Regulation of Inflammatory Cytokine Storms by Mesenchymal Stem Cells간엽줄기세포에 의한 염증성 사이토카인 폭풍의 조절Review Published on 2021-07-292022-09-12 Journal: Frontiers in Immunology [Category] MERS, SARS, 진단, [키워드] Affect Anti-inflammatory anti-inflammatory properties candidate cellular and molecular clinical trial complex coronavirus disease COVID-19 Cytokine storm syndrome death described develop disease Diseases Efficacy Factor immune regulation immune system Immunity immunosuppressive Inflammation Inflammatory factor Inflammatory response Interaction mechanism mesenchymal stem cell Mesenchymal stem cells molecular MSC MSCs Pathogenesis Pathways Sepsis shown STEM stem cell Stem cell therapy storm therapeutic Treatment vital role [DOI] 10.3389/fimmu.2021.726909 PMC 바로가기 [Article Type] Review
Diverse Effects of Exosomes on COVID-19: A Perspective of Progress From Transmission to Therapeutic DevelopmentsCovid-19에 대한 엑소 좀의 다양한 효과 : 전염에서 치료 적 발전으로의 진보의 관점Review Published on 2021-07-282022-08-31 Journal: Frontiers in Immunology [Category] MERS, SARS, 바이오마커, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus administration Anti-viral antiviral drug antiviral drugs approach causative agent cells combating Combination communication coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 Cytokine storm Defense develop development Diagnosis disease Effect ENhance Exosome Exosomes global pandemic Host immunomodulatory infected cells Infection intercellular Intervention lung injuries mesenchymal stem cell Mesenchymal stem cells mitochondrial Mitochondrial function modulate MSCs new strain new strain of coronavirus Numerous pathway Pathways Patient Perspective produced Progress promote reduce respiratory respiratory tract SARS-CoV-2 SARS-COV-2 infection secreted secretion severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 similarity Spread stem cell structures suppress the cytokine storm therapeutic agents Therapeutic benefit therapeutic benefits Therapeutics Therapies Transmission Treatment Treatment strategies treatment strategy uninfected cells Vaccine development Vaccines virus virus-infected cell virus-infected cells viruses with COVID-19 [DOI] 10.3389/fimmu.2021.716407 PMC 바로가기 [Article Type] Review
Cell therapy in patients with COVID-19 using Wharton’s jelly mesenchymal stem cells: a phase 1 clinical trialWharton 's Jelly Mesenchymal 줄기 세포를 사용한 Covid-19 환자의 세포 요법 : 1 상 임상 시험Clinical Trial Published on 2021-07-162022-08-13 Journal: Stem Cell Research & Therapy [Category] SARS, 임상, [키워드] addition antibody antibody tests base biochemical tests both lungs caused CD4 CD8 Cell Cell therapy clinical trial COVID-19 antibody test COVID-19 antibody tests cytokine Cytokine storm Cytokine storms Cytokines Cytometry Efficacy enzyme tests FIVE flow cytometry headache IFN-γ IgG antibodies IgM and IgG IL-10 IL-6 immune system indicated Inflammation inflammation test inflammation tests Inflammatory cytokines inflammatory phase inhibit injecting intravenous injection Intravenous injection lung lung CT scan medication mesenchymal stem cell Mesenchymal stem cells modulate mortality rates MSCs myocardial enzyme tests New Patient patients patients with COVID-19 patients with COVID19 performed reduce mortality rate reduction in resolved respond Result Routine hematology tests routine tests SARS-CoV-2 SDF-1 serious complication severe COVID-19 stem cell subject supplementary material test results TGF-β therapy TNFα total score treated Treatment VEGF was done was performed were measured Wharton’s jelly Wharton’s jelly-derived mesenchymal stem cells Wharton’s jelly-derived MSC WJ-MSC zonal involvement [DOI] 10.1186/s13287-021-02483-7 PMC 바로가기 [Article Type] Clinical Trial
Targeted Mitochondrial Therapy With Over-Expressed MAVS Protein From Mesenchymal Stem Cells: A New Therapeutic Approach for COVID-19Cell and Developmental Biology Published on 2021-06-112022-10-31 Journal: Frontiers in Cell and Developmental Biology [Category] COVID-19, [키워드] ACE2 addition affecting approach cause Cell cellular cellular immunity COVID-19 damaged cell damaged tissue disease Diseases element expression expression of SARS-CoV-2 healthy host cell IFN immune immune response Impaired IMPROVE induce Inflammation innate immune response innate immune responses innate immune system interferon Ligand MAVS mesenchymal stem cell Mitochondria mitochondrial mitochondrial antiviral-signaling protein MSC MSCs New outer membrane pathogenesis of COVID-19 Probability Protein pulmonary involvement reduce regenerative regulate Regulatory rejection Replication S protein SARS-CoV-2 STEM stem cell Stress Symptom the SARS-CoV-2 these cell tissue inflammation transferring Transport viable treatment viral spike protein virus [DOI] 10.3389/fcell.2021.695362 PMC 바로가기 [Article Type] Cell and Developmental Biology
Advances in mesenchymal stem cell therapy for immune and inflammatory diseases: Use of cell‐free products and human pluripotent stem cell‐derived mesenchymal stem cellsMesenchymal Stem Cells Published on 2021-05-192022-10-28 Journal: Stem cells translational medicine [Category] Coronavirus, SARS, [키워드] addition advance Allogeneic Autoimmune diseases autologous Cell clinical trial clinical trials COVID‐19 demonstrated Efficacy Endpoint Evidence Exosome Exosomes Extracellular vesicles graft rejection Human human pluripotent stem cells immune Immune cell immunomodulatory property Increasing indication Inflammatory inflammatory disease inflammatory disorders liver Liver cirrhosis mesenchymal stem cell mesenchymal stem/stromal cell therapy MSC MSCs organ transplantation Osteoarthritis outcome prevalent pulmonary disease pulmonary inflammation rejection stem cell Stem cell therapy supported therapeutic therapeutic use therapy tissue Trial while [DOI] 10.1002/sctm.21-0021 PMC 바로가기 [Article Type] Mesenchymal Stem Cells
Treatment of COVID-19 by stage: any space left for mesenchymal stem cell therapy?코로나19 단계별 치료, 중간엽줄기세포 치료 여지는?Review Published on 2021-05-142022-09-10 Journal: Regenerative Medicine [Category] SARS, 임상, [키워드] acute respiratory distress syndrome approach Cell Cell therapy China Controlled trial controlled trials coronavirus COVID-19 Cytokine storm death develop disease severity Diseases Efficacy effort epithelial cells focus immune immune response Infection Inflammation Inflammatory inhibit mesenchymal stem cell Mesenchymal stem cells Numerous Organ failure Pandemics Patient Premature Prevent protocol Result SARS-CoV-2 entry severe COVID-19 severity shown stem cell Stem cell therapy the cell the disease therapeutic therapy Treatment Trial USA vascular cells Viral [DOI] 10.2217/rme-2020-0189 PMC 바로가기 [Article Type] Review
Stem cell therapies and benefaction of somatic cell nuclear transfer cloning in COVID-19 era코로나19 시대의 줄기세포 치료제와 체세포 핵이식 복제의 장점Review Published on 2021-05-122022-09-12 Journal: Stem Cell Research & Therapy [Category] SARS, 진단, [키워드] acute respiratory distress acute respiratory distress syndrome Anti-inflammatory antivirals ARDS being benefit Bio-pharming boost caused Cell cell type Cell-based therapy cellular Clinical studies cloned COVID-19 COVID-19 patient COVID-19 patients damage dependence develop Drug testing Embryo embryonic embryos generate Genome reprogramming Health health emergency immunomodulatory effect immunomodulatory effects Interaction mesenchymal stem cell Mesenchymal stem cells MSC MSCs nuclear organ Organoid organoids potential benefit potential benefits prominence regenerative regenerative medicine Research respiratory distress Respiratory distress syndrome SARS-CoV-2 SARS-COV-2 infection SCNT somatic cell STEM stem cell stem cells structures syndrome therapeutic Therapies therapy transfer transgenic treat unique Vaccinations Vascular [DOI] 10.1186/s13287-021-02334-5 PMC 바로가기 [Article Type] Review
Efficacy and safety of umbilical cord mesenchymal stem cells for the treatment of patients with COVID-19Research article Published on 2021-05-112022-10-05 Journal: Clinics [Category] SARS, 바이오마커, 치료법, [키워드] acute respiratory syndrome allergic reaction baseline Biomarker Cell changes in Clinicians Computerized tomography control group coronavirus coronavirus disease COVID-19 Decreased demonstrated drug Effect effective Efficacy evaluated healthy hematology tests IgM Immunoglobulin Inflammatory intravenous infusion large cohort lung mesenchymal stem cell Mesenchymal stem cells MSC MSC therapy MSC-treated MSCs Occurrence outbreak oxygenation index patients with COVID-19 pilot study public health pulmonary inflammation Randomized controlled trial reducing restored Serious Adverse Events significant changes in significantly stem cell Stem cell therapy therapeutic potential therapy tissue treated Treatment umbilical [DOI] 10.6061/clinics/2021/e2604 [Article Type] Research article
Therapeutic mechanisms of mesenchymal stem cells in acute respiratory distress syndrome reveal potentials for Covid-19 treatment급성 호흡곤란 증후군에서 중간엽 줄기세포의 치료 기전은 Covid-19 치료의 가능성을 보여줍니다Review Published on 2021-05-102022-09-10 Journal: Journal of Translational Medicine [Category] SARS, 비임상, [키워드] acute respiratory distress acute respiratory distress syndrome adipose Adipose tissue administration adverse effect adverse effects Allogeneic analyzed animal experiments ARDS attenuate Bone marrow breath cell infusion cells Clinical studies clinical trial coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patients Critically ill Critically ill patient critically ill patients cytokine Cytokines Effects Endoplasmic reticulum Evidence Exosome Exosomes experiment fibrosis highlight inflammatory cells inhibit mechanism mesenchymal stem cell Mesenchymal stem cells modulate mortality rate MSC MSC therapy MSCs paracrine patients with ARDS pulmonary fibrosis raising recent respiratory distress severe COVID-19 stem cell Stress syndrome therapeutic tissue Treatment umbilical Umbilical cord [DOI] 10.1186/s12967-021-02862-x PMC 바로가기 [Article Type] Review
Mesenchymal Stem Cells and COVID-19: Cure, Prevention, and VaccinationReview Article Published on 2021-05-062022-10-29 Journal: Stem Cells International [Category] COVID-19, [키워드] acute respiratory distress approved Cell Clinical outcome clinical study COVID-19 COVID-19 disease cure Cytokine storm damaged cell Defense disease effort Evidence Health host immune system Hyperinflammatory immune disorder Inflammatory cytokines Intervention lung cell mesenchymal stem cell MSC MSCs Patient platform Prevent prevention provided Research Safe severe cases Spread STEM stem cell syndrome the disease therapy tissue regeneration Treatment treatment for COVID-19 vaccinate vaccination against COVID-19 Vaccine viral disease virus infection [DOI] 10.1155/2021/6666370 PMC 바로가기 [Article Type] Review Article