Mutational spectra of SARS-CoV-2 orf1ab polyprotein and signature mutations in the United States of AmericaSARS-CoV-2 orf1ab 다단백질의 돌연변이 스펙트럼 및 미국의 시그니처 돌연변이Article Published on 2021-03-012022-09-11 Journal: Journal of medical virology [Category] SARS, 변종, [키워드] affected Alter America Amino acid amino acids Analysis analyzed antiviral therapeutics Asia calculated caused changes in Clustal Omega Comparative analysis Complete complex COVID-19 COVID-19 outbreak database death domain Europe followed by Helicase imperative in viral Infection Multiple Multiple sequence alignment Mutation mutational spectra NCBI nonstructural proteins ORF1 ORF1ab ORF1ab polyprotein pandemic pathogen Patient polyprotein polyproteins predicted predominant protein sequence Proteins replicase reported resulting RNA synthesis SARS-CoV-2 sequence Sequence alignment statistical significance the United State The United States unique United State United States United States of America Viral Viral RNA viral RNA synthesis virus [DOI] 10.1002/jmv.26417 PMC 바로가기 [Article Type] Article
SARS-CoV-2 infection: molecular mechanisms of severe outcomes to suggest therapeuticsSARS-CoV-2 감염: 치료법을 제안하는 심각한 결과의 분자 메커니즘Review Published on 2021-02-012022-09-11 Journal: Expert review of proteomics [Category] MERS, 유전자 메커니즘, 진단, [키워드] acute respiratory distress acute respiratory distress syndrome acute respiratory distress syndrome. ARDS Area base pair base pairs Biomarker Biomarkers Clinical course clinical risk factor Clinical risk factors Combination COVID-19 cytokine cytokine signaling dataset datasets defined door drug endotheliopathy expert genetics Google Scholar Human Impact infect Infection literature MODS molecular molecular mechanism multiple organ dysfunction multiple organ dysfunction syndrome NCBI NETosis opens organ dysfunction syndrome outcome pathology pathway Patient patients with COVID-19 Pneumonia positive feedback positive feedback loop Precision pyroptosis respiratory distress Respiratory distress syndrome Risk factors RNA SARS-CoV-2 SARS-CoV-2 genome secondary infections severe COVID-19 SRA Support syndrome tested the SARS-CoV-2 genome therapeutic Therapeutics thrombocytopathy treat Treatment Treatment strategies treatment strategy understanding unique [DOI] 10.1080/14789450.2021.1908894 PMC 바로가기 [Article Type] Review
Potential compound from herbal food of Rhizoma Polygonati for treatment of COVID-19 analyzed by network pharmacology: Viral and cancer signaling mechanismsResearch article Published on 2021-02-012022-10-05 Journal: Journal of Functional Foods [Category] 치료법, [키워드] 3CL hydrolase analyzed binding Cancer China Chinese component Compound COVID-19 database docked enzyme II higher affinity homology host cell mechanism molecular docking NCBI network pharmacology New coronavirus pneumonia other compound pandemic Potential prediction Protein Rhizoma polygonati RNA-dependent RNA polymerase SARS-CoV-2 SARS-CoV-2 protein Signaling spike target targets TCMSP tested treating COVID-19 Treatment [DOI] 10.1016/j.jff.2020.104149 [Article Type] Research article
A protocol for adding knowledge to Wikidata: aligning resources on human coronavirusesWikidata에 지식을 추가하기 위한 프로토콜: 인간 코로나바이러스에 대한 리소스 정렬Methodology Article Published on 2021-01-222022-09-10 Journal: BMC Biology [Category] Fulltext, MERS, 유전자 메커니즘, [키워드] added aligned aligning applicability applied automated automatically bases Biotechnology can be used caused center commons coronavirus COVID-19 COVID-19 pandemic defined demonstrated example Genome genomes help helping HKU1 human coronavirus human coronavirus 229E integration knowledge knowledge bases Knowledge graph Linked data MERS NCBI new virus NL63 Open Science pandemic platform problems proteome proteomes protocol related virus related viruses required resource Result SARS-CoV-2 pandemic SARS-CoV-2 virus shape ShEx taxonomy the SARS-CoV-2 the SARS-CoV-2 virus UniProt unique viruses Wikidata Wikipedia [DOI] 10.1186/s12915-020-00940-y PMC 바로가기 [Article Type] Methodology Article
The UCSC Genome Browser database: 2021 updateUCSC 게놈 브라우저 데이터베이스: 2021년 업데이트AcademicSubjects/SCI00010 Published on 2021-01-082022-09-10 Journal: Nucleic Acids Research [Category] MERS, 유전자 메커니즘, [키워드] added annotation Community coronavirus database display elements ENCODE feature gene annotation gene annotations Genome genome browser Genomics heatmap Improvements include Matched NCBI New outbreak promoter promoters provided RefSeq released required Research RNA the SARS-CoV-2 Trio UCSC Genome Browser VCF files [DOI] 10.1093/nar/gkaa1070 PMC 바로가기 [Article Type] AcademicSubjects/SCI00010
Potential Mechanisms for Traditional Chinese Medicine in Treating Airway Mucus Hypersecretion Associated With Coronavirus Disease 2019Molecular Biosciences Published on 2020-12-142022-10-31 Journal: Frontiers in Molecular Biosciences [Category] COVID-19, [키워드] Affect airway Airway mucus Algorithm Analysis applied association binding Bioconductor biological basis Bronchiole Chinese clearance collected complications Compound coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 disease COVID-19 patient Critical cytokine receptor cytokine-related pathways Cytoscape software death Deterioration dysfunction expectorant formulae Frequency functional enrichment Health hypersecretion Hypoxemia ingredient Interaction MAPK mechanism mechanisms Medicine modulating Mortality mucins Mucus NCBI network analysis network pharmacology objective pandemic pathway Potential PPI Protein Receptor binding regulate Result retrieved subsequent target targets TCM TCMSP database Therapies Traditional Traditional Chinese medicine treating treating COVID-19 Treatment was done [DOI] 10.3389/fmolb.2020.577285 PMC 바로가기 [Article Type] Molecular Biosciences
Conservation analysis of SARS-CoV-2 spike suggests complicated viral adaptation history from bat to humanOriginal Research Article Published on 2020-11-052022-11-01 Journal: Evolution, Medicine, and Public Health [Category] COVID-19, [키워드] acute respiratory syndrome analyses Analysis analyzed bat coronavirus RaTG13 carried caused conservation conservation analysis Contact coronavirus coronavirus disease coronavirus strains CoV COVID-19 domain GISAID groups Host identify Multiple sequence alignment N-terminal domain NCBI pandemic pangolin coronavirus pangolin CoV Phylogenetic plague public health emergency RaTG13 RBD Receptor-binding domain recombination event recombine Result reveal S2 subunit SARS-CoV-2 SARS-CoV-2 RBD SARS-CoV-2 spike sequence similarity spike strain Strains Transmission Variation viral adaptation virus was used whole-genome [DOI] 10.1093/emph/eoaa041 PMC 바로가기 [Article Type] Original Research Article
Non-SARS-CoV-2 genome sequences identified in clinical samples from COVID-19 infected patients: Evidence for co-infectionsMicrobiology Published on 2020-11-022022-10-28 Journal: PeerJ [Category] COVID-19, [키워드] 2019-nCoV acute respiratory syndrome Adenovirus Bacteria Bacterial caused China clinical sample Co-infection Co-infections concern coronavirus coronavirus disease COVID-19 Critical database Emergency extension genome sequence H7N9 Hepatitis Host immune response Human Human immunodeficiency virus Infection infections influenza A virus K -mer Kraken 2 métapneumovirus NCBI Next-generation sequencing NL63 outbreak outcome patients PHEIC Pneumonia Population Public reported Result retrieved SARS-CoV-2 SARS-CoV-2 infected patient SARS-CoV-2 infected patients sequence Sequence Read Archive Taxonomic viral fitness virus virus genome was performed WHO World Health Organization Wuhan [DOI] 10.7717/peerj.10246 PMC 바로가기 [Article Type] Microbiology
Transcriptomic analysis reveals novel mechanisms of SARS‐CoV‐2 infection in human lung cellsOriginal Research Published on 2020-10-302022-10-30 Journal: Immunity, Inflammation and Disease [Category] COVID-19, MERS, SARS, [키워드] ACE2 acute respiratory syndrome Analysis approach Bioinformatics analysis clade conducted coronavirus COVID‐19 COVID‐19 database demonstrated downloaded effective enzyme expression facilitate feature Gene Expression Omnibus Gene ontology Genes global pandemic host cell human lung cell human lung cells immune induce interferon response Interpretation Kyoto mechanism metabolism NCBI objective ORF1ab ORF6 pathway positive correlation pyrimidine metabolism Replication responsible Result reveal RNA virus SARS‐CoV‐2 SARS‐CoV‐2 infection SARS‐CoV‐2 steroid biosynthesis Treatment upregulation virus [DOI] 10.1002/iid3.366 PMC 바로가기 [Article Type] Original Research
Prediction and evolution of B cell epitopes of surface protein in SARS-CoV-2Research Published on 2020-10-292022-10-28 Journal: Virology Journal [Category] COVID-19, MERS, SARS, [키워드] Amino acid Analysis analyzed antibodies antibody antigenic applied B cell epitope bioinformatics caused Characteristics conformational conserved coronavirus determinant disease effective epitope Epitopes Evolution experiment facilitate form Frequency GISAID immune system linear linear epitope membrane Mutation natural proteins NC_045512.2 NCBI polypeptide polypeptides predict predicted prediction Prevent Proteins recognize reference Result SARS-CoV-2 SARS-CoV-2 genomes SARS-CoV-2 vaccine sequence stimulate surface protein the SARS-CoV-2 the vaccine threat Vaccine development vector whole genome [DOI] 10.1186/s12985-020-01437-4 PMC 바로가기 [Article Type] Research