Flavonoids for Treating Viral Acute Respiratory Tract Infections: A Systematic Review and Meta-Analysis of 30 Randomized Controlled Trials바이러스성 급성 호흡기 감염 치료를 위한 플라보노이드: 30건의 무작위 대조 시험에 대한 체계적인 검토 및 메타 분석Meta-Analysis Published on 2022-02-162022-09-11 Journal: Frontiers in Public Health [Category] COVID19(2023년), SARS, 임상, [키워드] achievement acute bronchitis acute respiratory tract infection adverse event adverse events Adverse reaction Adverse reactions alleviation alleviation of symptoms analyzed bronchial pneumonia bronchitis BSS changes in clearance common cold complementary and alternative medicine control group Controlled Controlled trial controlled trials COVID-19 duration of illness Efficacy analyses efficacy analysis Efficacy and safety eligible flavonoid flavonoids Hospitalization ICU Identifier incidence infections Influenza intensity limitations mechanical ventilation meta-analyses Meta-analysis Mortality not differ oxygen Patient patients hospitalized performed positive RCT RCTs respiratory respiratory tract infection Respiratory tract infections Result review rhinosinusitis RT-PCR Safe Safety severity sinusitis subject substantial risk suggested Symptom Symptoms systematic review TNF-α tonsillitis tonsillopharyngitis tract treating trials TSS Tumor tumor necrosis tumor necrosis factor tumor necrosis factor-α upper respiratory tract upper respiratory tract infections Viral [DOI] 10.3389/fpubh.2022.814669 PMC 바로가기 [Article Type] Meta-Analysis
The Impact of the COVID-19 Pandemic on Drug Use Behaviors, Fentanyl Exposure, and Harm Reduction Service Support among People Who Use Drugs in Rural SettingsCOVID-19 Pandemic이 약물 사용 행동, 펜타닐 노출 및 농촌 환경에서 약물을 사용하는 사람들의 피해 감소 서비스에 미치는 영향Article Published on 2022-02-162022-08-31 Journal: International Journal of Environmental Research an [Category] COVID19(2023년), MERS, SARS, 치료제, [키워드] acquisition affected Anxiety beans characterized Community conducted Contamination COVID-19 COVID-19 knowledge COVID-19 pandemic demographics Depression Disruption drug exposure fentanyl fentanyl beans fentanyl buttons gel harm reduction heroin Hope Impact life limitations Local loneliness mental health methamphetamine naloxone opioid overdose pandemic participant performed poverty Protective PWID reduction reported resource risk rural rural areas service setting social isolation Substance use supply Symptoms test strips vulnerable population witness worsened [DOI] 10.3390/ijerph19042230 PMC 바로가기 [Article Type] Article
Coping With Stress: The Mitokine GDF-15 as a Biomarker of COVID-19 Severity스트레스 대처 : Covid-19 심각도의 바이오 마커로서 미토 카인 GDF-15Review Published on 2022-02-162022-08-31 Journal: Frontiers in Immunology [Category] MERS, 바이오마커, [키워드] adaptive metabolic response Biomarker Cancer cancers coping COVID-19 COVID-19 cytokine storm cytokine disease disease severity disease tolerance GDF-15 growth factor hypoxia immune infections inflammatory conditions involved limitations marker mechanism mediator metabolism mitochondrial potential mechanism potential mechanisms predictor protective role Regulation report SARS-CoV-2 severity Stress the strongest therapeutic interventions tissue tissue damage Tolerance transforming growth factor Viral viral infection viral infections [DOI] 10.3389/fimmu.2022.820350 PMC 바로가기 [Article Type] Review
Quantum dots assembly enhanced and dual-antigen sandwich structured lateral flow immunoassay of SARS-CoV-2 antibody with simultaneously high sensitivity and specificitySARS-CoV-2 항체의 양자점 조립이 강화되고 이중 항원 샌드위치 구조의 측면 유동 면역분석이 동시에 높은 감도와 특이성을 나타냄Article Published on 2022-02-152022-09-12 Journal: Biosensors & bioelectronics [Category] Coronavirus, COVID19(2023년), MERS, SARS, 진단, [키워드] amplification antibody Antigen applied approach characteristic chemiluminescence immunoassay CLIA COVID-19 COVID-19 negative dendritic Diagnosis Dual-antigen sandwich immunoassay False negative rate false positive rate false-negative False-positive fluorescent groups human SARS-CoV-2 hydrophobic indicated Interpretation lateral flow immunoassay LFIA limitations Misinterpretation over overcome Patient PCR POC point-of-care point-of-care testing polymerase chain Population screening positive public health Quantitative Quantum dot Quantum dots assembly Receptor binding domain reduce resource risk robust SARS-CoV-2 antibody SARS-CoV-2 spike sensitivity Sensitivity and specificity serum signal signal amplification specificity statistical analysis viruses [DOI] 10.1016/j.bios.2021.113810 PMC 바로가기 [Article Type] Article
OxVent: Design and evaluation of a rapidly-manufactured Covid-19 ventilatorArticles Published on 2022-02-132022-11-01 Journal: EBioMedicine [Category] Coronavirus, COVID19(2023년), MERS, SARS, [키워드] anaesthetised ASV, assisted spontaneous ventilation biomedical engineering breath CO, cardiac output component components Continuous COVID-19 Critical care CRS, respiratory system compliance DBP, diastolic blood pressure demonstrated Evidence FIO2, Fraction of inspired oxygen female finding funding Hb, Haemoglobin HR, heart rate inspiratory flow limitations LoA, limits of agreement lung Lung injury MAP, mean arterial pressure mechanical ventilator Medicine meet MHRA Oxford PaCO2, arterial partial pressure of carbon dioxide PADP, pulmonary artery diastolic pressure PaO2, arterial partial pressure of oxygen PASP, pulmonary artery systolic pressure PEEP PEEP, positive end-expiratory pressure PFR, PaO2: FIO2 ratio PIP, proportional integral derivative Positive end-expiratory pressure product provided RAW, airways resistance Real-time monitoring required Respiration (artificial) respiratory rate SaO2, arterial oxygen saturation SBP, systolic blood pressure Support supported Texp, expiratory time therapy Tinsp, inspiratory time triggered university VCV, volume controlled ventilation Ventilation ventilator Volume VT, tidal volume work [DOI] 10.1016/j.ebiom.2022.103868 PMC 바로가기 [Article Type] Articles
Nanobiotechnology approaches for cardiovascular diseases: site-specific targeting of drugs and nanoparticles for atherothrombosisReview Published on 2022-02-082022-10-29 Journal: Journal of Nanobiotechnology [Category] COVID-19, [키워드] antibodies antigenic approach Atherosclerosis atherosclerotic cardiovascular disease complex diseases creating current CVD death diffusion Disease progression drug epitope expressed gene delivery lesion limitation limitations Nanobiotechnology Nanoparticles overcome pathological mechanism Perspective pharmacological progression Recombinant protein Side effect target Targeted drug delivery therapy thrombosis unique [DOI] 10.1186/s12951-022-01279-y PMC 바로가기 [Article Type] Review
Computational methods for inferring location and genealogy of overlapping genes in virus genomes: approaches and applications바이러스 게놈에서 겹치는 유전자의 위치 및 계보를 추론하는 전산 방법: 접근 방식 및 응용Review Published on 2022-02-012022-09-11 Journal: Current opinion in virology [Category] COVID19(2023년), SARS, 치료기술, [키워드] accessory proteins applied approach Atypical Computational methods COVID-19 pandemic detect etiological agent facilitate feature Genes genetic information Genome genomes in viral limitations Metrics nine overlap overlapping pathogenicity Recognition SARS-CoV-2 Spread statistically significant reduction synonymous Variability viral pathogenicity virus [DOI] 10.1016/j.coviro.2021.10.009 PMC 바로가기 [Article Type] Review
Delivery of CRISPR-Cas tools for in vivo genome editing therapy: Trends and challengesReview article Published on 2022-02-012022-10-05 Journal: Journal of controlled release : official journal o [Category] 비임상, [키워드] AAV approach caused clinical trial clinical trials component CRISPR CRISPR-Ca CRISPR-Cas delivery Diseases effective Gene therapy Genome genomic integration High dose highlight in vivo limitations Lipid nanoparticle liver LNP Mutagenesis overcome palindromic repeat Safe shown therapy Toxicity trend virus Virus-like particle VLP [DOI] 10.1016/j.jconrel.2022.01.013 [Article Type] Review article
Phytomedicines to Target Hepatitis B Virus DNA Replication: Current Limitations and Future ApproachesReview Published on 2022-01-302023-06-03 Journal: International Journal of Molecular Sciences [Category] B형 간염, [키워드] DNA replication future approaches Hepatitis B virus limitations phytomedicines/phytochemicals [DOI] 10.3390/ijms23031617 PMC 바로가기 [Article Type] Review
Strategies for Proteome-Wide Quantification of Glycosylation Macro- and Micro-HeterogeneityReview Published on 2022-01-302022-10-29 Journal: International Journal of Molecular Sciences [Category] COVID-19, [키워드] biological sample Biomarker changes changes in Disease progression glycoproteomics glycosylation human cells human disease improvement label free limitations macro mass spectrometry methodology physiological promote proteome quantification Quantitative Regulation sensitivity stable-isotope labeling Strategy therapeutic targets [DOI] 10.3390/ijms23031609 PMC 바로가기 [Article Type] Review