COVID-19–Related Hospitalization Rates and Severe Outcomes Among Veterans From 5 Veterans Affairs Medical Centers: Hospital-Based Surveillance StudyOriginal Paper Published on 2021-01-222022-10-31 Journal: JMIR Public Health and Surveillance [Category] COVID-19, MERS, [키워드] adjusted relative risk Admission Admitted Patient Affair affected age Alto At-risk Atlanta black calculated center Clinical outcome clinical outcomes COVID-19 COVID-19 hospitalization death demographics demonstrated diagnose died ethnic group fatality Fatality rate groups highest highlight Hispanic hospital Hospitalization Hospitalized hospitalized COVID-19 Houston incidence incidence rate increased risk intensive care Invasive mechanical ventilation Laboratory laboratory-confirmed Latino Los Angeles male median age Medical conditions Mortality MOST multisite not differ objective Older outcome Patient platform prevention Racial Rate required Result risk Surveillance surveillance network the disease the patient the United State The United States Treatment veteran white with COVID-19 [DOI] 10.2196/24502 PMC 바로가기 [Article Type] Original Paper
BCG vaccination history associates with decreased SARS-CoV-2 seroprevalence across a diverse cohort of health care workersObservational Study Published on 2021-01-192022-10-05 Journal: The Journal of Clinical Investigation [Category] 임상, [키워드] acute respiratory syndrome age and sex Analysis anti-SARS-CoV-2 IgG BCG BCG vaccination Care caused Clinical characteristics clinical symptom Cohort collected coronavirus coronavirus disease COVID-19 death decrease determine develop Effects HCW HCWs Health Health care worker incidence Influenza information Innate Innate immunity Los Angele multisite nonspecific participant pneumococcal Prospective clinical trial Protective protective effect Questionnaires Randomized reported retrospective SARS-CoV-2 SARS-CoV-2 IgG SARS-COV-2 infection SARS-CoV-2 seroprevalence Seroconversion Seroprevalence Therapeutic strategies vaccination Vaccine Vaccines [DOI] 10.1172/JCI145157 PMC 바로가기 [Article Type] Observational Study
Remote Methods for Conducting Tobacco-Focused Clinical Trials담배 중심 임상 시험을 수행하기 위한 원격 방법Review Published on 2020-12-122022-09-11 Journal: Nicotine & tobacco research : official journal of [Category] SARS, 임상, [키워드] approach benefit Biomarker clinical clinical trial clinical trials Community conducted Conducting coronavirus disease Coronavirus disease 2019 costly COVID-19 example focus Health implementation include inefficient Informed consent Local management medication Mobile health MOST multisite offer overcome pandemic provide recruitment Regulatory remote Research Trial unique [DOI] 10.1093/ntr/ntaa105 PMC 바로가기 [Article Type] Review
Clinical Performance of the Point-of-Care cobas Liat for Detection of SARS-CoV-2 in 20 Minutes: a Multicenter Study20분 내 SARS-CoV-2 검출을 위한 현장 진료 cobas Liat의 임상 성능: 다기관 연구Multicenter Study Published on 2020-11-252022-09-10 Journal: Journal of Clinical Microbiology [Category] 진단, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Care clinical clinical laboratories cobas 68/8800 SARS-CoV-2 cobas Liat SARS-CoV-2 and influenza A/B coronavirus coronavirus disease Coronavirus disease 2019 Coronavirus disease 2019 (COVID-19) detection diagnostic diagnostics drug Emergency Care enrolled FIVE food gold gold standard infection control Influenza Laboratory Laboratory test Liat molecular multicenter study multisite Nasopharyngeal swab nasopharyngeal swab specimen nucleic acid test Patient performance performed POC POC test point of care Point-of-Care (POC) positive provide Rapid respiratory reverse transcription reverse transcription-polymerase chain reaction (RT-PCR) RT-PCR RT-PCR testing SARS-CoV-2 SARS-CoV-2 test severe acute respiratory syndrome Coronavirus specimen [DOI] 10.1128/JCM.02811-20 PMC 바로가기 [Article Type] Multicenter Study
Protecting Frontline Health Care Workers from COVID-19 with Hydroxychloroquine Pre-exposure Prophylaxis: A structured summary of a study protocol for a randomised placebo-controlled multisite trial in Toronto, CanadaLetter Published on 2020-07-142022-10-29 Journal: Trials [Category] COVID-19, SARS, [키워드] 1:1 Activation age All participants anticipated baseline blinded block sizes blocked blood sample Canada Chloroquine circulating cirrhosis clinical clinician composite endpoint computer-generated Concomitant medication correlation Course COVID-19 COVID-19 negative criteria deficiency determine diabete diagnostic disease severity dissemination ECG element Encephalopathy endothelial Enrollment extension FIVE fixed Follow-up G6PD HCQ HCW Health care worker Hepatitis high risk hospital Hospitalization Hospitalized Host Hydroxychloroquine immune include individually randomized insulin intensive care units Intervention intervention arm intubation investigator Laboratory Liver disease Long marker microbiologically Mortality multisite neutralize non-invasive ventilation non-specific number objective offered Older open label Oropharyngeal outcome outcome measure parallel-group participant patients per day Placebo placebo-controlled plasma porphyria positive positive result pregnant Prevent Primary outcome Prophylaxis Protecting protocol Psychological distress psychological Impact QTc QTc interval randomised randomised placebo controlled trial reactive reduce Registered renal reported Research Respiratory failure risk of COVID-19 Sample size SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 virus secondary Seroconversion serology Standard status study period Study protocol Support symptom duration symptomatic syndrome Tablet tablets term Toronto Trial two group Two-arm undergo use of hydroxychloroquine ventilator viral PCR Viral RNA website worker [DOI] 10.1186/s13063-020-04577-8 PMC 바로가기 [Article Type] Letter
Safety and immunogenicity of a parenteral trivalent P2-VP8 subunit rotavirus vaccine: a multisite, randomised, double-blind, placebo-controlled trial비경구 3가 P2-VP8 소단위 로타바이러스 백신의 안전성 및 면역원성: 다중 부위, 무작위, 이중 맹검, 위약 대조 시험Article Published on 2020-07-012022-09-06 Journal: The Lancet. Infectious Diseases [Category] Communicable Disease, [키워드] adjusted Adults adverse event adverse events African age All participants analysed Antigen assigned baseline block block size block sizes blocks blood sample Blood samples Comparisons death Deltoid muscle dose dose-escalation double-blind Efficacy elicited eligible enrolment evaluate febrile febrile convulsion Final finding FIVE foundation funding geometric mean geometric mean titre gestation GRADE group groups HIV infection IgA IgG IgG seroresponse IgG seroresponses immunogenic immunogenicity immunogenicity endpoint Infant Infants injection Injections Intramuscular injection Laboratory Local Melinda Gate Melinda Gates Meningitis multisite neutralising antibody neutralising antibody response Neutralising antibody responses neutralising antibody seroresponse neutralising antibody seroresponses no significant difference no significant differences occurred parent parents participant Participants Placebo placebo group placebo recipient placebo recipients placebo-controlled placebo-controlled trial pneumococcal pneumococcal meningitis protocol randomisation randomised Randomly receive recipient Registered Research respiratory Respiratory tract infections response responses against rotavirus vaccination rotavirus vaccine Safety safety endpoint Serious Adverse Event Serious Adverse Events serum significantly higher South South Africa Strains subunit Support systemic adverse events systemic reaction systemic reactions the placebo group the vaccine timepoints Treatment Trial trivalent USA Vaccine was done were assessed [DOI] 10.1016/S1473-3099(20)30001-3 PMC 바로가기 [Article Type] Article
Efficacy of hydroxychloroquine for post-exposure prophylaxis to prevent severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection among adults exposed to coronavirus disease (COVID-19): a structured summary of a study protocol for a randomised controlled trialLetter Published on 2020-06-032022-10-29 Journal: Trials [Category] COVID-19, SARS, [키워드] 1:1 access acute respiratory syndrome addition age anticipated assigned Asymptomatic Baltimore baseline blinded blocked Bone marrow Boston Care Chloroquine clinically suspected close contact Complete Compound Concomitant concomitant use conducted Contact coronavirus coronavirus disease cough COVID-19 criteria current Date defined determine Diagnosis disorder dissemination Efficacy element eligible eligible participant etiology excluded first dose HCQ Health care worker healthcare worker history Hospitalized household household contact Hydroxychloroquine hypersensitivity incidence index case Infection Intervention leukocyte Los Angele medication moderate multisite neutropenia New Orlean New York City number objective outcome participant PCR-confirmed Pharmacist polymerase chain polymorphonuclear Post-exposure prophylaxis Prevent Primary outcome prolonged exposure Prophylaxis protocol psoriasis randomised randomised controlled trial randomization Randomized receive receiving Registered registry renal impairment responders resulting Sample size SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 PCR test Seattle Secondary objective Seven severe liver disease Shortness of breath statistical statistician stratified study drug study period Study protocol subjective fever syndrome Tamoxifen telehealth therapy Tolerability Treatment Trial Vaccine virus website women [DOI] 10.1186/s13063-020-04446-4 PMC 바로가기 [Article Type] Letter
Species‐specific clinical characteristics of human coronavirus infection among otherwise healthy adolescents and adultsShort Article Published on 2018-02-022022-10-30 Journal: Influenza and Other Respiratory Viruses [Category] Coronavirus, MERS, [키워드] adolescents and adult adolescents and adults Clinical characteristics coronavirus Coronavirus infection distribution Gastrointestinal symptom healthy Human ILI Infection influenza‐like illness multisite observé severity subject [DOI] 10.1111/irv.12538 PMC 바로가기 [Article Type] Short Article