moderate disease – Page 5 – Communicable Diseases Research

SARS-CoV-2 Neutralizing Monoclonal Antibodies for the Treatment of COVID-19 in Kidney Transplant Recipients

신장 이식 환자의 코로나19 치료를 위한 SARS-CoV-2 중화 단일클론 항체

Article

Published on 2021-10-202022-09-11
Journal: Kidney360 [Category] MERS, SARS, 진단, 치료기술,

Annexin A1 as a potential prognostic biomarker for COVID-19 disease: Case-control study

COVID-19 질병에 대한 잠재적인 예후 바이오마커로서의 Annexin A1: 사례 대조 연구

Article

Published on 2021-10-012022-09-11
Journal: International journal of clinical practice [Category] MERS, 바이오마커,

[키워드] 95% CI Admission Analysis Annexin annexin A1 ANXA1 AUC Biomarker Blood blood sample Blood samples calculated case-control study characteristic conducted contribute control group COVID-19 COVID-19 disease COVID-19 patient COVID-19 pneumonia cut-off Cytokines determine diagnosis of COVID-19 disease emergency department enzyme enzyme-linked immunosorbent enzyme-linked immunosorbent assay evaluated group Health Organization healthy volunteer hospital Hospital admission ICU ICU treatment Inflammation intensive care intensive care unit Isolation Mild moderate moderate disease neutrophil participated Patient patients with COVID-19 Pneumonia pro-inflammatory cytokines prognostic biomarker Protein receiver receiver operating characteristic serum significantly lower suppression training Treatment were measured World Health Organization
[DOI] 10.1111/ijcp.14606 PMC 바로가기 [Article Type] Article

A poor and delayed anti-SARS-CoV2 IgG response is associated to severe COVID-19 in children

불량하고 지연된 항-SARS-CoV2 IgG 반응은 어린이의 심각한 COVID-19와 관련이 있습니다

Observational Study

Published on 2021-10-012022-09-12
Journal: EBioMedicine [Category] MERS, SARS, 임상, 진단,

[키워드] acute infection acute phase acute respiratory syndrome Admission analyzed antibodies antibody Antibody Response Asymptomatic Asymptomatic disease children circulating Cohort Comorbidity convalescent coronavirus COVID-19 detectable develop disease disease severity Disease severity, antibodies, T cells Frequency had no IgG and IgM IgG response Infection Inflammatory Inflammatory cytokines kinetic Mild MIS-C moderate disease MOST outcome Patient pediatric pediatric COVID-19 plasma concentration Plasma cytokine plasmablast prevalent pro-inflammatory promotion SARS-CoV-2 seronegative severe COVID-19 severe disease severity stratified syndrome T helper cell the spike protein
[DOI] 10.1016/j.ebiom.2021.103615 PMC 바로가기 [Article Type] Observational Study

[COVID-19: epidemiology and mutations : An update]

[COVID-19: 역학 및 돌연변이 : 업데이트]

Review

Published on 2021-10-012022-09-11
Journal: Radiologe [Category] SARS, 변종,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition Alpha Alpha variant antibody antibody treatment approach AstraZeneca B.1.1.28.1 B.1.1.7 B.1.351 B.1.617 bamlanivimab Beta variant Brazil caused circulating coronavirus Course courses decrease delta variant described disease severity dominant Effectiveness English ENhance Epidemiology fatal disease Germany herd immunity Immunity India Infection infectiousness Kingdom less life-threatening Mild moderate disease monoclonal antibodies monoclonal antibody mortality risk Mutation mutations neutralization ability offer outcome P.1 pandemic protective effect rule SARS-CoV-2 SARS-CoV‑2 severe acute respiratory syndrome Coronavirus South Africa Spread symptomatic disease the disease the vaccine vaccination vaccination rate Vaccinations Vaccine variant variants virus strain virus variants wild type
[DOI] 10.1007/s00117-021-00909-0 PMC 바로가기 [Article Type] Review

Long-Term Course of Humoral and Cellular Immune Responses in Outpatients After SARS-CoV-2 Infection

SARS-CoV-2 감염 후 외래 환자의 체액 및 세포 면역 반응의 장기 경과

Public Health

Published on 2021-09-272022-09-11
Journal: Frontiers in Public Health [Category] MERS, SARS, 진단, 치료기술,

[키워드] acquired B acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 anti-SARS-CoV-2 IgG antibodies anti-SARS-CoV-2 IgG antibody anti-SARS-CoV-2 immunoglobulin antibody borderline characterization circulating circulating antibody Concentration conducted coronavirus Course COVID-19 COVID-19 disease COVID-19 recovered patient cross-sectional analysis enrolled IFN-γ IgG IgG antibodies IgG antibody IGRA immune response immune responses Immunity Immunoglobulin Immunoglobulin G immunological reaction individual Infection interferon Interferon-gamma interferon-gamma release assay majority marker Mild moderate disease natural infection Neutralizing antibodies neutralizing antibody Outpatient Patient patients Peripheral blood peripheral blood cell peripheral blood cells positive public health respiratory response robust S-protein SARS-CoV-2 Seroprevalence severe acute respiratory syndrome Coronavirus study visit subject sustained T cell titre Vaccination strategies Vaccination strategy
[DOI] 10.3389/fpubh.2021.732787 PMC 바로가기 [Article Type] Public Health

Type I interferon autoantibodies are associated with systemic immune alterations in patients with COVID-19

I형 인터페론 자가항체는 COVID-19 환자의 전신 면역 변화와 관련이 있습니다

Research Article

Published on 2021-09-222022-09-10
Journal: Science Translational Medicine [Category] MERS, 유전자 메커니즘, 진단,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 alteration antibodies autoantibodies autoantibody caused change circulating leukocyte circulating leukocytes Control coronavirus coronavirus disease Coronavirus disease 2019 correlated Course COVID-19 Critical Critical disease dendritic cell description diagnosed disease course disease pathogenesis Effect elevated epitope evaluated Evidence evidence of expressed expression functional healthy controls help IFNs immune immune system Immunoglobulin in some increased expression individual individuals with COVID-19 inhibitory receptor interferon interferon response interferons ISG lack LAIR1 leukocyte leukocytes longitudinal mechanisms moderate disease monocyte Monocytes mononuclear cell mononuclear cells myeloid cell myeloid cells Patient patients with COVID-19 Peripheral blood Peripheral blood mononuclear cells peripheral blood samples Population Prevalence producing receptor reduced respiratory response SARS-CoV-2 severe acute respiratory syndrome Coronavirus Severe case severe cases severe disease severity single-cell Single-cell transcriptomics subset Support systemic impact systemic impacts the disease Transcriptome transcriptome sequencing transcriptomics turn Type type I Type I IFN type I interferon type I interferons
[DOI] 10.1126/scitranslmed.abh2624 PMC 바로가기 [Article Type] Research Article

Ivermectin for Prophylaxis and Treatment of COVID-19: A Systematic Review and Meta-Analysis

Systematic Review

Published on 2021-09-082022-10-31
Journal: Diagnostics [Category] COVID-19,

[키워드] 95% CIs 95% confidence interval Admission adverse event Analysis baseline benefit CIs Clinical efficacy clinical trial registry Control control group COVID-19 decreased mortality Disease progression Evidence fine-tune Guidance include indicated indication intensive care Ivermectin likelihood mechanical ventilation Meta-analysis methodology Mild moderate disease Mortality negative RT-PCR no difference outcome Participants Patient patients Potential treatment Prophylaxis RCT recipient reported Repository review risk Risk of bias SARS-CoV-2 searched severe disease severe pneumonia significantly subjects Support systematic review Treatment treatment for COVID-19 Treatment protocol was used
[DOI] 10.3390/diagnostics11091645 PMC 바로가기 [Article Type] Systematic Review

Cytokine Profiles Associated With Worse Prognosis in a Hospitalized Peruvian COVID-19 Cohort

입원한 페루 COVID-19 코호트에서 더 나쁜 예후와 관련된 사이토카인 프로필

Immunology

Published on 2021-09-012022-09-11
Journal: Frontiers in Immunology [Category] SARS, 바이오마커, 진단,

[키워드] 95% confidence interval 95%CI activated adaptive analyses Analysis analyzed anti-Spike IgG anti-spike IgG antibodies Anti-spike IgG antibody antibody concentration baseline Biomarker Biomarkers C-reactive protein chemokine chemokines clinical parameter Clinical parameters Cohort Concentration correlated COVID-19 COVID-19 patient creatinine criteria CRP cytokine Cytokines D-dimer D-dimer levels death determine died discharge disease severity e parameters ELISA enrolled evaluated exacerbated expression expression profile fatal COVID-19 form Frequency GM-CSF groups growth factor Growth factors hazard ratio hemoglobin hospital Hospitalization Hospitalized hospitalized COVID-19 patients identify IL-10 IL-12p70 IL-15 IL-5 IL-6 IL-8 IL1RA Immune cell immune cells Inflammation laboratory-confirmed Laboratory-confirmed COVID-19 Logistic regression longitudinal longitudinal analysis longitudinal samples lymphocyte Lymphocytes MCP-1 MIP-1α moderate disease Mortality multivariable analysis Neutrophils obesity outcome outcomes parameter Patient patient information patients with moderate Peripheral blood pro-inflammatory cytokines profile Prognosis proinflammatory Protein Quantitative Result risk factor SARS-CoV-2 IgG SARS-CoV-2 infected patient SARS-CoV-2 infected patients SARS-COV-2 infection sera severe disease severity Significant significant difference significant differences spike IgG Stratification TNFα worse prognosis
[DOI] 10.3389/fimmu.2021.700921 PMC 바로가기 [Article Type] Immunology

Impact of COVID-19 on serum melatonin levels and sleep parameters in children

Article

Published on 2021-08-302022-10-29
Journal: Turkish Journal of Medical Sciences [Category] COVID-19, MERS, SARS,

Low 25(OH)D Level Is Associated with Severe Course and Poor Prognosis in COVID-19

Article

Published on 2021-08-292022-10-31
Journal: Nutrients [Category] COVID-19, MERS, SARS,