Longitudinal assessment of IFN-I activity and immune profile in critically ill COVID-19 patients with acute respiratory distress syndrome급성 호흡 곤란 증후군이 있는 중환자 COVID-19 환자의 IFN-I 활성 및 면역 프로파일에 대한 종단 평가Clinical Trial Published on 2021-04-122022-08-13 Journal: Critical Care [Category] MERS, 바이오마커, 임상, [키워드] acute respiratory distress acute respiratory distress syndrome alteration appear ARDS ARDS patient ARDS patients Bacterial sepsis cellular COVID-19 COVID-19 patient COVID-19 patients Critically ill critically ill COVID-19 patients Critically ill patient critically ill patients cytokine cytokine levels Cytokines decrease described Elevation expression followed by Hospital stay ICU admission IFN response IFN-I IFN-stimulated gene IFN-stimulated genes IFNα2 immune immune parameter Immune profile immune response immune responses immuno-inflammatory Immunosuppression intensity ISG longitudinal longitudinal immune monitoring lymphocyte Lymphocyte count marker mHLA-DR non-survivor normal values Occurrence outcome pandemic plasma question respiratory distress Result SARS-CoV2 infection Secondary infection secondary infections Sepsis similarities similarity supplementary material Survivors syndrome TNF-α Type-I IFN [DOI] 10.1186/s13054-021-03558-w PMC 바로가기 [Article Type] Clinical Trial
Sex- and age-specific clinical and immunological features of coronavirus disease 2019Research Article Published on 2021-03-262022-10-29 Journal: PLoS Pathogens [Category] COVID-19, SARS, [키워드] acute respiratory syndrome adult COVID-19 patient age age and sex alanine aminotransferase ALT Analysis analyzed assigned association AST B cell C-reactive protein (CRP CD8 cell count Concentration concentrations Control coronavirus coronavirus disease COVID-19 COVID-19 disease severity COVID-19 pathogenesis COVID-19 patient COVID-19 patients Critical CRP decrease determine disease feature female female patient females four group had more Immune profile immunological Immunological response incidence Infection Inflammatory response leukocyte limit Liver damage lymphocyte Lymphocyte count male males Multiple linear regression natural killer neutrophil count neutrophil counts NK cell Patient patients plasma positive previous study reduced resulting Retrospective study SARS-CoV-2 SARS-COV-2 infection Sex significantly higher susceptibility T cell T-cell Treatment variable Variation [DOI] 10.1371/journal.ppat.1009420 PMC 바로가기 [Article Type] Research Article
Profiles of Peripheral Immune Cells of Uncomplicated COVID-19 Cases with Distinct Viral RNA Shedding PeriodsArticle Published on 2021-03-192022-10-28 Journal: Viruses [Category] COVID-19, SARS, [키워드] Blood CD19 CD4 CD8 Cell change clinically Cohort collected comparable Course COVID-19 COVID-19 case COVID-19 patient determine disease disease severity downregulated downregulation evaluate evaluated expressed HCs healthy control heterogeneity Immune cell Immune profile immune response immune signature immune system mononuclear cell NK cell patients PBMCs Period peripheral profile Prognosis recruited remained reported RNA severe disease shedding submitted subsequent the disease upregulated upregulation viral RNA clearance viral RNA-shedding while [DOI] 10.3390/v13030514 PMC 바로가기 [Article Type] Article
Blood Interferon-α Levels and Severity, Outcomes, and Inflammatory Profiles in Hospitalized COVID-19 Patients입원한 COVID-19 환자의 혈액 인터페론-α 수준 및 중증도, 결과 및 염증 프로필Immunology Published on 2021-03-092022-09-11 Journal: Frontiers in Immunology [Category] MERS, SARS, 바이오마커, 치료기술, 치료제, [키워드] association Blood blood lymphocyte blood sample Blood samples clinical clinical condition clinical manifestation clinical manifestations clinically Cohort conditions Control control patient controls COVD-19 COVID-19 COVID-19 patient COVID-19 severity COVID−19 Deficient defined detectability died each time-point enrolled Enrollment evaluate Evolution expression hospitalized patient identify IFN-α IFN-β IL-10 Immune cell immune cells Immune profile immunoassay immunological pathway immunological pathways improvement Infection interferon interferon response Intervention Level Lymphocytes manifestation matched controls mechanism mediators Mortality multiplex Patient patients who survived pharmacological profile proportion Prospective Study recruitment required respiratory Respiratory failure Respiratory Support SARS-COV-2 infection SARS–CoV−2 severe manifestations of COVID-19 severity significant increase study period study population subjects survived survivor target the interferon threshold were assessed [DOI] 10.3389/fimmu.2021.648004 PMC 바로가기 [Article Type] Immunology
Epigenetic Landscapes of Single-Cell Chromatin Accessibility and Transcriptomic Immune Profiles of T Cells in COVID-19 PatientsImmunology Published on 2021-02-242022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, MERS, [키워드] Accessibility accompanied Activation Analysis approaches CD4 CD69 CD8 Cell Characteristics chromatin chromatin accessibility Control coronavirus diseases COVID-19 creating Critical element enhancer Epigenetic expressed function Genes HCs healthy HLA class II HLA-DRA HLA-DRB1 HLA-DRB5 immune Immune profile infected with COVID-19 inflammatory genes inflammatory pathways inflammatory state involved key factor landscape less MAPK moderate mononuclear cell motif Necrosis NFKBIA nine Pathogenesis Patient patients with COVID-19 PBMCs performed Peripheral blood PIK3R1 profile profiles promoter proportion Protein provided regions RNA S100A9 SARS-CoV-2 scATAC-seq scRNA-seq ScRNA-seq analysis seq Sequencing signaling pathway significantly Single Cell single-cell T cell T cells T-cell TBX21 Th1 TNF transcriptome profiling transcriptomic upregulated were used [DOI] 10.3389/fimmu.2021.625881 PMC 바로가기 [Article Type] Immunology
Immune transcriptomes of highly exposed SARS-CoV-2 asymptomatic seropositive versus seronegative individuals from the Ischgl communityIschgl 커뮤니티에서 고도로 노출된 SARS-CoV-2 무증상 혈청 양성 대 혈청 음성 개인의 면역 전사체Comparative Study Published on 2021-02-192022-09-01 Journal: Scientific Reports [Category] MERS, 변종, 유전자 메커니즘, 진단, [키워드] Activation Asymptomatic Asymptomatic disease asymptomatic infection Blood characterized Community Computational biology and bioinformatics Control COVID-19 Cystic cystic fibrosis evidence of examined fibrosis Follow-up Health immune immune activation Immune cell Immune profile immunological immunology in some Incontinentia pigmenti individual individuals Infection Medical research negative negative controls no evidence of one individual Patient positive controls Post-infection remained reported sample collection SARS-CoV-2 SARS-COV-2 infection seronegative seropositive seropositive individual statistically significant difference symptomatic Transcriptome transcriptomes whole blood transcriptome [DOI] 10.1038/s41598-021-83110-6 PMC 바로가기 [Article Type] Comparative Study
Disease‐duration based comparison of subsets of immune cells in SARS CoV‐2 infected patients presenting with mild or severe symptoms identifies prognostic markers for severity경증 또는 중증 증상을 나타내는 SARS CoV-2 감염 환자의 면역 세포 하위 집합의 질병 기간 기반 비교는 중증도에 대한 예후 마커를 식별합니다.Comparative Study Published on 2021-01-162022-09-12 Journal: Immunity, Inflammation and Disease [Category] MERS, SARS, 진단, [키워드] absence adaptive adaptive immune cells Adaptive immunity addition Analysis analyzed Antibody titer association B cells CD8 T cells Cell dendritic cells determined by disease disease severity event expression flow cytometry follicular forms Frequency functional healthy subject help Humoral immunity Hyperactivation identification identify IgG IL‐6 Imbalance Immune cell immune cells Immune profile India indicated infected patient Infection innate immune cell Innate immune cells Lower lymphocyte Lymphocytes management material maturation mDC mDCs memory B cell memory B cells Mild modulation Monocytes Multivariate analysis Neutralizing antibody titer neutralizing antibody titers NK cells observation Older age pandemic Pathogenesis Patient patient cohort patients positive presenting PRNT PRNT50 Prognostic marker Prognostic markers receptor Result SARS CoV‐2 SARS‐CoV‐2 SARS‑CoV2 Severe case severe cases severe disease severe symptom severity Spectrum subset Symptoms T cell T cells T helper cells therapy understanding [DOI] 10.1002/iid3.402 PMC 바로가기 [Article Type] Comparative Study
Peripheral Blood Immune Profiling of Convalescent Plasma Donors Reveals Alterations in Specific Immune Subpopulations Even at 2 Months Post SARS-CoV-2 Infection회복기 혈장 기증자의 말초혈액 면역 프로파일링은 SARS-CoV-2 감염 후 2개월에도 특정 면역 하위 집단의 변화를 보여줍니다Article Published on 2020-12-252022-09-01 Journal: Viruses [Category] MERS, SARS, 진단, 치료기술, [키워드] alteration analyzed antibody B cells Blood cause CD16 CD4 CD56 CD8 characterized control subject control subjects convalescent plasma convalescent plasma donors COVID-19 COVID-19 patients deficiency Donor donors Exhaustion Follow-up full recovery Granulocytes highest Hospitalized Humoral immunity immune cells Immune profile immune profiling immune system lowest lymphocyte Lymphocytes lymphopenia Monocytes Month multiparametric flow cytometry natural killer NKT cells patients with COVID-19 peripheral Peripheral blood phenotype pro-inflammatory monocytes pro-inflammatory response Profiling promotion reduced regulatory T cells restored SARS-CoV-2 serum shown Specific subpopulations T and B cells T cells Th17 cells Th2 [DOI] 10.3390/v13010026 PMC 바로가기 [Article Type] Article
T cell and antibody responses induced by a single dose of ChAdOx1 nCoV-19 (AZD1222) vaccine in a phase 1/2 clinical trial Research Published on 2020-12-172022-10-05 Journal: Nature Medicine [Category] SARS, 유전자 메커니즘, 임상, [키워드] acute respiratory syndrome Adenovirus Adults antibody production Antibody Response antigen-specific T cell AZD1222 caused CD4+ T cell CD8+ T cells cell-mediated immune cell-mediated immune response ChAdOx1 nCoV-19 ChAdOx1 nCoV-19 vaccine characterized clinical trial contribute coronavirus COVID-19 cytokine secretion Cytotoxic T cell disease effective vaccine Efficacy Exploratory analysis expressing full-length SARS-CoV-2 global pandemic host cell humoral IgG1 IgG3 Immune profile immune response immunogenicity data infected with SARS-CoV-2 interferon-γ neutralizing antibody Patient phase 2/3 trial Phenotypes progression Protective protective role reduce reported Safe SARS-CoV-2 SARS-CoV-2 vaccine single dose Spike protein Strong suggested T cell T cell response the SARS-CoV-2 Trial tumor necrosis factor-α two-dose regimen vaccination Vaccine vaccine candidate [DOI] 10.1038/s41591-020-01194-5 [Article Type] Research
Early Phases of COVID-19 Are Characterized by a Reduction in Lymphocyte Populations and the Presence of Atypical MonocytesImmunology Published on 2020-12-092022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, MERS, SARS, [키워드] 28-day mortality acute respiratory syndrome Admission association Atypical CD14 CD3+ CD4+ cell CD8+ Cell cells characterized composed coronavirus coronavirus disease COVID-19 Diagnosis died early phase evaluated expression HLA-DR Immune profile immune profiling immunological change include Infection Inflammation Inflammatory biomarker IQR lymphocyte lymphocytopenia mean value median value monocyte Monocytes mononuclear cell mononuclear cells natural killer pathogen patients patients with COVID-19 Peripheral blood Peripheral blood mononuclear cells phase Population Presence preserved reduced reduction responsible Result SARS-CoV-2 side scatter subpopulation [DOI] 10.3389/fimmu.2020.560330 PMC 바로가기 [Article Type] Immunology