granulocyte – Page 5 – Communicable Diseases Research

Comorbidities and inflammation associated with ovarian cancer and its influence on SARS-CoV-2 infection

난소암과 관련된 동반 질환 및 염증 및 SARS-CoV-2 감염에 대한 영향

Review

Published on 2021-02-252022-09-12
Journal: Journal of Ovarian Research [Category] MERS, 진단,

From SARS-CoV-2 hematogenous spreading to endothelial dysfunction: clinical-histopathological study of cutaneous signs of COVID-19

SARS-CoV-2 혈행성 확산에서 내피 기능 장애까지: COVID-19의 피부 징후에 대한 임상-조직병리학적 연구

Case Reports

Published on 2021-02-252022-09-11
Journal: Diagnostic Pathology [Category] MERS, 치료기술,

[키워드] Activation Arterioles Atypical Atypical pneumonia Azithromycin Capillaries capillary Case report caused Chest Chest CT Coagulopathy conducted correlation COVID-19 Cytokines dermatitis died disorder Disruption edema edematous endothelial Endothelial cell endothelial cells Endothelial dysfunction endothelial integrity Endothelial swelling ENhance erythematous erythroderma expression extravasation granulocyte Ground-glass opacities healing hematogenous histological Histopathology Hospitalized Hydroxychloroquine immune system impairment inflammatory cell inflammatory cells initiated Injury intensive care unit Intubated Lopinavir Lopinavir-ritonavir lung microvascular permeability Morphological Nasopharyngeal swab Neck non-specific papillary dermis Patient perivascular Pneumonia positive Rash respiratory respiratory symptom respiratory symptoms Reticular dermis Ritonavir SARS-CoV-2 SARS-COV-2 infection Seven skin spongiosis swelling tested Tocilizumab transferred treated trunk upper limbs vascular abnormalities Viral with COVID-19
[DOI] 10.1186/s13000-021-01075-6 PMC 바로가기 [Article Type] Case Reports

Human Dental Pulp Stem Cells Modulate Cytokine Production in vitro by Peripheral Blood Mononuclear Cells From Coronavirus Disease 2019 Patients

Cell and Developmental Biology

Published on 2021-02-052022-10-31
Journal: Frontiers in Cell and Developmental Biology [Category] COVID-19,

[키워드] activated acute respiratory syndrome co-culture Concentration conditions Contact coronavirus coronavirus disease COVID-19 COVID-19 patient COVID-19 patients cytokine dental dental pulp stem cells deregulated DPSC DPSCs form GM-CSF granulocyte healthy subject Human hyper-inflammation IFNγ IL-10 IL-12 IL-13 IL-17A IL-18 IL-1β IL-2 IL-21 IL-22 IL-23 IL-27 IL-4 IL-5 IL-6 IL-9 immune response immunomodulation in vitro interleukin investigated Macrophage mechanism mesenchymal stem cell Mesenchymal stem cells modulate modulation mononuclear cell MSC MSCs Multi-organ damage not affected Patient PBMC PBMCs peripheral Peripheral blood Pneumonia Production promote Pulp Real-time PCR Result SARS-CoV-2 STEM stem cell subset supernatant tissue regeneration TNFα
[DOI] 10.3389/fcell.2020.609204 PMC 바로가기 [Article Type] Cell and Developmental Biology

Cytokine Signature Induced by SARS-CoV-2 Spike Protein in a Mouse Model

마우스 모델에서 SARS-CoV-2 스파이크 단백질에 의해 유도된 사이토카인 시그니처

Immunology

Published on 2021-01-282022-09-11
Journal: Frontiers in Immunology [Category] MERS, SARS, 진단, 치료기술,

[키워드] acute respiratory distress acute respiratory distress syndrome Adenovirus alveolitis angiotensin Angiotensin-converting enzyme ARDS BALB/c mice BALF Bronchoalveolar lavage fluid change Clinical use colony-stimulating factor Combination contribute COVID-19 COVID-19 patient CSS cytokine Cytokine storm Cytokine storm syndrome Cytokines domain drugs effective enzyme Extracellular global health GM-CSF granulocyte granulocyte-macrophage colony-stimulating factor Health Human angiotensin-converting enzyme 2 IL-1α IL-6 IL-6 inhibitor immunostimulant indicated induced Inflammatory cytokines inhibitor inhibitors Injury interleukin interleukin 6 interleukin 6 (IL-6 investigated Jak lead lung Lung injury mAb mAbs magnetic resonance imaging mechanism Model monoclonal antibodies monoclonal antibody mortalities mouse murine model myeloperoxidase Neutralizing neutrophilic Occurrence opens phenotype polyinosinic-polycytidylic acid pro-inflammatory Protein reduced respiratory distress Respiratory distress syndrome resulting Safe SARS-CoV-2 signature spike syndrome the cytokine storm therapeutic TNF-α Tocilizumab Treatment wild-type
[DOI] 10.3389/fimmu.2020.621441 PMC 바로가기 [Article Type] Immunology

Disease severity-specific neutrophil signatures in blood transcriptomes stratify COVID-19 patients

혈액 전사체의 질병 중증도별 호중구 서명은 COVID-19 환자를 계층화합니다

Research

Published on 2021-01-132022-08-07
Journal: Genome Medicine [Category] 신약개발, 유전자 메커니즘, 진단, 치료제,

[키워드] acute respiratory distress acute respiratory distress syndrome analyzed Asymptomatic available data blood cell blood transcriptome Blood transcriptomics capture Cell changes in clinical Clinical parameters Clinical presentations Co-expression analysis Cohort Combination control sample COVID-19 COVID-19 patient data-driven death disease severity dissect Donor driver drug candidate drug candidates targeting Drug repurposing drug target dysregulated explained granulocyte granulocyte sample Granulocytes groups Host host responses identify immune immune system independent Infection Inflammatory diseases Mild mild respiratory mild respiratory tract infection Molecular disease phenotypes molecular phenotype molecular subgroup neutrophil neutrophil activation Neutrophil activation-associated signature Neutrophils other diseases parameters Patient performed phenotype Phenotypes predicted provide report respiratory respiratory distress Respiratory failure respiratory tract infection Result RNA-Seq SARS-CoV-2 pandemic Severe case severe cases severe COVID-19 patient Severe patient Stratification stratified supplementary material syndrome systemic immune response Transcriptome transcriptomes Viral viral infections was used Whole blood whole blood transcriptome
PMC 바로가기 [Article Type] Research

Time to revisit the use of G-CSF after allogeneic haematopoietic cell transplantation in COVID-19 era?

Comment

Published on 2021-01-042022-10-28
Journal: British Journal of Cancer [Category] Coronavirus, MERS, SARS,

A Granulocytic Signature Identifies COVID-19 and Its Severity

과립구 시그니처는 COVID-19 및 그 심각성을 식별합니다

Observational Study

Published on 2020-11-132022-09-11
Journal: The Journal of Infectious Diseases [Category] SARS, 바이오마커, 임상,

[키워드] (neutrophil accompanied Admission Alter Analysis approach association basophil basophils Biomarker CD11b CD16 circulating conducted COVID-19 COVID-19 patient COVID-19 patients CRTH2 disease downregulation dysregulation eosinophil eosinophils expression Frequency functional phenotype granulocyte Granulocytes Granulocytic healthy control healthy controls hospital ward identify immune immune checkpoint immune dysregulation immune marker immune markers immunoparalysis Immunophenotyping Increased individual integrin intensive care intensive care unit admission leukocyte leukocytes lymphocyte marker Mild monocyte neutrophil Neutrophils pathophysiological Patient PD-L1 Phenotypic marker Phenotypic markers predict SARS-CoV-2 severe disease severity signature stages subset supported uninfected was performed
[DOI] 10.1093/infdis/jiaa591 PMC 바로가기 [Article Type] Observational Study

Application of Humanized Zebrafish Model in the Suppression of SARS-CoV-2 Spike Protein Induced Pathology by Tri-Herbal Medicine Coronil via Cytokine Modulation

Article

Published on 2020-11-022022-10-30
Journal: Molecules [Category] COVID-19,

[키워드] A549 A549 cells abnormality affecting Analysis Anti-inflammatory application Ayurveda behavioral fever Cell cellular Coronil cytokine develop dose doses epithelial cells feature Fever granulocyte hemorrhage herbal medicine human lung humanized humanized zebrafish IL-1β IL-6 immunomodulatory property induced inhibited Macrophage Medicine Model Mortality Necrosis pandemic Pathologies protective effect renal rescued restored rosmarinic acid SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike protein SARS-CoV-2 viral infection significantly skin spike Spike protein suppression swim bladder the disease the SARS-CoV-2 Therapies TNF-α transcriptional activity Treatment UHPLC zebrafish
[DOI] 10.3390/molecules25215091 PMC 바로가기 [Article Type] Article

Increased Complement Receptor-3 levels in monocytes and granulocytes distinguish COVID-19 patients with pneumonia from those with mild symptoms

Research article

Published on 2020-10-012022-10-05
Journal: International Journal of Infectious Diseases [Category] SARS, 바이오마커,

[키워드] analysed antibody panel Antigen approach Biomarker CD11b Cell circulating leukocyte clinically Complement receptor 3 count COVID-19 COVID-19 patient COVID-19 patients cytokine release develop diagnostic eight examined explain feature febrile fibrinogen finding flow cytometry granulocyte healthy volunteers hypoxia hypoxic Immunological memory Immunology and inflammation Increased infected individual Infection Inflammatory innate immune cell innate immune response innate immune system leukocyte leukocyte activation Level memory Mild symptom mild symptoms monocyte natural NK cell over-expression Patient patients with COVID-19 Pneumonia potential therapeutic target Rapid receptor remained required Respiratory complications Respiratory failure specimen subsequent Therapeutics thrombotic understanding Ventilated ventilatory support with COVID-19
[DOI] 10.1016/j.ijid.2020.08.004 [Article Type] Research article

Azithromycin in viral infections

Review

Published on 2020-09-232022-10-29
Journal: Reviews in Medical Virology [Category] COVID-19,

[키워드] Activation affecting antibiotic Apoptosis Azithromycin Bacterial clinical study conducted coronavirus Coronaviruses COVID‐19 COVID‐19 degranulation disease Ebola effective ENhance expression GM‐CSF granulocyte in silico in viral in vitro Infection infections Inflammatory response influenza A inhibit inhibiting interferon investigated Lysosomes Macrolide mammalian mechanism mechanisms murine mycobacterial Neutrophils NFκB Novel coronavirus infection Patient pattern recognition receptor Randomised clinical trials randomised trial data Rapamycin reduce Replication responses review rhinovirus SARS‐CoV‐2 SARS‐CoV‐2 T cell target therapeutic TNF Treatment Trial type I virus Zika virus
[DOI] 10.1002/rmv.2163 PMC 바로가기 [Article Type] Review