SARS-CoV-2 Infection in the Immunodeficient Host: Necessary and Dispensable Immune PathwaysArticle Published on 2021-07-152023-07-01 Journal: The journal of allergy and clinical immunology. In [Category] SARS, [키워드] ACE2, angiotensin-converting enzyme 2 Acquired immunodeficiency ARDS, acute respiratory distress syndrome COVID-19 COVID-19, Coronavirus disease 2019 ICU, Intensive care unit IEI, Inborn errors of immunity IFN-I, type I interferon Immunosuppression inborn errors of immunity MIS-C MIS-C, Multisystemic inflammatory syndrome in children NK, natural killer S protein, spike protein SARS-CoV-2 SARS-CoV-2, Severe acute respiratory syndrome coronavirus 2 TLR, Toll-like receptor [DOI] 10.1016/j.jaip.2021.06.045 PMC 바로가기
Atypical Inflammatory Syndrome Triggered by SARS-CoV-2 in Infants with Down SyndromeCase Report Published on 2021-06-052023-06-17 Journal: Journal of Clinical Immunology [Category] MERS, SARS, [키워드] COVID-19 Down syndrome inborn errors of immunity MIS-C [DOI] 10.1007/s10875-021-01078-4 PMC 바로가기 [Article Type] Case Report
Immunogenicity of Pfizer-BioNTech COVID-19 vaccine in patients with inborn errors of immunityArticle Published on 2021-06-012023-06-16 Journal: The Journal of Allergy and Clinical Immunology [Category] MERS, SARS, [키워드] ACE2, angiotensin-converting enzyme 2 ALPS, Autoimmune lymphoproliferative syndrome anti-N, Antinucleocapsid anti-S, Antispike AU, Arbitrary unit AUC, area under the curve CID, Combined immunodeficiency COVID-19 COVID-19, Coronavirus disease 2019 CVID CVID, Common variable immunodeficiency HIES IEI IEI, Inborn errors of immunity inborn errors of immunity inhibiting antibodies IVIG, intravenous immunoglobulin NF-κB1, Nuclear factor-κB1 NFkB1 NFKB1-HI, Nuclear factor-κB1 haploinsufficiency Pfizer-BioNTech PIDD Primary immunodeficiency disorders RBD, receptor-binding domain SARS-CoV-2 SARS-CoV-2, Severe acute respiratory syndrome coronavirus 2 STAT, Signal transducer and activator of translation STAT1-GOF STAT1-GOF, STAT1 gain-of-function STAT3-LOF Vaccine XLA XLA, X-linked agammaglobulinemia [DOI] 10.1016/j.jaci.2021.05.029 PMC 바로가기
Infection‐induced inflammation from specific inborn errors of immunity to COVID‐19Review Published on 2021-05-202023-07-01 Journal: The Febs Journal [Category] SARS, [키워드] anticytokine autoantibodies COVID‐19 inborn errors of immunity SARS‐CoV‐2 XLP‐2 [DOI] 10.1111/febs.15961 PMC 바로가기 [Article Type] Review
COVID-19 Outcomes in Patients Undergoing B Cell Depletion Therapy and Those with Humoral Immunodeficiency States: A Scoping ReviewResearch Article Published on 2021-05-142022-10-28 Journal: Pathogens and Immunity [Category] COVID-19, [키워드] Analysis Antibodies, CD20 Antibody Response B-cell biologic CD20 Clinical outcome confounder COVID-19 COVID-19 in patient COVID-19 severity CVID death Depletion disease severity dysregulated form highlight humoral Humoral immunity iatrogenic identify Immunity immunodeficiency inborn errors of immunity increased risk Infection infection risk knowledge less methodology Patient patients patients with COVID-19 Population predictor question reducing review risk of COVID-19 risk of infection scoping review severe COVID-19 severity of COVID-19 susceptible underlying disease viral clearance with COVID-19 X-linked agammaglobulinemia [DOI] 10.20411/pai.v6i1.435 PMC 바로가기 [Article Type] Research Article
SARS-CoV-2 infection associated with hepatitis in an infant with X-linked severe combined immunodeficiencyX-연관 중증 복합 면역결핍증이 있는 유아의 간염과 관련된 SARS-CoV-2 감염Case Reports Published on 2021-03-012022-09-11 Journal: Clinical immunology (Orlando, Fla.) [Category] SARS, 치료기술, [키워드] adaptive Adaptive immunity Allogeneic Antigen B cells caused CD34 Cell clinically combined immunodeficiency Conditioning convalescent plasma COVID-19 deficiencies deficiency disorder Donor dysfunction Gene therapy Hepatitis IL-2 receptor Immunity immunodeficiency Inborn error inborn errors of immunity Infant infected with SARS-CoV-2 Mutation Nasopharyngeal swab nasopharyngeal swabs Natural killer cells NK cells opportunistic Infections Patient respiratory respiratory symptom respiratory symptoms resulting RT-PCR SARS CoV SARS CoV-2 SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 specific antibodies SCID selected severe combined immunodeficiency specific antibodies stem cell Transplant transplantation treated X-linked [DOI] 10.1016/j.clim.2020.108662 PMC 바로가기 [Article Type] Case Reports
The Ever-Increasing Array of Novel Inborn Errors of Immunity: an Interim Update by the IUIS CommitteeOriginal Article Published on 2021-02-182023-06-13 Journal: Journal of Clinical Immunology [Category] MERS, [키워드] autoinflammatory disorders immune dysregulation inborn errors of immunity Primary immunodeficiencies [DOI] 10.1007/s10875-021-00980-1 PMC 바로가기 [Article Type] Original Article
Minor Clinical Impact of COVID-19 Pandemic on Patients With Primary Immunodeficiency in Israel이스라엘의 원발성 면역 결핍증 환자에 대한 COVID-19 유행병의 경미한 임상 영향Immunology Published on 2021-01-142022-09-11 Journal: Frontiers in Immunology [Category] MERS, SARS, 치료기술, [키워드] adaptive affected agammaglobulinemia assumed Asymptomatic Awareness clinical Clinical and laboratory data clinical impact component components coronavirus disease Coronavirus disease 2019 Course COVID-19 COVID-19 pandemic Critical Data collection disease genetic defect global pandemic human immunity immune pathway immune response immune system immunodeficiency Impact in some inborn errors of immunity include individual Infection innate cell interferon IVIG laboratory data lack minor not affected pandemic pathway Pathways Patient patients PID Population positive Primary Immunodeficiency Protective replacement therapy required respiratory risk SARS-CoV-2 second wave Self-isolation Severe acute respiratory syndrome severe acute respiratory syndrome-coronavirus-2 Signaling tested the patient therapy type I interferon virus detection was collected while [DOI] 10.3389/fimmu.2020.614086 PMC 바로가기 [Article Type] Immunology
Coronavirus disease 2019 in patients with inborn errors of immunity: An international studyMulticenter Study Published on 2020-09-242023-06-15 Journal: The Journal of Allergy and Clinical Immunology [Category] MERS, SARS, [키워드] AGS, Aicardi-Goutieres syndrome AIHA, Autoimmune hemolytic anemia ALPS, Autoimmune lymphoproliferative syndrome AR, Autosomal-recessive CGD, Chronic granulomatous disease CID, Combined immunodeficiency COVID-19 COVID-19, Coronavirus disease 2019 CVID, Common variable immune deficiency HLH, Hemophagocytic lymphohistiocytosis HSCT, Hematopoietic stem cell transplantation Hypogammaglobulinemia ICU, Intensive care unit IEI, Inborn errors of immunity immune dysregulation inborn errors of immunity P, Patient PID, Primary immunodeficiency Primary immunodeficiencies SARS-CoV-2 SARS-CoV-2, Severe acute respiratory syndrome coronavirus 2 X-CGD, X-linked chronic granulomatous disease X-SCID, X-linked severe combined immunodeficiency [DOI] 10.1016/j.jaci.2020.09.010 PMC 바로가기 [Article Type] Multicenter Study
The role of host genetics in susceptibility to severe viral infections in humans and insights into host genetics of severe COVID-19: A systematic reviewReview Published on 2020-09-092022-10-04 Journal: Virus research [Category] SARS, 유전자 메커니즘, [키워드] accompanied addition C-lectin pathways candidate gene Case report caused CCR1 CCR9 coronavirus coronavirus endoribonuclease COVID-19 COVID-19 case COVID-19 GWAS COVID-19 pathogenesis Cytokine storm DC-SIGN DC-SIGN, Dendritic Cell-Specific Intercellular adhesion molecule-3-Grabbing Non-integrin DC-SIGNDendritic Cell-Specific Intercellular adhesion molecule-3-Grabbing Non-integrin deficiency Dendritic Cell-Specific Intercellular adhesion molecule-3-Grabbing Non-integrin disease double-strand RNA dsRNA, double-strand RNA dsRNAdouble-strand RNA dysregulated endoU, coronavirus endoribonuclease endoUcoronavirus endoribonuclease Evidence explain expression genetic study Genetic variant genome wide association studies GWAS GWAS, genome wide association studies GWASgenome wide association studies Herpes Simplex Virus 1 herpses simplex encephalitis Host host genetics Host immune defenses HSE, herpses simplex encephalitis HSEherpses simplex encephalitis HSV-1, Herpes Simplex Virus 1 HSV-1Herpes Simplex Virus 1 Human hypothese IL-18 IL-18 binding protein IL-18BP, IL-18 binding protein IL-18BPIL-18 binding protein immune immune response gene immune system implicated inborn errors of immunity Inclusion Inflammasome inflammasome activation Interaction interferon Interleukins International Union of Immunological Societies IUIS, International Union of Immunological Societies IUISInternational Union of Immunological Societies lactate dehydrogenase latency LDH, lactate dehydrogenase LDHlactate dehydrogenase lectin manifestation medical subject heading MeSH, medical subject heading MeSHmedical subject heading Meta-analysis minor allele frequency NLRP1 objective OMIM, Online Mendelian Inheritance in Man (OMIM) OMIMOnline Mendelian Inheritance in Man (OMIM) Online Mendelian Inheritance in Man (OMIM) Pathogenesis pathway Pathways PBMCs, peripheral blood mononuclear cells PBMCsperipheral blood mononuclear cells Peripheral blood mononuclear cells Protein reported Result SARS Coronavirus SARS coronavirus 2 SARS-coronavirus 2 SARS-CoV SARS-CoV-2 SARS-CoV-2, SARS Coronavirus 2 SARS-CoV-2SARS Coronavirus 2 SARS-CoV, SARS Coronavirus SARS-CoVSARS Coronavirus severe COVID-19 Study design susceptibility systematic review therapeutic targets TLR pathway TLR pathways treatment for COVID-19 variant viral disease viral infection Viral susceptibility [DOI] 10.1016/j.virusres.2020.198163 PMC 바로가기 [Article Type] Review