A Membrane‐Targeting Photosensitizer with Aggregation‐Induced Emission Characteristics for Highly Efficient Photodynamic Combat of Human CoronavirusesResearch Article Published on 2021-06-302022-10-29 Journal: Small (Weinheim an der Bergstrasse, Germany) [Category] COVID-19, MERS, SARS, [키워드] absorbance acute respiratory syndrome aggregation‐induced emission Antiviral caused Characteristics combat combating Complete contribute coronavirus COVID‐19 Critical effective Efficiency efficient emission host cells Human human coronavirus human coronaviruses hydrophilic hydrophobic inactivated inactivation Infection loss of infectivity membrane membrane targeting membranes mimicking pandemic phospholipid photodynamic therapy photosensitizer photosensitizers Prevent Protein provide reactive oxygen specy reported ROS significant decrease Spread therapy Transmission treated virus RNA [DOI] 10.1002/smll.202101770 PMC 바로가기 [Article Type] Research Article
In Vitro Models for Studying Entry, Tissue Tropism, and Therapeutic Approaches of Highly Pathogenic CoronavirusesReview Article Published on 2021-06-212022-10-27 Journal: BioMed Research International [Category] COVID-19, [키워드] binding cell entry cell line cell receptor cellular protease CoV CoVs ENCODE family Coronaviridae Genome host cell in vitro model information inhibiting knowledge membranes methodology Model offer Pathogenesis positive-sense Protein RNA virus RNA viruses structural proteins the S protein the Spike therapeutic approaches therapeutic intervention tropism viral tropism [DOI] 10.1155/2021/8856018 PMC 바로가기 [Article Type] Review Article
In Vitro Models for Studying Entry, Tissue Tropism, and Therapeutic Approaches of Highly Pathogenic CoronavirusesReview Article Published on 2021-06-212022-10-27 Journal: BioMed Research International [Category] Coronavirus, COVID-19, MERS, SARS, [키워드] binding cell entry cell line cell receptor cellular protease CoV CoVs ENCODE family Coronaviridae Genome host cell in vitro model information inhibiting knowledge membranes methodology Model offer Pathogenesis positive-sense Protein RNA virus RNA viruses structural proteins the S protein the Spike therapeutic approaches therapeutic intervention tropism viral tropism [DOI] 10.1155/2021/8856018 PMC 바로가기 [Article Type] Review Article
How Children Are Protected From COVID-19? A Historical, Clinical, and Pathophysiological Approach to Address COVID-19 SusceptibilityCOVID-19로부터 어린이를 보호하는 방법은 무엇입니까? COVID-19 감수성을 해결하기 위한 역사적, 임상적, 병태생리학적 접근Immunology Published on 2021-06-112022-09-11 Journal: Frontiers in Immunology [Category] MERS, SARS, 유전자 메커니즘, 진단, [키워드] accompanied ACE-2 receptor acute respiratory syndrome acute respiratory syndrome coronavirus adaptive Adaptive immunity address affected autoimmune disorder B1 B cells Bacteria Bacterial bacterial pathogen Bacterial pathogens Behcet’s disease children China class clinical coronavirus coronavirus disease Coronavirus disease 2019 country COVID-19 Defense disease exhibiting favor genetics IgM Immunity Immunoglobulin innate immune Iran Italy Kawasaki-like disease mechanism membrane membranes molecular mechanisms Mortality Native natural IgM Neonate Neonates neutralize oxygen Pathogens Patient Pediatric patient Pediatric patients Prevalence progression reactive oxygen species reactive oxygen specy Recognition Region respiratory SARS-CoV-2 selective self-antigens severe acute respiratory syndrome Coronavirus severe COVID-19 silk road South Spread stressed cells Symptom the epidemic thrombosis Trigger Turkey Vasculitis Viral viral envelope virus [DOI] 10.3389/fimmu.2021.646894 PMC 바로가기 [Article Type] Immunology
SARS-CoV-2 envelope protein causes acute respiratory distress syndrome (ARDS)-like pathological damages and constitutes an antiviral targetSARS-CoV-2 외피 단백질은 급성 호흡곤란 증후군(ARDS)과 유사한 병리학적 손상을 유발하고 항바이러스 표적을 구성합니다.Article Published on 2021-06-102022-09-11 Journal: Cell Research [Category] MERS, SARS, 바이오마커, 변종, 유전자 메커니즘, 진단, 치료제, [키워드] activity acute respiratory distress acute respiratory distress syndrome administration angiotensin Anti-SARS-CoV-2 Activity antiviral target ARDS cation channels cause caused Cell cell death cell types channel inhibitor chemokine chemokines cytokine Cytokine storm Cytokines damages death dominant negative drug target exhibited expressing heterologous expression human Angiotensin-converting enzyme Human angiotensin-converting enzyme 2 in vitro in vivo infected cells Inflammation inhibitor Intravenous administration lung Lungs macrophages membranes mice Molecular biology multi-organ failure Mutation positively correlated Prophylactic Protective Protein purified reduced respiratory distress robust SARS-CoV-2 SARS-CoV-2 envelope SARS-CoV-2-infected cells secretion spleen Support susceptible cell syndrome the SARS-CoV-2 therapeutic transgenic mice Viral Viral load [DOI] 10.1038/s41422-021-00519-4 PMC 바로가기 [Article Type] Article
Can Antiviral Activity of Licorice Help Fight COVID-19 Infection?감초의 항 바이러스 활동이 CovID-19 감염과 싸울 수 있습니까?Review Published on 2021-06-082022-09-10 Journal: Biomolecules [Category] MERS, SARS, 치료제, [키워드] ACE2 activity angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 Anti-inflammatory antioxidant effect antioxidant effects antiviral properties antiviral property Can can not Cell chymotrypsin clinical trials component components Compound coronavirus COVID-19 COVID-19 disease COVID-19 emergency cysteine cysteine protease docking study enoxolone excluded feature Glycyrrhetinic acid glycyrrhiza glycyrrhizic acid glycyrrhizin Host in viral indicated interfere licorice liquorice membranes nonspecific pandemic pharmacological Replication reported SARS Coronavirus SARS-CoV-2 Serine Spike protein Spread supported the SARS-CoV-2 transmembrane serine protease Viral virus virus entry viruses [DOI] 10.3390/biom11060855 PMC 바로가기 [Article Type] Review
Engineering of Chinese Hamster Ovary Cells With NDPK-A to Enhance DNA Nuclear Delivery Combined With EBNA1 Plasmid Maintenance Gives Improved Exogenous Transient Reporter, mAb and SARS-CoV-2 Spike Protein ExpressionBioengineering and Biotechnology Published on 2021-06-042022-10-31 Journal: Frontiers in Bioengineering and Biotechnology [Category] COVID-19, [키워드] approach cell line characterisation Chinese Chinese hamster ovary cells CHO cells co-expression Combined complementary complex delivery dependent on Dilution DNA Efficiency element Engineering ENhance Epstein Barr Nuclear Antigen-1 Exogenous expressing Gene Expression glycoprotein growth hamster Improved initial mAb maintenance mammalian cell membranes NLS nuclear nuclear localisation signal nucleoside diphosphate kinase nucleus Ovary plasma Plasmid Protein reduce SARS-CoV-2 SARS-CoV-2 spike SARS-CoV-2 spike protein spike time-consuming Transient transient expression transient gene expression utilised [DOI] 10.3389/fbioe.2021.679448 PMC 바로가기 [Article Type] Bioengineering and Biotechnology
Direct hemoperfusion using a polymyxin B-immobilized polystyrene column for COVID-19COVID-19에 대해 폴리믹신 B 고정 폴리스티렌 컬럼을 사용한 직접 혈액 관류Observational Study Published on 2021-06-012022-09-11 Journal: Journal of clinical apheresis [Category] 바이오마커, 임상, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 avoidance Biomarker Case series case sery categories circuit Coagulation conducted coronavirus COVID-19 cytokine D-dimer defined Degradation Degradation product determine DHPs Direct direct hemoperfusion disease severity Efficacy Efficacy and safety eight endothelial endothelial injury evaluate evaluated expected extracorporeal membrane oxygenation Factor FIBRIN fibrin degradation product FIVE Future growth factor Hemoperfusion high risk hospital Hospitalization Infectious disease Infectious diseases interleukin-6 involved malfunctions membrane membranes microglobulin oxygen P/F P/F ratio partial pressure partial pressure of arterial oxygen patients performed Pneumonia Polymyxin B polystyrene problem respiratory SARS-CoV-2-positive patient Seven severe acute respiratory syndrome Coronavirus Steroids therapeutic effect treated Treatment Urine Vascular vascular endothelial growth factor ventilator was performed [DOI] 10.1002/jca.21861 PMC 바로가기 [Article Type] Observational Study
Ceramide and Related Molecules in Viral InfectionsReview Published on 2021-05-262022-10-29 Journal: International Journal of Molecular Sciences [Category] Coronavirus, SARS, [키워드] α-galactosylceramide acid sphingomyelinase Activation antiviral therapies Apoptosis Cell ceramide Cluster contribute Diseases entry receptor Enzymes expression form HIV-1 IAV immune evasion immune modulation immunomodulation in viral infected cells lipid-rafts membrane membranes metabolism molecule morbidity physical receptor regulate required SARS-CoV-2 sphingolipid sphingolipids sphingomyelinase Therapeutic benefit viral entry viral infection viral infections viral life cycle viral replication viral-induced virion virus [DOI] 10.3390/ijms22115676 PMC 바로가기 [Article Type] Review
Lipophilicity, Pharmacokinetic Properties, and Molecular Docking Study on SARS-CoV-2 Target for Betulin Triazole Derivatives with Attached 1,4-QuinoneArticle Published on 2021-05-232022-10-28 Journal: Pharmaceutics [Category] COVID-19, [키워드] 1,4-quinone Affect Analysis betulin calculate Compound compounds correlation derivative determine influence inhibit lipophilicity membranes MLR molecular docking parameter parameters pharmacokinetic physicochemical property profile Research SARS-CoV-2 SARS-CoV-2 proteins selected similarity target tested triazole [DOI] 10.3390/pharmaceutics13060781 PMC 바로가기 [Article Type] Article