The nucleocapsid proteins of mouse hepatitis virus and severe acute respiratory syndrome coronavirus share the same IFN-β antagonizing mechanism: attenuation of PACT-mediated RIG-I/MDA5 activationResearch Paper Published on 2017-07-252022-10-28 Journal: Oncotarget [Category] Coronavirus, [키워드] activate Activation acute respiratory syndrome antiviral response association cellular circumvent coronavirus CoV CoV-infected cells CoVs epidemic diarrhea Human IFN IFN-β IFNs inhibited Innate immunity innate immunity evasion Interaction interferon MDA5 mechanism Melanoma MHV molecular mouse hepatitis virus N protein N proteins Nidovirale nucleocapsid protein PACT PEDV Protein reproductive RIG-I RIG-I/MDA5 SARS-CoV N protein Sendai virus syndrome the N protein turn type I interferon upstream Viral protein virus [DOI] 10.18632/oncotarget.17912 PMC 바로가기 [Article Type] Research Paper
Middle East respiratory syndrome coronavirus ORF4b protein inhibits type I interferon production through both cytoplasmic and nuclear targetsArticle Published on 2015-12-032022-10-29 Journal: Scientific Reports [Category] Coronavirus, [키워드] abrogated Analysis Antiviral antiviral response antiviral responses antiviral signaling Asia binding contribute coronavirus country cytoplasm cytoplasmic determinant Europe evade highly pathogenic IFN IFN-α/β IFN-β IKKε inhibit Interaction interferon IRF3 IκB MAVS MDA5 mechanism MERS-CoV Middle East mitochondrial molecular interaction Mortality North nuclear nuclear localization signal nucleus ORF4b other coronavirus Pathogenesis pathogenicity Phosphorylation previous study Protein Regulatory respiratory syndrome coronavirus RIG-I shown significantly spread to subsequent suppress TANK target TBK1 the interferon therapeutic Type I IFN type I interferon virulence virus [DOI] 10.1038/srep17554 PMC 바로가기 [Article Type] Article
Coronavirus non-structural protein 16: Evasion, attenuation, and possible treatmentsArticle Published on 2014-09-302022-11-01 Journal: Virus research [Category] Coronavirus, MERS, [키워드] 2′O-Methyl-transferase 2′O-MTase Antiviral treatment approach component conserved CoV CoV infection CoVs highlight Host immune response identify immune innate immune Interaction manuscript MDA5 MERS-CoV Middle East motif motifs mutant mutants non-structural protein nsp16 Pathogenesis pathway Protein required respiratory SARS-CoV Strains Therapeutic treatment Treatment viruses [DOI] 10.1016/j.virusres.2014.09.009 PMC 바로가기 [Article Type] Article
Strain-specific innate immune signaling pathways determine malaria parasitemia dynamics and host mortalityArticle Published on 2014-01-282024-08-28 Journal: Microbial Cell Factories [Category] 말라리아, [키워드] interferon MAVS MDA5 phagocytosis rodent
Regulation of macrophage and dendritic cell function by pathogens and through immunomodulation in the avian mucosaReview Published on 2013-11-012023-06-02 Journal: Developmental and comparative immunology [Category] 조류인플루엔자, [키워드] (Draining) lymph nodes Ag AIV Antigen antigen-presenting cells APC Avian influenza virus BALT BM Bone marrow bronchus-associated lymphoid tissue C-type lectin receptors CG chicken galectin chicken lung lectin CLL CLR DC DC-SIGN DC-specific intercellular adhesion molecule-3-grabbing non-integrin dendritic cells DLN GALT gut-associated lymphoid tissue HA Haemagglutinin highly-pathogenic avian influenza HPAI IAV IBDV IBV immunomodulation Infection Infectious Bronchitis Virus infectious bursal diease virus influenza A virus laboratory of genetics and physiology 2 LGP2 lipopolysaccharide Low pathogenic influenza LPAI LPS macrophage galactose binding lectin macrophage mannose receptor macrophages MDA5 Melanoma differentiation-associated protein 5 MGL MMR MPh mucosal NA NALT nasal associated lymphoid tissue NDV neuraminidase newcastle disease virus Pattern recognition receptors PRR respiratory tract retinoic acid-inducible gene I RIG-I Rt TLR Toll-like receptors [DOI] 10.1016/j.dci.2013.03.008 [Article Type] Review
Strategies of highly pathogenic RNA viruses to block dsRNA detection by RIG-I-like receptors: Hide, mask, hitArticle Published on 2013-10-122023-08-30 Journal: Antiviral Research [Category] E형 간염, [키워드] Innate immune system evasion Interferon alpha/beta LGP2 MDA5 RIG-I Viral dsRNA detection [DOI] 10.1016/j.antiviral.2013.10.002 PMC 바로가기 [Article Type] Article