The genetic architecture of pneumonia susceptibility implicates mucin biology and a relationship with psychiatric illness Research Published on 2022-06-292022-10-05 Journal: Nature Communications [Category] 신약개발, 유전자 메커니즘, [키워드] Analysis association cause clinically correlation death Diagnosis Evidence Genetic genetic architecture genetics histocompatibility complex region identify implicated mapped Meta-analysis MUC5AC Necrosis overlap pathway phenotype Pneumonia Precision Psychiatric receptor risk risk score smoking Support susceptibility target targets TNFRSF1A Treatment utilised variant widespread [DOI] 10.1038/s41467-022-31473-3 [Article Type] Research
COVID-19 & differential effects in twins: Insights from Placenta PathologyCOVID-19 및 쌍둥이의 차별적 영향: 태반 병리학의 통찰력Case Reports Published on 2022-06-242022-09-11 Journal: Placenta [Category] COVID19(2023년), SARS, 변종, 치료기술, [키워드] ACE2 age COVID-19 Effect expression female fetal gestational age identify Infection insight Interaction interactions male Necrosis outcomes Placenta Placentas Pregnancy Premature premature delivery receptor SARS-CoV-2 Sex survival Task Force tissue twin twin pregnancy unique were used [DOI] 10.1016/j.placenta.2022.05.014 PMC 바로가기 [Article Type] Case Reports
Risks of SARS-CoV-2 Infection and Immune Response to COVID-19 Vaccines in Patients With Inflammatory Bowel Disease: Current Evidence염증성 장 질환 환자의 코로나19 백신에 대한 SARS-CoV-2 감염 및 면역 반응의 위험: 현재 증거Review Published on 2022-06-232022-09-11 Journal: Frontiers in Immunology [Category] 변종, [키워드] aberrant immune response Affect available data bowel Combination condition Corticosteroid Corticosteroids Course COVID-19 COVID-19 vaccine COVID-19 vaccines Crohn's disease Crohn’s disease current disease dysregulated environmental factors Factor forms healthy subjects IBD immune immune response immunogenicity Immunosuppressant immunosuppressants increased risk infection with SARS-CoV-2 infections Inflammatory Inflammatory bowel disease inflammatory bowel diseases intestinal intestinal disease less majority many case many cases measure modify Necrosis occur pandemic Pathogens Patient patients treated PROTECT Psychological psychological factors question receive reduce reduced response risk SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 variant SARS-CoV-2 variants significantly increased subject susceptibility susceptibility to infection susceptible individual therapy ulcerative colitis Vaccine [DOI] 10.3389/fimmu.2022.933774 PMC 바로가기 [Article Type] Review
Biochemical, biophysical, and immunological characterization of respiratory secretions in severe SARS-CoV-2 infections중증 SARS-CoV-2 감염에서 호흡기 분비물의 생화학적, 생물물리학적 및 면역학적 특성 규명Article Published on 2022-06-222022-09-12 Journal: JCI Insight [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] Cadaveric characterized collected component control sample correlated COVID-19 COVID-19 infection DNA DNase elevated exhibited fibrosis genetic disease heterogeneous histologic immunological increases in indicated Infection Inflammatory Inflammatory cytokine Innate Innate immunity Intubated COVID-19 patients lung tissue Necrosis pathogenic patients percentage physical Protein Pulmonology reduced Respiration secretion sensitivity severe SARS-CoV-2 staining suggested therapeutic target Thick Treatment type I interferon [DOI] 10.1172/jci.insight.152629 PMC 바로가기 [Article Type] Article
TNF-α + CD4 + T cells dominate the SARS-CoV-2 specific T cell response in COVID-19 outpatients and are associated with durable antibodiesTNF-α + CD4 + T 세포는 COVID-19 외래 환자에서 SARS-CoV-2 특이적 T 세포 반응을 지배하고 내구성 항체와 관련이 있습니다Article Published on 2022-06-212022-09-11 Journal: Cell Reports Medicine [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, [키워드] acute infection acute respiratory syndrome acute respiratory syndrome coronavirus Alpha antibodies antibody boost CD4 Cell Cohort coronavirus Coronavirus 2019 COVID-19 COVID-19 outpatient Cytokines enrolled feature IFNγ IL-21 Immunity Infection interferon gamma longitudinal maintenance mRNA mRNA vaccination NCT04331899 Necrosis Neutralizing antibodies neutralizing antibody percentage Post-infection predominant producing respiratory SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2-neutralizing antibodies SARS-CoV-2-neutralizing antibody severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 T cell T cell response T cells Tfh the SARS-CoV-2 These data TNF-α Tumor tumor necrosis tumor necrosis factor tumor necrosis factor alpha [DOI] 10.1016/j.xcrm.2022.100640 PMC 바로가기 [Article Type] Article
Serological Response to BNT162b2 Anti-SARS-CoV-2 Vaccination in Patients with Inflammatory Rheumatic Diseases: Results From the RHEUVAX Cohort염증성 류마티스 질환 환자에서 BNT162b2 Anti-SARS-CoV-2 백신 접종에 대한 혈청학적 반응: RHEUVAX 코호트의 결과Article Published on 2022-06-172022-09-12 Journal: Frontiers in Immunology [Category] MERS, SARS, 진단, [키워드] abatacept age Analysis anti-SARS-CoV-2 vaccine antibody Antibody titer Antibody titers Arthritis Autoimmunity autoinflammatory disease BNT162b2 CCS Community connective tissue connective tissue disease connective tissue disease (CTD) Control Corticosteroid COVID-19 COVID-19 epidemic CTD CTRL disease dose Effective vaccines eight Factor Health profession higher risk identify immune immunological Immunosuppressive medication impair inhibitor IQR jak inhibitors Logistic regression Lower median MMF mycophenolate Necrosis of BNT162b2 Patient patients performed Protein protocol recruited response response to vaccination Result rheumatic and muscoluskeletal disease rheumatic disease rheumatoid arthritis rituximab Sample seroconversion rate severe COVID-19 Specific spike Treatment vaccination vaccine dose Vaccines Vasculitis [DOI] 10.3389/fimmu.2022.901055 PMC 바로가기 [Article Type] Article
The Spike Protein of SARS-CoV-2 Impairs Lipid Metabolism and Increases Susceptibility to Lipotoxicity: Implication for a Role of Nrf2SARS-CoV-2의 스파이크 단백질은 지질 대사를 손상시키고 지방독성에 대한 감수성을 증가시킵니다: Nrf2의 역할에 대한 의미Article Published on 2022-06-142022-09-11 Journal: Cells [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 alterations autophagic autophagic pathway autophagy Cell cell line cell membrane cell membranes control cell control cells controls coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 dose-dependent manner dysregulation exhibited expression expression profile Ferroptosis Gene Expression Gene expression profiles HEK293 host cells impair increase inhibitor investigated Lipid lipid metabolism lipotoxicity mechanism metabolism molecules multifunctional Necrosis Nrf2 nuclear palmitic acid pathway Patient Protein role SARS-CoV-2 severe acute respiratory syndrome Coronavirus significant increase spike Spike protein suppressed susceptibility the Spike transcriptional trigonelline upregulation was used [DOI] 10.3390/cells11121916 PMC 바로가기 [Article Type] Article
Plasma Markers of Neurologic Injury and Inflammation in People With Self-Reported Neurologic Postacute Sequelae of SARS-CoV-2 InfectionSARS-CoV-2 감염의 자가 보고된 신경학적 후급성 후유증이 있는 사람들의 신경학적 손상 및 염증의 혈장 표지자Article Published on 2022-06-142022-09-11 Journal: Neurology® neuroimmunology & neuroinflammation [Category] COVID19(2023년), MERS, SARS, 바이오마커, [키워드] 95% CI absolute levels Acidic acute infection acute respiratory syndrome acute respiratory syndrome coronavirus biologic CNS Cohort coronavirus correlated correlation correlations defined demonstrated early recovery elevated Elevation elevations examined exhibited Fold change Fold changes GFAp greater identify immune activation immunologic marker individuals Infection Inflammation inflammatory pathway initial Injury interleukin interleukin 6 Intervention involved less light chain linear marker mechanism mixed-effects model monocyte monocyte chemoattractant protein 1 Necrosis neurologic not differ PASC Prevent primary clinical outcome Protein Recovery time reported respiratory SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 Symptom Symptoms treat Tumor tumor necrosis tumor necrosis factor tumor necrosis factor α [DOI] 10.1212/NXI.0000000000200003 PMC 바로가기 [Article Type] Article
Intravenous Injection of Coronavirus Disease 2019 (COVID-19) mRNA Vaccine Can Induce Acute Myopericarditis in Mouse Model코로나바이러스 질환 2019(COVID-19) mRNA 백신의 정맥 주사가 마우스 모델에서 급성 심근염을 유발할 수 있음Article Published on 2022-06-102022-09-12 Journal: Clinical Infectious Diseases: An Official Publicat [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] acute respiratory syndrome antigen expression Apoptosis Ballooning degeneration Blood Can cardiac Cardiac pathology change changes clinical manifestations coronavirus coronavirus disease COVID-19 COVID-19 mRNA vaccine different time point dose Evidence evidenced hepatocyte histological change histopathological IL-6 immunization immunostaining in vivo induce infiltrating immune cell inflammatory cell infiltration injection interferon intracardiac intramuscular intravenous Intravenous injection Messenger RNA mice Model mouse mouse model mRNA mRNA expression mRNA vaccine myocytes Myopericarditis Necrosis other organ provided reduce reported risk SARS-CoV-2 serum Serum level significantly significantly higher skeletal tissue Vaccine vaccine injection Vaccines vascular endothelial cells visceral weight loss Withdrawal [DOI] 10.1093/cid/ciab707 PMC 바로가기 [Article Type] Article
Early Th2 inflammation in the upper respiratory mucosa as a predictor of severe COVID-19 and modulation by early treatment with inhaled corticosteroids: a mechanistic analysis중증 COVID-19의 예측인자로서 상부 호흡기 점막의 초기 Th2 염증 및 흡입 코르티코스테로이드 조기 치료에 의한 조절: 기계론적 분석Clinical Trial Published on 2022-06-012022-09-11 Journal: The Lancet. Respiratory Medicine [Category] COVID19(2023년), SARS, 바이오마커, 신약개발, 임상, 치료법, 치료제, [키워드] 1:1 adaptive airway Analysis Anti-viral antipyretics assigned AstraZeneca Biomarker Blood blood sample Blood samples Budesonide CCL17 chemokine clinical benefit clinical symptom clinical trial clinically Cohort collected Concentration Corticosteroid Course COVID-19 COVID-19 disease COVID-19 disease course Data collection decrease deteriorate dose early treatment Efficacy elevated enzyme eosinophil epithelial epithelial lining Evolution experimental analysis healthy controls healthy individuals IL-33 immunoassay individual Inflammation Inflammatory Inflammatory mediators Inflammatory response Inhaled inhaled budesonide inhaled corticosteroid initial interferon interferon response interleukin Intervention investigated Ligand marker mechanism Meso Scale Discovery modulated modulation mucosa mucosal nasal Nasal sample nasal samples Necrosis negative control nose Observational data open label outcomes over Oxford parallel group participant Patient patients with SARS-CoV-2 Phase 2 Primary outcome Proteins randomisation randomised Randomly receive recruited reducing Registered respiratory tract SARS-COV-2 infection severe COVID-19 severe COVID-19 disease shown systemic inflammation T-cell Response Th2 the SARS-CoV-2 Treatment Trial tumour necrosis factor tumour necrosis factor-α twice a day University of Oxford upper respiratory usual care usual care group was collected were assessed were used Whole blood with COVID-19 [DOI] 10.1016/S2213-2600(22)00002-9 PMC 바로가기 [Article Type] Clinical Trial