Humoral and Cellular Immune Responses Against Severe Acute Respiratory Syndrome Coronavirus 2 Variants and Human Coronaviruses After Single BNT162b2 Vaccination단일 BNT162b2 백신 접종 후 중증 급성 호흡기 증후군 코로나바이러스 2 변이체 및 인간 코로나바이러스에 대한 체액 및 세포 면역 반응Article Published on 2021-12-062022-09-11 Journal: Clinical Infectious Diseases: An Official Publicat [Category] 변종, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Against antibodies B.1.1.7 B.1.351 B.1.351 variant B.1.351 variants BNT162b2 boost cellular immunity combating contribute coronavirus coronavirus 2 coronavirus disease Coronavirus disease 2019 courses COVID-19 Defense detectable Endemic endemic human coronavirus endemic human coronaviruses evade exacerbate frequencies Frequency HCoV HCoVs host cell Human humoral IgG Immunity immunization Immunoglobulin Immunoglobulin G individual Infection Neutralizing antibodies neutralizing antibody P.1 pandemic question reactive Receptor-binding domain respiratory response S protein SARS-CoV-2 SARS-CoV-2 S protein SARS-CoV-2 WT second vaccination severe acute respiratory syndrome Coronavirus severe disease significantly single dose single vaccination South Africa T cell T cells T-cell T-cell Response T-cell responses the receptor-binding domain the SARS-CoV-2 United Kingdom vaccination Vaccine vaccinee variants of concern VoC wild-type [DOI] 10.1093/cid/ciab555 PMC 바로가기 [Article Type] Article
Questionnaire Survey of Possible Association of Allergic Diseases with Adverse Reactions to SARS-CoV-2 VaccinationArticle Published on 2021-12-012022-10-28 Journal: Vaccines [Category] COVID-19, [키워드] absence Adverse adverse effect allergic disease allergy analyzed anaphylaxis Asthma atopic dermatitis bronchial asthma Care conducted contribute COVID-19 Effect fatigability Fever first dose food allergy frequencies headache hospital individual injection intensity joint less Local non-allergic occur Pain Pfizer–BioNTech PROTECT questionnaire reaction Reactions receive SARS-CoV-2 SARS-CoV-2 vaccine second dose severe adverse effect subject subjects survey systemic reaction systemic reactions Vaccine [DOI] 10.3390/vaccines9121421 PMC 바로가기 [Article Type] Article
A novel diagnostic test to screen SARS-CoV-2 variants containing E484K and N501Y mutationsE484K 및 N501Y 돌연변이를 포함하는 SARS-CoV-2 변이체를 선별하기 위한 새로운 진단 테스트Article Published on 2021-12-012022-09-11 Journal: Emerging Microbes & Infections [Category] SARS, 변종, 진단, [키워드] carried change collected concerning COVID patient Covid patients diagnostic dramatic increase E484K epidemiological frequencies Frequency geographical areas Hackensack Meridian Health network hospital Meridian molecular Molecular assay Mutation N501Y N501Y mutation Nasopharyngeal swab Neutralizing antibodies neutralizing antibody New Protein SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants screened Screening Sequencing spike Spike protein Transmissibility unmet need variant variants Viral virus while [DOI] 10.1080/22221751.2021.1929504 PMC 바로가기 [Article Type] Article
Efficacy and safety of baricitinib for the treatment of hospitalised adults with COVID-19 (COV-BARRIER): a randomised, double-blind, parallel-group, placebo-controlled phase 3 trial입원한 성인 COVID-19(COV-BARRIER) 치료를 위한 바리시티닙의 효능 및 안전성: 무작위, 이중 맹검, 병행군, 위약 대조 3상 시험Clinical Trial Published on 2021-12-012022-09-11 Journal: The Lancet. Respiratory Medicine [Category] Fulltext, SARS, 임상, 치료법, 치료제, [키워드] 1:1 95% CI Abstract addition all-cause mortality anti-inflammatory properties antivirals Asia assigned available data Baricitinib baseline Care Combination company Corticosteroids country death defined Dexamethasone Disease progression dose double-blind Efficacy and safety enrolled Europe evaluate event exploratory Follow-up French frequencies Frequency hazard ratio High-flow oxygen hospitalised inhibitor intention-to-treat population Invasive mechanical ventilation Janus kinase Japanese Lilly material Mortality non-invasive ventilation North America Odds ratio oxygen parallel-group participant Participants Phase 3 phase 3 trial Placebo placebo group placebo-controlled placebo-controlled trial prevented primary endpoint progressed proportion randomised Randomly receive receiving reduced reduction in Registered Remdesivir risk risk difference safety analyses safety analysis safety population safety profile secondary endpoint selective Serious Adverse Event Serious Adverse Events serious infection serious infections South America Spanish Standard Standard of care study drug systemic corticosteroid systemic corticosteroids the placebo group the primary endpoint thromboembolic translation Treatment two groups venous thromboembolic were assessed with COVID-19 [DOI] 10.1016/S2213-2600(21)00331-3 PMC 바로가기 [Article Type] Clinical Trial
Mild Adverse Events of Sputnik V Vaccine in Russia: Social Media Content Analysis of Telegram via Deep LearningOriginal Paper Published on 2021-11-292022-10-30 Journal: Journal of Medical Internet Research [Category] COVID-19, MERS, SARS, [키워드] addition Administered Adverse adverse event adverse events AEs age analyzed applied average caused chills chose clinical trial co-occurrence collected comparable concerning conducted content corpus COVID-19 COVID-19 vaccines database dataset deep deep learning diarrhea doses drugs elderly Euclidean distance fatigue Fever first dose frequencies Gam-COVID-Vac Gender headache information Insomnia Lancet learning lymph node enlargement media men Messenger RNA Mild nausea/vomiting objective Pain Pearson correlation performed Phase 3 pruritus reported representation Result resulting Russian language safety profile SARS-CoV-2 second dose sequence significantly more social media Sputnik V Symptom systemic AE Telegram transformer Trial unique vaccination Vaccine vaccine safety Vaccines vector [DOI] 10.2196/30529 PMC 바로가기 [Article Type] Original Paper
Recovery of Memory B-cell Subsets and Persistence of Antibodies in Convalescent COVID-19 Patients회복기 COVID-19 환자에서 기억 B 세포 하위 집합의 회복 및 항체 지속성Article Published on 2021-11-272022-09-12 Journal: The American Journal of Tropical Medicine and Hygi [Category] 진단, [키워드] activated acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 Antibody Response Atypical B cell B cells B-cell cells central memory Chain Reaction classical convalescent individual convalescent individuals Coronavirus-2 COVID-19 Ex vivo examined exhibited frequencies Frequency group Humoral immunity IgG immature immune response individuals with COVID-19 Infection Longevity memory B cell memory B cells memory B-cell Mild Modification modifications naïve B cells naive cells Neutralizing antibodies neutralizing antibody Patient persistence Plasma cell Plasma cells polymerase chain polymerase chain reaction SARS-CoV-2 SARS-COV-2 infection Seven Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus-2 severe COVID-19 subset with COVID-19 [DOI] 10.4269/ajtmh.21-0883 PMC 바로가기 [Article Type] Article
An analysis of the COVID-19 laboratory dataset at AiBST Laboratory in Harare, Zimbabwe, 2020Research Published on 2021-11-252022-10-28 Journal: The Pan African Medical Journal [Category] COVID-19, MERS, SARS, [키워드] African age analysed Analysis average coronavirus disease Coronavirus disease 2019 (COVID-19) country COVID-19 dataset described effort Epi female frequencies generate globe greater group help IMPROVE increase in Laboratory laboratory data limit males median age men Older age pandemic proportion public health remained reported Result retrospective risk SARS-CoV-2 Science Spread spread to TAT technology the disease the patient was done was used Wuhan, China Zimbabwe [DOI] 10.11604/pamj.2021.40.183.28520 PMC 바로가기 [Article Type] Research
Differences in COVID-19 Vaccine Acceptance, Hesitancy, and Confidence between Healthcare Workers and the General Population in JapanArticle Published on 2021-11-242022-10-28 Journal: Vaccines [Category] COVID-19, [키워드] acceptance adjusted adverse event Analysis Characteristics collected conducted confidence coronavirus disease COVID-19 COVID-19 vaccination COVID-19 vaccine cross-sectional survey difference Effectiveness enrolled evaluated examined Factor frequencies Frequency General population Health health literacy healthcare healthcare worker Hesitancy hypothetical immunization IMPROVE Intervention Japan men and women multinomial logistic regression Nurse Nurses Population significantly higher significantly lower smoker Socioeconomic Factors Vaccine Vaccine acceptance Vaccine hesitancy worker [DOI] 10.3390/vaccines9121389 PMC 바로가기 [Article Type] Article
Whole‐organ transdermal photobiomodulation ( PBM ) of COVID ‐19: A 50‐ patient case studyResearch Article Published on 2021-11-222022-10-31 Journal: Journal of Biophotonics [Category] COVID-19, COVID19(2023년), MERS, SARS, [키워드] Algorithms appear ARDS average body ache Concentration condition conducted coronavirus correlated COVID COVID‐19 COVID‐19 distress Dyspnea eliminated extreme Fever frequencies full recovery incidence include Inflammation Inflammatory initial lung malaise Mitochondria noninvasive nonrandomized optical outcome paroxysmal Patient patients Photobiomodulation pulse red/NIR LED reductions in regimen required resolved sequenced severity Severity of disease SpO2 study population supplemental oxygen requirements Symptom symptomatic Symptoms temperature therapeutic therapy transdermal Treatment [DOI] 10.1002/jbio.202100194 PMC 바로가기 [Article Type] Research Article
Differences in children and adolescents with SARS-CoV-2 infection: a cohort study in a Brazilian tertiary referral hospitalSARS-CoV-2 감염 아동과 청소년의 차이: 브라질 3차 위탁 병원의 코호트 연구Original Article Published on 2021-11-172022-09-10 Journal: Clinics [Category] MERS, SARS, 치료기술, [키워드] 95% CI 95% confidence interval acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Admission Adolescent age Anosmia Autoimmune disease Autoimmune diseases children chronic condition chronic conditions chronic disease cohort study coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 case cross-sectional cross-sectional study death diagnosed difference dysgeusia enoxaparin Factor Final frequencies Frequency headache Hospitalization immunosuppressive conditions individual Inflammatory Inpatient Inpatients laboratory-confirmed Laboratory-confirmed COVID-19 less Logistic regression analysis lymphopenia MIS-C mortality rate Multisystem inflammatory syndrome myalgia nausea Neonates occurred Odds ratio Odds ratios outcome outpatients Patient pediatric Pediatric patient Pediatric patients positive processed reduced regression analysis respiratory SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome Coronavirus Shock significantly significantly lower sore throat syndrome tertiary referral hospital vasoactive agent were excluded with COVID-19 [DOI] 10.6061/clinics/2021/e3488 PMC 바로가기 [Article Type] Original Article