hyper-inflammation – Page 5 – Communicable Diseases Research

Immunopathogenesis and treatment of cytokine storm in COVID-19

COVID-19에서 면역 병인 및 사이토 카인 폭풍의 치료

Review

Published on 2021-01-012022-09-01
Journal: Theranostics [Category] 임상, 진단,

Glucocorticoids with low-dose anti-IL1 anakinra rescue in severe non-ICU COVID-19 infection: A cohort study

Research Article

Published on 2020-12-162022-10-28
Journal: PLoS ONE [Category] COVID-19, MERS, SARS,

[키워드] 95% CIs 95%CI Algorithm Bayesian analysis benefit Clinical deterioration cohort study consecutive patients control group controls Corticosteroid COVID-19 COVID-19-related death cytokine release Day death death rate decrease diabete disease evaluate Evolution glucocorticoid hyper-inflammation ICU Inpatient intensive care invasive ventilation Logistic regression low-dose material Methylprednisolone Mortality non-ICU occurred oxygen Patient per-protocol analysis posterior probability Prevent Probability Ratio receiving Result risk Standard of care steroid symptoms onset therapeutic treat Treatment treatment effects Ventilation
[DOI] 10.1371/journal.pone.0243961 PMC 바로가기 [Article Type] Research Article

Complement C3 vs C5 inhibition in severe COVID-19: Early clinical findings reveal differential biological efficacy

Research article

Published on 2020-11-012022-10-05
Journal: Clinical immunology (Orlando, Fla.) [Category] SARS, 바이오마커,

[키워드] abrogate Activation acute respiratory distress AMY-101 anti-inflammatory response ARDS Biomarkers blockade C-reactive protein C3 inhibition C3a C5 blockade C5a candidate drug clinical evidence Clinical finding Cohort complement consequence COVID-19 COVID-19 hyper-inflammation COVID-19 patient COVID-19 therapeutics detrimental drug candidate Drug efficacy eculizumab effector Efficacy elicit exploratory study faster hyper-inflammation IL-6 levels immunopathology immunothrombosis implicated independent indicate inhibitor inhibitory Intervention LDH Lung function lymphocyte monoclonal antibody multi-organ failure NET neutrophil counts Neutrophil extracellular trap offer outcome pathogenic pathway reflected robust SARS-COV-2 infection SC5b-9 serum severe COVID-19 patients Support syndrome therapeutic Thromboinflammation thrombotic trials upstream
[DOI] 10.1016/j.clim.2020.108598 [Article Type] Research article

Do free radical NETwork and oxidative stress disparities in African Americans enhance their vulnerability to SARS-CoV-2 infection and COVID-19 severity?

아프리카 계 미국인의 자유 라디칼 네트워크 및 산화 스트레스 불균형이 SARS-CoV-2 감염 및 COVID-19 심각성에 대한 취약성을 강화합니까?

Review

Published on 2020-10-012022-09-11
Journal: Redox Biology [Category] SARS, 신약개발,

[키워드] African African American African Americans amplifying Autoimmune autoimmune and inflammatory diseases Bacteria black Black Americans Care cells Comorbidities Comorbidity Complication contribute coronavirus COVID-19 COVID-19 patient COVID-19 patients COVID-19 severity Critical deaths decrease diabetes disease severity Diseases drug elevated ENhance Factor free radical Free radicals fungi Health Health care host cells hyper-inflammation hypertension hypothetical identifying immune cells individual infected with SARS-CoV-2 Inflammation Inflammatory biomarker inflammatory disease Inflammatory diseases inhibiting killing lack mechanism mice mitigate Mortality NET NETs neutrophil Neutrophil extracellular trap Neutrophil extracellular traps Neutrophils obesity Oxidant oxidants Oxidants. oxidative stress pathogen Pathogens preventive measure preventive measures pro-inflammatory PROTECT SARS-CoV-2 SARS-COV-2 infection socioeconomic status Treatment viruses Vitamin
[DOI] 10.1016/j.redox.2020.101721 PMC 바로가기 [Article Type] Review

The Rheumatologist’s Role in the Battle Against COVID-19: Insights from the Front Line and Challenges for the Future

Viewpoint

Published on 2020-09-212022-10-31
Journal: Mediterranean Journal of Rheumatology [Category] COVID-19,

In Silico Prediction of Molecular Targets of Astragaloside IV for Alleviation of COVID-19 Hyperinflammation by Systems Network Pharmacology and Bioinformatic Gene Expression Analysis

Pharmacology

Published on 2020-09-162022-10-31
Journal: Frontiers in Pharmacology [Category] COVID-19,

[키워드] ADORA2A ADRB2 alleviation Analysis Anti-inflammatory antioxidant approach Astragaloside IV Bioinformatic Bioinformatics analysis caused chemokine contribute COVID-19 COVID-19 patients cytokine cytokine storms dataset DEGs differentially expressed gene down-regulated genes drug candidate GBP1 Gene Expression Omnibus Genes GEO GO term GSE147507 hyper-inflammation hyperinflammation IL1B IL6 Inflammation KEGG KEGG pathway Kyoto MLNR MMP13 network network pharmacological network pharmacology NFKBIA NLRP3 Ontology overlap overlapping pathway pathway enrichment performed pharmacological mechanism Pharmacology Potential prediction PTAFR Result SARS-CoV-2 screened System target TNF Treatment TRIM21 up-regulated
[DOI] 10.3389/fphar.2020.556984 PMC 바로가기 [Article Type] Pharmacology

The COVIRL002 Trial-Tocilizumab for management of severe, non-critical COVID-19 infection: A structured summary of a study protocol for a randomised controlled trial

Letter

Published on 2020-09-032022-10-29
Journal: Trials [Category] Coronavirus, SARS,

[키워드] 1:1 48 hours absence Admission all-cause mortality Arm blinded chest imaging clinical commenced Confirmed COVID-19 criteria CRP D-dimer Data analysis database death defined demonstrated determine disease dissemination dose Efficacy element eligible participant enrolled EudraCT Evidence evidence of evidenced facilitate ferritin fibrinogen hospital humanized monoclonal antibody hyper-inflammation IL-6 IL6 immunology independent Infection inflammatory state infused inhibit interleukin-6 intravenous tocilizumab intubation investigators Ireland LDH low dose management Mater moderate to severe multicentre non-invasive ventilation number objective Older open label outcome PaO participant Patient patients with COVID-19 PCR-confirmed COVID-19 performed positive PCR Potential treatment primary endpoint Primary outcome progression protocol pulmonary randomisation randomised randomised controlled trial Randomised trial receive recruited reduced Registered reported Respiratory failure Respiratory function Sample size SARS-CoV2 infection single dose Stage stage 2 Standard Standard dose status Study protocol subject subjects subsequent systemic inflammation target temperature Therapeutics Tocilizumab treatment group Trial ULN university Ventilation website
[DOI] 10.1186/s13063-020-04680-w PMC 바로가기 [Article Type] Letter

Icosapent Ethyl – A Successful Treatment for Symptomatic COVID-19 Infection

Anesthesiology

Published on 2020-09-022022-10-31
Journal: Cureus [Category] COVID-19,

Mitochondria and microbiota dysfunction in COVID-19 pathogenesis

Review article

Published on 2020-09-012022-10-05
Journal: Mitochondrion [Category] SARS, 유전자 메커니즘,

[키워드] “cytokine storm” accelerated addition aggravate Apoptosis caused cellular Coagulation coagulation cascade contribute coronavirus Coronavirus infections COVID-19 pandemic COVID-19 pathogenesis COVID-19 patient disease severity DNA dysfunction dysregulation event events Evidence Extracellular Extracellular mitochondria extracellular space extracellular vesicle homeostasis hyper-inflammation hypercoagulability Hyperferritinemia identify include induce Infectious disease Interaction iron manifested microbiota Mitochondria mitochondrial mitochondrial dysfunction Mitochondrial function morbidity and mortality Mounting outcome oxidative oxidative stress pathway perturbations Platelet Platelet mitochondria Platelets progression promote reactive oxygen specy reduce Respiratory failure ROS SARS-CoV-2 severity the disease therapeutic target thrombus formation vicious cycle
[DOI] 10.1016/j.mito.2020.06.008 [Article Type] Review article

Macrophage activation syndrome as an unusual presentation of paucisymptomatic severe acute respiratory syndrome coronavirus 2 infection A case report

4900

Published on 2020-08-072022-10-30
Journal: Medicine [Category] COVID-19, MERS,