Protein-protein conjugation enhances the immunogenicity of SARS-CoV-2 receptor-binding domain (RBD) vaccinesResearch article Published on 2022-07-092022-10-05 Journal: iScience [Category] 비임상, [키워드] Antigen binding collected conjugate Conjugates crosslinked demonstrated domain effective Efficacy ENhance functional generate hACE2 immunology isolate mice pandemic persist Protein Pseudovirus neutralization assays RBD SARS-CoV-2 SARS-CoV-2 vaccine sera Th1 Vaccine variant variants Virology [DOI] 10.1016/j.isci.2022.104739 [Article Type] Research article
A mRNA Vaccine Encoding for a RBD 60-mer Nanoparticle Elicits Neutralizing Antibodies and Protective Immunity Against the SARS-CoV-2 Delta Variant in Transgenic K18-hACE2 MiceRBD 60-mer 나노입자를 암호화하는 mRNA 백신은 형질전환 K18-hACE2 마우스에서 SARS-CoV-2 Delta 변이체에 대한 중화 항체 및 보호 면역을 유발합니다Article Published on 2022-07-062022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] Against Antigen COVID-19 pandemic Delta delta variant displaying domain effective elicit encoding flexible hACE2 K18-hACE2 messenger Messenger RNA mRNA mRNA vaccine nanoparticle Neutralizing neutralizing antibody Neutralizing antibody response platform protective immunity provide RBD RBDs Receptor binding domain Receptor-binding domain RNA vaccine robust SARS-CoV-2 SARS-CoV-2 variant severe disease Spread the RBD the SARS-CoV-2 Transgenic mouse Vaccine [DOI] 10.3389/fimmu.2022.912898 PMC 바로가기 [Article Type] Article
Resilience of S309 and AZD7442 monoclonal antibody treatments against infection by SARS-CoV-2 Omicron lineage strainsSARS-CoV-2 Omicron 계통 균주에 의한 감염에 대한 S309 및 AZD7442 단일클론 항체 치료의 회복력Article Published on 2022-07-022022-09-11 Journal: Nature Communications [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] acting Antibody neutralization AstraZeneca Cell culture changes in Combination correlation analyses Correlation analysis Effect Efficacy Express FcγR hACE2 human ACE2 humans in vitro In vitro studies in vitro study in vivo Infection Interaction K18-hACE2 Lineage Lung infection mAb mechanism mice monoclonal antibody monoclonal antibody therapies monoclonal antibody treatment monotherapy neutralization neutralization potency Neutralizing activity omicron Omicron variant Omicron variants Prevent Prophylactic Protective reduced reductions reductions in Resilience retained S309 SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 infections SARS-CoV-2 isolates SARS-CoV-2 variant Spike protein strain suggested susceptible the spike protein therapeutic therapy transgenic mice treat Treatment variant variants Viral viral burden [DOI] 10.1038/s41467-022-31615-7 PMC 바로가기 [Article Type] Article
Investigation of the binding and dynamic features of A.30 variant revealed higher binding of RBD for hACE2 and escapes the neutralizing antibody: A molecular simulation approachA.30 변이체의 결합 및 동적 특징 조사 결과 hACE2에 대한 RBD의 더 높은 결합 및 중화 항체 탈출: 분자 시뮬레이션 접근Article Published on 2022-07-012022-09-11 Journal: Computers in biology and medicine [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] A.30 variant ACE2 approach atomic binding binding affinity binding free energy calculated complex complexes coronavirus coronavirus disease cross-protective Deletion deletions Delta demonstrated dissociation Dissociation constant docking result domain drug Effects evade feature Free free energy global pandemic greater hACE2 help Host immune response Interaction interactions investigation mAb molecular Molecular simulation monoclonal antibodies mutated Mutation N terminal domain Neutralizing Neutralizing antibodies NTD omicron Omicron variants protein-protein docking RBD RBD complex reduce reported residue robust salt-bridge SARS-CoV-2 Simulation spike gene Spike protein Spread Substitution the spike protein variant variants variants of SARS-CoV-2 wild type [DOI] 10.1016/j.compbiomed.2022.105574 PMC 바로가기 [Article Type] Article
Comparative genomics, evolutionary epidemiology, and RBD-hACE2 receptor binding pattern in B.1.1.7 (Alpha) and B.1.617.2 (Delta) related to their pandemic response in UK and IndiaB.1.1.7(알파) 및 B.1.617.2(델타)의 비교 유전체학, 진화 역학 및 RBD-hACE2 수용체 결합 패턴이 영국 및 인도의 대유행 반응과 관련됨Article Published on 2022-07-012022-09-11 Journal: Infection, genetics and evolution : journal of mol [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, [키워드] Analysis analyzed B.1.1.7 B.1.617.2 binding Cluster Comparative Comparative genomics COVID-19 infection Critical D614G Delta delta variant Epidemiology Evolutionary epidemiology Frequency genome sequence geographical distribution hACE2 help increase in India L452R MD simulation molecular Mutation mutations N501Y offer P681R pandemic performed phylogenetics plot Receptor binding reference strain Scatter plot scatter plots second second wave Spread stability submission Transmission variance Variance of UK and India. variant variants was performed Wuhan [DOI] 10.1016/j.meegid.2022.105282 PMC 바로가기 [Article Type] Article
Molecular modelling identification of phytocompounds from selected African botanicals as promising therapeutics against druggable human host cell targets of SARS-CoV-2SARS-CoV-2의 약물 가능한 인간 숙주 세포 표적에 대한 유망한 치료제로서 선택된 아프리카 식물의 식물 화합물의 분자 모델링 식별Article Published on 2022-07-012022-09-11 Journal: Journal of molecular graphics & modelling [Category] COVID19(2023년), SARS, 치료제, [키워드] active site acute respiratory syndrome coronavirus African Amino acid amino acid residue angiotensin Angiotensin converting enzyme-2 bafilomycin binding binding energy candidate drug cathepsin cathepsin L caused Cell clinical evaluation clinical evaluations Compound compounds Computational methods coronavirus 2 coronavirus disease Coronavirus disease 2019 COVID-19 Critical enzyme galactoside hACE2 highly pathogenic host cell Host cell targets human cell human cells human host in vitro inhibitor inhibitors of TMPRSS2 inhibitory inhibitory action investigated kaempferol mechanism MLN-4760 Modification modifications modulate molecular dynamics Molecular dynamics simulation myricetin nafamostat Phytocompounds Protein Proteins Replication Research respiratory Respiratory disease respiratory diseases rutinoside SARS-CoV-2 selected Serine severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 Structural analysis subjects subsequent target Therapeutic benefit these compound these compounds TMPRSS2 transmembrane serine protease Verbascoside viral entry viral spike protein viral spike proteins while [DOI] 10.1016/j.jmgm.2022.108185 PMC 바로가기 [Article Type] Article
Chronological brain lesions after SARS-CoV-2 infection in hACE2-transgenic micehACE2 형질전환 마우스에서 SARS-CoV-2 감염 후 시간적 뇌 병변Article Published on 2022-07-012022-09-11 Journal: Veterinary pathology [Category] COVID19(2023년), SARS, 변종, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus Affect Analysis animal model astrogliosis Beta Brain cause Central nervous system Cerebellum characterized coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 develop different time points distribution Encephalitis hACE2 hACE2-transgenic mice histopathological immunohistochemistry immunolabeling inoculation lesion meningoencephalitis mice mucosa necropsies necropsy Neuroinflammation Neurological disease neuronal neurons Neuropathology nonsuppurative olfactory other organ other organs panel of antibodies panel of antibody performed post inoculation processed question reached Respiratory disease SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 lineage SARS-CoV-2 neuroinvasion severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 spongiosis Spread susceptible thrombosis transgenic mice vacuolar vacuolar degeneration variants Vasculitis virological assay virological assays virus [DOI] 10.1177/03009858211066841 PMC 바로가기 [Article Type] Article
SARS-CoV-2 Omicron Variant Binds to Human Cells More Strongly than the Wild Type: Evidence from Molecular Dynamics SimulationSARS-CoV-2 오미크론 변이체는 야생형보다 더 강력하게 인간 세포에 결합합니다: 분자 역학 시뮬레이션의 증거Article Published on 2022-06-302022-09-11 Journal: The journal of physical chemistry. B [Category] COVID19(2023년), SARS, 변종, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition angiotensin B.1.1.529 bind binding affinities binding affinity binding free energy calculated comparable complex computational studies Computational study contagious coronavirus COVID-19 pandemic Critical distribution domain Dynamics electrostatic interaction ENhance examined free energy glycan glycans hACE2 heterogeneous homogeneous Human human Angiotensin-converting enzyme Human angiotensin-converting enzyme 2 human cell human cells infection rate Interaction molecular molecular dynamics Molecular dynamics simulation Molecular mechanics Mutation omicron Omicron variant Open problem pandemic RBD Receptor binding domain reported residue SARS-CoV-2 severe acute respiratory syndrome Coronavirus shown Simulation Spike protein stability surface area T478K the binding affinity the RBD variant viral RBD wild type [DOI] 10.1021/acs.jpcb.2c01048 PMC 바로가기 [Article Type] Article
Human ACE2 Polymorphisms from Different Human Populations Modulate SARS-CoV-2 Infection다양한 인간 집단의 인간 ACE2 다형성이 SARS-CoV-2 감염을 조절합니다Article Published on 2022-06-302022-09-11 Journal: Viruses [Category] COVID19(2023년), SARS, 변종, [키워드] ACE2 ACE2 variant ACE2 variants acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Affect Asian caused cell entry receptor cells contrary coronavirus COVID-19 COVID-19 mortality COVID-19 pandemic COVID-19 symptom COVID-19 symptoms death determinant E35K ENCODE environmental factor Ethnic groups expression Genetic genetic determinant hACE2 high variability Host Human human ACE2 Human genome human population Infection modulate pandemic polymorphism Polymorphisms Population populations PROTECT Protective protective effect reduced risk SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome Coronavirus severe COVID-19 severity of COVID-19 surface expression susceptibility Symptoms two allele Two alleles variant virus infection wild-type [DOI] 10.3390/v14071451 PMC 바로가기 [Article Type] Article
Analysis of SARS-CoV-2 in Nasopharyngeal Samples from Patients with COVID-19 Illustrates Population Variation and Diverse Phenotypes, Placing the Growth Properties of Variants of Concern in Context with Other LineagesCOVID-19 환자의 비인두 샘플에서 SARS-CoV-2 분석은 다른 계통과 관련하여 우려되는 변이체의 성장 특성을 배치하여 인구 변이 및 다양한 표현형을 보여줍니다Article Published on 2022-06-292022-09-11 Journal: mSphere [Category] COVID19(2023년), SARS, 변종, [키워드] A549 cells Alpha amplified Beta Beta variant Biology biology of SARS-CoV-2 causative agent Cell Cell culture cell line cells change characterized clinical isolates clinical samples concern Context coronavirus COVID-19 Delta disease effective Evolution genetic diversity genetics genome sequence genomic global pandemic growth growth kinetics hACE2 hospitalized patient hospitalized patients humans immune evasion increased risk indicated Infection isolate isolates less Lineage minor minor genomic variants morbidity Mortality Nasopharyngeal swab nasopharyngeal swabs New no difference not different omicron Other other coronaviruses other variant other variants pandemic patients pattern planet Population Population dynamics Population genetics Postinfection preserved property Research RNA RNA sequencing Sample SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 genomes sequence several variants Spread suggested Transmission vaccination Vaccine Variability variant variants variants of concern variants of SARS-CoV-2 Variation Vero E6 Vero E6 cell VERO E6 cells virus Virus evolution VoC VOCs widespread with COVID-19 [DOI] 10.1128/msphere.00913-21 PMC 바로가기 [Article Type] Article