myeloid cell – Page 5 – Communicable Diseases Research

Mild and Asymptomatic COVID-19 Convalescents Present Long-Term Endotype of Immunosuppression Associated With Neutrophil Subsets Possessing Regulatory Functions

경증 및 무증상 COVID-19 회복기 조절 기능을 보유한 호중구 하위 집합과 관련된 면역 억제의 장기 엔도타입 제시

Immunology

Published on 2021-09-292022-09-11
Journal: Frontiers in Immunology [Category] SARS, 진단, 치료기술,

Type I interferon autoantibodies are associated with systemic immune alterations in patients with COVID-19

I형 인터페론 자가항체는 COVID-19 환자의 전신 면역 변화와 관련이 있습니다

Research Article

Published on 2021-09-222022-09-10
Journal: Science Translational Medicine [Category] MERS, 유전자 메커니즘, 진단,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 alteration antibodies autoantibodies autoantibody caused change circulating leukocyte circulating leukocytes Control coronavirus coronavirus disease Coronavirus disease 2019 correlated Course COVID-19 Critical Critical disease dendritic cell description diagnosed disease course disease pathogenesis Effect elevated epitope evaluated Evidence evidence of expressed expression functional healthy controls help IFNs immune immune system Immunoglobulin in some increased expression individual individuals with COVID-19 inhibitory receptor interferon interferon response interferons ISG lack LAIR1 leukocyte leukocytes longitudinal mechanisms moderate disease monocyte Monocytes mononuclear cell mononuclear cells myeloid cell myeloid cells Patient patients with COVID-19 Peripheral blood Peripheral blood mononuclear cells peripheral blood samples Population Prevalence producing receptor reduced respiratory response SARS-CoV-2 severe acute respiratory syndrome Coronavirus Severe case severe cases severe disease severity single-cell Single-cell transcriptomics subset Support systemic impact systemic impacts the disease Transcriptome transcriptome sequencing transcriptomics turn Type type I Type I IFN type I interferon type I interferons
[DOI] 10.1126/scitranslmed.abh2624 PMC 바로가기 [Article Type] Research Article

Fatal cytokine release syndrome by an aberrant FLIP/STAT3 axis

비정상적인 FLIP/STAT3 축에 의한 치명적인 사이토카인 방출 증후군

Article

Published on 2021-09-132022-09-10
Journal: Cell Death and Differentiation [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, 치료제,

[키워드] approach caspase caspase-8 characterized clinical phenotype Control COVID-19 CRS cytokine Cytokine release syndrome Cytokines death detect dysregulated elevated expressed expression homolog immune disorders immune response immune responses Inflammation Inflammatory inflammatory pathology Inflammatory responses inflammatory state Intervention life-threatening Lung injury Lungs lymphopenia mice multiple organ dysfunction myeloid cell myeloid cells organ dysfunctions Organ failure organ failures pandemic pathogen invasion pathophysiology pathway Pathways Protein provoke regulated response SARS-CoV-2 pandemic STAT3 suppress syndrome the SARS-CoV-2 triggered Viral
[DOI] 10.1038/s41418-021-00866-0 PMC 바로가기 [Article Type] Article

Machine learning identifies molecular regulators and therapeutics for targeting SARS‐CoV2‐induced cytokine release

Article

Published on 2021-09-062022-10-31
Journal: Molecular Systems Biology [Category] COVID-19, SARS,

[키워드] Baricitinib cellular Chemical biology Combination COVID‐19 COVID‐19 patient cytokine cytokine production cytokine release Dexamethasone domain downstream drugs EPHA7 identify immunology induce Inflammatory inhibit inhibiting inhibitor IRAK1 JAK1 kinase kinases Lung inflammation machine machine learning MAP3K8 MAPK12 massive Microbiology, Virology & Host Pathogen Interaction moderate molecular myeloid cell N‐terminal domain NTD outcomes outperform PBMCs phenotypic phenotypic screening Ponatinib protein kinases required SARS‐CoV‐2 SARS‐CoV‐2 infection SARS‐CoV‐2 signaling pathway Spike protein therapeutic option Treatment Trigger variants
[DOI] 10.15252/msb.202110426 PMC 바로가기 [Article Type] Article

Neutrophils and lymphopenia, an unknown axis in severe COVID-19 disease

Opinion

Published on 2021-09-022022-10-29
Journal: PLoS Pathogens [Category] COVID-19, SARS,

[키워드] acute respiratory distress addition ARDS Asymptomatic Betacoronavirus caused CD4 CD8 Cell cells characterized coronavirus 2 COVID-19 defined degranulation described dysregulated effective Evidence fatal infection Granulocytic heterogeneous group Immunity implication lymphopenia Macrophage monocyte multi-organ failure myeloid cell NETosis neutralizing antibody neutrophil Phenotypes physiological Pneumonia pro-inflammatory required respiratory SARS-CoV-2 severe COVID-19 severe COVID-19 disease Severe COVID-19 Infection severe disease severe inflammation syndrome T cell response T lymphocyte T lymphocytes thrombosis triggered virus
[DOI] 10.1371/journal.ppat.1009850 PMC 바로가기 [Article Type] Opinion

Systems vaccinology of the BNT162b2 mRNA vaccine in humans

인간에서 BNT162b2 mRNA 백신의 시스템 백신학

Observational Study

Published on 2021-08-012022-09-11
Journal: Nature [Category] Fulltext, MERS, 변종, 비임상, 유전자 메커니즘, 임상, 진단,

[키워드] Adaptive immune response Analysis Antigen AP-1 approach B.1.351 B.1.351 variant BNT162b2 BNT162b2 mRNA vaccine booster booster vaccination CD14 CD16 CD4 CD8 T cell CD8 T cells Cluster Concentration demonstrated elicit Emergency use authorization evidenced Frequency greater healthy volunteer Human immune response immune responses immune system immunization increase in Inflammatory inflammatory monocytes innate antiviral immunity innate immune response innate immune system interferon landmark less monocyte Monocytes mRNA vaccination mRNA vaccine mRNA vaccines myeloid cell Neutralizing antibodies neutralizing antibody Neutralizing antibody response neutralizing antibody responses pathway Pfizer-BioNTech mRNA vaccine plasma protective immune response reduced robust SARS-CoV-2 second dose secondary immunization significant increases in single-cell stimulate stimulated System T cell T cells These data transcription factor transcription factors transcriptional transcriptomics vaccination wild-type SARS-CoV-2
[DOI] 10.1038/s41586-021-03791-x PMC 바로가기 [Article Type] Observational Study

Myeloid phenotypes in severe COVID-19 predict secondary infection and mortality: a pilot study

Research

Published on 2021-07-142022-10-28
Journal: Annals of Intensive Care [Category] COVID-19,

[키워드] Admission Analysis analyzed Antigen Cell Characteristics characterized circulating COVID-19 COVID-19 patient Critical Critically ill critically ill patients diagnose dysregulation evaluate expression flow cytometry HLA-DR host response Immune cell immunological Infection intensive care leukocyte lymphocyte mHLA-DR monocyte Mortality myeloid myeloid cell myeloid-derived suppressor cells Occurrence Patient patients died patients with COVID-19 phenotype phenotypic Phenotyping pilot study predict Result Secondary infection Sepsis Sepsis-induced immunodepression severe coronavirus disease severe COVID-19 significantly subpopulation supplementary material was performed
[DOI] 10.1186/s13613-021-00896-4 PMC 바로가기 [Article Type] Research

C9orf72 Intermediate Repeats Confer Genetic Risk for Severe COVID-19 Pneumonia Independently of Age

C9orf72 중간 반복은 연령과 관계없이 심각한 COVID-19 폐렴에 대한 유전적 위험을 부여합니다

Article

Published on 2021-06-292022-09-12
Journal: International Journal of Molecular Sciences [Category] MERS, SARS, 진단,

[키워드] 95% confidence interval acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 adjusted age allele ALS Amyotrophic lateral sclerosis association Autoimmune Autoimmune disorders autophagy C9orf72 caused characterized Clinical outcome Cohort contribute coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 pneumonia Critical Cytokine storm Cytokines Degradation determinants driving dysfunction expressed feature frontotemporal dementia functions Gene Expression genetic background genetic cause genetic risk haploinsufficiency Host immune functions impair independent Infection innate immune response Innate immunity intermediate intermediate alleles involved Lateral Sclerosis lysosomal magnitude mechanical ventilation modulate Mutation myeloid cell myeloid cells Neuroinflammation Non-invasive non-invasive or mechanical ventilation Odds ratio pathogenic Patient phenotype Phenotypes proinflammatory cytokines Regulation Repeat responsible risk risk factor SARS-CoV-2 SARS-CoV-2 infected patients severe acute respiratory syndrome Coronavirus severe coronavirus disease severe COVID-19 Severe COVID-19 pneumonia significantly systemic level These data
[DOI] 10.3390/ijms22136991 PMC 바로가기 [Article Type] Article

Severe COVID-19 Recovery Is Associated with Timely Acquisition of a Myeloid Cell Immune-Regulatory Phenotype

심각한 COVID-19 회복은 골수 세포 면역 조절 표현형의 적시 획득과 관련이 있습니다

Immunology

Published on 2021-06-232022-09-11
Journal: Frontiers in Immunology [Category] MERS, SARS, 치료기술,

[키워드] Aberrant inflammatory responses acquisition Activation Admission age and sex alteration Analysis basophil basophils best CD14 CD163 CD80 CD86 Cell circulating contribute COVID-19 COVID-19 outbreak cytokine Cytokine storm demonstrated dendritic cell described detectable discharge evaluated expansion expression flow cytometry HCs healthy control healthy controls healthy subjects ICU ICU Patients IFN-γ IL-10 IL-12p40 IL1RA immune-regulation increased expression Inflammatory responses innate immune system Innate immunity intensive care intensive care unit admission M2-like differentiation management marker mDCs mediators monocyte Monocytes myeloid myeloid cell pandemic pathogenic mechanism Patient patients patients with COVID-19 PD-L1 pDCs phenotype plasma positively correlated Prognosis reduced reduction Regulatory respiratory insufficiency SARS-CoV-2 SARS-COV-2 infection serum severe COVID-19 severe disease significantly significantly higher Slan specific antibodies stratified subset Support therapeutic agent therapeutic agents therapeutic interventions Treatment Viral Viral load
[DOI] 10.3389/fimmu.2021.691725 PMC 바로가기 [Article Type] Immunology

COVID-19 and RA share an SPP1 myeloid pathway that drives PD-L1 + neutrophils and CD14 + monocytes

COVID-19와 RA는 PD-L1 + 호중구 및 CD14 + 단핵구를 구동하는 SPP1 골수성 경로를 공유합니다

Research Article

Published on 2021-06-182022-09-10
Journal: JCI Insight [Category] MERS, 바이오마커,

[키워드] Activation alveoli appear Arthritis Autoimmune diseases BALF Bronchoalveolar lavage fluid cause CD14 CD48 Chronic inflammatory arthritis Cluster Concentration COVID-19 COVID-19 pathogenesis disease driven by FABP4 FCN1 hallmark healthy high plasma levels IHC Infectious disease Inflammation innate response intensive care unit investigation lung Macrophage macrophage cluster macrophage clusters macrophages mechanism mediators monocyte Monocytes myeloid cell neutrophil Neutrophils pathogenic pathology pathway PD-L1 plasma plasma concentrations Pneumonitis predicted Predictive predominant proinflammatory remained rheumatoid arthritis S100A12 severe COVID-19 severe pneumonia SPP1 synovial synovitis tissue trajectory transcriptionally transfer TREM2 unique upstream
[DOI] 10.1172/jci.insight.147413 PMC 바로가기 [Article Type] Research Article