Oxidative stress and endogenous DNA damage in blood mononuclear cells may predict anti-SARS-CoV-2 antibody titers after vaccination in older adults혈액 단핵 세포의 산화 스트레스와 내인성 DNA 손상은 노인에서 예방 접종 후 항 SARS-CoV-2 항체 역가를 예측할 수 있습니다Article Published on 2022-06-012022-09-11 Journal: Biochimica et biophysica acta. Molecular basis of [Category] COVID19(2023년), SARS, 치료기술, [키워드] age All participants anti-S anti-SARS-CoV-2 antibodies anti-SARS-CoV-2 antibody Anti-spike antibodies antibody Biomarker Biomarkers Blood BNT162b2 circulating correlated DNA DNA damage DNA damage response double-strand break DSBs Efficacy Efficiency first dose genomic humoral immune response Humoral response humoral responses Hypothesis IgG antibodies Immune cell immune cells immune senescence increase in Increased individual inverse correlation mononuclear cell mRNA vaccination neutralizing capacity Older oxidative oxidative stress Participants Peripheral blood Peripheral blood mononuclear cells pre-vaccination predict SARS-CoV-2 SARS-CoV-2 antibody SARS-CoV-2 vaccination second dose Stress tested titers vaccination Vaccine vaccine efficacy [DOI] 10.1016/j.bbadis.2022.166393 PMC 바로가기 [Article Type] Article
Soluble P2X7 Receptor Is Elevated in the Plasma of COVID-19 Patients and Correlates With Disease Severity가용성 P2X7 수용체는 COVID-19 환자의 혈장에서 상승하고 질병 중증도와 상관관계가 있습니다Article Published on 2022-05-182022-09-12 Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] activated Activation acute respiratory distress Bacterial Biomarker C-reactive protein concentration cause cell death characterized Concentration COVID-19 COVID-19 disease COVID-19 patient COVID-19 patients COVID-19 severity cytokine danger signal death experimental evidence extracellular ATP hypoxia IL-1 receptor antagonist IL-18 IL-1β IL-6 increase in induce inflammasome activation Inflammation Inflammatory response lung mononuclear cell NLRP3 NLRP3 inflammasome P2X7 Peripheral blood pharmacological target plasma Pneumonia positively correlated pro-inflammatory cytokines purinergic receptors pyroptosis receptor SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2-infected individual supernatant syndrome triggered triggering viral infections with COVID-19 [DOI] 10.3389/fimmu.2022.894470 PMC 바로가기 [Article Type] Article
Incidence and immunomic features of apyretic COVID-19 in patients affected by solid tumors: a prospective cohort study고형 종양의 영향을 받는 환자에서 발열성 COVID-19의 발병률 및 면역학적 특징: 전향적 코호트 연구Article Published on 2022-05-142022-09-11 Journal: Journal of Translational Medicine [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, [키워드] affected Asymptomatic case Asymptomatic cases Asymptomatic COVID-19 asymptomatic infection asymptomatic patient asymptomatic patients baseline Cancer Cancer center changes in chemokine collected COVID-19 COVID-19 in patient COVID-19 pandemic downregulation evaluated feature First wave General population IgM Immunoglobulin interleukin 6 Italy KEGG mononuclear cell mononuclear cells Nasopharyngeal swab NPs p-values pathway Pathways Patient patients PBMC PBMCs performed Peripheral blood Peripheral blood mononuclear cells positive prospective cohort study rationale receptor recruited RNA SARS-CoV-2 SARS-CoV-2 IgM Sequencing Seroconversion seroconversion rate serology Signaling solid cancer subset T-cell receptor tested Transcriptome transcriptome sequencing transcriptomic analysis transcriptomics treated upregulated Viral Viral RNA was performed [DOI] 10.1186/s12967-022-03429-0 PMC 바로가기 [Article Type] Article
The expression patterns of MALAT-1, NEAT-1, THRIL, and miR-155-5p in the acute to the post-acute phase of COVID-19 diseaseCOVID-19 질병의 급성기에서 후기 급성기 MALAT1, NEAT1, THRILL 및 miR-155-5p의 발현 패턴Article Published on 2022-05-012022-09-11 Journal: The Brazilian journal of infectious diseases : an [Category] COVID19(2023년), SARS, 바이오마커, 진단, [키워드] acute COVID-19 acute phase addition Analysis Biomarker COVID-19 COVID-19 diagnosis COVID-19 disease COVID-19 infection diagnose diagnosis of COVID-19 disease evaluated expression level expression levels expression pattern expression patterns hallmark hallmarks healthy control healthy individual Infection Inflammation Inflammatory factor inflammatory factors Long Long non-coding RNAs MicroRNAs miR-150 miR-155 MONITOR mononuclear cell ncRNA ncRNAs non-coding RNA Non-coding RNAs Pathogenesis pathogenesis of COVID-19 Patient PBMC peripheral Peripheral blood real-time PCR assay RNA ROC Curve selected severity of COVID-19 significantly increased significantly lower the SARS-CoV-2 THRIL Total total RNA [DOI] 10.1016/j.bjid.2022.102354 PMC 바로가기 [Article Type] Article
Long-Lasting T Cell Responses in BNT162b2 COVID-19 mRNA Vaccinees and COVID-19 Convalescent PatientsBNT162b2 COVID-19 mRNA 백신 및 COVID-19 회복기 환자에서 장기간 지속되는 T 세포 반응Article Published on 2022-04-222022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] Activation acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Alpha antibody antibody levels Beta BNT162b2 Breakthrough infection breakthrough infections Cell mediated immunity coronavirus COVID-19 COVID-19 disease COVID-19 patients cytokine cytokine production delta variant Delta variants Gamma Health care Health care worker health care workers humoral Humoral immunity Infection marker mononuclear cell mononuclear cells more difficult mRNA neutralize Peripheral blood Peripheral blood mononuclear cells persistence Prevent PROTECT question raise report respiratory response SARS-CoV-2 severe acute respiratory syndrome Coronavirus T cell T cell mediated immunity T cell response T cell responses Th1 vaccination Vaccine Vaccines variant variants virus [DOI] 10.3389/fimmu.2022.869990 PMC 바로가기 [Article Type] Article
Activation of STAT3 signaling pathway in the kidney of COVID-19 patients코로나19 환자의 신장에서 STAT3 신호전달 경로 활성화Observational Study Published on 2022-04-012022-09-11 Journal: Journal of Nephrology [Category] COVID19(2023년), MERS, SARS, 임상, 진단, 치료기술, [키워드] ACE2 expression activated Acute kidney injury AKI Autopsy cells COVID-19 COVID-19 patient cytokine Cytokine storm Cytokines detect died disease electron microscopy glomerular glomerular disease glomerulosclerosis immunofluorescence immunostaining In situ hybridization Injury investigated kidney Kidney injury light microscopy mechanism Microscopy mononuclear cell mononuclear cells Mount Sinai NF-kB observational study pandemic Pathologists pathology Patient patients with COVID-19 performed peritubular capillary Phosphorylation renal Renal pathology. SARS-CoV-2 Serine signaling pathway significant increase STAT3 TMPRSS2 transcription factor transcription factors tubular cell tubular cells two patients tyrosine was increased was reduced with COVID-19 [DOI] 10.1007/s40620-021-01173-0 PMC 바로가기 [Article Type] Observational Study
Immunological features that associate with the strength of antibody responses to BNT162b2 mRNA vaccine against SARS-CoV-2SARS-CoV-2에 대한 BNT162b2 mRNA 백신에 대한 항체 반응의 강도와 관련된 면역학적 특징Article Published on 2022-03-252022-09-12 Journal: Vaccine [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] activated analyzed anti-SARS-CoV-2 antibody antibody Antibody Response Antibody titer Antibody titers B cell B cells BNT162b2 BNT162b2 mRNA vaccine CD8 clinical factor correlated COVID-19 feature fold Frequency healthcare worker immunological individual memory B cell mononuclear cell naïve naïve B cells naïve B cells. PBMC PBMCs Peripheral blood plasmablast positively correlated reducing reported response responses SARS-CoV-2 T cell transitional B cell underlie vaccination Vaccine [DOI] 10.1016/j.vaccine.2022.02.045 PMC 바로가기 [Article Type] Article
Recombinant human interleukin-7 reverses T cell exhaustion ex vivo in critically ill COVID-19 patientsResearch Published on 2022-03-052022-10-28 Journal: Annals of Intensive Care [Category] COVID-19, [키워드] administration Admission alteration alterations approaches Bacterial sepsis Blood Cell cell proliferation characteristic clinical setting collected COVID-19 COVID-19 patient COVID-19 patients Critically ill Critically ill patient CTLA-4 described evaluated Ex vivo Exhaustion expression feature flow cytometry hallmark Hospitalized ICU ICU admission ICU patient IFN-γ immune immunostimulation inhibited intensive care interleukin-7 lymphopenic marker mononuclear cell over-expression pathophysiology Pathways Patient PD-L1 peripheral proliferation recombinant Result reversed SARS-CoV-2 Sepsis severe coronavirus disease severe COVID-19 severe COVID-19 patient significantly supplementary material T cell T cell activation T cell proliferation T lymphocyte T lymphocyte response T lymphocytes therapeutic therapeutic strategy therapy transcriptomic profile treat [DOI] 10.1186/s13613-022-00982-1 PMC 바로가기 [Article Type] Research
Anticoagulation in Patients With COVID-19: JACC Review Topic of the WeekReview article Published on 2022-03-012022-10-05 Journal: Journal of the American College of Cardiology [Category] 임상, [키워드] anticoagulation association Autopsy being randomized benefit Care characterized clinical clinical trial Coagulopathy contributing to coronavirus COVID-19 COVID-19 infection Critically ill element Evidence Hospitalized hospitalized patient IMPROVE incidence intensive care investigated Laboratory mononuclear cell observational study outcome pathology Patient patients with COVID-19 prophylactic dose randomized trial reactivity review small blood vessels Strategy Support therapeutic therapeutic anticoagulation thromboembolic disease thrombosis Trial venous Week with COVID-19 [DOI] 10.1016/j.jacc.2021.12.023 [Article Type] Review article
Durable T-cellular and humoral responses in SARS-CoV-2 hospitalized and community patientsSARS-COV-2 입원 및 지역 사회 환자의 내구성 T- 세포 및 체액 반응Clinical Trial Published on 2022-02-222022-09-10 Journal: PLoS ONE [Category] COVID19(2023년), MERS, SARS, 변종, 임상, 진단, 치료기술, [키워드] age analyzed antibody Antibody Response Antibody responses assays Blood blood sample Blood samples boost Clinical data clinical observations collected Community Comorbidity determine diagnosed ELISA Gender Hospitalized Humoral response IFN-γ IgA IgG IgM IL-2 immune response Immunity immunosorbent impacted infected patients Infection interferon interferon-γ interleukin investigated long-term memory memory response microneutralization mononuclear cell mononuclear cells neutralization Neutralizing antibodies neutralizing antibody pandemic Patient patients peripheral Peripheral blood Peripheral blood mononuclear cells prospective cohort Protein pseudotype Re-infection recruited response Result risk RT-PCR SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike SARS-CoV-2 virus secreting serum sample serum samples severity severity of illness specific antibodies specific antibody T-cell Response T-cell responses vaccination variant variants of concern virus-specific T-cell response virus-specific T-cell responses viruses [DOI] 10.1371/journal.pone.0261979 PMC 바로가기 [Article Type] Clinical Trial