Intravenous IgM-enriched immunoglobulins in critical COVID-19: a multicentre propensity-weighted cohort study중요한 COVID-19에서 정맥내 IgM이 풍부한 면역글로불린: 다기관 성향 가중 코호트 연구Multicenter Study Published on 2022-07-072022-09-12 Journal: Critical Care [Category] COVID19(2023년), SARS, 진단, [키워드] 30-Day mortality acute respiratory distress addition applied Characteristics clinical clinically Cohort cohort study Complication concerning confidence interval controls coronavirus disease COVID-19 COVID-19 patients Cox regression models Critical Critically ill Critically ill patient daily dose dose early administration Effect Efficacy high mortality ICU ICU Patients Immunoglobulin immunoglobulin M immunoglobulins Inflammatory intravenous laboratory-confirmed Lung injury mechanical ventilation mechanically ventilated Mortality multicentre overcome Patient Primary outcome randomization randomized clinical trials retrospective SARS-CoV-2 selection bia statistical significance statistically statistically significant difference subgroup analysis subgroups survival treated Treatment treatment regimen two group was performed Weighting with COVID-19 [DOI] 10.1186/s13054-022-04059-0 PMC 바로가기 [Article Type] Multicenter Study
Nasopharyngeal Bacterial Microbiota Composition and SARS-CoV-2 IgG Antibody Maintenance in Asymptomatic/Paucisymptomatic Subjects무증상/무증상 피험자의 비인두 세균성 미생물총 구성 및 SARS-CoV-2 IgG 항체 유지 관리Article Published on 2022-07-062022-09-11 Journal: Frontiers in Cellular and Infection Microbiology [Category] COVID19(2023년), MERS, SARS, 유전자 메커니즘, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Adaptive immune response Analysis anti-RBD antibody Asymptomatic Asymptomatic carriers Bacterial best cause characterized condition coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 enrolment Evidence IgG antibody immune response immunoglobulins Immunological memory Infection influence investigated knowledge Lung injury maintenance mechanism microbiota multi-organ failure nasopharyngeal nasopharyngeal bacterial microbiota. Nasopharyngeal swab Odds ratio performed positive positive serology predict Regulation respiratory respiratory infection respiratory infections SARS-CoV-2 SARS-CoV-2 IgG SARS-CoV-2 infections SARS-CoV-2 RNA serum severe acute respiratory syndrome Coronavirus severity subject tested UNICORN Viral viral entry viral infections [DOI] 10.3389/fcimb.2022.882302 PMC 바로가기 [Article Type] Article
Potential use of convalescent plasma for SARS-CoV-2 prophylaxis and treatment in immunocompromised and vulnerable populations면역 저하 및 취약 집단에서 SARS-CoV-2 예방 및 치료를 위한 회복기 혈장의 잠재적 사용Article Published on 2022-07-012022-09-11 Journal: Expert review of vaccines [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] Administered anti-SARS-CoV-2 Antibody titers Area case reports Case series case sery convalescent plasma COVID-19 effective Efficacy expert Health hyperimmune hyperimmune serum iatrogenic Immunocompromised Immunocompromised patients immunodeficiency Immunoglobulin immunoglobulins Neutralizing Neutralizing antibodies neutralizing antibody titers Patient patients plasma polyclonal polyclonal immunoglobulins Population Potential Prophylaxis Safe SARS-CoV-2 SARS-CoV-2 pandemic SARS-CoV-2 variants Treatment [DOI] 10.1080/14760584.2021.1932475 PMC 바로가기 [Article Type] Article
Miller-Fisher syndrome associated with SARS-CoV-2: a case reportSARS-CoV-2와 관련된 Miller-Fisher 증후군: 사례 보고Case Reports Published on 2022-07-012022-09-11 Journal: Microbes and infection [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] areflexia artificial Artificial respiration Ataxia ataxic ataxic gait Care Case report COVID COVID-19 infection CSF analysis Diagnosis dysfunction early administration examination facial Fisher syndrome Guillain-barrè syndrome Immune-mediated immunoglobulins immunological increasingly Infection intensive care unit intravenous Intravenous immunoglobulins level 2 life-threatening Mild Miller–Fisher syndrome nasal oxygen Neurological complications Neuropathy ophthalmoplegia oxygen Oxygen therapy Patient presenting Prognosis required respiratory Respiratory failure SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 infections supported syndrome therapy Treatment triad variant weakness [DOI] 10.1016/j.micinf.2022.104954 PMC 바로가기 [Article Type] Case Reports
IgG N-glycome changes during the course of severe COVID-19: An observational study중증 코로나19 기간 동안 IgG N-글리코메 변화: 관찰 연구Meta-Analysis Published on 2022-07-012022-09-12 Journal: EBioMedicine [Category] COVID19(2023년), MERS, SARS, 바이오마커, 진단, [키워드] 95% CI acute respiratory syndrome adjusted Affect age analysed Analysis bind Bisecting GlcNAc cause change changes in circulating Cohort cohorts competence complement system activation contrary coronavirus disease Coronavirus-2 Course COVID-19 COVID-19 case cytotoxicity determine education European Fc region foundation functions Fund Galactosylation glycan glycans glycosylation Health IgG IgG glycosylation immune cells immune response Immunoglobulin immunoglobulins immunosuppressive independent indicate Investment IQR lack magnitude males median age Meta-analysis Mild mild case Molecular epidemiology molecular mechanism Multiple Patient performed problem proinflammatory receptor regulate released Respiratory illness SARS-CoV-2 Science Severe case severe COVID-19 severe COVID-19 patient severity significantly statistically statistically significant supported the disease Youth [DOI] 10.1016/j.ebiom.2022.104101 PMC 바로가기 [Article Type] Meta-Analysis
Neutralizing antibody activity against SARS-CoV-2 variants in gestational age-matched mother-infant dyads after infection or vaccination감염 또는 예방 접종 후 재태 연령이 일치하는 모자에서 SARS-CoV-2 변이체에 대한 중화 항체 활성Article Published on 2022-06-222022-09-11 Journal: JCI Insight [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] Adaptive immunity age analyzed antibody COVID-19 Delta disease during pregnancy effective elicit first trimester gestation gestational age immune response immune responses immunoglobulins individuals Infection Infectious disease less mother mRNA vaccine mRNA vaccines NAb NAbs neutralization neutralization activity Neutralizing plasma plasma sample Pregnancy pregnant Protein SARS-CoV-2 SARS-CoV-2 spike SARS-CoV-2 vaccination SARS-CoV-2 variant second trimester sequence Spike protein spike variants time of delivery transfer unique vaccination Vaccine variant virion was measured with infection women WT spike [DOI] 10.1172/jci.insight.157354 PMC 바로가기 [Article Type] Article
Silent Antibodies Start Talking: Enhanced Lateral Flow Serodiagnosis with Two-Stage Incorporation of Labels into Immune ComplexesSilent Antibodies Start Talking: 면역 복합체에 라벨을 2단계 통합하여 향상된 측면 흐름 혈청 진단Article Published on 2022-06-212022-09-11 Journal: Biosensors [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료기술, [키워드] added antibody Antigen applied approach binding Blood carried coloration complexes conjugate coronavirus COVID-19 demonstrated diagnostic diagnostic sensitivity diagnostic specificity enhanced false-negative false-negative results first stage Flow gold Gold nanoparticle Immune complexes immunochromatographic immunochromatography Immunoglobulin immunoglobulins incorporation increase in intensity lAbel Lateral lateral flow immunoassay LFIA magnitude membrane non-specific pathogen pathogen-specific Protein protein A RBD RBD protein recombinant RBD protein reduction risk SARS-CoV-2 separated serodiagnostic specific antibodies specificity staphylococcal test strip test strips. The diagnostic sensitivity variant zone [DOI] 10.3390/bios12070434 PMC 바로가기 [Article Type] Article
Evaluation of the safety and immunogenicity of different COVID-19 vaccine combinations in healthy individuals: study protocol for a randomized, subject-blinded, controlled phase 3 trial [PRIBIVAC]건강한 개인에서 다양한 COVID-19 백신 조합의 안전성 및 면역원성 평가: 무작위, 피험자 맹검, 대조 3상 시험을 위한 연구 프로토콜 [PRIBIVAC]Article Published on 2022-06-162022-09-11 Journal: Trials [Category] COVID19(2023년), MERS, SARS, 변종, 임상, 진단, [키워드] adverse event adverse events anti-SARS-CoV-2 antibodies antibody approval best blood sample Blood samples BNT162b2 boost booster booster dose booster vaccinations cellular Cellular immune response collected Combination Comprehensive control arm Controlled clinical trial CoronaVac country COVID-19 COVID-19 vaccination COVID-19 vaccine COVID-19 vaccines demonstration different time point different time points dose Effectiveness Eligible participants Endpoint enrolment evade excluded group healthy Heterologous homologous host immunity humoral immune immune profiling immune response Immunity Immunocompromised immunogenicity Immunoglobulin immunoglobulins Inactivated vaccine Infection Intervention intervention arm Laboratory test Laboratory tests Local maintain mRNA mRNA vaccine mRNA-1273 omicron over parameters participant performed persistence phase Phase 3 phase 3 trial physical population immunity pregnant primary endpoint Probability quantity raising randomization Randomized Randomized controlled trial regimen Regulatory SARS-CoV-2 SARS-COV-2 infection Serious Adverse Event Serious Adverse Events Singapore Study protocol vaccination Vaccine vaccine availability vaccine booster vaccine candidate variants variants of concern volunteers wildtype [DOI] 10.1186/s13063-022-06345-2 PMC 바로가기 [Article Type] Article
Fcγ-Receptor-Based Enzyme-Linked Immunosorbent Assays for Sensitive, Specific, and Persistent Detection of Anti-SARS-CoV-2 Nucleocapsid Protein IgG Antibodies in Human Sera인간 혈청에서 항-SARS-CoV-2 뉴클레오캡시드 단백질 IgG 항체의 민감하고, 특이적이고, 지속적인 검출을 위한 Fcγ-수용체 기반 효소 연결 면역흡착 분석법Article Published on 2022-06-152022-09-11 Journal: Journal of Clinical Microbiology [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, 치료법, [키워드] Accuracy acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 African analytical sensitivity anti-SARS-CoV-2 IgG anti-SARS-CoV-2 IgG antibodies anti-SARS-CoV-2 IgG antibody antibody antibody waning Antigen antigen-antibody complexes Asia binding complexes Concentration convalescence convalescent phase coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient cross-reactivity detection diagnostic diagnostic sensitivities dilutions ELISA ELISAs enzyme-linked immunosorbent assay enzyme-linked immunosorbent assays epidemiological studies Epidemiological study Europe FcγR Human IgG IgG antibody Immune complexes immunoassay immunofluorescence immunoglobulins immunological indirect immunofluorescence Infection Infectious disease Laboratory laboratory methods and tools longitudinal samples mandatory morbidity morbidity and mortality mortality rates nucleocapsid protein Pathogens persistent platform Population Postinfection Prevalence prozone receptor Region respiratory SARS-CoV-2 SARS-CoV-2 IgG SARS-CoV-2 IgG antibody sensitive sensitivity serological test Serological tests serum serum sample serum samples severe acute respiratory syndrome Coronavirus significantly significantly higher solution South America Specific Specificities specificity titer Vaccine validation Viral Viral diseases was performed while [DOI] 10.1128/jcm.00075-22 PMC 바로가기 [Article Type] Article
Data on immunogenicity and reactogenicity to COVID-19 vaccination among patients receiving maintenance dialysisData article Published on 2022-06-012022-10-05 Journal: Sensors (Basel, Switzerland) [Category] 변종, [키워드] acute respiratory syndrome assays cellular Cellular immune response Complete coronavirus coronavirus disease COVID-19 COVID-19 vaccination dialysis dose Effectiveness ELISPOT exclusion General population Hemodialysis homologous humoral immune response immune response Immunity immunoassay immunoglobulins increased risk interferon-γ Microparticle morbidity and mortality Patient Peritoneal dialysis produced reactogenicity receiving regimen SARS-CoV-2 SARS-CoV-2 vaccination SARS-CoV-2 vaccine single dose T cells tested the vaccine trials vaccination [DOI] 10.1016/j.dib.2022.108271 [Article Type] Data article