Aging in COVID-19: Vulnerability, immunity and interventionReview Published on 2020-10-312023-06-14 Journal: Ageing research reviews [Category] MERS, SARS, [키워드] aging anti-IL-6 therapy COVID-19 Cytokine storm immunopathology immunosenescence inflammaging SARS-CoV-2 vaccination [DOI] 10.1016/j.arr.2020.101205 PMC 바로가기 [Article Type] Review
I mmunosenescence and Inflammaging: Risk Factors of Severe COVID-19 in Older PeopleI 면역노화와 염증: 고령자의 중증 COVID-19 위험 요인Review Published on 2020-10-272022-09-11 Journal: Frontiers in Immunology [Category] MERS, SARS, 유전자 메커니즘, [키워드] Adaptive immune response addition advanced age aging aging process change condition coronavirus correlation COVID-19 Cytokines decrease decreases disease disease pathogenesis dysfunction exacerbated Factor immune responses immunological immunological change immunological changes immunosenescence include individual Infection inflammaging Inflammatory cytokines Influenza involved main mechanism main mechanisms mechanism occur Older SARS-CoV-2 SARS-COV-2 infection susceptibility susceptible the disease [DOI] 10.3389/fimmu.2020.579220 PMC 바로가기 [Article Type] Review
Immunesenescence: A Predisposing Risk Factor for the Development of COVID-19?Immunology Published on 2020-10-062022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, MERS, SARS, [키워드] accelerated activated acute respiratory syndrome advanced age aging Bearing characterized co-morbidity coronavirus Coronavirus disease 2019 COVID-19 COVID-19 treatment demographic group described development dysregulated effective exacerbate Factor feature females functional Gender group high risk highlight immune dysfunction Immune profile immune response immune system Immunesenescence inflammaging Inflammatory less Lymphocytes male Monocytes obese obesity occur Older pathogen patients phenotypic Premature question response risk factor SARS-Cov_2 SARS-CoV-2 senescent severe COVID-19 subject susceptibility T cells T2D therapeutic options Treatment type 2 diabete [DOI] 10.3389/fimmu.2020.573662 PMC 바로가기 [Article Type] Immunology
SARS-CoV-2, immunosenescence and inflammaging: partners in the COVID-19 crimeReview Published on 2020-09-302022-10-28 Journal: Aging (Albany NY) [Category] COVID-19, [키워드] acute respiratory syndrome adverse outcome age aging Central nervous system characteristic chronic inflammation Chronic low-grade inflammation Combination consequence COVID-19 detrimental disease immune system immunosenescence inflammaging neurodegenerative Neuroinflammation outbreak outcome pandemic predisposition risk factor SARS-CoV-2 SARS-COV-2 infection severity viral infection virus Wuhan, China [DOI] 10.18632/aging.103989 PMC 바로가기 [Article Type] Review
Covid-19 Pandemic: Maximizing Future Vaccination Treatments Considering Aging and FrailtyMedicine Published on 2020-09-182022-10-31 Journal: Frontiers in Medicine [Category] COVID-19, [키워드] accelerate addressed Adherence to treatment ageotype aging Clinical practice cognitive complex complications consequence coronavirus COVID-19 COVID-19 outbreak COVID-19 pandemic disorders dysregulation effective elderly patients expression frailty Future Geriatrics Health higher risk homeostatic identify immune system immunization immunology immunosenecence Infection inflammaging initiated Italy less medication mental health North physical physiological Population predict public health question reduced regimen Research respond response seasonal flu shown silent South Stressor syndrome Treatment vaccination Vaccine [DOI] 10.3389/fmed.2020.558835 PMC 바로가기 [Article Type] Medicine
Immunosenescence is both functional/adaptive and dysfunctional/maladaptiveReview Published on 2020-09-152024-09-04 Journal: Seminars in immunopathology [Category] 대상포진, [키워드] adaptation centenarians immunosenescence Immunosuppressive mechanisms inflammaging Maladaptation trained immunity [DOI] 10.1007/s00281-020-00818-9 PMC 바로가기 [Article Type] Review
Utility of COVID-19 Screening in Cancer PatientsArticle Published on 2020-09-142023-06-19 Journal: Cancer cell [Category] Fulltext, SARS, [키워드] aging bats inflammaging Inflammation Longevity [DOI] 10.1016/j.ccell.2020.07.009 PMC 바로가기
A public health perspective of aging: do hyper-inflammatory syndromes such as COVID-19, SARS, ARDS, cytokine storm syndrome, and post-ICU syndrome accelerate short- and long-term inflammaging?Opinion Published on 2020-08-242022-10-30 Journal: Immunity & Ageing : I & A [Category] COVID-19, [키워드] accelerate accelerated acute respiratory disease ARDS co-morbidities condition COVID-19 COVID-19 pandemic Cytokine storm syndrome elicited frailty Hospitalization hyperinflammatory state ICU care individual individuals inflammaging Inflammation Inflammatory pandemic Perspective post-COVID-19 patient public health question respiratory resulting survivor susceptibility syndrome systemic inflammation worsening [DOI] 10.1186/s12979-020-00196-8 PMC 바로가기 [Article Type] Opinion
COVID-19 mortality in Lombardy: the vulnerability of the oldest old and the resilience of male centenariansResearch Paper Published on 2020-08-152022-10-28 Journal: Aging (Albany NY) [Category] COVID-19, MERS, [키워드] affected age cause centenarians checked Cluster connection COVID-19 COVID-19 cases COVID-19 mortality Cytokine storm death European females Gender increase Infection inflammaging Italian Italy lombardy male males men Mortality much lower occurred Older oldest-old populations predicted presenting Resilience survival those with comorbidities [DOI] 10.18632/aging.103872 PMC 바로가기 [Article Type] Research Paper
Remodeling of the Immune Response With Aging: Immunosenescence and Its Potential Impact on COVID-19 Immune ResponseImmunology Published on 2020-08-072022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, MERS, SARS, [키워드] activated Activation adaptive Adaptive immune response age all-cause mortality antibody-secreting cell antigenic caused change clinical consequence Combination complementary coronavirus disease COVID-19 Cytokine release syndrome Cytokine storm disease effective Efficacy elderly endothelial injury Enhancing explain follicular Frequency helper T cell immune response Immunity Immunopathogenesis immunosenescence Impact individual Infection Inflamm-aging inflammaging inflammatory state inhibiting innate immune response less management memory T cell naïve neo-antigens occur organ injury Patient Potential pro-inflammatory Prognosis remodeling response SARS-CoV-2 severe COVID-19 susceptible T cell Therapeutic approach thought tissue damage triggered vaccination viral replication virus [DOI] 10.3389/fimmu.2020.01748 PMC 바로가기 [Article Type] Immunology