CoV-RBD121-NP Vaccine Candidate Protects against Symptomatic Disease following SARS-CoV-2 Challenge in K18-hACE2 Mice and Induces Protective Responses That Prevent COVID-19-Associated ImmunopathologyArticle Published on 2021-11-172022-10-28 Journal: Vaccines [Category] COVID-19, [키워드] Antibody Response betacoronaviridae Betacoronavirus C57BL/6 candidate challenge characteristic component COVID-19 CXCL5 cytokine demonstrated domain dysregulation elicit fused human IgG1 Fc immunization indicated induce Inflammatory inflammatory mediator K18-hACE2 K18-hACE2 mice mice Mortality neutralizing antibody Neutralizing antibody response Prevent PROTECT Protective required response restrict SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 replication SARS-CoV-2 vaccine Severe case severe disease spike glycoprotein suggested symptomatic disease the receptor-binding domain TMV Vaccine [DOI] 10.3390/vaccines9111346 PMC 바로가기 [Article Type] Article
SARS-CoV-2 B.1.1.7 (alpha) and B.1.351 (beta) variants induce pathogenic patterns in K18-hACE2 transgenic mice distinct from early strainsSARS-CoV-2 B.1.1.7(알파) 및 B.1.351(베타) 변이체는 초기 균주와 구별되는 K18-hACE2 형질전환 마우스에서 병원성 패턴을 유도합니다Article Published on 2021-11-122022-09-10 Journal: Nature Communications [Category] MERS, SARS, 변종, 진단, 치료기술, [키워드] (alpha (Beta Adaptive immunity Alpha Antibody neutralization Antimicrobial responses B.1.1.7 B.1.351 caused combating COVID-19 cytokine D-dimer death hACE2 help hypoxia Immunity immunization induce Infection intramuscular K18-hACE2 K18-hACE2 mice K18-hACE2 transgenic mice lesion less medical intervention mice Mutant SARS-CoV-2 neutralization titer organ pathogenic pathology Receptor binding domain reduced Reinfection resulting SARS-CoV-2 SARS-CoV-2 B.1.1.7 SARS-CoV-2 strain SARS-CoV-2 strains SARS-CoV-2 variant SARS-CoV-2 variants Signaling strain Strains Transgenic mouse Transmissibility variant variants variants of concern Viral viral infection viral spike virulence VoC VOCs [DOI] 10.1038/s41467-021-26803-w PMC 바로가기 [Article Type] Article
Fc-Independent Protection from SARS-CoV-2 Infection by Recombinant Human Monoclonal AntibodiesArticle Published on 2021-11-082022-10-27 Journal: Antibodies [Category] COVID-19, [키워드] a-glycosylated Activation antibody antibody-based therapies approach binding C1q complement death distinct domain effective effector cell expected Fc-mediated function Fc-mediated functions FcγR fragment crystallizable (Fc) function glycosylation Human human monoclonal antibodies immune system In-vitro include initiated K18-hACE2 K18-hACE2 transgenic mice mice monoclonal antibodies (mAbs) morbidity Mutation neutralization Neutralizing neutralizing antibody NTD prevented protection Protective provide RBD recombinant recruitment reduced rescued retained SARS-CoV-2 SARS-COV-2 infection Treatment Viral load Virus neutralization was tested [DOI] 10.3390/antib10040045 PMC 바로가기 [Article Type] Article
564. SARS-CoV-2 Ferritin Nanoparticle Vaccines Elicit Broad SARS Coronavirus ImmunogenicityPoster Abstracts Published on 2021-11-042022-10-29 Journal: Open Forum Infectious Diseases [Category] COVID-19, [키워드] analyzed antibody antigenic approach binding breadth clinical trial Combination domain elicit elicited Emergency use authorization global pandemic Heterologous High-dose highlight immune response immunization immunogen immunogenicity K18-ACE2 K18-hACE2 mice Multiple murine mutations N-terminal domain nanoparticle neutralization Neutralizing NTD observation pandemic platform prefusion pseudovirus RBD reported responses Result robust SARS-CoV RBD SARS-CoV-1 SARS-CoV-1 RBD SARS-CoV-1 virus SARS-CoV-2 SARS-CoV-2 neutralizing antibody SARS-CoV-2 RBD SARS-CoV-2 variant SARS-CoV-2 virus SARS-CoV-2 virus variant SARS-like coronavirus sera spike the SARS-CoV-2 transfused transgenic mice Transgenic mouse Vaccine Vaccine design vaccine platform variant variants of concern virus were assessed zoonotic [DOI] 10.1093/ofid/ofab466.762 PMC 바로가기 [Article Type] Poster Abstracts
Development of an Inactivated Vaccine against SARS CoV-2SARS COV-2에 대한 불활성 백신의 개발Article Published on 2021-11-022022-09-10 Journal: Vaccines [Category] 비임상, [키워드] Adenovirus Aluminium aluminium hydroxide animal models approved AstraZeneca BALB/c mice breath candidate candidate vaccine changed clinical development clinical trial Complete COVID-19 COVID-19 pandemic COVID-19 vaccine develop development Device distribution Efficacy elicited Emergency use ERUCoV-VAC ferrets hACE2 HCoV help human clinical trial human clinical trials hydroxide immunogenic immunogenicity inactivated Inactivated vaccine include Johnson & Johnson K18-hACE2 Medical devices Medicine mice Moderna mRNA name outbreak Pfizer-BioNTech Phase 3 phase 3 clinical trial progression Protective respiratory safety evaluation SARS CoV-2 SARS-CoV-2 SARS-CoV-2 vaccine Sinopharm Sinovac Spread strain strong immune response the vaccine the WHO transgenic mice TURKOVAC university upper respiratory tract upper respiratory tracts Vaccine vaccine candidate Vaccines Viral viral clearance rate Viral vector viral vectors was used [DOI] 10.3390/vaccines9111266 PMC 바로가기 [Article Type] Article
Pharmacological inhibition of fatty acid synthesis blocks SARS-CoV-2 replication지방산 합성의 약리학적 억제는 SARS-CoV-2 복제를 차단합니다Article Published on 2021-11-012022-09-11 Journal: Nature metabolism [Category] MERS, SARS, 변종, 신약개발, 진단, 치료제, [키워드] ACACA acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 airway airways block cellular clinical clinical trials contagious coronavirus COVID-19 death Delta drug Drug administration drug candidate drug candidates Efficacy evaluate FASN fatty Fatty acid food Genes hACE2 humans identify in vitro inflammatory disease inhibit inhibiting inhibitor injection Injections Intervention K18-hACE2 K18-hACE2 transgenic mice leads lung Lung pathology Lungs metabolic genes mouse model Multi-organ damage offer orlistat pathway pharmacological promote reduced replication of SARS-CoV-2 required respiratory RNA SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 replication SARS-CoV-2 variants SARS-CoV-2 viral SARS-CoV-2 viral infection screened Screening severe acute respiratory syndrome Coronavirus severe COVID-19 survival target transgenic mice Treatment treatment of COVID-19 Trial variants Viral [DOI] 10.1038/s42255-021-00479-4 PMC 바로가기 [Article Type] Article
The K18-Human ACE2 Transgenic Mouse Model Recapitulates Non-severe and Severe COVID-19 in Response to an Infectious Dose of the SARS-CoV-2 VirusArticle Published on 2021-10-202023-06-17 Journal: Journal of Virology [Category] MERS, SARS, [키워드] COVID-19 Infectious disease K18-hACE2 Lung infection mouse model SARS-CoV-2 [DOI] 10.1128/JVI.00964-21 PMC 바로가기
A mouse model of lethal respiratory dysfunction for SARS-CoV-2 infectionSARS-CoV-2 감염에 대한 치명적인 호흡기 기능 장애의 마우스 모델Article Published on 2021-09-012022-09-11 Journal: Antiviral Research [Category] SARS, 변종, 비임상, 진단, [키워드] angiotensin animal model Brain brains Central nervous system CNS COVID-19 COVID-19 cases COVID-19 patient disease phenotype dysfunction enzyme expressing feature full genome sequencing genetic differences Genetic variant genetic variants Genome sequencing hACE2 Infection inoculation Isolation K18-hACE2 K18-hACE2 mice lung Lungs mice Mild mild to moderate moderate morphology Mortality pandemic plaque Pneumonia pulmonary disease Pulmonary infection replicate rodent SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 isolate SARS-CoV-2 isolates SARS-CoV-2 variant SARS-CoV-2 variants shown Spread Therapeutics transgenic mice Vaccine wild-type SARS-CoV-2 with COVID-19 [DOI] 10.1016/j.antiviral.2021.105138 PMC 바로가기 [Article Type] Article
Protective Effects of Astodrimer Sodium 1% Nasal Spray Formulation against SARS-CoV-2 Nasal Challenge in K18-hACE2 MiceK18-HACE2 마우스에서 SARS-COV-2 코 챌린지에 대한 아스 토드리머 나트륨 1% 코 스프레이 제제의 보호 효과Article Published on 2021-08-202022-08-31 Journal: Viruses [Category] MERS, SARS, 치료기술, 치료제, [키워드] administration animal animal model animals anti-SARS-CoV-2 Antiviral astodrimer blocked Brain challenge chemokine COVID-19 Cytokines Day dendrimer detectable Effect Efficacy Formulation hACE2 IL-1 IL-1α IL-1β IL-6 Incubation infected intranasally Infection Infectious virus intranasally K18-hACE2 K18-hACE2 mice lack liver lung MCP-1 nasal Nasal cavity Nasal spray neutralisation pathogen PBS Post-infection pro-inflammatory cytokine pro-inflammatory cytokines product PROTECT reduced reducing reduction reduction in SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 replication secretion serum severity of COVID-19 significantly sodium SPL7013 spray Strategy TGFβ These data TNFα Trachea treated Treatment undetectable Viraemia Viral viral genome viral replication viral shedding virus virus replication virus transmission was used were infected [DOI] 10.3390/v13081656 PMC 바로가기 [Article Type] Article
Mild and Severe SARS-CoV-2 Infection Induces Respiratory and Intestinal Microbiome Changes in the K18-hACE2 Transgenic Mouse Model경증 및 중증 SARS-CoV-2 감염은 K18-hACE2 형질전환 마우스 모델에서 호흡기 및 장내 미생물군유전체 변화를 유도합니다Research Article Published on 2021-08-112022-09-10 Journal: Microbiology Spectrum [Category] MERS, SARS, 치료제, [키워드] absence acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition Affect Antiviral Antiviral treatment Bacteroidete Bacteroidetes cecum change changes in characterized Clinical sign Clinical signs coronavirus COVID-19 COVID-19 pandemic death deaths declining Decreased develop disease dissimilarity dosage dose dose-dependent manner family Firmicute firmicutes groups hACE2 High dose High-dose immune system increasingly independent independent of Infection inhibitor intestinal intestine K18-hACE2 K18-hACE2 mice K18-hACE2 transgenic mice less lung Lungs M pro mice microbe microbes microbial Microbiome Model mouse presence or absence prevalent Proteobacteria respiratory respiratory infection respiratory infections SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome Coronavirus severe SARS severe SARS-CoV-2 significantly Treatment Verrucomicrobia Viral viral infections virus with infection [DOI] 10.1128/Spectrum.00536-21 PMC 바로가기 [Article Type] Research Article