monocyte – Page 5 – Communicable Diseases Research

COVID-19 lung disease shares driver AT2 cytopathic features with Idiopathic pulmonary fibrosis

COVID-19 폐 질환은 특발성 폐 섬유증과 드라이버 AT2 세포 변성 기능을 공유합니다

Article

Published on 2022-08-012022-09-12
Journal: EBioMedicine [Category] COVID19(2023년), MERS, SARS, 바이오마커, 변종, 진단,

Single-cell RNA sequencing to decipher the immunogenicity of ChAdOx1 nCoV-19/AZD1222 and mRNA-1273 vaccines in patients with autoimmune rheumatic diseases

자가면역 류마티스 질환 환자에서 ChAdOx1 nCoV-19/AZD1222 및 mRNA-1273 백신의 면역원성을 해독하기 위한 단일 세포 RNA 시퀀싱

Article

Published on 2022-08-012022-09-12
Journal: Frontiers in Immunology [Category] SARS, 진단,

[키워드] Analysis analyzed anti-rheumatic medications anti-SARS-CoV-2 IgG antibodies Antigen presentation Arthritis Autoimmune AZD1222 CD16 CD4 ChAdOx1 COVID-19 COVID-19 vaccine database domain dose electrochemiluminescence immunoassay enriched pathway enrolled exhibited Gene Expression Omnibus GEO healthy controls HLA-DRA immunized inhibitor Interaction Janus kinase methotrexate MHC class Moderna monocyte mononuclear cell mRNA-1273 mRNA-1273 vaccine mRNA-based vaccine Necrosis Oxford-AstraZeneca participant pathway Patient patients PBMC PBMCs Peripheral blood predominant quantified receiving rheumatic disease RNA sequencing scRNA-seq serum IgG antibody Single-cell RNA sequencing the SARS-CoV-2 vaccination Vaccine
[DOI] 10.3389/fimmu.2022.920865 PMC 바로가기 [Article Type] Article

Evaluation of hematological parameters and inflammatory markers in children with COVID-19

COVID-19 소아의 혈액학적 매개변수 및 염증 표지자 평가

Article

Published on 2022-08-012022-09-11
Journal: Irish Journal of Medical Science [Category] 바이오마커,

[키워드] 95% CI abnormality applied best blood cell C-reactive protein C-reactive protein (CRP can be used children children with COVID-19 COVID-19 CRP cutoff value D-dimer determine distribution Effect evaluate hematological hematological parameter hematological parameters hemoglobin Hospitalization identify independent predictor independent predictors Inflammatory biomarker inflammatory biomarkers Inflammatory marker inflammatory markers Inpatient Inpatients lymphocyte lymphopenia mean platelet volume monocyte multivariate logistic regression neutrophil Outpatient outpatients Patient Platelet platelet counts procalcitonin procalcitonin level Red cell retrospective risk factor Risk factors ROC analysis separated significantly higher significantly lower single-center study study population two groups Volume was performed WBC White blood cell
[DOI] 10.1007/s11845-021-02762-5 PMC 바로가기 [Article Type] Article

The SARS-CoV-2 Nucleoprotein Induces Innate Memory in Human Monocytes

SARS-CoV-2 핵단백질은 인간 단핵구에서 선천적 기억을 유도합니다

Article

Published on 2022-07-192022-09-11
Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 치료법,

Exploring the Immunomodulatory Aspect of Mesenchymal Stem Cells for Treatment of Severe Coronavirus Disease 19

중증 코로나바이러스 질환 치료를 위한 중간엽 줄기세포의 면역조절 측면 탐색 19

Review

Published on 2022-07-122022-09-11
Journal: Cells [Category] COVID19(2023년), SARS, 치료법,

[키워드] ACE-2 acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 acute respiratory syndrome coronavirus-2 administration affected Alpha alveolar epithelial cell alveolar epithelial cells angiotensin angiotensin converting enzyme angiotensin converting enzyme 2 anti-apoptotic Anti-inflammatory anti-oxidative aspect Asymptomatic average Betacoronavirus breathlessness cause cellular characterized chemokines chest pain Clinical outcome Clinical symptoms colony-stimulating factor coronavirus 2 COVID-19 COVID-19 patient Critically ill critically ill COVID-19 patients curative cytokine Cytokine storm Cytokine storms damaged dependent on Deterioration disease severity dry cough Effectiveness Effects elicited endothelial engage enzyme epithelial cells excessive inflammation family Coronaviridae fatigue Fever fibroblast fibroblast growth factor functional GCSF genus genus Betacoronavirus granulocyte granulocyte colony-stimulating factor growth factor Growth factors Health healthy histological IL-6 IL-7 IL-8 IL-9 immune cells immune response immune responses immunomodulation immunomodulatory immunomodulatory capabilities immunomodulatory capability Incubation period individual infected individual infected individuals infiltrating immune cells Inflammatory Inflammatory cytokines inflammatory protein inhalation Injury Intention interferon interleukin intravenous intravenous infusion Invasion IP10 lung Lungs Macrophage majority MCP1 Mesenchymal stem cells MIP1A mitigate monocyte monocyte chemotactic protein-1 MSC MSCs multitude myriad Necrosis organ PDGFB persistence Platelet platelet-derived growth factor positioned positive Protein receptor reduce respiratory Respiratory droplets RNA SARS-CoV-2 SARS-COV-2 infection secretion Secretome Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus-2 sore throat STEM stem cell stem cells subunit supportive therapy symptomatic therapeutic therapy tissue TNF-α translational transmitted Treatment Tumor tumor necrosis tumor necrosis factor tumor necrosis factor alpha undergo Vascular virus widespread
[DOI] 10.3390/cells11142175 PMC 바로가기 [Article Type] Review

Immune Cells Profiles In The Peripheral Blood Of Patients With Moderate To Severe COVID-19 And Healthy Subjects With and Without Vaccination With The Pfizer-BioNTech mRNA Vaccine

Pfizer-BioNTech mRNA 백신 접종 여부에 관계없이 중등도에서 중증 COVID-19 환자 및 건강한 피험자의 말초혈 면역 세포 프로필

Article

Published on 2022-07-112022-09-11
Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 치료기술,

[키워드] acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 adaptive analyzed B cell B cells Blood causative agent caused CD14 CD16 CD19 CD19+ CD3+ CD4+ CD4+ T cells CD4+ T lymphocyte CD56 CD56+ CD8+ T cell CD8+ T cells clinical manifestations coronavirus 2 coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient COVID-19 patients detectable determine dysregulated flow cytometry Frequency group healthy control healthy subject healthy subjects HLA-DR host response immune Immune cell immune cells immune response Inflammatory Kuwait lymphocyte Lymphocyte subset Lymphocyte subsets Lymphocytes moderate moderate to severe monocyte monocyte subsets Monocytes mRNA mRNA vaccine NK cell NK cells no symptom no symptoms percentage percentages peripheral Peripheral blood Perturbation perturbations Pfizer Pfizer-BioNTech profile profiles PROTECT required respiratory SARS-CoV-2 Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe disease significantly higher significantly lower subjects subset T cells T lymphocytes the patient three group three groups vaccination was performed with COVID-19
[DOI] 10.3389/fimmu.2022.851765 PMC 바로가기 [Article Type] Article

Usefulness of monocyte distribution width and presepsin for early assessment of disease severity in COVID-19 patients

COVID-19 환자의 질병 중증도 조기 평가를 위한 단핵구 분포 폭 및 프리셉신의 유용성

Article

Published on 2022-07-082022-09-11
Journal: Medicine [Category] COVID19(2023년), MERS, SARS, 바이오마커, 치료기술,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Admission antibody Blood blood count C-reactive protein Complete complete blood count coronavirus coronavirus disease Coronavirus disease 2019 correlated COVID-19 COVID-19 patient COVID-19 patients COVID-19 severity disease severity distribution early diagnosis elevated enrolled erythrocyte sedimentation erythrocyte sedimentation rate exhibited ferritin group groups high-flow nasal cannula oxygen therapy Hospital stay identify Inpatient intensive care Lactate lactate dehydrogenase mechanical ventilation monocyte Mortality nasal nasal cannula neutralization Neutralizing antibodies neutralizing antibody not differ on admission oxygen Oxygen therapy Patient predictor procalcitonin respiratory Respiratory Support SARS-CoV-2 sedimentation rate Sepsis severe acute respiratory syndrome Coronavirus severe coronavirus disease severity significantly significantly higher Symptom utility with COVID-19
[DOI] 10.1097/MD.0000000000029592 PMC 바로가기 [Article Type] Article

Multi-omics personalized network analyses highlight progressive disruption of central metabolism associated with COVID-19 severity

Research article

Published on 2022-07-082022-10-05
Journal: Cell Systems [Category] 바이오마커, 치료기술,

B cell-derived cfDNA after primary BNT162b2 mRNA vaccination anticipates memory B cells and SARS-CoV-2 neutralizing antibodies

1차 BNT162b2 mRNA 백신 접종 후 B 세포 유래 cfDNA는 기억 B 세포 및 SARS-CoV-2 중화 항체를 예상합니다

Article

Published on 2022-07-082022-09-12
Journal: Med (New York, N.Y.) [Category] COVID19(2023년), MERS, SARS, 진단,

[키워드] actual acute respiratory syndrome adaptive administration Alex B cell BNT162b2 BNT162b2 mRNA vaccination booster Booster vaccine cell count cell-free DNA cellular center cfDNA chair circulating Coronavirus-2 correlated demonstrated DNA DNA methylation dose effective family foundation heart Human humoral immune cell type immune system Immunity innate immune cell liquid biopsy lymphocyte counts Medicine memory memory B cell memory B-cell monocyte mRNA mRNA vaccine network Neutralizing neutralizing antibody neutrophil Pfizer/BioNTech Program reduction in remained response Robert SARS-CoV-2 SARS-CoV-2 neutralizing antibody SARS-CoV-2 vaccine Science supported T cell tissue tissue dynamics. Translation to patients Trust university vaccination Vaccine
[DOI] 10.1016/j.medj.2022.05.005 PMC 바로가기 [Article Type] Article

Beneficial ex vivo immunomodulatory and clinical effects of clarithromycin in COVID-19

Research article

Published on 2022-07-012022-10-05
Journal: Journal of infection and chemotherapy : official j [Category] COVID19(2023년), SARS, 임상,

[키워드] addition amoxicillin Anti-bacterial agents Antibiotics benefit CD4+ CD8+ clarithromycin Clinical effect Co-incubation confounder COVID COVID-19 COVID-19 patients Critical care Critically ill patient Cytokines decrease Effect Ex vivo had no healthy hospital ICU patient IFN-alpha IL-10 IL-2 IL-6 immunomodulation immunomodulatory immunomodulatory properties immunomodulatory property in viral increase in infections intensive care intracellular cytokine investigated lymphocyte Macrolide monocyte no effect PBMC phagocytosis reduction in mortality Result retrospective cohort study SARS-CoV-2 Spike protein stimulated synergistic T cell response TNF-alpha Univariate analysis was performed with COVID-19
[DOI] 10.1016/j.jiac.2022.04.001 [Article Type] Research article