25-Hydroxycholesterol-Conjugated EK1 Peptide with Potent and Broad-Spectrum Inhibitory Activity against SARS-CoV-2, Its Variants of Concern, and Other Human CoronavirusesArticle Published on 2021-11-012022-10-29 Journal: International Journal of Molecular Sciences [Category] COVID-19, MERS, SARS, [키워드] 25-Hydroxycholesterol activity Anti-SARS-CoV-2 Activity antiviral activity caused CH25H cholesterol Combination concern CoV COVID-19 pandemic effective feasible fusion inhibitor global public health HCoV-229E HCoV-OC43 Human human coronavirus human CoVs IMPROVE Infection inhibitor lipopeptide mice Modification Newborn Other peptide peptide-based potent PROTECT reported SARS-CoV-2 SARS-COV-2 infection synergistic variants of concern VOCs [DOI] 10.3390/ijms222111869 PMC 바로가기 [Article Type] Article
Impacts of p97 on Proteome Changes in Human Cells during Coronaviral ReplicationArticle Published on 2021-10-292022-10-31 Journal: Cells [Category] Coronavirus, [키워드] Analysis antiviral activity ATPase Cell cell line cellular senescence change coronavirus cytopathic effects DNA repair early stage favor H1299 HCoV-229E HCoV-OC43 host cell host protein host response Human human cell human lung identify Impact infected cell infected cells Infection inhibit inhibition inhibitor knockdown p97 pathway PROTECT Protein proteome proteomics Quantitative Replication small molecule inhibitor Spread therapeutic target treat Viral RNA virus Virus life cycle virus replication [DOI] 10.3390/cells10112953 PMC 바로가기 [Article Type] Article
Robust Evaluation of Ultraviolet-C Sensitivity for SARS-CoV-2 and Surrogate CoronavirusesResearch Article Published on 2021-10-202022-10-30 Journal: Microbiology Spectrum [Category] COVID-19, MERS, SARS, [키워드] absorbance adopted baculovirus baculovirus vector collimated beam coronavirus COVID-19 pandemic Disinfection distribution dose Effectiveness eliminating Evidence for disinfection hazard HCoV-229E HCoV-OC43 highlight HuCoV 229E HuCoV OC43 inactivated inactivation indicator organism intensity irradiation medium methodology MHV mouse hepatitis virus optical organism reducing reduction SARS-CoV-2 sensitivity surrogate T1 bacteriophage Treatment ultraviolet UV light Variability virus [DOI] 10.1128/Spectrum.00537-21 PMC 바로가기 [Article Type] Research Article
The therapeutic promises of Lianhuaqingke in the mice model of coronavirus pneumonia (HCoV-229E and SARS-CoV-2)Research Published on 2021-10-182022-11-01 Journal: Chinese Medicine [Category] COVID-19, [키워드] 16HBE cell acute pneumonia airway alleviate Anti-HCoVs therapy Anti-viral Antiviral effect approved BALB/c mice caused Cell cells ciliary Coronavirus pneumonia COVID-19 dose-dependent Effect ELISA epithelial expression expression level flow cytometry H&E staining hACE2 HCoV-229E human coronaviruses (HCoVs) identify immune response immunofluorescence staining immunomodulation immunomodulatory in vitro in vivo indicated inhibit inhibited inhibiting Injury Lianhuaqingke (LHQK) lung lung tissue lung tissues mice morphological change MUC5AC Peripheral blood Pneumonia positive pro-inflammatory cytokine reduce reduced reducing Replication Result SARS-CoV-2 staining subset Th cell Th1 Th17 Th2 the SARS-CoV-2 virus therapeutic therapeutic effect Therapies TNFα Transgenic mouse treated Treatment Treg Vero E6 viral replication virus virus titer was measured was used weight loss were measured [DOI] 10.1186/s13020-021-00513-3 PMC 바로가기 [Article Type] Research
Epigenetic targeting of the ACE2 and NRP1 viral receptors limits SARS-CoV-2 infectivityACE2 및 NRP1 바이러스 수용체의 후성적 표적화는 SARS-CoV-2 감염성을 제한합니다Research Published on 2021-10-112022-09-10 Journal: Clinical Epigenetics [Category] MERS, SARS, 유전자 메커니즘, 치료제, [키워드] 2-propylpentanoic acid ACE-2 ACE2 addition Affect angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 anti-inflammatory effect Antiviral approved BEAS-2B block Caco-2 Cell cell line cell lines cells Clinical use COVID-19 COVID-19 patients Cytokines dampen decrease dose-dependent manner downregulate effective elements Engagement Epigenetic expression genomic gRNA HCoV HCoV-229E HDAC HDAC inhibitor host protein Huh-7 hyperinflammation IL-6 impair Infection Infectious virus infectious viruses Inflammatory cytokine Inflammatory cytokines Inflammatory response inhibit inhibition inhibitor inhibitory activity limit mechanism Messenger RNA mRNAs N protein neuropilin NRP1 Patient Post-infection priming protease Protease activity protein level protein levels receptor reduce reduced reducing Replication Result S protein Safe SARS-CoV-2 SARS-COV-2 infection Serine serine protease serine protease TMPRSS2 severity of COVID-19 shown significantly supplementary material TMPRSS2 TNF-α Treatment treatment for COVID-19 triggered Vaccine Valproic acid Viral viral spread virion virus viruses VSV [DOI] 10.1186/s13148-021-01168-5 PMC 바로가기 [Article Type] Research
Vapourized hydrogen peroxide decontamination in a hospital setting inactivates SARS-CoV-2 and HCoV-229E without compromising filtration efficiency of unexpired N95 respirators병원 환경에서 기화된 과산화수소 오염 제거는 만료되지 않은 N95 호흡기의 여과 효율을 손상시키지 않으면서 SARS-CoV-2 및 HCoV-229E를 비활성화합니다.Article Published on 2021-10-012022-09-11 Journal: American journal of infection control [Category] SARS, 치료기술, [키워드] approach coronavirus COVID-19 COVID-19 pandemic decontamination determine effective Efficiency filtration for disinfection HCoV HCoV-229E hospital hydrogen hydrogen peroxide Hydrogen peroxide vapor investigated Mask Mask reprocessing N95 N95 respirator not affected reduced replicate Respirator respiratory Respiratory protection retained reuse SARS-CoV-2 SARS-CoV-2 virus Sterilization surrogate treated Treatment Viable viral burden virus was determined was tested [DOI] 10.1016/j.ajic.2021.07.012 PMC 바로가기 [Article Type] Article
Evaluation of a multiplexed coronavirus antigen array for detection of SARS-CoV-2 specific IgG in COVID-19 convalescent plasmaCOVID-19 회복기 혈장에서 SARS-CoV-2 특이 IgG 검출을 위한 다중 코로나바이러스 항원 어레이 평가Article Published on 2021-10-012022-09-11 Journal: Journal of Immunological Methods [Category] MERS, SARS, 진단, 치료기술, 치료법, 치료제, [키워드] Antibody Response Antibody test Antibody titers Antigen Antigen array antigens comparable convalescent plasma convalescent plasma samples coronavirus COVID-19 COVID-19 pandemic cross-reactivity domain ELISA ELISAs Endemic evaluated Extracellular focus FRNT full-length HCoV HCoV-229E HCoV-HKU1 HCoV-NL63 HCoV-OC43 HKU1 IgG IgG antibody Inc InDevR lack Live virus MERS MERS-CoV Mitigation Neutralizing activity neutralizing antibody neutralizing antibody titers NL63 nucleocapsid nucleocapsid IgG OC43 other coronavirus other coronaviruses plasma samples platform positive result positive sample proximal question reactivity Receptor binding domain reduction remained reported Sample SARS-CoV SARS-CoV spike SARS-CoV-2 SARS-CoV-2 antigen SARS-CoV-2 antigens SARS-CoV-2 IgG SARS-CoV-2 IgG antibody SARS-CoV-2 nucleocapsid Sensitivity and specificity significantly higher specificity spike Spike antigen the antibody response the SARS-CoV-2 while [DOI] 10.1016/j.jim.2021.113104 PMC 바로가기 [Article Type] Article
Ginkgolic Acid Inhibits Coronavirus Strain 229E Infection of Human Epithelial Lung CellsCommunication Published on 2021-09-262022-10-28 Journal: Pharmaceuticals [Category] COVID-19, [키워드] 229E acid added affected Antiviral antiviral activity Antiviral compound caused coronavirus Coronaviruses COVID-19 pandemic CPE Cytopathic effect deaths demonstrated disrupting Ebola effective effective antiviral treatment Efficacy epithelial Epstein Barr virus exhibited expression fusion inhibitor ginkgolic acid globe HCoV-229E Herpe HIV HSV-1 Human human coronavirus in vitro in vivo individual Infection influenza A inhibit inhibited inhibiting lung cell Post-infection progeny Proteins reduced reported SARS-CoV-2 significantly similarity strain Vaccine Viral mutations Viral protein Viral proteins virus production viruses [DOI] 10.3390/ph14100980 PMC 바로가기 [Article Type] Communication
Multi-level inhibition of coronavirus replication by chemical ER stressArticle Published on 2021-09-202022-10-04 Journal: Nature Communications [Category] SARS, 치료제, [키워드] Analysis Antiviral antiviral effects autophagic flux block bronchial epithelial cells cell type chaperone complexes component coronavirus Coronavirus replication counteract CoV replication CoVs Degradation derivative downregulation drugs ER stress Evidence Factor HCoV-229E HERPUD1 Host human pathogen IMPROVE inducer infected cell Infection inhibit inhibiting mechanism MERS-CoV modulate pathway Pathways pharmacological Protein proteome Quality control Replication required SARS-CoV-2 selective specific treatment suppress suppresse Systems virology translational UBA6 unfolded protein response viability viral infection Virus-host interactions ZNF622 [DOI] 10.1038/s41467-021-25551-1 PMC 바로가기 [Article Type] Article
Biology and Pathogenesis of SARS-CoV-2: Understandings for Therapeutic Developments against COVID-19Review Published on 2021-09-192022-10-28 Journal: Pathogens [Category] COVID-19, [키워드] alphacoronavirus Analysis animal models antiviral drugs antivirals Biology caused Characteristics Complete Coronavirus disease 2019 Coronaviruses COVID-19 development EVs extracellular vesicle FIVE Genetic HCoV-229E HCoV-HKU1 HCoV-NL63 HCoV-OC43 HCoVs host-pathogen interaction host-virus interaction Human immune-evasion knowledge MERS-CoV Nidovirale Pathogenesis pathophysiology positive Research RNA virus SARS-CoV SARS-CoV-2 single-stranded the Coronaviridae the disease understanding Vaccine Vaccines virus [DOI] 10.3390/pathogens10091218 PMC 바로가기 [Article Type] Review