myeloid cells – Page 5 – Communicable Diseases Research

Hydroxychloroquine (HCQ) decreases the benefit of anti-PD-1 immune checkpoint blockade in tumor immunotherapy

Research Article

Published on 2021-06-282022-10-28
Journal: PLoS ONE [Category] COVID-19,

AI-guided discovery of the invariant host response to viral pandemics

바이러스 전염병에 대한 불변 숙주 반응의 AI 유도 발견

Research Paper

Published on 2021-06-112022-09-11
Journal: EBioMedicine [Category] MERS, 바이오마커, 진단, 치료제,

[키워드] “cytokine storm” abrogate ACE2 acting analyzed Angiotensin converting enzyme (ACE)-2 Antiviral antiviral agent Apoptosis approach Artificial intelligence/machine learning Boolean equivalent clusters candidate drugs cause cell senescence center clinical conserved Cooperative Coronavirus COVID-19 coronavirus disease Coronavirus disease 2019 COVID-19 cytokine Cytokine storm dataset determine Diego disease severity EIDD-2801 elevated ENCODE entry of SARS-CoV-2 epithelial facilitate fatal COVID-19 fatal disease fatality finding Fund funding hamster Healthcare system High-dose host cells Host immune response host response Human IL15 IL15RA immune response immunologist implicated in viral Interleukin 15 (IL15) knowledge limit limits LJI lung Lung alveoli lung epithelial Lungs myeloid cell myeloid cells natural killer (NK) cells Neutralizing antibodies neutralizing antibody NIH NK cell office over Pandemics paradoxical Patient plasma Plasma levels President Program Quantitative receptor scientist signature STEM stem cell subset supported System therapeutic to define transcriptomic University of California utility Viral virus was used
[DOI] 10.1016/j.ebiom.2021.103390 PMC 바로가기 [Article Type] Research Paper

The immune modulatory effects of umbilical cord-derived mesenchymal stromal cells in severe COVID-19 pneumonia

Short Report

Published on 2021-06-022022-10-29
Journal: Stem Cell Research & Therapy [Category] COVID-19, MERS, SARS,

[키워드] accompanied addition assays baseline bronchoalveolar cellular chemokine circulating circulating monocyte Coronavirus disease 2019 COVID-19 Cytokines decrease effective ELISA Exploratory analysis flow cytometry functional immune modulatory effect immune reaction immunological immunomodulatory property immunosuppressive Infection Inflammatory inflammatory neutrophils Inflammatory response intensive care unit interleukin-6 life-threatening low-density Mesenchymal stromal cells MSC MSCs myeloid cells neutrophil neutrophil recruitment Patient Peripheral blood plasma Pneumonia pro-inflammatory cytokines pro-thrombotic reduction renal scRNA-seq Serum level severe COVID-19 Severe COVID-19 pneumonia Single-cell RNA sequencing stromal cell supplementary material T lymphocyte treated Treatment Trial tumor necrosis factor-α umbilical were assessed
[DOI] 10.1186/s13287-021-02376-9 PMC 바로가기 [Article Type] Short Report

SARS-CoV-2 exacerbates proinflammatory responses in myeloid cells through C-type lectin receptors and Tweety family member 2

Article

Published on 2021-05-092023-06-15
Journal: Immunity [Category] MERS, SARS,

[키워드] ASGR1 CLEC10A COVID-19 DC-SIGN L-SIGN LSECtin myeloid cells proinflammatory responses SARS-CoV-2 TTYH2
[DOI] 10.1016/j.immuni.2021.05.006 PMC 바로가기 [Article Type] Article

Colchicine acts selectively in the liver to induce hepatokines that inhibit myeloid cell activation

Research

Published on 2021-04-122022-10-05
Journal: Nature metabolism [Category] 바이오마커, 신약개발,

Heterogeneous NLRP3 inflammasome signature in circulating myeloid cells as a biomarker of COVID-19 severity

COVID-19 중증도의 바이오마커로서 순환하는 골수 세포의 이종 NLRP3 인플라마좀 시그니처

Article

Published on 2021-03-092022-09-11
Journal: Blood advances [Category] SARS, 바이오마커,

[키워드] Activation acute respiratory syndrome Biomarker Blood caspase caspase-1 CD66b Cell circulating coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient COVID-19 severity Critical critical COVID-19 patients dysregulated immune response eosinophil eosinophils Evolution granulocyte Granulocytes healthy donor healthy donors immature neutrophil immune response Infection Innate immunity key factor Mild monocyte Monocytes myeloid cell myeloid cells Neutrophils nigericin NLRP3 NLRP3 inflammasome outcome pathogen pathogen-associated molecular Patient predict proportion Registered respiratory restored severe acute respiratory syndrome Coronavirus Trial
[DOI] 10.1182/bloodadvances.2020003918 PMC 바로가기 [Article Type] Article

Deciphering the state of immune silence in fatal COVID-19 patients

Article

Published on 2021-03-052022-10-04
Journal: Nature Communications [Category] SARS, 바이오마커, 신약개발, 진단, 치료기술, 치료법, 치료제,

[키워드] Activation Analysis BAL Blood blood sample CD4-positive T cells Cell cell type characterized Clinical outcome COVID-19 COVID-19 patient Critical CXCR6 disease dysregulation effector memory Evolution Ex vivo expression fatal COVID-19 feature Features functional hallmark highlighting immune immune mechanism immune signature Immune suppression immunological impairment lung lymphoid lymphoid cell Monocytes myeloid cells naïve pandemic pathology Patient Prognosis Regulatory SARS-CoV-2 severe COVID-19 severe patients severity Single-cell RNA sequencing single-cell RNA-seq analysis T cell subset tissue tissue site to define unique viral infection
[DOI] 10.1038/s41467-021-21702-6 PMC 바로가기 [Article Type] Article

Arginase 1 ( Arg1 ) as an Up-Regulated Gene in COVID-19 Patients: A Promising Marker in COVID-19 Immunopathy

Article

Published on 2021-03-042022-10-30
Journal: Journal of Clinical Medicine [Category] COVID-19,

[키워드] acute respiratory syndrome Analysis antiviral immune responses antiviral immunity ARG1 arginase AUC Blood caused cDNA characteristic complementary coronavirus coronavirus disease COVID-19 COVID-19 patient COVID-19 patients demonstrated diagnostic diagnostic value DNA dysregulated expressed expression Gene Expression global pandemic healthy individual healthy individuals immune cells immune responses macrophages marker myeloid cells neutrophil outbreak Pathogenesis qPCR Real-time PCR relative expression RNA extraction ROC SARS-CoV-2 SARS-COV-2 infection significantly increased the disease was measured Whole blood
[DOI] 10.3390/jcm10051051 PMC 바로가기 [Article Type] Article

Afucosylated IgG characterizes enveloped viral responses and correlates with COVID-19 severity

Afucosylated IgG는 외피 바이러스 반응을 특성화하고 COVID-19 심각성과 상관 관계가 있습니다.

Research Article

Published on 2021-02-262022-09-10
Journal: Science (New York, N.y.) [Category] MERS, SARS, 변종, 진단,

[키워드] acute phase acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 ADCC amplify amplifying anti–SARS-CoV-2 IgG antibody antibody-dependent cellular cytotoxicity anticancer Antigen antigens Antiviral association Attenuated Virus B cell B cell response binding Blood blood cell Blood cells Blood Group C-reactive protein C-reactive protein (CRP cause Cell cellular circumvent Clinical outcome complement Concentration condition conserved coronavirus COVID-19 COVID-19 patient COVID-19 patients Critical Critically ill critically ill COVID-19 patients cytokine Cytokine storm dengue virus destruction determined by disparate domain domains elevated Exacerbation example excessive inflammation Fc receptor Fc receptors FcγRIIIa foreign antigen foreign antigens fucose functions glycoprotein Glycoproteins glycosylation help hepatitis B Hepatitis B virus HIV host cell host cells humans Hypothesis IgG IgG antibody IgG immune response IgG response IgG responses IL-6 Immune cell immune response immune responses Immune-mediated Immunoglobulin Immunoglobulin G in some in vitro individual individuals induce initiate interleukin-6 invading pathogens investigated isotype Macrophage macrophages membrane Mild disease mild symptoms mRNA vaccines myeloid cells natural infection natural killer occur over Pathogens Pathologies pathology Patient patients plasma position proinflammatory Proinflammatory cytokine promote promoted Protective Protein Protein subunit receptor receptors Region report reported required respiratory response responses responses against SARS-CoV-2 Science Seroconversion severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 severe COVID-19 severe symptom severe symptoms severity strength subclass subunit sugar surface protein target target cell target cells tested therapeutic therapeutic antibodies Treatment Trigger vaccination Vaccinations Vaccine variant Viral Viral load virus viruses with COVID-19 with mild disease
[DOI] 10.1126/science.abc8378 PMC 바로가기 [Article Type] Research Article

CXCL17 Is a Specific Diagnostic Biomarker for Severe Pandemic Influenza A(H1N1) That Predicts Poor Clinical Outcome

Immunology

Published on 2021-02-262022-11-01
Journal: Frontiers in Immunology [Category] COVID-19, MERS, 신종인플루엔자,

[키워드] A549 cell Admission Algorithm alveolar analyzed Anti-viral assays Autopsy Cell culture chemokine chemokines chemotactic clinical Cohort cohort of patient coronavirus disease COVID-19 COVID-19 patients CXCL17 died ELISA enrolled enzyme-linked immunosorbent evaluated exhibit expressed expression expression pattern functions Future Hospitalization humans immunohistochemistry incidence Influenza influenza A(H1N1) Ligand lung lung tissue machine-learning Mexico City monocyte-derived macrophage Mortality motif myeloid cells other respiratory infection pandemic Patient patients Peripheral blood Peripheral blood sample Poor poor prognosis post-mortem lung predict processed Prognostic value PTB pulmonary tuberculosis Regression analyses renal required respiratory pathogen respiratory tract SARS-CoV-2 Seasonal influenza serum Serum level Seven Specific specimen the disease Tuberculosis utility virus infection was tested
[DOI] 10.3389/fimmu.2021.633297 PMC 바로가기 [Article Type] Immunology