Robust and efficient COVID-19 detection techniques: A machine learning approachArticle Published on 2022-09-152022-11-15 Journal: PLoS ONE [Category] SARS, 치료기술, 치료제, [키워드] Accuracy approach classical Confusion COVID-19 Critical dataset death drug Evidence experimental evidence gene cluster Genetic help identify include infection rate microRNA miRNAs pandemic pre-miRNAs Protein random reducing respiratory responsible RNA RNAs SARS-CoV-2 SARS-CoV-2 genome sequence similarity target region the SARS-CoV-2 genome the SARS-CoV-2 virus Transmission virus Virus life cycle [DOI] 10.1371/journal.pone.0274538 PMC 바로가기
Understanding the epigenetic mechanisms in SARS CoV-2 infection and potential therapeutic approachesSARS CoV-2 감염의 후성유전학적 기전과 잠재적인 치료적 접근의 이해Review Published on 2022-09-012022-09-11 Journal: Virus research [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus Anti-viral immune response association build caused Community coronavirus COVID-19 disease severity DNA DNA methylation drug effective eliminating Epigenetic epigenetic regulator epigenetics Escalation Health highlight histone Histone modification host cell host cells immune immune responses Immunity Infection initial Interaction mechanism microRNA Modification Mortality pandemic Pathogenesis pathogenesis of SARS-CoV-2 reduced risk SARS CoV-2 SARS- CoV-2 SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 severity subsequent the disease Therapeutic approach therapeutic intervention Therapies understanding variants of SARS-CoV-2 viral infection Virology [DOI] 10.1016/j.virusres.2022.198853 PMC 바로가기 [Article Type] Review
Dysregulated miRNAs network in the critical COVID-19: An important clue for uncontrolled immunothrombosis/thromboinflammation중요한 COVID-19에서 조절되지 않는 miRNA 네트워크: 통제되지 않는 면역혈전증/혈전염증에 대한 중요한 단서Review Published on 2022-09-012022-09-11 Journal: International immunopharmacology [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, 치료기술, [키워드] accompanied activated Activation adenine affecting anti-inflammatory factors Anticoagulant cause clinical complication Coagulation Coagulation system complement complement system Complication components conserved coronavirus disease Coronavirus disease 2019 COVID-19 Critical Cytokine storm Defensive mechanism deviation diffusion Effect expression expression level facilitate Factor function Genetic higher risk homeostasis hyperinflammation immune immunothrombosis incidence Interaction involved life-threatening mechanism microRNA MicroRNAs miRNA miRNAs miRNAs-based therapy. molecules Mortality NADPH nicotinamide nicotinamide adenine dinucleotide Nicotinamide adenine dinucleotide phosphate Non-coding RNAs nucleotide oxygen Pathogens Patient phosphate reactive oxygen species reactive oxygen specy reduction response restrict SARS-CoV-2 severe complications Therapeutic approach therapy Thromboinflammation thrombotic underlie vicious cycle [DOI] 10.1016/j.intimp.2022.109040 PMC 바로가기 [Article Type] Review
Plasma microRNA and metabolic changes associated with pediatric acute respiratory distress syndrome: a prospective cohort study Research Published on 2022-08-262022-10-05 Journal: Scientific Reports [Category] 바이오마커, [키워드] acute respiratory distress ARDS Bacterial infection Biomarker Biomarkers both groups change circulating circulation Clinical characteristics conducted control patient correlated Critically ill defined differential expression differentially expressed distress evaluate heterogeneous identify intensive care patients metabolite metabolomics microRNA MicroRNAs miRNA miRNA expression morbidity and mortality non-coding RNA pathophysiological Patient pediatric Pediatric patient Pediatric patients pilot study prognostic biomarker progression prospective cohort study provide Random forest random forest classification responsible risk selected single-center sub-cohort subset syndrome therapeutic intervention [DOI] 10.1038/s41598-022-15476-0 [Article Type] Research
Gene Network Analysis of the Transcriptome Impact of SARS-CoV-2 Interacting MicroRNAs in COVID-19 DiseaseCOVID-19 질병에서 SARS-CoV-2 상호작용 MicroRNA의 전사체 영향에 대한 유전자 네트워크 분석Review Published on 2022-08-172022-09-11 Journal: International Journal of Molecular Sciences [Category] SARS, 유전자 메커니즘, [키워드] affected Analysis biochemical biological processes Cell cell cycle cell surface receptor changes characterized COVID-19 COVID-19 disease cytokine death DEGs differentially expressed differentially expressed gene Differentially expressed genes downregulated exploratory FIVE functional enrichment Functional enrichment analysis Gene Expression gene network Health Organization heart Impact involved kidneys list lung Lymph node microRNA MicroRNAs mitochondrial mitotic mitotic cell modulation molecular Multiorgan multiorgan disease network network analysis pathological mechanism Pathways Perspective predicted provide reported SARS-CoV-2 SARS-CoV-2 virus signaling pathway submitted surface receptor target tissue tissues transcriptomes translated upregulated WHO with COVID-19 World Health Organization [DOI] 10.3390/ijms23169239 PMC 바로가기 [Article Type] Review
Circulating microRNA signatures associated with disease severity and outcome in COVID-19 patientsArticle Published on 2022-08-112022-11-15 Journal: Frontiers in Immunology [Category] SARS, 치료제, [키워드] 95% CI adaptive immune responses Angiogenesis antiviral response antiviral responses asymptomatic infection AUROC Biomarker Biomarkers chemokines circulating miRNA clinical condition collected Combination COVID-19 COVID-19 pathogenesis COVID-19 patient DE miRNA death differentially expressed disease disease severity downregulation driven by experiment Genes healthy control heart failure highlighting Hospital admission human cell impairment in vitro induce Inflammation inhibit Innate immunity interferon involved leukocyte life threatening Lung disease Lung epithelial cells Lung fibrosis microRNA Mild miR-4433b-5p miRNA miRNA signature miRNAs moderate modulated Mortality organ damage outcome Patient predicted pro-inflammatory cytokine pro-inflammatory factors provided RNA-sequencing SARS-CoV-2 SARS-COV-2 infection Sensitivity and specificity serum serum sample severe COVID-19 severe disease severity Stress subset the cytokine storm upregulation Vascular damage was performed with COVID-19 [DOI] 10.3389/fimmu.2022.968991 PMC 바로가기
MicroRNA of N-region from SARS-CoV-2: Potential sensing components for biosensor developmentSARS-CoV-2의 N-영역 MicroRNA: 바이오센서 개발을 위한 잠재적 감지 구성 요소Article Published on 2022-08-012022-09-11 Journal: Biotechnology and applied biochemistry [Category] SARS, 치료기술, 치료제, [키워드] acute respiratory syndrome Analysis bioinformatics Biomarker biosensor carried complementary Complementary DNA component coronavirus coronavirus disease coronavirus strains COVID-19 Cross-validation database diagnosis of COVID-19 DNA DNA probe early diagnosis framework GC content GCA gene analysis Genome identity In silco analysis Local microRNA miRbase Multiple sequence alignment N-gene parameter Potential probe regions SARS-CoV-2 selectivity sequence Sequence alignment Sequence analysis Severe acute respiratory syndrome strain virus was used [DOI] 10.1002/bab.2239 PMC 바로가기 [Article Type] Article
Fluorescent Platforms for RNA Chemical Biology ResearchRNA 화학 생물학 연구를 위한 형광 플랫폼Review Published on 2022-07-272022-09-11 Journal: Genes [Category] 치료제, [키워드] activities activity applied assays binding Biology Biotin change Chemical Chemical biology Clinical research clinically COVID-19 test COVID-19 tests CRISPR Degradation demonstrated detect Drug discovery drugs targeting Efficacy Efficiency efficient energy transfer ENhance enzyme Enzyme labeling example facilitate fit Fluorescence fluorescence anisotropy Fluorescence imaging fluorescent fluorescent assays. Forced In situ hybridization increase invention lAbel labeling living cells Mango microRNA miRNA movement mRNA ncRNAs non-coding RNA Non-coding RNAs Nuclease observation overcome probe Research ribonucleoprotein RNA ROI subcellular T-box tumors [DOI] 10.3390/genes13081348 PMC 바로가기 [Article Type] Review
SARS-CoV-2 nucleocapsid protein triggers hyperinflammation via protein-protein interaction-mediated intracellular Cl – accumulation in respiratory epitheliumSARS-CoV-2 뉴클레오캡시드 단백질은 단백질-단백질 상호작용 매개 세포내 Cl-호흡 상피에서의 축적을 통해 과염증을 유발합니다Article Published on 2022-07-272022-09-11 Journal: Signal Transduction and Targeted Therapy [Category] COVID19(2023년), SARS, 신약개발, 치료법, [키워드] abrogated Airway inflammation CAMP cell lines cells CFTR Concentration COVID-19 cystic fibrosis Cytokine storms Defense demonstrated depleting downregulated elicit epithelial epithelial cell epithelial cells expression fibrosis glucocorticoid Host host defense human airway epithelial hyperinflammation immune response immune responses Inflammatory response Inflammatory responses inhibition inhibitor Intracellular knockout microRNA modulating murine model murine models N protein pathogen phosphodiesterase Phosphorylation promoted Protein pulmonary inflammation raised reducing regulated respiratory epithelium resulting robust Rolipram SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 nucleocapsid second messenger selective serum SGK1 signaling pathway Smad3 structural protein suggested sustained targeting therapeutic strategy transmembrane Trigger upregulation [DOI] 10.1038/s41392-022-01048-1 PMC 바로가기 [Article Type] Article
Nanoligomers Targeting Human miRNA for the Treatment of Severe COVID-19 Are Safe and Nontoxic in Mice심각한 COVID-19 치료를 위해 인간 miRNA를 표적으로 하는 나노 올리고머는 마우스에서 안전하고 독성이 없습니다Article Published on 2022-07-112022-09-11 Journal: ACS Biomaterials Science & Engineering [Category] COVID19(2023년), SARS, 치료제, [키워드] accumulation acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 administration antisense therapy Antiviral strategies Antiviral treatment bind biodistribution biodistribution study body weight Compound coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 disease Effect fatality Histopathology Host Host immune response Human human cell human cells immune immunogenicity Infection Inflammation intranasal intraperitoneal intravenous Intravenous administration kidney kidneys liver Lungs mice microRNA miRNA MOST mouse model organ organs pandemic parameters produced question response Safe Safety SARS-CoV-2 serum biomarker serum biomarkers severe acute respiratory syndrome Coronavirus Severe case severe cases spleen targeting tested Urine with infection [DOI] 10.1021/acsbiomaterials.2c00510 PMC 바로가기 [Article Type] Article