Impaired neutralizing antibody response to COVID-19 mRNA vaccines in cancer patientsLetter to the Editor Published on 2021-11-212022-11-01 Journal: Cell & Bioscience [Category] COVID-19, [키워드] Breast cancer cancer patient Cell CLL COVID-19 mRNA vaccine Critical determine diagnosed dose Efficacy exhibited HCWs Health care worker healthy controls hematological cancer immunization strategy Immunocompromised patients Impaired leukemia lowest lung cancer mRNA mRNA vaccines Neutralizing antibody response Neutralizing antibody titer NHL non-Hodgkin’s lymphoma Patient reduced SARS-CoV-2 SARS-CoV-2 vaccination significantly supplementary material Therapies therapy [DOI] 10.1186/s13578-021-00713-2 PMC 바로가기 [Article Type] Letter to the Editor
Impaired Functional T-Cell Response to SARS-CoV-2 After Two Doses of BNT162b2 mRNA Vaccine in Older People고령자에서 BNT162b2 mRNA 백신 2회 접종 후 SARS-CoV-2에 대한 기능적 T-세포 반응 손상Comparative Study Published on 2021-11-162022-09-12 Journal: Frontiers in Immunology [Category] MERS, SARS, 진단, [키워드] acute respiratory syndrome addition Adults Affect alteration analyzed antibody Antibody Response antibody response against Antibody titer baseline BNT162b2 vaccine CD4 CD8 Cell cellular collected coronavirus COVID-19 infection dose Efficiency ELISPOT flow cytometry Frequency functional greater high plasma level Humoral immunity IFNγ IgG IL-2 immune response Immunity Immunocompromised Impaired injection Long-term care median age memory response mRNA mRNA vaccination mRNA-based vaccines neutralizing antibody neutralizing antibody titers of BNT162b2 Older older people and ageing parameter participant Participants physiological postvaccination quantified response SARS – CoV – 2 SARS-CoV-2 Specific T-cell response subjects suggested T cell T cells T cells response T-cell T-cell responses TNFα vaccination Vaccine vaccine responses [DOI] 10.3389/fimmu.2021.778679 PMC 바로가기 [Article Type] Comparative Study
Impaired Dendritic Cell Homing in COVID-19Medicine Published on 2021-11-042022-10-31 Journal: Frontiers in Medicine [Category] COVID-19, [키워드] accompanied accumulation Activation acute respiratory distress adaptive immune system antigen expression antigen-presenting cell APC appear ARDS artificial intelligence Autopsy Cell cell count cell population COVID-19 Cytokine storm DAD DCs dendritic cell dendritic cells description Diffuse alveolar damage diffuse alveolar damage (DAD) dysregulation high mortality histopathological homing immature immune cells Impaired impairing Inflammatory investigated Local lung Lymph node lymph nodes marker maturation mDC mDCs MERS-CoV multiplexed immunofluorescence Quantitative SARS-CoV SARS-CoV-2 severe COVID-19 Stage stages subsequent syndrome T-cell Response T-cells upregulation Viral load [DOI] 10.3389/fmed.2021.761372 PMC 바로가기 [Article Type] Medicine
Impact of baseline SARS-CoV-2 antibody status on syndromic surveillance and the risk of subsequent COVID-19—a prospective multicenter cohort study기준 SARS-COV-2 항체 상태의 증후군 감시 및 후속 COVID-19의 위험-전향 적 다기관 코호트 연구에 미치는 영향Multicenter Study Published on 2021-10-142022-09-10 Journal: BMC Medicine [Category] MERS, SARS, 치료법, [키워드] 95% CI 95% confidence interval analyzed Anti-nucleocapsid antibodies anti-nucleocapsid antibody Antigen Asymptomatic baseline Baseline serology baseline serostatus best chill chills Cohort coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 symptoms Follow-up HCW healthcare healthcare worker Healthcare workers Impact Impaired information less median multicenter cohort study muscle pain nasopharyngeal Nasopharyngeal swab nasopharyngeal swabs occurrence of COVID-19 Pain participant participated performed positive positive result provide questionnaire Re-infection reported Result risk risk ratio SARS-CoV-2 SARS-CoV-2 antibody SARS-COV-2 infection SARS-CoV-2 test Screening serology seronegative participants seropositive seropositive individual seropositive individuals subsequent supplementary material Surveillance Symptom symptomatic [DOI] 10.1186/s12916-021-02144-9 PMC 바로가기 [Article Type] Multicenter Study
Impaired function and delayed regeneration of dendritic cells in COVID-19코로나19에서 손상된 수지상 세포의 기능 장애 및 재생 지연Clinical Trial Published on 2021-10-062022-09-10 Journal: PLoS Pathogens [Category] MERS, SARS, 바이오마커, 임상, [키워드] accompanied activated acute illness acute phase adaptive Adaptive immune response adaptive immune responses alteration analyzed antibody antibody-secreting cells antiviral immunity Blood CD14 CD14+ cell CD14+ cells CD163 CD4 CD86 Cell cells circulating classical monocyte classical monocytes Clinical management consequence contribute correlated COVID-19 COVID-19 patient COVID-19 patients COVID-19 severity DCs dendritic cell dendritic cells Depletion disease disease severity downregulation dysregulated dysregulated innate immune response expansion follicular Frequency functional healthy controls helper cells HLADR hospitalized COVID-19 patient Host immune response identify immune responses immunopathology Impaired impairment Increased Inflammatory response Inflammatory responses inhibitory innate immune response long-lasting manifestation Mild modulation monocyte monocyte subsets Monocytes naïve Patient PD-L1 persistent recognize reduced reduction regeneration SARS-COV-2 infection Secondary infection secondary infections severe disease stimulate subpopulation subset susceptibility systemic inflammation T cell T cells T follicular helper cells the disease therapy these cell These cells Trigger upregulation Viral viral infection viral infections [DOI] 10.1371/journal.ppat.1009742 PMC 바로가기 [Article Type] Clinical Trial
How Much the Swimming Performance Leading to Tokyo 2020 Olympic Games Was Impaired Due to the Covid-19 Lockdown?Observational Study Published on 2021-10-012022-10-05 Journal: Journal of sports science & medicine [Category] 임상, [키워드] analyzed ANOVA association correlation coefficients COVID-19 COVID-19 lockdown events FINA FIVE game Impaired impairment leading lockdown male measure performance post-hoc progression reached retrieved retrospective stability stroke swimmers Tokyo training cessation. Variation was impaired was performed was selected website [DOI] 10.52082/jssm.2021.714 PMC 바로가기 [Article Type] Observational Study
Impaired Antibody-Dependent Cellular Cytotoxicity in a Spanish Cohort of Patients With COVID-19 Admitted to the ICUICU에 입원한 COVID-19 환자의 스페인 코호트에서 손상된 항체 의존성 세포 세포 독성Observational Study Published on 2021-09-202022-09-11 Journal: Frontiers in Immunology [Category] SARS, 임상, 진단, 치료기술, [키워드] analysed antibody antibody-dependent cell-mediated cytotoxicity antibody-dependent cellular cytotoxicity (ADCC) B cell B cells cause Cell-mediated cytotoxicity Clinical management CMV CMV reactivation COVID-19 COVID-19 severity Critical Critical disease critical patient critical patients cytotoxicity detectable EBV EBV reactivation elicited enhanced Gender herpesvirus Hospitalization Hospitalized HSV-1 humoral immune response Humoral response ICU IgG level immune response immunologic response immunologic responses Impaired individuals levels of antibody male memory Mild mild patient mild patients neutralization ability outcomes pandemic parameter Patient Phenotypes plasma recruited SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 neutralizing antibodies severe disease Severe patient severe patients significantly Spain Spanish subjects symptomatic Viremia [DOI] 10.3389/fimmu.2021.742631 PMC 바로가기 [Article Type] Observational Study
Increased Autotaxin Levels in Severe COVID-19, Correlating with IL-6 Levels, Endothelial Dysfunction Biomarkers, and Impaired Functions of Dendritic Cells중증 코로나19에서 증가된 오토탁신 수치, IL-6 수치, 내피 기능 장애 바이오마커 및 수지상 세포 기능 손상과 상관관계Article Published on 2021-09-162022-09-10 Journal: International Journal of Molecular Sciences [Category] SARS, 바이오마커, 진단, 치료기술, 치료제, [키워드] ARDS Autotaxin autotaxin (ATX; ENPP2) Biomarkers cohorts correlated COVID-19 COVID-19 pathogenesis COVID-19 patients Cytokine storm dataset dendritic cells dendritic cells (DCs) Dexamethasone endothelial damage ENPP2 expression Extracellular fibrosis function functional homeostasis Hospitalization hyperinflammation IL-6 Immune cell immune cells Impaired include Increased independent Inflammation Level LPA lysophosphatidic acid (LPA) mechanically ventilated mechanically ventilated patient mechanically ventilated patients mRNA level multifunctional Nasopharyngeal swab nasopharyngeal swab sample Nasopharyngeal swab samples pathologic pharmacological pleiotropic pulmonary fibrosis pulmonary injury reduced RNA sequencing scale analysis secreted Serum level severe COVID-19 patients shown Signaling Single Cell suggested suppression Therapeutic benefit therapeutic benefits therapeutic option Treatment vascular dysfunction [DOI] 10.3390/ijms221810006 PMC 바로가기 [Article Type] Article
The effect of COVID-19 on mental well-being in Switzerland: a cross-sectional survey of the adult Swiss general populationObservational Study Published on 2021-09-102022-10-04 Journal: BMC Family Practice [Category] SARS, 임상, [키워드] addition addressed analysed Analysis Consequences coronavirus covariate COVID-19 COVID-19 pandemic cross-sectional cross-sectional survey emotional Factors General population Health Impaired individual less Logistic regression measure median age Mental mental health mental health concerns outbreak pandemic participant performed physical Prevalence problem problems promote reported Result risk risk factor SARS-CoV-2 severe COVID-19 smoking supplementary material women [DOI] 10.1186/s12875-021-01532-7 PMC 바로가기 [Article Type] Observational Study
Immunological Response Against SARS-COV-2 After BNT162b2 Vaccine Administration Is Impaired in Allogeneic but Not in Autologous Stem Cell Transplant RecipientsOncology Published on 2021-09-062022-10-31 Journal: Frontiers in Oncology [Category] COVID-19, [키워드] administration Against Allogeneic allogeneic HSCT Antibody Response Antibody titer autologous autologous HSCT B cell B lymphocyte BNT162b2 CD19 CD19+ CD20 CD56+ Cell control group correlated correlation COVID-19 immunity cyclosporine Cytometry develop Efficacy evaluate Flow glycoprotein healthy subjects HSCT HSCT recipients immune response immunosuppressive Impaired mRNA-based natural killer negatively affected NK cell NK cells Patient performed Peripheral blood Pfizer-BioNTech platform Prospective Study recipient response rituximab SARS-CoV-2 IgG SARS-CoV-2 vaccine SARS-CoV2 second dose Seroconversion serum sample STEM Stem cell transplantation submitted T cells tested the antibody response the Spike Transplant vaccination Vaccine [DOI] 10.3389/fonc.2021.737300 PMC 바로가기 [Article Type] Oncology