immunological mechanism – Page 5 – Communicable Diseases Research

Viral Infections, the Microbiome, and Probiotics

Cellular and Infection Microbiology

Published on 2021-02-122022-10-31
Journal: Frontiers in Cellular and Infection Microbiology [Category] COVID-19, MERS, SARS,

The Physiological Mechanisms of the Sex-Based Difference in Outcomes of COVID19 Infection

Physiology

Published on 2021-02-092022-10-31
Journal: Frontiers in Physiology [Category] COVID-19,

Baricitinib treatment resolves lower-airway macrophage inflammation and neutrophil recruitment in SARS-CoV-2-infected rhesus macaques

바리시티닙 치료는 SARS-CoV-2에 감염된 붉은털 원숭이의 하기도 대식세포 염증 및 호중구 모집을 해결합니다

Article

Published on 2021-01-212022-09-11
Journal: Cell [Category] Fulltext, SARS, 비임상, 유전자 메커니즘,

[키워드] animal animals antiviral response antiviral responses approved Baricitinib bronchoalveolar chemokine chemokines clinical trials clinically COVID-19 COVID-19 severity cytokine Cytokines Efficacy hypercytokinemia IFN immune immune activation Immunologic immunological mechanism immunology Inflammation inflammatory cells interferon investigated JAK1 JAK1/JAK2 inhibitor JAK2 lung lung infiltration Lung pathology Macrophage nasal nasal and throat swabs NETosis neutrophil neutrophil recruitment nonhuman primate Pathogenesis reduced remained responsible rhesus rhesus macaque SARS-CoV-2 SARS-COV-2 infection severity Support T cell T cell response These data throat swabs tissue tissues treated Treatment two groups Type type I interferon Viral viral shedding with COVID-19
[DOI] 10.1016/j.cell.2020.11.007 PMC 바로가기 [Article Type] Article

Immunological response to COVID-19 and its role as a predisposing factor in invasive aspergillosis

Review Article

Published on 2020-12-012022-11-01
Journal: Current Medical Mycology [Category] COVID-19,

[키워드] acute respiratory distress acute respiratory syndrome addition Affect airway epithelia aspergillosis Aspergillus fumigatus asymptomatic infection caused changes Clinical course clinical manifestation complex conducted coronavirus COVID-19 described disease domain enzyme expressed Factors fungal immune regulation immune responses immunological mechanism Inflammatory response Influenza information Innate immunity Interaction invasive involved lung parenchyma mechanical ventilation pandemic coronavirus Patient patients with COVID-19 persistence Protective pulmonary impairment receptor reported response SARS-CoV-2 syndrome
[DOI] 10.18502/cmm.6.4.5442 PMC 바로가기 [Article Type] Review Article

Early expansion of myeloid-derived suppressor cells inhibits SARS-CoV-2 specific T-cell response and may predict fatal COVID-19 outcome

Article

Published on 2020-10-272022-11-01
Journal: Cell Death & Disease [Category] COVID-19, MERS, SARS,

Harnessing the immune system to overcome cytokine storm and reduce viral load in COVID-19: a review of the phases of illness and therapeutic agents

Review

Published on 2020-10-152022-10-28
Journal: Virology Journal [Category] COVID-19, MERS, SARS,

[키워드] activated acute respiratory distress acute respiratory distress syndrome alveolar macrophage angiotensin converting enzyme 2 antibody Antiviral article B cell bind blunt caused characterized China Chloroquine Combination coronavirus 2 Coronavirus disease 2019 COVID-19 COVID-19 illness CRS cytokine Cytokine release syndrome Cytokine storm drug target dysregulation enzyme epithelial cells Fever global pandemic hemodynamic instability hypoxia identify IFN IL-1β immune system immunological mechanism Immunotherapy imperative Innate immunity involved manifestation Necrosis Novel coronavirus nuclear Obstetric organ damage overcome Pathogenesis pathophysiology Patient pediatric Phase 2 Phase 3 receptor reduce respiratory respiratory symptoms responsible resulting SARS-CoV-2 SARS-CoV-2 epidemiology severe COVID-19 Signaling syndrome therapeutic agent therapeutic interventions tissue injury TLR Tocilizumab triggering Viral load viral replication virus Virus-host interaction Virus-host interactions World Health Organization worsening
[DOI] 10.1186/s12985-020-01415-w PMC 바로가기 [Article Type] Review

Single-Cell RNA Sequencing Reveals the Diversity of the Immunological Landscape following Central Nervous System Infection by a Murine Coronavirus

Pathogenesis and Immunity

Published on 2020-09-302022-10-30
Journal: Journal of Virology [Category] Coronavirus,

[키워드] Adaptive immune response addition Analysis Antiviral approach Brain C57BL/6 CD45 Cell cellular pathway Central nervous system Central nervous system infections CNS contributing to coronavirus Critical Defense defined Demyelination disease Diversity effective evaluate expressed expressing heterogeneity Host host defense identify Immune cell immune response Immune-mediated immunological immunological mechanism immunology infecting Infection Intracranial involved landscape macrophages mice microglia molecular molecular network mouse hepatitis virus mRNA expression profile murine nervous nervous system Neuroimmunology neurologic neurotropic pathway RNA scRNAseq Single-cell RNA sequencing Stage subset susceptible System the Coronaviridae understanding unique viral infection viral persistence viral replication virus
[DOI] 10.1128/JVI.01295-20 PMC 바로가기 [Article Type] Pathogenesis and Immunity

Distinct Early Serological Signatures Track with SARS-CoV-2 Survival

Report

Published on 2020-09-152022-10-30
Journal: Immunity [Category] COVID-19, Fulltext, SARS,

[키워드] antibody Biomarker Cohort complement convalescent convalescent individuals COVID-19 patients death Deceased defined disease elevated feature fraction functional functional antibody functional antibody response group heterogeneity highlighting Hospitalized humoral immune response Humoral immunity Humoral response Immunity immunodominant immunological mechanism individual individuals Infection inter-individual Limited Mild neutralization no difference nucleocapsid outcome outcomes pathogen-specific Patient care phagocytic predict resolved SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2-infected individual SARS-CoV-2-specific antibody SARS-CoV-2-specific IgG separated signature Spike-specific antibody track trajectory underlie Vaccine development validation cohort
[DOI] 10.1016/j.immuni.2020.07.020 PMC 바로가기 [Article Type] Report