Pharmaco-immunomodulatory interventions for averting cytokine storm-linked disease severity in SARS-CoV-2 infectionSARS-CoV-2 감염에서 사이토카인 폭풍 관련 질병 중증도를 예방하기 위한 약물-면역 조절 중재Review Published on 2022-02-012022-09-11 Journal: Inflammopharmacology [Category] COVID19(2023년), SARS, 비임상, [키워드] acute respiratory distress acute respiratory distress syndrome administration approval ARDS breath clinical trial Cohort COVID-19 COVID-19 infection COVID-19 pandemic COVID-19 patients cytokine Cytokine storm Cytokines Cytokines syndrome death demonstrated disease severity Diseases distress effective Fatality rate Hospital stay hospitalisation hospitalisations hospitalised patient Hospitalised patients hypercytokinemia Immune modulators immune response immunomodulatory drug immunomodulatory drugs Immunomodulatory therapies in some India Infectious diseases Intervention life mitigate Mortality Mutation occur Organ failure Patient respiratory distress responsible risk factor Safe SARS-COV-2 infection SARS-CoV-2 virus Severe COVID-19 Infection severe COVID-19 patient severe COVID-19 patients severity subsequent syndrome the disease Therapeutics treat vaccination Vaccine [DOI] 10.1007/s10787-021-00903-x PMC 바로가기 [Article Type] Review
Randomised controlled trial of intravenous nafamostat mesylate in COVID pneumonitis: Phase 1b/2a experimental study to investigate safety, Pharmacokinetics and PharmacodynamicsCOVID 폐렴에서 정맥내 나파모스타트 메실레이트의 무작위 대조 시험: 안전성, 약동학 및 약력학을 조사하기 위한 1b/2a상 실험 연구Clinical Trial Published on 2022-02-012022-09-11 Journal: EBioMedicine [Category] COVID19(2023년), MERS, SARS, 바이오마커, 신약개발, 임상, 치료제, [키워드] 95% CI Administered adverse events Analysis Anti-inflammatory Anticoagulant anticoagulant effect anticoagulant effects antiviral activity assigned average characterisation Controlled trial COVID COVID-19 COVID19 creatinine credible interval demonstrated dose Edinburgh Endpoint endpoints Evidence evidence of Hospital stay hospitalised hospitalised patient Hospitalised patients inactive independent Infectious diseases intravenous intravenous infusion manuscript maximum mean difference mesylate metabolites nafamostat Nafamostat mesylate observé Odds ratio open open label Oxford oxygen Patient patients Pharmacodynamics pharmacokinetics phase Phase 2 PK data plasma platform Pneumonitis Primary outcome Primary outcomes progressed randomised randomised controlled trial Randomly rate ratio receive reported Repurposed drug Research respiratory Respiratory medicine response SARS-CoV-2/COVID-19 Seven significantly higher significantly more SOC Standard of care statistically significant difference therapy Tolerability Total Total manuscript word count. Trial university with COVID-19 [DOI] 10.1016/j.ebiom.2022.103856 PMC 바로가기 [Article Type] Clinical Trial
Sensitivity of RT-PCR testing of upper respiratory tract samples for SARS-CoV-2 in hospitalised patients: a retrospective cohort studyResearch Article Published on 2022-02-012022-10-28 Journal: Wellcome Open Research [Category] COVID-19, [키워드] 95% confidence interval acute respiratory syndrome analysed Clinical diagnosis Clinical features clinically coronavirus disease Coronavirus-2 COVID-19 defined determine Diagnosis diagnostics discharge gold standard Haematology hospitalised hospitalised patient increase majority multiplex negative and positive negative RT-PCR NHS Patient positive positive result proportion respiratory sample retrospective cohort study reverse transcription PCR RNase P RT-PCR RT-PCR test RT-PCR testing RT-PCR tests SARS-CoV-2 SARS-CoV-2 RT-PCR sensitivity Sensitivity and specificity sequence tested United Kingdom upper respiratory tract [DOI] 10.12688/wellcomeopenres.16342.2 PMC 바로가기 [Article Type] Research Article
COVID-19 reinfections among naturally infected and vaccinated individuals자연적으로 감염되고 예방 접종을받은 개인의 COVID-19 재감염Article Published on 2022-01-262022-09-10 Journal: Scientific Reports [Category] SARS, 변종, 치료기술, 치료법, [키워드] 1080 95% CI added age antibody baseline Chain Reaction clinical feature Cohort COVID-19 COVID-19 testing Critical disease diabetes Diabetes Mellitus died elicited Epidemiology Follow-up Genome sequences hospitalised patient Hospitalised patients Hospitalized hospitalized patients hypertension individual individuals less male naïve natural infection Naturally oxygen oxygen support participant polymerase chain reaction Population positive positive patient Post-infection proportion real-time reverse transcriptase-polymerase chain reaction Registered Reinfection required responsible reverse transcriptase risk risk of infection risk ratio rRT-PCR SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 strain SARS-CoV-2 variant SARS-CoV-2 variants sequence severe disease significantly higher tested vaccinated individual vaccinated individuals vaccination variants viral infection whole-genome sequencing [DOI] 10.1038/s41598-022-05325-5 PMC 바로가기 [Article Type] Article
A case–control study of the causes of acute respiratory infection among hospitalized patients in Northeastern LaosArticle Published on 2022-01-182022-10-04 Journal: Scientific Reports [Category] 진단, [키워드] accounted Acute respiratory infection Admitted Patient aetiology age Analysis ARI attributable fraction calculated cause caused Chest collected conducted Control controls cough Determining difficulty breathing disease eight facilitate febrile patient Fever healthy control hospital hospitalised patient hospitalized patient inclusion criteria influenza A virus influenza B Medical research métapneumovirus Microbiology microorganism multiplex nasal congestion Nasopharyngeal swab participant Participants pathogen Patient predominant presenting Real-time PCR real-time RT-PCR recruited respiratory respiratory syncytial virus respiratory viruses RSV SARS-CoV-2 Sex sore throat Swab Symptom tested upper respiratory tract virus [DOI] 10.1038/s41598-022-04816-9 PMC 바로가기 [Article Type] Article
Azithromycin and hydroxychloroquine in hospitalised patients with confirmed COVID-19: a randomised double-blinded placebo-controlled trialRandomized Controlled Trial Published on 2022-01-062022-10-05 Journal: The European Respiratory Journal [Category] Fulltext, SARS, 임상, [키워드] acute respiratory syndrome airway antibiotic antiviral properties Azithromycin cause Combination control group coronavirus coronavirus disease COVID-19 criteria days alive death discharged double-blind double-blinded enrolment hospital hospitalisation hospitalised hospitalised patient Hydroxychloroquine immunomodulatory effects IMPROVE in vitro induce intensive care interim analysis interquartile range Intervention intervention group median monitoring board multicentre nine occurred outcome Patient patients patients receiving placebo patients with COVID-19 Placebo placebo-controlled trial positive Primary outcome randomisation randomised recruited reverse transcription PCR SARS-CoV-2 survival the placebo group Trial [DOI] 10.1183/13993003.00752-2021 PMC 바로가기 [Article Type] Randomized Controlled Trial
Safety and clinical outcomes of remdesivir in hospitalised COVID-19 patients: a retrospective analysis of active surveillance database입원 COVID-19 환자에서 Remdesivir의 안전 및 임상 결과 : 활발한 감시 데이터베이스의 후 향적 분석Research Article Published on 2022-01-042022-09-10 Journal: BMC Infectious Diseases [Category] SARS, 치료제, [키워드] Active surveillance Administered adverse event Analysis Antibiotics cardiac disease Clinical outcome clinical status Comorbidities concomitant medications conducted COVID-19 Data analysis Data collection database diabete diabetes died Factor High-flow oxygen hospitalised hospitalised patient Hospitalised patients hypertension increased liver enzyme increased liver enzymes India liver enzymes low-flow oxygen management mechanical ventilation men Mortality mortality rate nausea nausea and vomiting non-invasive ventilation oxygen Oxygen therapy Patient patients receiving Remdesivir Result Retrospective analysis Retrospective studies Safety safety profile significantly higher significantly lower steroid Steroids Subgroup analyses subgroup analysis supplementary material treatment for COVID-19 used data vomiting with COVID-19 [DOI] 10.1186/s12879-021-07004-8 PMC 바로가기 [Article Type] Research Article
First and second waves among hospitalised patients with COVID-19 with severe pneumonia: a comparison of 28-day mortality over the 1-year pandemic in a tertiary university hospital in Italy중증 폐렴으로 입원한 COVID-19 환자의 1차 및 2차 유행: 이탈리아의 한 대학병원의 1년 대유행 동안 28일 사망률 비교Observational Study Published on 2022-01-032022-09-11 Journal: BMJ Open [Category] SARS, 변종, 임상, [키워드] 28-day mortality 95% CI 95% CIs age all-cause mortality Analysis circulating cohort study Comorbidity contributed COVID-19 COVID-19 pneumonia Cox regression model death duration of symptom epidemic wave Epidemiology European Factor First wave hospital Hospital admission hospitalised patient Hospitalised patients identify IQR Italy Kaplan-Meier Kaplan-Meier curve log-rank test median median age Modena mortality rate multivariable Cox regression multivariable Cox regression model Observational cohort study pandemic PaO Patient predictor reduced respiratory infections risk of death second wave sensitivity analysis Severe COVID-19 pneumonia severe pneumonia shown Standard suggested survival survival analysis university university hospital variant was performed Wave Waves were used with COVID-19 women [DOI] 10.1136/bmjopen-2021-054069 PMC 바로가기 [Article Type] Observational Study
A SARS-CoV-2 nucleocapsid ELISA represents a low-cost alternative to lateral flow testing for community screening in LMI countriesSARS-CoV-2 뉴클레오캡시드 ELISA는 LMI 국가에서 지역사회 스크리닝을 위한 측면 흐름 테스트에 대한 저렴한 대안을 나타냅니다.Article Published on 2022-01-012022-09-11 Journal: The Journal of Infection [Category] MERS, SARS, 진단, 치료기술, 치료법, [키워드] Antigen applied Asymptomatic Care Community controlling country cut-off Diagnosis diagnostic driven by effective ELISA ELISA assay Health Health care help hospitalised patient identify individual individuals lateral flow limit of detection nose nose and throat nucleocapsid Patient patients positive pre-symptomatic provide Real-time PCR reported required resources Result rising SARS-CoV-2 SARS-CoV-2 nucleocapsid sensitivity Sensitivity and specificity specificity Spread Sputum sample sputum samples swab sample Test tested Transmission Trial variety virus were excluded [DOI] 10.1016/j.jinf.2021.08.049 PMC 바로가기 [Article Type] Article
Clinical profile and outcomes of COVID-19 patients with acute kidney injury: a tertiary centre experience from South IndiaObservational Study Published on 2022-01-012022-10-05 Journal: Clinical and experimental nephrology [Category] 임상, [키워드] acute kidney Acute kidney injury age AKI AKI patient Analysis Care Chronic kidney disease CKD clinical COVID-19 COVID-19 patient Diabetes Mellitus dialysis discharge disease Factor hospitalisation hospitalised COVID-19 patient hospitalised patient hypertension ICU ICU care India kidney male mechanical ventilation Mortality Most patient multivariable outcome Patient patients with AKI Prevalence Regression reported retrospective south India study population survivor Survivors was done with COVID-19 [DOI] 10.1007/s10157-021-02123-7 PMC 바로가기 [Article Type] Observational Study