Specific dynamic variations in the peripheral blood lymphocyte subsets in COVID-19 and severe influenza A patients: a retrospective observational studyCOVID-19 및 중증 인플루엔자 A 환자의 말초 혈액 림프구 하위 집합의 특정 동적 변화: 후향적 관찰 연구Observational Study Published on 2020-12-012022-09-10 Journal: BMC Infectious Diseases [Category] MERS, SARS, 유전자 메커니즘, 임상, [키워드] (T cells Affect alteration Blood donors CD4 CD8 change Clinical significance Comorbidities contribute Coronavirus disease-19 (COVID-19) COVID-19 determine different time point different time points Disease progression early infection examined Flow cytometric analysis four group four groups healthy blood donors healthy controls healthy donor healthy donors hospital immune mechanism increased mortality Influenza influenza A leukocytes lymphocyte Lymphocyte subset Lymphocyte subsets Lymphocytes Patient patients’ data performed Peripheral blood Prognosis Result retrospective severe COVID-19 Severe influenza A significantly lower Specific stages supplementary material T cell T cells T cells subsets the patient turn Variation [DOI] 10.1186/s12879-020-05637-9 PMC 바로가기 [Article Type] Observational Study
Continuous tracking of COVID-19 patients’ immune statusCOVID-19 환자의 면역 상태를 지속적으로 추적Article Published on 2020-12-012022-09-11 Journal: International immunopharmacology [Category] SARS, 치료기술, [키워드] Admission AUC basophils Blood blood cell CD3 CD4 CD8 Cell change clinical evolution Continuous contrary correlated COVID-19 COVID-19 patient COVID-19 patients cytokine Cytokine storms Cytokines Depletion diagnostic Efficacy enrolled eosinophil eosinophils flow cytometer HCs Health healthy control help hospital IFN-γ IL-10 IL-2 IL-6 Immune monitoring Immune status increase in Infection Laboratory leucocytes lymphocyte Lymphocyte subset Lymphocyte subsets Lymphocytes Mild mild case Monocytes neutrophil Neutrophils predict Secondary infection severe cases severe group significantly sustained T cells the disease [DOI] 10.1016/j.intimp.2020.107034 PMC 바로가기 [Article Type] Article
Circulating Cytokines and Lymphocyte Subsets in Patients Who Have Recovered from COVID-19Research Article Published on 2020-11-262022-10-27 Journal: BioMed Research International [Category] COVID-19, [키워드] Alpha Analysis analyzed B cell B cells CD19 CD3 CD4 CD56 CD8 circulating Cohort Concentration consequence correlation COVID-19 COVID-19 infections cytokine decrease discharge Efficacy flow cytometry growth factor healthy controls hospital Hyperinflammatory IFN IL-10 IL-17 IL-2 IL-4 IL-6 IL-8 Immune status immune system increases in independent predictor Infection interferon gamma longitudinal study lymphocyte Lymphocyte subset Lymphocyte subsets Lymphocytes Necrosis NK cell NK cells observation Patient patients positively correlated recovered recovered patient recruited rehabilitation remained ROC Curve serum significantly higher significantly lower sustained T cell T cells TGF TNF- α [DOI] 10.1155/2020/7570981 PMC 바로가기 [Article Type] Research Article
Circulating Cytokines and Lymphocyte Subsets in Patients Who Have Recovered from COVID-19Research Article Published on 2020-11-262022-10-27 Journal: BioMed Research International [Category] Coronavirus, COVID-19, MERS, SARS, [키워드] Alpha Analysis analyzed B cell B cells CD19 CD3 CD4 CD56 CD8 circulating Cohort Concentration consequence correlation COVID-19 COVID-19 infections cytokine decrease discharge Efficacy flow cytometry growth factor healthy controls hospital Hyperinflammatory IFN IL-10 IL-17 IL-2 IL-4 IL-6 IL-8 Immune status immune system increases in independent predictor Infection interferon gamma longitudinal study lymphocyte Lymphocyte subset Lymphocyte subsets Lymphocytes Necrosis NK cell NK cells observation Patient patients positively correlated recovered recovered patient recruited rehabilitation remained ROC Curve serum significantly higher significantly lower sustained T cell T cells TGF TNF- α [DOI] 10.1155/2020/7570981 PMC 바로가기 [Article Type] Research Article
Safety and feasibility of umbilical cord mesenchymal stem cells in patients with COVID‐19 pneumonia: A pilot studyOriginal Article Published on 2020-11-172022-10-31 Journal: Cell Proliferation [Category] COVID-19, SARS, [키워드] addition adverse event Allergic reactions CD4 CD8 Clinical efficacy conducted CORD coronavirus coronavirus disease‐2019 COVID‐19 COVID‐19 patients cytokine Cytokine storm Day enrolled enrolment evaluated feasibility feasible Ground glass opacity inflammatory biomarkers investigated Lymphocyte count Lymphocyte subset Mortality mortality rate NK cells objective oxygenation index Patient performed pilot study Pneumonia radiological recorded Result Safe Safety Standard therapy STEM stem cell subset T cell T cells the disease Treatment Trial umbilical umbilical cord mesenchymal stem cells [DOI] 10.1111/cpr.12947 PMC 바로가기 [Article Type] Original Article
CD4 and CD8 Lymphocyte Counts as Surrogate Early Markers for Progression in SARS-CoV-2 Pneumonia: A Prospective StudyCD4 및 CD8 림프구는 SARS-CoV-2 폐렴의 진행을 위한 대리 조기 마커로 계산: 전향적 연구Article Published on 2020-11-092022-09-10 Journal: Viruses [Category] SARS, 바이오마커, [키워드] Admission appear Area association AUC best bilateral pneumonia CD3+CD4+ CD3+CD8+ CD4 CD4+ CD4+ T cells CD8 Complete count COVID-19 criteria Critical Curve decrease demographics disease dysregulation evaluate Evolution Factor Follow-up high correlation Hospital admission hospital discharge involved IQR Laboratory tests Linear regression model linear regression models lymphocyte Lymphocyte subset Lymphocyte subsets Lymphocytes median medical history parameter pathophysiology Patient patients with SARS-CoV-2 Pneumonia Predictive Predictive value predictive values Prospective prospective cohort study receiver receiver operating characteristic recruited ROC ROC Curve ROC curves SARS-CoV-2 SARS-COV-2 infection severe disease severity subset suggested surrogate T cell T cells Treatment were recorded were used [DOI] 10.3390/v12111277 PMC 바로가기 [Article Type] Article
Clinical features of patients undergoing hemodialysis with COVID‐19Original Article Published on 2020-10-292022-10-29 Journal: Seminars in dialysis [Category] COVID-19, MERS, SARS, [키워드] age Asymptomatic chest CT scan clinical Clinical characteristics Clinical features Comorbidity conducted coronavirus disease Coronavirus disease 2019 COVID‐19 dialysis died dry cough epidemiological feature Fever group Hemodialysis indicated Intervention Lymphocyte subset lymphocytopenia male manifestation Mortality nine Nosocomial infection patchy Patient proportion reduce reduced Retrospective study risk risk factor routine test SARS‐CoV‐2 infection SARS‐CoV‐2 significantly susceptible Symptom the median Treatment uninfected [DOI] 10.1111/sdi.12928 PMC 바로가기 [Article Type] Original Article
Elevated Exhaustion Levels of NK and CD8 + T Cells as Indicators for Progression and Prognosis of COVID-19 DiseaseCOVID-19 질병의 진행 및 예후 지표로서의 NK 및 CD8 + T 세포의 고갈 수준 증가Immunology Published on 2020-10-142022-09-11 Journal: Frontiers in Immunology [Category] MERS, SARS, 치료기술, [키워드] (PD-1) acute respiratory syndrome coronavirus analyzed association Blood CD16 CD244 CD3 CD4 CD56 CD8 Cell cell population Characteristics circulating Clinical data collected contribute coronavirus coronavirus 2 coronavirus disease Coronavirus disease 2019 Coronavirus disease 2019 (COVID-19) COVID-19 COVID-19 patient Critical Critical illness cytokine Cytokines demographic disease disease severity dysregulation effector molecule elevated eliminating enrolled evaluated Exhaustion expression flow cytometry functional IL-10 IL-6 immune dysregulation immune system IMPROVE Indicator infected cells Level Logistic regression logistic regression model lymphocyte Lymphocyte subset Lymphocyte subsets natural killer natural killer (NK) cells NK cell NK cells NKT cell NKT cells Pathogenesis Patient patients with COVID-19 PD-1 percentage percentages perforin phenotypic predict Prognosis progression public health reduced Regulatory respiratory Result risk factor Risk factors SARS-CoV-2 screened serum Serum IL-6 Serum level serum levels severe acute respiratory syndrome coronavirus 2 Severe case severe cases severe COVID-19 patients severe patients severe symptoms severity of COVID-19 significantly significantly increased subset T cell T cells TNF-α Union Hospital virus Wuhan [DOI] 10.3389/fimmu.2020.580237 PMC 바로가기 [Article Type] Immunology
Compassionate use of JAK1/2 inhibitor ruxolitinib for severe COVID-19: a prospective observational study중증 COVID-19에 대한 JAK1/2 억제제 룩소리티닙의 동정적 사용: 전향적 관찰 연구Clinical Trial Published on 2020-08-192022-08-13 Journal: Leukemia [Category] MERS, SARS, 바이오마커, 신약개발, 임상, 치료제, [키워드] 95% confidence interval activated adverse event age Anemia anti-inflammatory properties clinical Clinical improvement Comorbidities Comorbidity compassionate-use compassionate-use protocol contribute Controlled clinical trial controlled clinical trials COVID-19 cumulative incidence cytokine defined discharge home distress Efficacy exposure time FiO2 high-flow oxygen support improvement Infectious diseases Inflammatory cytokine inflammatory cytokine profile inflammatory reaction inhibitor JAK1 JAK1/JAK2 inhibitor JAK2 less lymphocyte Lymphocyte subset median age median dose intensity not affected observational study Ordinal Scale overall survival oxygen oxygen saturation PaO2 paO2/fiO2 PaO2/FiO2 ratio Patient patients with COVID-19 prospective cohort prospective observational study pulmonary disease Pulmonary function pulmonary infiltrate pulmonary infiltrates respiratory distress ruxolitinib Safe severe COVID-19 severe pulmonary disease Therapeutics thrombocytopenia urinary tract infections [DOI] 10.1038/s41375-020-01018-y PMC 바로가기 [Article Type] Clinical Trial
Blood cell counts and lymphocyte subsets of patients admitted during the COVID-19 pandemic: a prospective cohort studyClinical Trial Published on 2020-08-012022-10-05 Journal: British Journal of Haematology [Category] SARS, 임상, [키워드] Abstract blood cell COVID-19 Immunophenotyping Lymphocyte subset Lymphocytes lymphopenia Patient prospective cohort study subsets. [DOI] 10.1111/bjh.16983 PMC 바로가기 [Article Type] Clinical Trial