macaque – Page 5 – Communicable Diseases Research

Beta RBD boost broadens antibody-mediated protection against SARS-CoV-2 variants in animal models

Article

Published on 2021-10-232022-10-31
Journal: Cell Reports Medicine [Category] COVID-19, MERS, SARS,

COVA1-18 neutralizing antibody protects against SARS-CoV-2 in three preclinical models

세 가지 전임상 모델에서 COVA1-18 중화 항체가 SARS-CoV-2로부터 보호

Article

Published on 2021-10-202022-09-10
Journal: Nature Communications [Category] MERS, SARS, 변종, 신약개발, 유전자 메커니즘, 진단, 치료제,

[키워드] acute respiratory syndrome coronavirus Administered animal model antibody antiviral activity B.1.1.7 B.1.1.7 isolate cause clinical evaluation coronavirus COVID-19 patients cynomolgus macaques Efficacy evaluate hACE2 hamsters High dose Immunotherapy in vivo Infectious diseases lung lung lesions Lungs lymphopenia macaque mathematical mathematical model mice monoclonal antibodies neutralizing antibody patients Preclinical research Prophylactic PROTECT reduce reduction in respiratory SARS-CoV-2 severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 shown therapeutic therapeutic effect Therapeutic treatment treated Treatment undetectable upper respiratory upper respiratory tract Viral viral infectivity Viral load viral loads
[DOI] 10.1038/s41467-021-26354-0 PMC 바로가기 [Article Type] Article

COVID-19 cynomolgus macaque model reflecting human COVID-19 pathological conditions

인간의 COVID-19 병리학적 상태를 반영하는 COVID-19 시노몰구스 원숭이 모델

423

Published on 2021-10-082022-09-10
Journal: Proceedings of the National Academy of Sciences of [Category] MERS, SARS, 진단, 치료기술,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 age animal model animals chemokine chemokines clinical condition Computed tomography coronavirus COVID-19 COVID-19 crisis cynomolgus macaques Cytokines elderly elderly patients examined Health healthy Human indicated individual Infection Inflammatory response Inflammatory responses initial inoculated intranasally life macaque metabolic disease mucosal nonhuman primate overcome pandemic pathogenicity pathological condition pathological conditions pathology pathophysiology Patient Pneumonia Primary infection Prophylactic reflect Reinfection required respiratory SARS-CoV-2 serum cytokine serum cytokines severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 severe pneumonia shown Significance swab samples therapeutic therapeutic agent therapeutic agents underlying disease underlying diseases Vaccines Viral Viral RNA virus detection were infected
[DOI] 10.1073/pnas.2104847118 PMC 바로가기 [Article Type] 423

SARS-CoV-2 binding and neutralizing antibody levels after Ad26.COV2.S vaccination predict durable protection in rhesus macaques

Ad26.COV2.S 백신 접종 후 SARS-CoV-2 결합 및 중화 항체 수준은 붉은털 원숭이의 지속적인 보호를 예측합니다

Article

Published on 2021-10-072022-09-10
Journal: Nature Communications [Category] MERS, SARS, 변종, 진단,

[키워드] Ad26 Ad26.COV2.S Ad26.COV2.S vaccine Analysis Antibody titer Antibody titers approval authorization binding clinical development COVID-19 vaccine Efficacy Emergency use Evidence Human Immunity immunization immunogenicity immunological indicate knowledge Limited lung Lungs macaque natural infection Neutralizing antibodies neutralizing antibody other coronavirus other coronaviruses post vaccination predict predicted Predictive markers preliminary evidence Protective Protein Replication replication of SARS-CoV-2 rhesus macaque rhesus macaques SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike protein selected short-lived spike Spike protein the SARS-CoV-2 vaccination Vaccine Vaccines variant vector viral infection
[DOI] 10.1038/s41467-021-26117-x PMC 바로가기 [Article Type] Article

Similarities and Differences in the Acute-Phase Response to SARS-CoV-2 in Rhesus Macaques and African Green Monkeys

Immunology

Published on 2021-10-062022-11-01
Journal: Frontiers in Immunology [Category] COVID-19, MERS, SARS,

[키워드] absolute monocyte count acute response African African green monkey AGM AGMs alteration Analysis Blood breadth Cohort Correlation analysis COVID-19 COVID-19 disease Critical defined difference effective vaccine Evidence exhibiting gene network greater green hallmark help immune Infection interferon ISG ISGs macaque Monkey nasopharyngeal neutrophil (PMN) neutrophil degranulation NHP normalized occurred outcome pathology pathway Post-infection presenting Pulmonary pathology Regulation response rhesus macaque SARS-CoV-2 SARS-COV-2 infection similarity stimulated Systems biology timepoint transcriptional transcriptional change Transcriptome type I understanding upregulation WGCNA
[DOI] 10.3389/fimmu.2021.754642 PMC 바로가기 [Article Type] Immunology

A Meta-Analysis of Rhesus Macaques ( Macaca mulatta), Cynomolgus Macaques ( Macaca fascicularis), African green monkeys ( Chlorocebus aethiops), and Ferrets ( Mustela putorius furo) as Large Animal Models for COVID-19

붉은털원숭이( Macaca mulatta), Cynomolgus Macaques( Macaca fascicularis), 아프리카 녹색원숭이(Chlorocebus aethiops), 흰족제비( Mustela putorius furo)를 COVID-19의 대형 동물 모델로 메타 분석

Meta-Analysis

Published on 2021-10-012022-09-12
Journal: Comparative medicine [Category] MERS, SARS, 진단,

Intradermal-delivered DNA vaccine induces durable immunity mediating a reduction in viral load in a rhesus macaque SARS-CoV-2 challenge model

피내 전달 DNA 백신은 붉은털 원숭이 SARS-CoV-2 챌린지 모델에서 바이러스 부하 감소를 매개하는 내구성 면역을 유도합니다

Article

Published on 2021-09-282022-09-12
Journal: Cell Reports Medicine [Category] MERS, SARS, 비임상, 진단,

[키워드] Abstract adaptive immune system ADCD ADCP anti-SARS-CoV-2 Antigen Arm caused cellular challenge clinical trials clinically coronavirus Coronavirus disease 2019 COVID-19 COVID-19 disease DNA vaccine Efficacy Electroporation evaluated humoral humoral immune response ID DNA vaccine immune immune response Immunity immunization induce Infectious disease INO-4800 lung macaque neutralized neutralizing antibody responses protection Protective pseudotype viruses public health RBD binding antibody recall reduced viral load reduction in regimen respond response resulting rhesus rhesus macaque SARS-CoV-2 SARS-CoV-2 spike Spike protein Support the SARS-CoV-2 the SARS-CoV-2 virus vaccination vaccine dose Viral load
[DOI] 10.1016/j.xcrm.2021.100420 PMC 바로가기 [Article Type] Article

Efficacy and breadth of adjuvanted SARS-CoV-2 receptor-binding domain nanoparticle vaccine in macaques

마카크에서 보조제 SARS-CoV-2 수용체 결합 도메인 나노입자 백신의 효능 및 범위

420

Published on 2021-09-212022-09-10
Journal: Proceedings of the National Academy of Sciences of [Category] SARS, 변종, 진단,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition adjuvant animals antibody Antibody titers B.1.351 betacoronaviruses breadth CD4+ T cell Cellular immune response cellular response Cellular responses concerning coronavirus Coverage COVID-19 vaccine cross-neutralization activity displaying domain Efficacy eight elicit emergence evaluate ferritin Formulation High-dose highlighting humoral Humoral and cellular immune responses immune responses Immunity lower airway macaque macaques nanoparticle Neutralizing pandemic potency PROTECT Protein QS-21 Rapid receiving Receptor-binding domain reduce Replication respiratory respiratory tract response robust SARS-CoV-1 SARS-CoV-2 SARS-CoV-2 spike SARS-CoV-2 spike protein SARS-CoV-2 variant SARS-CoV-2 variants Serum neutralizing antibody Seven severe acute respiratory syndrome Coronavirus Significance Spike protein Support T cell T cell responses Th1 the receptor-binding domain the Sarbecovirus the SARS-CoV-2 two-dose regimen undetectable upper and lower airways vaccination Vaccine Vaccine development variant Viral viral replication VoC VOCs WA1/2020
[DOI] 10.1073/pnas.2106433118 PMC 바로가기 [Article Type] 420

Development of an mRNA-LNP Vaccine against SARS-CoV-2: Evaluation of Immune Response in Mouse and Rhesus Macaque

Article

Published on 2021-09-102022-10-28
Journal: Vaccines [Category] COVID-19,

Targeting SARS-CoV-2 receptor-binding domain to cells expressing CD40 improves protection to infection in convalescent macaques

CD40을 발현하는 세포에 대한 SARS-COV-2 수용체-결합 도메인을 표적으로하는 것은 회복기 원숭이의 감염에 대한 보호를 향상시킨다.

Article

Published on 2021-09-012022-08-31
Journal: Nature Communications [Category] SARS, 바이오마커, 변종, 유전자 메커니즘,

[키워드] adjuvant animal models antibody antigen-presenting cells approach approved B cells B1.351 boost CD40 Cell children convalescent Coverage cross-neutralize D614G domain expressing High-dose humanized IMPROVE individuals induce Infection injected long-term memory macaque Marlin memory mRNA vaccines Neutralizing antibodies neutralizing antibody NHPs non-human primate Phenotypes Preclinical research pregnant women Protein vaccines rapid increase RBD Receptor-binding domain SARS-CoV-2 SARS-CoV-2 spike protein SARS-CoV-2 variants significant level significantly single dose Spike protein Subunit vaccine subunit vaccines T and B cells targeting the receptor-binding domain the SARS-CoV-2 vaccination Vaccine Viral Viral antigen viral antigens viral infection Viral vector viral vector and mRNA vaccines virulent
[DOI] 10.1038/s41467-021-25382-0 PMC 바로가기 [Article Type] Article