Potent universal beta-coronavirus therapeutic activity mediated by direct respiratory administration of a Spike S2 domain-specific human neutralizing monoclonal antibodySpike S2 도메인 특이적 인간 중화 단일클론 항체의 직접적인 호흡기 투여에 의해 매개되는 강력한 보편적인 베타-코로나바이러스 치료 활성Article Published on 2022-07-212022-09-11 Journal: PLoS Pathogens [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] (Beta acute respiratory syndrome acute respiratory syndrome coronavirus-2 Administered administration antibody Beta beta-coronavirus check conserved convalescent coronavirus coronavirus vaccine Delta demonstrated determine dose Epsilon Gamma hACE2 hamster hamsters Human human monoclonal antibodies Human monoclonal antibody IgG Immune escape in vivo infected with SARS-CoV-2 Infection infection with SARS-CoV-2 intranasal K18 Lineage mAb mAbs MERS-CoV mice monoclonal antibody Mortality Mutation neutralize SARS-CoV neutralized Neutralizing omicron plasma potent pre-fusion Prevent Prophylactic Recognition recognize reduced respiratory respiratory viral S1 and S2 S2 domain SARS-CoV Urbani SARS-CoV-2 SARS-CoV-2 delta SARS-CoV-2 spike screened Severe acute respiratory syndrome severe acute respiratory syndrome coronavirus-2 significantly spike subject subjects tested therapeutic activity therapeutic potential Vaccine variants of concern Viral virus weight loss β-coronavirus [DOI] 10.1371/journal.ppat.1010691 PMC 바로가기 [Article Type] Article
Nanoligomers Targeting Human miRNA for the Treatment of Severe COVID-19 Are Safe and Nontoxic in Mice심각한 COVID-19 치료를 위해 인간 miRNA를 표적으로 하는 나노 올리고머는 마우스에서 안전하고 독성이 없습니다Article Published on 2022-07-112022-09-11 Journal: ACS Biomaterials Science & Engineering [Category] COVID19(2023년), SARS, 치료제, [키워드] accumulation acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 administration antisense therapy Antiviral strategies Antiviral treatment bind biodistribution biodistribution study body weight Compound coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 disease Effect fatality Histopathology Host Host immune response Human human cell human cells immune immunogenicity Infection Inflammation intranasal intraperitoneal intravenous Intravenous administration kidney kidneys liver Lungs mice microRNA miRNA MOST mouse model organ organs pandemic parameters produced question response Safe Safety SARS-CoV-2 serum biomarker serum biomarkers severe acute respiratory syndrome Coronavirus Severe case severe cases spleen targeting tested Urine with infection [DOI] 10.1021/acsbiomaterials.2c00510 PMC 바로가기 [Article Type] Article
Protection of hamsters challenged with SARS-CoV-2 after two doses of MVC-COV1901 vaccine followed by a single intranasal booster with nanoemulsion adjuvanted S-2P vaccineMVC-COV1901 백신 2회 접종 후 SARS-CoV-2에 감염된 햄스터 보호 및 나노에멀젼 보조제 S-2P 백신이 포함된 단일 비강 내 부스터Article Published on 2022-07-052022-09-11 Journal: Scientific Reports [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] alum booster booster vaccination country COVID-19 COVID-19 vaccine COVID-19 vaccines CpG1018 death Delta disease dose elicit followed by hamster Hospitalization Immunity immunization immunogenicity Infection intramuscular intranasal Lung pathology medical need mucosal offer omicron Pandemics Patient prefusion problem promote protection protective immunity protocol reduced regimen respiratory respiratory tracts resurgence robust S-2P SARS-CoV-2 SARS-CoV-2 spike severe COVID-19 severe disease solution Transmission vaccination Vaccine variants variants of SARS-CoV-2 Viral viral challenge viral clearance viral infection waning immunity weight loss were used [DOI] 10.1038/s41598-022-15238-y PMC 바로가기 [Article Type] Article
Exposure modality influences viral kinetics but not respiratory outcome of COVID-19 in multiple nonhuman primate species노출 방식은 여러 비인간 영장류 종에서 바이러스 역학에 영향을 미치지만 COVID-19의 호흡기 결과에는 영향을 미치지 않습니다Article Published on 2022-07-052022-09-11 Journal: PLoS Pathogens [Category] COVID19(2023년), SARS, 변종, [키워드] aerosol exposure African African green monkeys AGM AGMs animal model animal models ARDS change Characteristics Chlorocebus clinical clinical response Clinical sign Clinical signs Cohort conserved COVID-19 COVID-19 disease cytokine response demonstrated demonstration develop expand exposure functional greater include infected with SARS-CoV-2 Infection influence intranasal lack lung damage magnitude Medical countermeasures mucosal mucosal exposure myeloid cell Novel coronavirus novel coronavirus SARS-CoV-2 outcome pandemic status Pathogenesis Pathologies pleuritis Pulmonary pathology reached regenerative Research rhesus rhesus macaques route SARS-COV-2 infection severe disease small particle aerosol species tested therapeutic utility variants variants of concern viral kinetics Viral load [DOI] 10.1371/journal.ppat.1010618 PMC 바로가기 [Article Type] Article
Nanoparticle-delivered TLR4 and RIG-I agonists enhance immune response to SARS-CoV-2 subunit vaccine나노입자 전달 TLR4 및 RIG-I 작용제는 SARS-CoV-2 소단위 백신에 대한 면역 반응을 향상시킵니다Article Published on 2022-07-012022-09-11 Journal: Journal of controlled release : official journal o [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] activated Adaptive immune response adjuvant adjuvants agonist Anti-spike anti-Spike IgG Antibody titer Antibody titers Antigen antigen-presenting cell antigen-presenting cells APC APCS B cell B cells BAL Bcl6 Blood bronchoalveolar CD4 CD44 Cell cell population characterized Combination adjuvant COVID-19 COVID-19 protein subunit vaccine CpG DLNs draining lymph node draining lymph nodes Efficacy ENhance follicular Germinal center GL7 helper cell humoral immune responses IgA IgG immune immune response immune responses Immunity IMPROVE in vitro in vivo Increases increases in Infection intramuscular intramuscular vaccination intranasal Intranasal versus intramuscular vaccination intranasally lead lung Lungs lymphocyte memory T memory T cell mice molecular Monophosphoryl lipid A MPLA Native neutralizing antibody titers Pattern recognition pattern recognition receptor Pattern recognition receptors Polymer Population Proinflammatory cytokine Protein subunit protein subunit vaccine Protein subunit vaccines PRR PRRs PUUC reaction receptor receptors responses against retinoic acid retinoic acid-inducible gene I RIG-I robust S1 subunit SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike protein secretion spike IgA Spike protein stabilized spike protein stimulate subunit Subunit vaccine T cell T cell proliferation the S1 subunit TLR TLR4 TLR7 TLR7/8 TLR9 TLRs Toll-like receptor Toll-like receptors Transmission unique Vaccine vaccine availability vaccine responses variants [DOI] 10.1016/j.jconrel.2022.05.023 PMC 바로가기 [Article Type] Article
Artificial intelligence and clinical data suggest the T cell-mediated SARS-CoV-2 nonstructural protein intranasal vaccines for global COVID-19 immunityDiscussion Published on 2022-07-012022-10-05 Journal: Vaccine [Category] COVID19(2023년), SARS, 변종, [키워드] artificial intelligence Clinical data COVID-19 COVID-19 immunity Immunity immunodominant intranasal long-lasting methodology mRNA vaccine nonstructural protein ORF1ab ORF3 ORF3a pathology peptide Protein SARS-CoV-2 SARS-CoV-2 protein suggested T cell Vaccine with COVID-19 [DOI] 10.1016/j.vaccine.2022.06.052 [Article Type] Discussion
Niclosamide-A promising treatment for COVID-19니클로사미드-코로나19에 대한 유망한 치료제Review Published on 2022-07-012022-09-11 Journal: British Journal of Pharmacology [Category] Coronavirus, COVID19(2023년), SARS, 신약개발, 치료제, [키워드] addition Anti-inflammatory Antibacterial anticancer antiviral activity Clinical studies clinical trial clinical trials concomitant therapies COVID-19 drug drug-resistant Effect health condition intranasal nebulized niclosamide Pandemics pleiotropic Primary infection rationale reduced repurposing robust Safe SARS-CoV-2 severity of COVID-19 shown strain susceptible individuals Therapies Transmission Treatment treatment for COVID-19 vaccine response [DOI] 10.1111/bph.15843 PMC 바로가기 [Article Type] Review
Intranasal immunization with avian paramyxovirus type 3 expressing SARS-CoV-2 spike protein protects hamsters against SARS-CoV-2 Research Published on 2022-06-282022-10-05 Journal: NPJ Vaccines [Category] 변종, 유전자 메커니즘, [키워드] acute respiratory syndrome Administered Beta clinical development controls coronavirus current domain dose Express expressing hamster hamsters Human IgA response Immunity immunization immunized immunogenic intranasal lack Lineage Lower respiratory tract Lung inflammation neutralized pre-existing immunity prefusion conformation proline substitution PROTECT Protective Protein replicated Replication respiratory tract response S-2P SARS-CoV-2 SARS-CoV-2 replication SARS-CoV-2 S protein SARS-CoV-2 spike protein serum IgG Serum neutralizing antibody stability stimulate the S protein the SARS-CoV-2 undetectable upper respiratory tract Vaccine vaccine candidates variants of concern WA1/2020 weight loss [DOI] 10.1038/s41541-022-00493-x [Article Type] Research
SARS-CoV-2 Omicron variant causes mild pathology in the upper and lower respiratory tract of hamstersSARS-CoV-2 오미크론 변이체는 햄스터의 상부 및 하부 호흡기에서 가벼운 병리를 유발합니다Article Published on 2022-06-202022-09-11 Journal: Nature Communications [Category] COVID19(2023년), SARS, 변종, 진단, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 alveolar cause caused changes in Coronavirus-2 Delta Gamma hamster hamsters Infection infectious virus titer infectious virus titers intranasal investigated lesion Lower respiratory tract lung Mild Olfactory epithelium omicron pathogenicity pathological pathology respiratory tissue respiratory tissues rhinitis RNA SARS-CoV-2 Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus Strains Syrian golden hamster Syrian Golden hamsters upper and lower respiratory tract upper and lower respiratory tracts variant variants variants of concern Viral antigen virus spread VoC VOCs [DOI] 10.1038/s41467-022-31200-y PMC 바로가기 [Article Type] Article
Intranasal inoculation of an MVA-based vaccine induces IgA and protects the respiratory tract of hACE2 mice from SARS-CoV-2 infectionMVA 기반 백신의 비강내 접종은 IgA를 유도하고 SARS-CoV-2 감염으로부터 hACE2 마우스의 호흡기를 보호합니다Article Published on 2022-06-142022-09-11 Journal: Proceedings of the National Academy of Sciences of [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료기술, [키워드] acute respiratory syndrome administration Antigen Beta Blood CD3 CD8 coronavirus coronavirus 2 coronavirus vaccine COVID-19 COVID-19 pandemic current effective expressing firefly luciferase hACE2 IFN-γ IgA IgG immune responses Immunity immunized Immunoglobulin immunoglobulin A Immunoglobulin G induce Infection Infectious virus intramuscular intramuscular vaccination intramuscularly intranasal intranasally K18-hACE2 less luciferase Luminescence lung Lungs mice modified vaccinia virus morbidity mucosal mucosal immunity nasal turbinate nasal turbinates neutralized Neutralizing antibodies neutralizing antibody omicron Prevent prevented priming PROTECT protective immune response pseudovirus pseudoviruses raise remained respiratory respiratory immunity respiratory tract S protein S proteins SARS-CoV-2 SARS-COV-2 infection serum severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 severity T cells the S protein Transmission upper respiratory tract vaccination Vaccine vaccinia virus variants Viral while Wuhan [DOI] 10.1073/pnas.2202069119 PMC 바로가기 [Article Type] Article