TREM-2 is a sensor and activator of T cell response in SARS-CoV-2 infectionTREM-2는 SARS-CoV-2 감염에서 T 세포 반응의 센서이자 활성제입니다.Research Article Published on 2021-12-082022-09-14 Journal: Science Advances [Category] 유전자 메커니즘, 진단, [키워드] activate activated acute respiratory syndrome Antiviral binding Blood Clinical management complex coronavirus coronavirus disease COVID-19 cytokine description domain Drug discovery expressed Immunoglobulin induce Infection interferon-γ intrinsic knockout mice Limited lung M protein membrane membrane protein mouse hepatitis virus murine myeloid cell Necrosis pathway patients with COVID-19 Phosphorylation promoted Protein pseudovirus receptor recognize SARS-CoV-2 SARS-COV-2 infection Stat1 T cell T cell response T helper cell Transcription triggering Vaccine development viral clearance [DOI] 10.1126/sciadv.abi6802 PMC 바로가기 [Article Type] Research Article
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Membrane (M) and Spike (S) Proteins Antagonize Host Type I Interferon ResponseCellular and Infection Microbiology Published on 2021-12-072022-10-31 Journal: Frontiers in Cellular and Infection Microbiology [Category] COVID-19, MERS, SARS, [키워드] acute respiratory syndrome antiviral immunity antiviral response association bind caused characterized coronavirus coronavirus 2 Coronavirus disease 2019 COVID-19 downstream evade evasion IFN-I IFN-I response increase inhibit interact interferon regulatory factor JAK1 Janus kinase 1 KPNA6 lack mechanism membrane protein molecular mechanism nuclear translocation patients performed respiratory response SARS-CoV-2 SARS-CoV-2 pathogenesis SARS-CoV-2 protein Signaling signaling pathway spike Spread Stat1 subunit the spike protein therapeutic target Transcription Treatment Type type I interferon Viral protein [DOI] 10.3389/fcimb.2021.766922 PMC 바로가기 [Article Type] Cellular and Infection Microbiology
Analysis and comparison of physiochemical properties, mutations and glycosylation patterns between RNA polymerase and membrane protein of SARS-CoV and SARS-CoV-2Original Article Published on 2021-12-012022-10-30 Journal: Molecular Biology Research Communications [Category] COVID-19, [키워드] addition Analysis Betacoronavirus cause coronavirus COVID-19 decrease feature genome sequence genomic sequence glycoprotein glycosylation glycosylation pattern host immune system Impact increase in membrane membrane protein MEME motifs Mutation pathogenicity physiochemical properties physiochemical property polymerase Protein Proteins Research respiratory RNA polymerase SARS-CoV SARS-CoV-2 SARS-CoV-2 RNA similarity stability Substitution mutation virus [DOI] 10.22099/mbrc.2021.42187.1692 PMC 바로가기 [Article Type] Original Article
Analysis of Glycosylation and Disulfide Bonding of Wild-Type SARS-CoV-2 Spike GlycoproteinArticle Published on 2021-11-242023-06-16 Journal: Journal of Virology [Category] COVID19(2023년), MERS, SARS, [키워드] coronavirus COVID-19 Disulfide glycosylation Golgi membrane protein SARS-CoV-2 spike glycoprotein Viral protein virus entry [DOI] 10.1128/jvi.01626-21 PMC 바로가기
Deciphering the Role of Humoral and Cellular Immune Responses in Different COVID-19 Vaccines—A Comparison of Vaccine Candidate Genes in Roborovski Dwarf Hamsters상이한 CovID-19 백신에서 체액 및 세포 면역 반응의 역할을 해독하는-Roborovski Dwarf 햄스터에서 백신 후보 유전자 비교Article Published on 2021-11-162022-09-01 Journal: Viruses [Category] MERS, SARS, 변종, 진단, 치료법, [키워드] adenoviral vector adenoviral vectors animal model Antigen candidate cellular immune responses compensated COVID-19 dwarf dwarf hamster Efficacy epitope Epitopes Evolution exposure to facilitate focus full-length full-length spike protein glycoprotein hamster immune response immune responses immunogenicity impairing Inactivated Vaccines membrane protein Mutation Neutralizing antibodies neutralizing antibody new SARS-CoV-2 nucleocapsid protein other SARS-CoV-2 genes prevented protective effect Protective effects provided question RBD Receptor binding domain response risk robust role SARS-CoV-2 SARS-CoV-2 antigen SARS-CoV-2 antigens SARS-CoV-2 genes SARS-CoV-2 vaccine SARS-CoV-2 variants selected severe pneumonia Spike protein spike-based vaccines Spread susceptible T-cell Response the spike protein triggered Vaccine Vaccine design vaccine genes Vaccines variants virus replication [DOI] 10.3390/v13112290 PMC 바로가기 [Article Type] Article
PDZ-Containing Proteins Targeted by the ACE2 ReceptorCommunication Published on 2021-11-152022-10-28 Journal: Viruses [Category] COVID-19, [키워드] ACE2 benefit binding binding assay Brain C-terminal COVID-19 domain enzyme expressed Extracellular host cell host factors human epithelial cell in viral intensity Interaction involved main receptor membrane protein Modification motif N-terminal peptidase Neurological symptom neuronal neuronal cells organs PDZ domain Protein protein trafficking SARS-CoV-2 SARS-CoV-2 entry SNX27 specificity transmembrane trimeric spike type I virus entry [DOI] 10.3390/v13112281 PMC 바로가기 [Article Type] Communication
Robust and Persistent B- and T-Cell Responses after COVID-19 in Immunocompetent and Solid Organ Transplant Recipient Patients면역 적합성 및 고체 장기 이식 수용자 환자에서 COVID-19 후 강력하고 지속적인 B- 및 T- 세포 반응Article Published on 2021-11-112022-09-01 Journal: Viruses [Category] MERS, SARS, 진단, 치료기술, 치료법, [키워드] analysed anti-Nucleocapsid IgG anti-Spike IgG antibody Antibody Response Antibody responses assays CD4 CD8 comparable COVID-19 Cytokines declined determined by develop elicited ELISA envelope envelope protein IgA IgG immune response immunocompetent patients Immunocompromised Immunocompromised patient Immunocompromised patients induced Infection lymphoproliferative membrane membrane protein mild symptoms Neutralization assay Neutralizing antibodies neutralizing antibody nucleocapsid protein Nucleocapsid proteins organ Patient patients patients with pneumonia peptide peptide pool peptide pools persistence persistent Pneumonia proliferative Protein recipient response SARS-CoV-2 SARS-COV-2 infection Solid solid organ spike Spike protein Stimulation T-cell Response T-cell responses the Spike Transplant transplanted patients was determined [DOI] 10.3390/v13112261 PMC 바로가기 [Article Type] Article
Heat shock protein 70 could enhance porcine epidemic diarrhoea virus replication by interacting with membrane proteinsResearch Article Published on 2021-10-302022-10-28 Journal: Veterinary Research [Category] Coronavirus, MERS, [키워드] assays Cell cells cellular complex diarrhoea downregulated early stage ENhance Epidemic expression Heat shock heat shock protein heat shock protein 7 Hsp70 immunofluorescence immunoprecipitation Infection investigated M protein membrane membrane protein MOST overexpression PEDV Porcine epidemic diarrhoea virus Protein protein expression reduction in Replication resulting significantly structural protein virions virus virus replication [DOI] 10.1186/s13567-021-01006-9 PMC 바로가기 [Article Type] Research Article
An antibody-based proximity labeling map reveals mechanisms of SARS-CoV-2 inhibition of antiviral immunityResearch article Published on 2021-10-222022-10-05 Journal: Cell chemical biology [Category] SARS, 치료제, [키워드] ACE2 Activation acute respiratory syndrome angiotensin-converting enzyme 2 Antiviral antiviral immunity biotinylated caused Clinical treatment Compound coronavirus coronavirus disease Coronavirus-2 COVID-19 domain drug Epidemic Human human cell humans identify immune responses Infection inhibit Interaction interactome ITGB1 knowledge labeling lysine MAVS mechanism membrane protein methyltransferase mitochondrial mitochondrial antiviral-signaling protein pathway Protein provide proximal proximity labeling replication of SARS-CoV-2 resource reveal SARS-CoV-2 SARS-CoV-2 entry SARS-CoV-2 protein SET SETD2 significantly the interferon Treatment TurboID viral infection Viral protein [DOI] 10.1016/j.chembiol.2021.10.008 [Article Type] Research article
BCEPS: A Web Server to Predict Linear B Cell Epitopes with Enhanced Immunogenicity and Cross-ReactivityBCEPS: 향상된 면역원성과 교차 반응성으로 선형 B 세포 에피토프를 예측하는 웹 서버Article Published on 2021-10-142022-09-11 Journal: Cells [Category] MERS, SARS, 치료기술, 치료제, [키워드] Accessibility Accuracy antibody antigen-specific antibody antigens B cell epitope B cell epitopes B cells best conformational cross-reactive antibodies cross-reactive antibody dataset detect ectodomain ectodomains enhanced epitope Epitopes flexibility hydrophilicity identify IEDB Immune Epitope Database immunogenic immunogenicity independent linear linear B machine learning machine learning model membrane protein Membrane proteins MHC II molecules N-glycosylation site Neutralizing antibodies peptide-based vaccines predicted prediction Protein protein structures reached retrieved SARS-CoV-2 SARS-CoV-2 spike protein server specific antibodies spike Spike protein structures Support support vector machine the SARS-CoV-2 Web web server [DOI] 10.3390/cells10102744 PMC 바로가기 [Article Type] Article