infiltration – Page 5 – Communicable Diseases Research

Neutrophil Extracellular Traps (NETs) and Covid-19: A new frontiers for therapeutic modality

Article

Published on 2022-01-062022-11-01
Journal: International immunopharmacology [Category] COVID-19, MERS, SARS,

Postmortem Biopsies of the Lung, Heart, Liver, and Spleen of COVID-19 Patients

Radiology

Published on 2021-12-272022-10-31
Journal: Cureus [Category] COVID-19,

[키워드] acquisition alteration autopsy studies biopsies biopsy Case series Characteristics Chest computed tomography collected Complete coronavirus disease correlated COVID-19 died Diffuse alveolar damage evaluate examined feasible FIVE Ground-glass opacities heart heart tissue histopathologic histopathological infiltration liver lung lung biopsy Lungs material Microscope mononuclear cell Necrosis neutrophil infiltration nonspecific objective Patient patients performed Postmortem Result SARS-CoV-2 specimens spleen spleen tissue Splenic steatosis the patient tissue Treatment underlying disease were stained
[DOI] 10.7759/cureus.20734 PMC 바로가기 [Article Type] Radiology

Pathologic and Neuropathologic Study of a Case of COVID-19

Case Report

Published on 2021-12-242022-10-30
Journal: JMA Journal [Category] COVID-19,

Inactivated SARS-CoV-2 induces acute respiratory distress syndrome in human ACE2 -transgenic mice

비활성화된 SARS-CoV-2는 인간 ACE2 형질전환 마우스에서 급성 호흡곤란 증후군을 유발합니다

Article

Published on 2021-12-242022-09-10
Journal: Signal Transduction and Targeted Therapy [Category] Fulltext, SARS, 유전자 메커니즘, 치료제,

[키워드] ACE2 Activated neutrophils Activation acute respiratory distress acute respiratory distress syndrome Adaptive immune response alveolar damage animal model animal models ARDS Biological models biosafety biosafety level captures change changes in Characteristics characterized consolidation COVID-19 cytokine Cytokines detrimental develop Dexamethasone Diffuse alveolar damage Disease progression formaldehyde generate hACE2 hemorrhage human ACE2 humans hyaline membrane hyaline membrane formation IL-1β IL-6 induce Infection Infectious diseases infiltration Inflammation Inflammatory inflammatory monocyte Laboratory limit live SARS-CoV-2 lung macrophages mice monocyte-macrophages mouse model necrotic necrotic debris Neutrophils open passive antibody therapy pathologic pathological mechanism progression reported Research researcher respiratory distress Respiratory distress syndrome resulting robust SARS-CoV-2 syndrome T cell T cells the disease Therapeutic strategies therapeutic strategy TNF-α utilization weight loss
[DOI] 10.1038/s41392-021-00851-6 PMC 바로가기 [Article Type] Article

Intrinsic Kidney Pathology Following COVID-19 Infection in Children and Adolescents: A Systematic Review

Systematic Review

Published on 2021-12-222022-10-31
Journal: Children [Category] COVID-19,

[키워드] acute COVID-19 adolescents Antibody testing article biopsy caused children Collapsing COVID-19 COVID-19 infection COVID-19 infection status COVID-19 pandemic defined Diagnosis dialysis disease English language highlight hospital discharge Hypothesis illnesses Infection infiltration Inflammatory interstitial intrinsic intrinsic kidney pathology item kidney kidneys limitation manifestation Meta Mild more difficult Mortality MPO nephrotic syndrome nuclear occurred Other pathology pathophysiological mechanism Patient positive positive result reduce rejection remained reported Reporting resulting review RT-PCR SARS-CoV-2 selected severity steroid treatment Support syndrome systematic literature search systematic review thrombotic vaccination Vasculitis viral invasion
[DOI] 10.3390/children9010003 PMC 바로가기 [Article Type] Systematic Review

Microglia Do Not Restrict SARS-CoV-2 Replication following Infection of the Central Nervous System of K18-Human ACE2 Transgenic Mice

소교세포는 K18-인간 ACE2 형질전환 마우스의 중추신경계 감염 후 SARS-CoV-2 복제를 제한하지 않습니다

Pathogenesis and Immunity

Published on 2021-12-222022-09-10
Journal: Journal of Virology [Category] COVID19(2023년), MERS, SARS, 유전자 메커니즘, 진단,

[키워드] accompanied ACE2 Activation addition administration Antiviral causative agent CCL19 CCL2 CCL5 Central nervous system characterized chemokine CNS colony-stimulating factor consequence contribute contributing to COVID-19 COVID-19 patient COVID-19 patients Critical CXCL10 CXCL9 cytokine Defense determined by disease eIF2 evaluate Evidence exhibited expression hACE2 Host host defense human ACE2 IFN-λ Immune cell infiltration immune response immune responses immunological immunological mechanism increased expression infect infecting Infection infection with SARS-CoV-2 infiltration Inflammatory response inhibitor K18 K18-hACE2 Lung pathology macrophages MERS MERS-CoV mice microglia Mild mind Monocytes monocytes/macrophages nervous nervous system Neuroinvasive neurologic Neuron neurons Neuropathology not affect PLX5622 Pro-inflammatory genes proinflammatory Proinflammatory cytokine receptor reduction in replicate responsible RNA sequencing SARS-CoV-1 SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 replication severity Signaling survival Symptom System TNF-α transcript transgenic mice understanding Viral viral infection viral pathogen viral replication virus viruses
[DOI] 10.1128/jvi.01969-21 PMC 바로가기 [Article Type] Pathogenesis and Immunity

Intrauterine Fetal Demise After Uncomplicated COVID-19: What Can We Learn from the Case?

복잡하지 않은 Covid-19 후 자궁 내 태아 사망 :이 사건에서 무엇을 배울 수 있습니까?

Case Reports

Published on 2021-12-192022-09-10
Journal: Viruses [Category] SARS, 치료기술, 치료법,

[키워드] abnormality ACE2 Autopsy B-lymphocytes Basigin Can case study CD147 changes in Clinical course clumping COVID-19 death demise deposition dominant dominant receptor Endothelial cell epithelial expression fetal fetal demise fetal movements fetus histology Immunity immunohistochemistry In situ hybridization indicate Infection infiltration interstitial Ischemia lead limit lung lung tissue maternal immunity Mild Morphological mother Neutrophils nucleocapsid over Patient persistence persistent infection Placenta placental placental tissue positive PCR test Pregnancy pregnant pregnant women prevalent Protein receptor reported RNA SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 nucleocapsid severity Spike protein syncytiotrophoblast T-lymphocyte the SARS-CoV-2 TMPRSS2 transfer transplacental infection transplacental transmission trophoblast villi Viral viral infection virus virus clearance
[DOI] 10.3390/v13122545 PMC 바로가기 [Article Type] Case Reports

COVID-19 and Sepsis

Article

Published on 2021-12-172022-10-29
Journal: Turkish Journal of Medical Sciences [Category] COVID-19, SARS,

[키워드] acute phase reactant acute respiratory distress addition affecting alterations ARDS assist association Autopsy Bacterial sepsis Blood cause caused Cell changes chemokine Clinical deterioration coagulation tests component consolidation contributing to Course COVID-19 COVID-19 pandemic COVID-19 pathogenesis COVID-19 patient COVID-19 sepsis CRP Cytokine storm D-dimer demonstrated Diffuse alveolar damage direct viral infection dominant dysregulated immune response endothelial injury explained Faeces feature ferritin Gallbladder hematological hemorrhage histopathological HLH hospitalized patient Hyperactivation hypercoagulability hypercoagulable hyperinflammation immune immune response IMPROVE indicated infiltration inflammatory cell intrinsic Laboratory laboratory parameter limit liver liver function tests lung tissue Lungs macrophages manifestation modulate multiorgan failure multiple organ organ systems organs outcome overlapping pandemic Pathogenesis pathogenesis of COVID-19 Pathogens Result SARS-CoV-2 Sepsis serum cytokine Severe case severe COVID-19 severe COVID-19 disease Severe COVID-19 Infection severe COVID-19 patients similarity syndrome systemic inflammation tissue Treatment unique Urine Vascular viral disease viral particle virus while
[DOI] 10.3906/sag-2108-239 PMC 바로가기 [Article Type] Article

Acute and Chronic Cardiovascular Manifestations of COVID-19: Role for Endotheliopathy

Review

Published on 2021-12-152022-10-30
Journal: Methodist DeBakey Cardiovascular Journal [Category] COVID-19, MERS, SARS,

[키워드] Adhesion Molecule alteration antioxidant Arrhythmias cardiovascular cause caused cerebrovascular attack chemokines chronic circulating cognitive conditions contribute coronavirus disease COVID-19 Deep venous thrombosis Dementia disease donors edema endothelial Endothelium Evidence expression heart failure homeostasis impairment indicate infiltration Inflammatory cytokine intercellular Invasion manifestation Manifestations Myocardial infarction myocarditis nitric oxide patients with COVID-19 promoted Pulmonary embolism pulmonary fibrosis role SARS-CoV-2 stroke therapeutic therapy Thromboembolism thrombosis Venous Thromboembolism ventricular virus
[DOI] 10.14797/mdcvj.1044 PMC 바로가기 [Article Type] Review

CD40L protects against mouse hepatitis virus-induced neuroinflammatory demyelination

Research Article

Published on 2021-12-132022-10-29
Journal: PLoS Pathogens [Category] Coronavirus,