A −436C>A Polymorphism in the Human FAS Gene Promoter Associated with Severe Childhood Malaria
A −436C>심각한 아동기 말라리아와 관련된 인간 FAS 유전자 프로모터의 다형성
Research Article
[키워드] 95% confidence interval
A allele
a major
activated
affected
allele
Analysis
Anemia
Apoptosis
applied
assigned
association
Author
carried
Case-control
caused
CD69
Cell
cell surface receptor
cerebral malaria
childhood
children
Community
compared
complex interplay
complications
Control
Donor
ENCODE
Endemic
Express
expression
FACS analysis
FAS
fatality
found
functional
Genetic variant
genetic variants
genetics
Health
healthy individual
help
heterozygote
homozygote
homozygous
Human
Human genetics
immune regulation
immune response
immune responses
increased expression
individual
Infection
investigated
involved
life-threatening
locus
lymphocyte
Lymphocytes
malaria
molecule
mononuclear cell
mononuclear cells
naïve
nucleotide
Occurrence
Odds ratio
outcome
Pediatric case
Peripheral blood
Peripheral blood mononuclear cells
phenotypic
Plasmodium
Plasmodium falciparum
predisposition
programmed cell death
promoter
promoter region
proportion
PROTECT
Protective
protective immune response
Replication
risk
severe
severe malaria
significantly
significantly higher
Single nucleotide variant
sub-Saharan Africa
subgroup
surface receptor
susceptibility
susceptible
syndrome
T-lymphocyte
the disease
Transmission dynamics
variant
West
[DOI] 10.1371/journal.pgen.1002066 PMC 바로가기 [Article Type] Research Article
[DOI] 10.1371/journal.pgen.1002066 PMC 바로가기 [Article Type] Research Article