SARS-CoV-2 variants and effectiveness of vaccines: a review of current evidenceSARS-CoV-2 변이체 및 백신의 효과: 현재 증거 검토Review Published on 2021-11-042022-09-11 Journal: Epidemiology and Infection [Category] MERS, SARS, 변종, 진단, [키워드] Adenovirus administration Alpha B.1.617.2 binding circulating variant contagious Delta dominant Effectiveness Epsilon Evidence human ACE2 receptor Immune escape increase morbidity Mortality mRNA Mutagenesis natural infection Neutralizing activity pandemic Protein provoke public health Recombinant protein Reinfection SARS-CoV-2 SARS-CoV-2 vaccines SARS-CoV-2 variant SARS-CoV-2 virus severe acute respiratory syndrome coronavirus 2 significantly spike mutations Transmissibility vaccination Vaccine Vaccines variant variants variants of concern variants of interest variants of SARS-CoV-2 VoC VOCs [DOI] 10.1017/S0950268821002430 PMC 바로가기 [Article Type] Review
Structural and Functional Analysis of Female Sex Hormones against SARS-CoV-2 Cell EntryArticle Published on 2021-10-262022-10-29 Journal: International Journal of Molecular Sciences [Category] COVID-19, MERS, SARS, [키워드] ACE2 ACE2 receptor alveolar cells COVID-19 disrupt ENhance Estrogen estrogenes Evidence female females glycosylation hormone human ACE2 human ACE2 receptor Interaction male mechanism molecular basis Protein reduced SARS-CoV-2 Severe infection sex hormone Sex hormones Spike protein susceptible the SARS-CoV-2 the SARS-CoV-2 virus therapy underlie variety [DOI] 10.3390/ijms222111508 PMC 바로가기 [Article Type] Article
In Vitro Effect of Taraxacum officinale Leaf Aqueous Extract on the Interaction between ACE2 Cell Surface Receptor and SARS-CoV-2 Spike Protein D614 and Four MutantsArticle Published on 2021-10-172022-10-28 Journal: Pharmaceuticals [Category] COVID-19, [키워드] ACE2 ACE2 binding inhibitor ACE2 receptor applicability aqueous B.1.617.2 Compound COVID-19 D614G dandelion Delta E484K Effect Efficacy Extract form human ACE2 receptor Immune escape in vitro result K417N kidney leaf lentivirus lung cell lung cells multiple mutation mutant N501Y new SARS-CoV-2 Non-invasive Particle prevented pro-inflammatory Prophylaxis Protein–protein interaction pseudotyped reported Research S1 spike mutation Safe SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 prevention SARS-CoV-2 spike secretion sequence shown spike surface Taraxacum officinale the spike protein variant wild type Wuhan [DOI] 10.3390/ph14101055 PMC 바로가기 [Article Type] Article
A novel predictor of ACE2-binding ability among betacoronavirusesOriginal Research Article Published on 2021-10-132022-11-01 Journal: Evolution, Medicine, and Public Health [Category] COVID-19, [키워드] ACE2 ACE2 binding ACE2 receptor acute respiratory syndrome Amino acid amino acids angiotensin-converting enzyme 2 applied approach Betacoronavirus betacoronavirus spike protein betacoronaviruses binding biosurveillance caused cell entry Cluster coronavirus Coronavirus disease 2019 Coronaviruses COVID-19 COVID-19 pandemic curtail death determine develop domains effort Evolution functional Host Human human ACE2 receptor human cell human cells humans infect less likelihood novel outbreak Outbreaks Phylogenetic phylogenetic analyses physicochemical physicochemical property Prevent Protein RBD receptor Receptor binding domain Result SARS-CoV SARS-CoV-2 sequence shown the spike protein Variation virus Virus evolution zoonotic Zoonotic coronavirus [DOI] 10.1093/emph/eoab032 PMC 바로가기 [Article Type] Original Research Article
Polymorphisms of ACE (I/D) and ACE2 receptor gene (Rs2106809, Rs2285666) are not related to the clinical course of COVID-19: A case studyACE(I/D)와 ACE2 수용체 유전자(Rs2106809, Rs2285666)의 다형성은 코로나19의 임상 경과와 관련이 없음: 사례 연구Article Published on 2021-10-012022-09-11 Journal: Journal of medical virology [Category] SARS, 유전자 메커니즘, [키워드] ACE ACE gene ACE2 ACE2 gene ACE2 receptor gene acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Affect allele frequency angiotensin Angiotensin-converting enzyme caused Chain Reaction Clinical course Clinical symptoms coagulation indicators coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 disease COVID-19 infection COVID-19 pathogenesis COVID-19 patient COVID-19 severity Critical Cytokines distribution enzyme Epigenetic Evidence expression Genotype groups human ACE2 receptor I/D I/D polymorphism Infection Infectious disease influence insertion/deletion mechanism Mild moderate outcome pandemic Pathogenesis PCR polymerase chain polymerase chain reaction polymorphism Polymorphisms pro-inflammatory cytokine pro-inflammatory cytokines reason receptor rs2106809 rs2285666 rs2285666. SARS-CoV-2 SARS-CoV-2 susceptibility SARS-CoV-2 virus severe acute respiratory syndrome Coronavirus severity severity of COVID-19 statistically significant study population suggested susceptibility the SARS-CoV-2 virus three group three groups Variation variations with COVID-19 [DOI] 10.1002/jmv.27160 PMC 바로가기 [Article Type] Article
The urgent need for more basic research on SARS-Cov2 infection and vaccines in assessing potential psychoneurological effects using maternal immune activation (MIA) and other preclinical modeling모성 면역 활성화(MIA) 및 기타 전임상 모델링을 사용하여 잠재적인 정신 신경학적 효과를 평가하기 위한 SARS-Cov2 감염 및 백신에 대한 보다 기초적인 연구가 시급합니다.Review Published on 2021-10-012022-09-11 Journal: Brain, behavior, and immunity [Category] SARS, 변종, [키워드] accumulates aging allergy Autoimmunity Behavior Clinical data during pregnancy Effect Efficacy expression foster General population heterogeneity human ACE2 receptor immune activation immune response immune responses incorporation Infection likelihood Maternal Maternal Immune Activation MIA mutants neurologic obesity pandemic Preclinical Preclinical Testing Pregnancy progeny receptor Research responses SARS-CoV2 Stage supported target tissue TLR Transgenic mouse Vaccine vaccine candidate vaccine candidates Vaccines variable [DOI] 10.1016/j.bbi.2021.06.009 PMC 바로가기 [Article Type] Review
AI-driven multiscale simulations illuminate mechanisms of SARS-CoV-2 spike dynamicsSpecial Issue Papers Published on 2021-09-012022-10-29 Journal: The International Journal of High Performance Computing Applications [Category] COVID-19, [키워드] accelerate AI Complete complex computational virology conformational COVID19 deep learning develop flexible glycan GPU heterogeneous HPC human ACE2 receptor Interaction mechanism modulating molecular molecular dynamics multiscale simulation resource SARS-CoV-2 SARS-CoV-2 spike SARS-CoV-2 viral Spike protein Summit the SARS-CoV-2 variety viral infection virus weighted ensemble [DOI] 10.1177/10943420211006452 PMC 바로가기 [Article Type] Special Issue Papers
Effects of common mutations in the SARS-CoV-2 Spike RBD and its ligand, the human ACE2 receptor on binding affinity and kineticsResearch Article Published on 2021-08-262022-10-31 Journal: eLife [Category] COVID-19, MERS, SARS, [키워드] ACE2 ACE2 allele ACE2 binding ACE2 variant addition Affect affinity analysed Analysis appear B.1.1.7 B.1.1.7 lineage B.1.351 Beta bind binding binding affinity binding site carrier Cell cells Combination concerning coronavirus COVID-19 COVID-19 pandemic E484K E484K mutation Effect ENhance example experiment facilitate FIVE Gamma health authorities help Human human ACE2 receptor human cells identify identifying Immune escape infecting interact Interaction K417N Ligand MOST Mutation N501Y new SARS-CoV-2 original form progressed Protein Proteins RBD RBD mutation Receptor binding domain required reversed risk S477N SARS-CoV-2 SARS-CoV-2 mutation SARS-CoV-2 variant spike Spread surface protein susceptible the RBD the SARS-CoV-2 the SARS-CoV-2 virus the Spike Transmission variant variants variants of SARS-CoV-2 viral infection Viral receptor virus weakened [DOI] 10.7554/eLife.70658 PMC 바로가기 [Article Type] Research Article
An easy method for developing fusion enabled SARS-CoV2 virus fusion mimic (SCFM), bypassing the need of Bio Safety Level (BSL) facilityResearch Article Published on 2021-08-262022-10-27 Journal: Bioengineered [Category] COVID-19, [키워드] Abbreviation Abstract acute respiratory syndrome Antiviral agents approach Balanced biohazard BSL BSL3 BSL3 laboratory bypassing coding conditions coronavirus COVID19 develop enzyme functional fusion fusion mimic global pandemic Human human ACE2 receptor in vitro Infection infective inhibition assay inhibitor Interaction Laboratory Level M protein mammalian cell mammalian cells mouse required resource restrict S protein Safety salt SARS-CoV2 SARS-CoV2 infection secure shown Syncytia target protein the S protein transfected with treat Vaccine virus [DOI] 10.1080/21655979.2021.1955509 PMC 바로가기 [Article Type] Research Article
An easy method for developing fusion enabled SARS-CoV2 virus fusion mimic (SCFM), bypassing the need of Bio Safety Level (BSL) facilityResearch Article Published on 2021-08-262022-10-27 Journal: Bioengineered [Category] Coronavirus, COVID-19, Fulltext, SARS, [키워드] Abbreviation Abstract acute respiratory syndrome Antiviral agents approach Balanced biohazard BSL BSL3 BSL3 laboratory bypassing coding conditions coronavirus COVID19 develop enzyme functional fusion fusion mimic global pandemic Human human ACE2 receptor in vitro Infection infective inhibition assay inhibitor Interaction Laboratory Level M protein mammalian cell mammalian cells mouse required resource restrict S protein Safety salt SARS-CoV2 SARS-CoV2 infection secure shown Syncytia target protein the S protein transfected with treat Vaccine virus [DOI] 10.1080/21655979.2021.1955509 PMC 바로가기 [Article Type] Research Article