A pair of noncompeting neutralizing human monoclonal antibodies protecting from disease in a SARS-CoV-2 infection modelSARS-CoV-2 감염 모델에서 질병으로부터 보호하는 한 쌍의 비경쟁 중화 인간 단일클론 항체Article Published on 2022-05-012022-09-11 Journal: European Journal of Immunology [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] Analysis animals antibodies antibody binding candidate cellular receptor cellular receptor hACE2 Cluster competing COVID-19 disease DNA DNA sequence hACE2 human ACE2 human immunoglobulin human monoclonal antibodies Human monoclonal antibody IC50 Immunoglobulin mice N-terminal domain neutralize neutralized Neutralizing Neutralizing antibodies neutralizing antibody pandemic platform powerful tool Prophylaxis Receptor-binding domain reduced SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 mutant SARS-CoV-2 mutants SARS-CoV-2 neutralizing antibody SARS-CoV-2 spike protein selected Spike protein Support the receptor-binding domain the SARS-CoV-2 the spike protein therapy transgenic variants variants of concern Viral viral spread weight loss [DOI] 10.1002/eji.202149374 PMC 바로가기 [Article Type] Article
Nanobodies Protecting From Lethal SARS-CoV-2 Infection Target Receptor Binding Epitopes Preserved in Virus Variants Other Than Omicron치명적인 SARS-CoV-2 감염 표적 수용체 결합 에피토프로부터 보호하는 나노바디는 오미크론 이외의 바이러스 변이체에 보존되어 있습니다Article Published on 2022-04-252022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 변종, [키워드] affinity antibody binding binding epitope binding mode blocked cell cultures cell entry cell entry receptor competition coronavirus COVID-19 COVID-19 pandemic cryo Cryo-electron microscopy electron microscopy Epitopes fusion glycoprotein groups hACE2 heavy chain human ACE2 humanized immune Immune escape immunized lethal mice Microscopy mono MOST nanobodies nanobody neutralization neutralized Neutralizing Neutralizing antibodies neutralizing antibody nine omicron Other Prevent prevented progression Protecting pseudotyped RBD RBD binding RBM receptor receptor binding motif Receptor-binding domain S protein SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 RBD SARS-CoV-2 variant SARS-CoV-2 variants selected target the receptor-binding domain the S protein therapeutic potential Therapeutics Vaccine variant variants of concern virus [DOI] 10.3389/fimmu.2022.863831 PMC 바로가기 [Article Type] Article
Emerging of composition variations of SARS-CoV-2 spike protein and human ACE2 contribute to the level of infection: in silico approachesSARS-CoV-2 스파이크 단백질과 인간 ACE2의 조성 변화가 감염 수준에 기여함: in silico 접근법Article Published on 2022-04-012022-09-11 Journal: Journal of biomolecular structure & dynamics [Category] COVID19(2023년), SARS, 변종, 치료기술, [키워드] ACE2 angiotensin bind binding affinity binds bioinformatics calculated Combination contribute COVID-19 detect determine docking domain eight FIVE Genetic variant global energy hACE2 human ACE2 human Angiotensin-converting enzyme Human angiotensin-converting enzyme 2 in silico in silico Approach in silico software Interaction investigated Laboratory moderate NCBI nsSNPs pandemic pathogenic PPI processed Protein Protein docking protein-protein interaction RBD RBD variant RBD variants Receptor-binding domain retrieved risk of infection SARS-CoV SARS-CoV-2 SARS-CoV-2 RBD SARS-CoV-2 spike protein sequence similarity significantly SNP SNPs Support the binding affinity V367F V483A variant variants Variation zone [DOI] 10.1080/07391102.2020.1841032 PMC 바로가기 [Article Type] Article
Exploring Zebrafish Larvae as a COVID-19 Model: Probable Abortive SARS-CoV-2 Replication in the Swim BladderCOVID-19 모델로 Zebrafish 유충 탐색: 수영 방광에서 SARS-CoV-2 복제 중단 가능성Article Published on 2022-03-112022-09-11 Journal: Frontiers in Cellular and Infection Microbiology [Category] SARS, 변종, 치료기술, [키워드] abortive infection animal animal model animal models Bath bladder wall bloodstream Brain Cell comparable COVID-19 decrease drug Embryo epithelial cell epithelial cells Evidence evidence of Host human ACE2 immunohistochemistry in some in vitro Infection inoculated interferon lung mammalian microinjection no evidence of organ overexpression pathophysiology Prophylactic SARS-CoV-2 SARS-CoV-2 nucleoprotein SARS-CoV-2 RNA several variant several variants similarity swim bladder tested therapeutic type I type I interferon Viral load Viral RNA virus wild-type zebrafish [DOI] 10.3389/fcimb.2022.790851 PMC 바로가기 [Article Type] Article
An engineered nano-liposome-human ACE2 decoy neutralizes SARS-CoV-2 Spike protein-induced inflammation in both murine and human macrophages조작된 나노 리포솜 인간 ACE2 미끼는 쥐와 인간 대식세포 모두에서 SARS-CoV-2 스파이크 단백질 유도 염증을 중화합니다Article Published on 2022-03-062022-09-11 Journal: Theranostics [Category] SARS, 유전자 메커니즘, [키워드] abrogate abrogated ACE2 activating Activation acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Analysis angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 binding biotinylated canonical CCL-2 chemokines competitive inhibitor complex coronavirus CXCL-10 cytokine D614G deficiency DEGs demonstrated differentially expressed gene Effect enzyme expressing expression fusion generate glycoprotein hACE2 human ACE2 human host cells human macrophage human macrophages IKKβ IKKβ/NF-κB signaling IL-1β IL-6 Immune cell immune cells in vitro in vivo Infection Inflammation Inflammatory response Inflammatory responses inhibit SARS-CoV-2 inhibitor internalization Intravenous injection IκB lentivirus Liposome Liposome-Human ACE2 Macrophage macrophages mechanism mice molecular murine myeloid-specific IKKβ knockout. neutralize NF-κB NF-κB activation NF-κB signaling Protein rationale receptor RNA sequencing SARS-CoV-2 SARS-CoV-2 spike glycoprotein severe acute respiratory syndrome Coronavirus Signaling spike spike glycoprotein Spike protein stimulated Therapeutic approach tissue inflammation TNFα Treatment was used wild type [DOI] 10.7150/thno.66831 PMC 바로가기 [Article Type] Article
Missense variants in human ACE2 strongly affect binding to SARS-CoV-2 Spike providing a mechanism for ACE2 mediated genetic risk in Covid-19: A case study in affinity predictions of interface variants인간 ACE2의 미스센스 변이체는 코로나19에서 ACE2 매개 유전적 위험에 대한 메커니즘을 제공하는 SARS-CoV-2 스파이크에 대한 결합에 강한 영향을 미칩니다. 인터페이스 변이체의 친화도 예측 사례 연구Article Published on 2022-03-022022-09-11 Journal: PLoS Computational Biology [Category] 변종, 유전자 메커니즘, [키워드] ACE2 ACE2 variant ACE2 variants Affect affinity African allele angiotensin bind binding calculated calibration Cell cell types Cohort cohorts distribution ENhance European experiment genetic risk gnomAD greater human ACE2 human Angiotensin-converting enzyme Human angiotensin-converting enzyme 2 Infection inhibited Interaction Kinetics mechanism missense variant parameter predicted predominant Prevalence PROTECT pseudotype receptor Receptor binding domain reduce reduced SARS-CoV-2 SARS-CoV-2 spike selected spike Spike receptor binding domain SPR strength surface plasmon surface plasmon resonance the Spike this system tissue tissues utility variant variants virulence ΔΔG [DOI] 10.1371/journal.pcbi.1009922 PMC 바로가기 [Article Type] Article
An engineered bispecific human monoclonal antibody against SARS-CoV-2 Research Published on 2022-02-282022-10-05 Journal: Nature Immunology [Category] COVID19(2023년), SARS, 변종, 비임상, 치료제, [키워드] ACE2 acute respiratory syndrome antibodies binding coronavirus coronavirus disease COVID-19 delta variant described develop effective effective therapy Efficiency escape mutant escape mutants feasible greater human ACE2 Human monoclonal antibody less mAb mAbs monoclonal antibody neutralize Neutralizing Neutralizing activity neutralizing antibody pandemic parental Prevent Prophylactic receptor reduced SARS-CoV-2 SARS-CoV-2 variant selected selective severe COVID-19 therapeutic therapy transgenic mice treat viral titer [DOI] 10.1038/s41590-022-01138-w [Article Type] Research
Co-circulation of two SARS-CoV-2 variant strains within imported pet hamsters in Hong Kong홍콩에서 수입된 애완용 햄스터 내에서 두 개의 SARS-CoV-2 변종 균주의 공동 순환Coronaviruses Published on 2022-02-272022-09-10 Journal: Emerging Microbes & Infections [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] adaptive animal animals aviation binding energy can not coronavirus COVID-19 Delta delta variant epidemiologically Europe European hamster hamsters Hong Kong Human human ACE2 interspecies molecular docking Netherland Netherlands outbreak Outbreaks Patient phylogenetically positive Prevent RBD reported respiratory Respiratory Coronavirus risk SARS-CoV-2 SARS-CoV-2 spike SARS-CoV-2 variant SARS-CoV-2 variants severe acute respiratory coronavirus spike mutation spike receptor-binding domain spike variant spike variants strain Strains subsequent suggested susceptible Testing these viruses Transmission triggered variant virus viruses warehouse while zoonosis [DOI] 10.1080/22221751.2022.2040922 PMC 바로가기 [Article Type] Coronaviruses
Polymorphisms and mutations of ACE2 and TMPRSS2 genes are associated with COVID-19: a systematic reviewACE2 및 TMPRSS2 유전자의 다형성 및 돌연변이는 코로나19와 관련이 있습니다. 체계적 검토Review Published on 2022-02-222022-09-11 Journal: European Journal of Medical Research [Category] COVID19(2023년), MERS, SARS, 변종, [키워드] abstracts ACE2 ACE2 gene acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Affect Analysis angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 article bind characterized Cochrane Library coronavirus correlated COVID-19 criteria debatable determine downloaded drug duplicates eliminated English enzyme epidemic of COVID-19 evaluated Evidence expression Factor Factors Final General population Genetic genetic data genetic factors genetic susceptibility human ACE2 inclusion criteria increase in intensity item Mortality Mutation objective occurred outbreak outcomes Patient patients with COVID-19 performed polymorphism Polymorphisms PRISMA Prognosis PROSPERO receptor receptors Region Reporting respiratory Result review SARS-CoV-2 SARS-COV-2 infection searched Serine severe acute respiratory syndrome Coronavirus SNP susceptibility systematic review systematic reviews TMPRSS2 transmembrane serine protease Trial registration Type Vaccine variant Virus Disease vital role vital roles vulnerability Web of Science were excluded with COVID-19 [DOI] 10.1186/s40001-022-00647-6 PMC 바로가기 [Article Type] Review
Bat coronaviruses related to SARS-CoV-2 and infectious for human cells Research Published on 2022-02-162022-10-05 Journal: Nature [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] ACE2 angiotensin-converting enzyme 2 antibody Asian bat bat virus cave cellular contribute coronavirus determine domain furin cleavage site Genome hACE2 hACE2 protein Host Human human ACE2 human cell human cells inhibited neutralize pathway RaTG13 receptor Replication residue responsible SARS-CoV-2 sequence the binding affinity the epidemic the receptor-binding domain the SARS-CoV-2 the spike protein virus Wuhan [DOI] 10.1038/s41586-022-04532-4 [Article Type] Research