linear regression medical resource National Outbreaks powerful tool public health reduction in retrospective robust Spread The United States United States variant [DOI] 10.1038/s41598-022-13162-9 PMC 바로가기 [Article Type] Article
Long-range enhancement of N501Y-endowed mouse infectivity of SARS-CoV-2 by the non-RBD mutations of Ins215KLRS and H655YIns215KLRS 및 H655Y의 비 RBD 돌연변이에 의한 SARS-CoV-2의 N501Y 부여 마우스 감염성의 장거리 향상Article Published on 2022-06-052022-09-11 Journal: Biology Direct [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, [키워드] ACE2 Alpha Beta changes in cooperation Cross-species transmission disrupt ENhance facilitate flexible Gamma H655Y high infectiousness hosts Impact impacts increase Ins215KLRS insertion Interaction intramolecular interaction less Local mice mouse Mouse infection mouse-adapted strain mutant Mutation N-terminal domain N501Y N501Y mutation NTD omicron Omicron variants peptide Protein RBD Receptor binding Receptor-binding domain resulting rodents SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants spike Spike protein suppressed targets the receptor-binding domain variant virus infectivity wild type [DOI] 10.1186/s13062-022-00325-x PMC 바로가기 [Article Type] Article
SARS CoV-2 (Delta Variant) Infection Kinetics and Immunopathogenesis in Domestic CatsSARS CoV-2(Delta Variant) 감염 역학 및 국내 고양이의 면역 병인 발생Article Published on 2022-06-012022-09-11 Journal: Viruses [Category] COVID19(2023년), SARS, 변종, [키워드] ACE2-expressing cell ACE2-expressing cells acute COVID-19 acute infection animal model animal models B.1.617.2 chemokine chemokine signaling circulating Clinical sign Cluster correlated correlation COVID-19 disease COVID-19 disease course Critical cytokine receptor Delta delta variant develop differentially expressed gene Differentially expressed genes disease Disease progression disease transmission Divergence domestic cats dose downstream dysregulated evaluate feline ferrets flexible genetic modification help highlight Host hub genes identify immunopathology include Infection Infectious virus Inflammatory inflammatory pathways inoculated Interaction interactions intranasally Kinetics lesion lesions limitation lung lung tissue Lungs Mild nasal network analysis non-human primates pathology pathway peribronchial Pneumocytes Post-infection Prevent progression pulmonary inflammation pulmonary lesion pulmonary lesions Respiratory disease RNA sequencing SARS CoV SARS CoV-2 SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 variant SARS-CoV-2 variants secretion significantly Spread target therapeutic timepoints transgenic mice translational upregulation variant Vascular endothelium Vasculitis Viral antigen Viral protein virus WGCNA wild-type SARS-CoV-2 [DOI] 10.3390/v14061207 PMC 바로가기 [Article Type] Article