Hyperglycemia and insulin resistance in COVID-19 versus non-COVID critical illness: Are they really different?Commentary Published on 2021-12-172022-11-01 Journal: Critical Care [Category] COVID-19, SARS, [키워드] COVID-19 Critical diabetes hyperglycemia insulin insulin resistance [DOI] 10.1186/s13054-021-03861-6 PMC 바로가기 [Article Type] Commentary
COVID-19 induces new-onset insulin resistance and lipid metabolic dysregulation via regulation of secreted metabolic factorsCOVID-19는 분비된 대사 인자의 조절을 통해 새로운 발병 인슐린 저항성 및 지질 대사 조절 장애를 유발합니다Article Published on 2021-12-162022-09-10 Journal: Signal Transduction and Targeted Therapy [Category] Fulltext, SARS, 바이오마커, 유전자 메커니즘, 임상, 진단, 치료기술, 치료법, [키워드] Apelin Cohort complications COVID-19 COVID-19 patient Diseases dysregulation Endocrine system and metabolic diseases expression Glucose HDL-C hyperglycemia induce Infectious diseases insulin insulin resistance investigated isobutyric acid lipid metabolism lipids mechanism mechanisms metabolic factor metabolism modulated myeloperoxidase myostatin patients Perturbation Potential biomarker potential biomarkers potential therapeutic target potential therapeutic targets propionic acid Regulation reported REST resulting SARS-COV-2 infection secreted transcription factor transcriptional level [DOI] 10.1038/s41392-021-00822-x PMC 바로가기 [Article Type] Article
Diabetes and susceptibility to infections: Implication for COVID-19당뇨병과 감염에 대한 감수성: COVID-19에 대한 시사점Review Published on 2021-11-012022-09-11 Journal: Immunology [Category] SARS, 바이오마커, 유전자 메커니즘, [키워드] activating binding Cell cell survival contribute COVID-19 COVID-19 infections diabete diabetes Diabetic differentiation dysregulated explain Factor healthcare immune immune activation Immune cell immune cells immune checkpoint blocker immune response immune-related genes in viral Infection infections Inflammation insulin insulin receptor insulin resistance involved lymphocyte Lymphocytes mechanism mTOR myeloid cell myeloid cells nucleus observation outcome pathology pathway Pathways peripheral tolerance PI3K polarization Proteins receptor regulate shown survival susceptibility susceptibility to infection the strongest Transcription translocate Viral viral infections [DOI] 10.1111/imm.13383 PMC 바로가기 [Article Type] Review
COVID-19 and obesity: the meeting of two pandemicsReview Published on 2021-11-012023-07-12 Journal: Archives of endocrinology and metabolism [Category] SARS, [키워드] COVID-19 Inflammation insulin resistance obesity Pandemics [DOI] 10.20945/2359-3997000000318 [Article Type] Review
Zinc as a Drug for Wilson’s Disease, Non-Alcoholic Liver Disease and COVID-19-Related Liver InjuryReview Published on 2021-10-312022-10-30 Journal: Molecules [Category] COVID-19, MERS, SARS, [키워드] affected characterized coronavirus COVID-19 COVID-19 pandemic deficiency disorder drug drug therapy Effect Elderly patient enzyme gastrointestinal tract histological human physiology indicated Infection insulin resistance introduced Liver disease metabolism Mortality non-alcoholic liver disease oxidative stress Patient positive progression recorded reducing responsible risk SARS-CoV-2 severe disease similarities susceptibility Therapeutic approach therapy transcription factors Treatment undergo Wilson’s disease Wilson’s disease Zinc zinc supplementation [DOI] 10.3390/molecules26216614 PMC 바로가기 [Article Type] Review
Molecular Insights on the Possible Role of Annexin A2 in COVID-19 Pathogenesis and Post-Infection ComplicationsCOVID-19 병인 및 감염 후 합병증에서 Annexin A2의 가능한 역할에 대한 분자적 통찰력Review Published on 2021-10-132022-09-10 Journal: International Journal of Molecular Sciences [Category] MERS, SARS, 유전자 메커니즘, 진단, [키워드] addition Annexin Annexin A2 Antiviral AnxA2 clinically Complication complications Continuous COVID-19 cytokine Cytokine storm develop docking effective drug effective drugs effort Evidence glycoprotein in silico individual Infection insight insulin insulin resistance interactions internalization knowledge lack management molecular molecular mechanism molecular mechanisms mutated outbreak Pathogenesis performed Post-infection Prophylactic Protein provide Replication respiratory RNA-dependent RNA polymerase role SARS-CoV-2 SARS-CoV-2 pathogenesis Severe acute respiratory syndrome spike glycoprotein the SARS-CoV-2 thrombosis treat Vaccine Viral viral infection viral pathogenesis viral spike [DOI] 10.3390/ijms222011028 PMC 바로가기 [Article Type] Review
Interaction of Severe Acute Respiratory Syndrome Coronavirus 2 and Diabetes중증급성호흡기증후군 코로나바이러스 2와 당뇨병의 상호작용Review Published on 2021-10-062022-09-11 Journal: Frontiers in Endocrinology [Category] MERS, 치료제, [키워드] ACE2 ACE2 protein acute respiratory syndrome acute respiratory syndrome coronavirus aggravate angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 animal models Anti-inflammatory binding cause cells coronavirus coronavirus 2 COVID – 19 damage diabete diabetes diabetes - quality of life Diabetic diabetic patient diabetic patients dipeptidyl peptidase DPP4 drug Effect Epidemic expression focus furin glucagon glucagon-like peptide glucagon-like peptide 1 identify immune disorder immunocellular response influence influences inhibitor insulin insulin resistance involved islets lung lung dysfunction mechanism metformin mTOR mTOR signaling OAD OADs organs outcome pancreatic Patient peptidase peptide PPARγ Rapamycin receptor respiratory risk SARS-CoV-2 SARS-CoV-2 (2019-nCoV) SARS-COV-2 infection SARS-CoV-2 infections severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 shown signaling pathway Spread suppression Treatment Trigger type 2 diabete Type 2 diabetes mellitus underlying disease underlying diseases [DOI] 10.3389/fendo.2021.731974 PMC 바로가기 [Article Type] Review
Clinical Predictors of Mortality and Critical Illness in Patients with COVID-19 PneumoniaArticle Published on 2021-10-022022-10-30 Journal: Metabolites [Category] COVID-19, [키워드] Accuracy Admission age Analysis analyzed Aspirin AUC biochemical BUN center clinical clinician collected COVID-19 COVID-19 patients COVID-19 severity Critical disease CXCL-10 cytokine level Cytokine storm death Department develop Diabetes Mellitus diagnosed with COVID-19 diagnostic discharge disease severity early treatment Factor GCSF help hematological Hemodialysis HFNC high flow higher risk hypertension identify identifying IL-2 IL-6 illness immunological include increased mortality insulin resistance Intervention invasive ventilation Laboratory Lung disease main outcome measure male Mortality multivariate NLR non-survivor Oxygen therapy Patient patients patients with COVID-19 PPV Predictive predictors Radiographic reduce reduced regression analysis risk of death SARS-CoV-2 sensitivity significantly specificity study population suffered Symptom utility variable were used with COVID-19 [DOI] 10.3390/metabo11100679 PMC 바로가기 [Article Type] Article
A scalable, secure, and interoperable platform for deep data-driven health managementArticle Published on 2021-10-012022-10-04 Journal: Nature Communications [Category] 유전자 메커니즘, [키워드] acquisition addition Cohort complex Computational platforms and environments COVID-19 Dashboard Data acquisition Data analysis Data integration data sets data-driven develop disease Electronic health records Health Healthcare systems individual level insulin resistance management molecular outcome outcomes PhD platform presenting presymptomatic provide raise secure Support [DOI] 10.1038/s41467-021-26040-1 PMC 바로가기 [Article Type] Article
Interplay Among the Oral Microbiome, Oral Cavity Conditions, the Host Immune Response, Diabetes Mellitus, and Its Associated-Risk Factors—An OverviewOral Health Published on 2021-09-092022-10-31 Journal: Frontiers in Oral Health [Category] COVID-19, [키워드] addition advanced age affected aggravate alteration association bidirectional relationship blood pressure bloodstream Care Cavity complications condition conditions contribute decrease Diabetes Mellitus disease Effect elevated exacerbate exacerbating exaggerated inflammatory response Frequency fungal infections glycemic glycemic control greater HDL Health Host immune response hyperglycemia hyperlipidemia hypertension immune response immune system increase increase in individual individuals induce Inflammatory response insulin insulin resistance lesion likelihood management mechanism microbial microbial community Microbiome Nitrate nitrite obese obesity oral oral cavity Oral microbiome oral mucosa oxidative stress pathogen Patient patients periodontal disease Prevalence pro-inflammatory mediator progression reduce reduction response risk factor Risk factors salivary SARS-COV-2 infection secretion selective syndrome Triglyceride [DOI] 10.3389/froh.2021.697428 PMC 바로가기 [Article Type] Oral Health