no effect – Page 5 – Communicable Diseases Research

Improved COVID-19 outcomes in a large non-invasive respiratory support cohort despite emergence of the alpha variant

알파 변이의 출현에도 불구하고 대규모 비침습적 호흡기 지원 코호트에서 개선된 COVID-19 결과

Article

Published on 2021-11-012022-09-11
Journal: BMJ Open Respiratory Research [Category] Coronavirus, SARS, 변종,

Resilience, coping, and distress among healthcare service personnel during the COVID-19 pandemic

Research

Published on 2021-10-062022-10-27
Journal: BMC Psychiatry [Category] Coronavirus, MERS, SARS,

Efficacy and secondary infection risk of tocilizumab, sarilumab and anakinra in COVID‐19 patients: A systematic review and meta‐analysis

코로나19 환자에서 토실리주맙, 사릴루맙, 아나킨라의 효능 및 2차 감염 위험: 체계적 고찰 및 메타분석

Review

Published on 2021-09-242022-09-12
Journal: Reviews in Medical Virology [Category] COVID19(2023년), SARS, 진단,

SARS-CoV-2-neutralising monoclonal antibodies for treatment of COVID-19

COVID-19 치료를 위한 SARS-CoV-2-중화 단일클론항체

Review

Published on 2021-09-022022-09-11
Journal: The Cochrane database of systematic reviews [Category] SARS, 변종, 임상,

[키워드] 95 % CI 95% CI 95% confidence interval Admission adverse event adverse events AEs all-cause mortality antibody approach average age B cell B cells bamlanivimab Blinding Casirivimab certainty certainty of evidence checked clinical Cochrane COVID-19 Study Register Combination combination therapy conducted coronavirus disease Coronavirus disease 2019 COVID-19 Data collection database death decrease dose Effectiveness etesevimab evaluated event Evidence excluded first test GRADE hospital Hospital admission Hospital admissions hospital discharge hospitalised Host Human identify Imdevimab IMV individual individuals with COVID-19 initial Intervention Invasive mechanical ventilation investigated lack life limitation mAb mAbs maintain moderate monoclonal antibodies monoclonal antibody Mortality NCT04427501 neutralising mAbs nine no effect non-hospitalised occurred outcome oxygen Oxygen requirement participant Participants patients with COVID-19 people with COVID-19 Placebo placebo group placebo treatment potential therapy progression Prophylactic provided Quality of life randomised controlled trial RCT reduce regdanvimab reported risk risk of bia risk ratio RoB2 SAE SAEs Sample size SARS-CoV-2 variant SARS-CoV-2 variants searched Selection Serious Adverse Event Serious Adverse Events severe symptom severe symptoms slight increase Sotrovimab submission Symptom systematic review target the placebo group treat treated Treatment treatment of COVID-19 usual care usual care alone
[DOI] 10.1002/14651858.CD013825.pub2 PMC 바로가기 [Article Type] Review

Effect of the coronavirus pandemic on tumor markers

코로나 바이러스 전염병이 종양 마커에 미치는 영향

Article

Published on 2021-09-012022-08-31
Journal: Journal of medical virology [Category] MERS, SARS, 바이오마커,

[키워드] acute respiratory syndrome addition AFP age Antigen C-reactive protein CA125 CA19-9 Cancer Carcinoembryonic antigen CEA conducted coronavirus coronavirus disease Coronavirus disease 2019 coronavirus disease-2019 COVID-19 COVID-19 patients creatinine died Effect elevated except for had no hospital infected with COVID-19 Injury intensive care intensive care unit Laboratory laboratory biomarker laboratory parameter Laboratory parameters leukopenia limits Liver function test liver function tests Multiple Multiple organ damage no effect normal ranges occur organ damage pandemic Patient patients Previous studies previous study procalcitonin procalcitonin level Research retrospective cohort study Severe acute respiratory syndrome shown the patient Tumor tumor marker tumor markers tumor markers. women
[DOI] 10.1002/jmv.27057 PMC 바로가기 [Article Type] Article

Resilience and personality as predictors of the biological stress load during the first wave of the Covid-19 pandemic in Germany

Observational Study

Published on 2021-08-282022-10-04
Journal: Translational Psychiatry [Category] MERS, SARS, 바이오마커, 임상,

COVID19-associated cardiomyocyte dysfunction, arrhythmias and the effect of Canakinumab

COVID19 관련 심근 세포 기능 장애, 부정맥 및 카나 키누맙의 효과

Research Article

Published on 2021-08-192022-09-10
Journal: PLoS ONE [Category] MERS, SARS, 신약개발, 진단,

[키워드] addition aims amplitude Anti-inflammatory therapy approach ARDS arrhythmia Arrhythmias baseline canakinumab cardiac function cardiac injury Cell cellular Co-incubation coronavirus coronavirus disease COVID19 COVID19 patient COVID19 patients cytokine cytokine release cytosolic decrease dysfunction Effect electrical evaluated event exposure to had no ICU IL-1β impaired cardiac function In-vitro Incubation Inflammatory response intensive care intensive care unit investigated Isolated LVEF membrane Microscopy mitigate Mortality no effect nuclear occur Patient patients pharmacological Precision RAT Result SARS-CoV-2 sensitivity serum severe ARDS Signaling significantly stem cell therapeutic potential veno-venous extracorporeal membrane oxygenation ventricular
[DOI] 10.1371/journal.pone.0255976 PMC 바로가기 [Article Type] Research Article

Association Between Administration of IL-6 Antagonists and Mortality Among Patients Hospitalized for COVID-19: A Meta-analysis

IL-6 길항제 투여와 COVID-19로 입원한 환자의 사망률 사이의 연관성: 메타 분석

Meta-Analysis

Published on 2021-08-102022-09-11
Journal: JAMA [Category] MERS, 임상, 진단,

[키워드] 95% CI Administered administration all-cause mortality antagonist antagonists assessment assessment tool association assumed benefit Bia clinical clinical trial clinical trials contact with Corticosteroid Corticosteroids COVID-19 criteria data extraction database death Efficacy eligible Hospitalized IL-6 IL-6 antagonist immunomodulator inconsistency Infection Invasive mechanical ventilation language median age medians Meta-analysis Mortality mortality risk no effect occurred Odds ratio Odds ratios Other outcomes outcome outcomes Patient patients hospitalized patients randomized patients treated Placebo primary analysis primary outcome measure progression randomization randomly assigned patient receiving reported risk risk of bia sample sizes sarilumab Secondary infection secondary infections secondary outcome synthesis through contact Tocilizumab Trial trials usual care women
[DOI] 10.1001/jama.2021.11330 PMC 바로가기 [Article Type] Meta-Analysis

Effect of multiple freeze–thaw cycles on the detection of anti-SARS-CoV-2 IgG antibodies

항 SARS-CoV-2 IgG 항체 검출에 대한 다중 동결-해동 주기의 영향

Disease, Diagnosis and Diagnostics

Published on 2021-08-062022-09-10
Journal: Journal of Medical Microbiology [Category] MERS, SARS, 진단, 치료기술, 치료법, 치료제,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 Analysis anti-SARS-CoV-2 IgG anti-SARS-CoV-2 IgG antibody antibodies Antibody detection average Coronavirus-2 COVID-19 detect detection Effect ELISA ELISA assay ELISA test except for freeze had no IgG IgG antibodies investigated Linear regression log no effect no significant difference nucleocapsid Participants positive random effect repeated replicate replicates respiratory RNA SARS-CoV-2 SARS-CoV-2 antibody SARS-CoV-2 IgG SARS-CoV-2 IgG antibodies sera serum Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus significant difference slope statistical analysis tested thaw was performed
[DOI] 10.1099/jmm.0.001402 PMC 바로가기 [Article Type] Disease, Diagnosis and Diagnostics

Remdesivir for the treatment of COVID-19

코로나19 치료제 렘데시비르

Article

Published on 2021-08-052022-09-11
Journal: The Cochrane database of systematic reviews [Category] SARS, 임상, 치료제,

[키워드] 95% CI 95% confidence interval adverse event adverse events age all-cause mortality antiviral medicine approach authorisation baseline CENTRAL certainty certainty of evidence chance citation clinical Clinical improvement Clinical outcome clinical outcomes clinical status Cochrane COVID-19 Study Register comparable conducted contribute Controlled controlled trials coronavirus disease coronavirus diseases COVID-19 COVID-19 patient COVID-19 patients COVID-19 research Data collection decrease defined diagnosed died disease severity Effect Efficacy and safety Emergency use Ethnicity evaluated Evidence excluded FIVE Future Gender high risk High-flow oxygen hospitalised hospitalised patient Hospitalised patients identify increase index individual information inhibit initial Invasive mechanical ventilation lack liberation life low-flow oxygen maintain Mask mechanical ventilation media medRxiv methodology Missing data missing value missing values Mortality MOST nasal prong nasal prongs need for oxygen no difference no effect Non-invasive non-invasive mechanical ventilation non-invasive ventilation observation outcome outcomes oxygen participant Participants Patient Placebo potential benefit potential benefits Quality of life randomised randomised controlled trial Randomised controlled trials RCT RCTs receive recruit registry Remdesivir reported required Respiratory Support risk risk difference risk of bia risk ratio RoB 2 SARS-CoV-2 SARS-COV-2 infection Science Citation Index searched Selection Serious Adverse Event Serious Adverse Events severity Source standard care subgroup subgroups supplemental oxygen systematic review Treatment viral replication Web of Science WHO WHO International Clinical Trials Registry Platform worsening
[DOI] 10.1002/14651858.CD014962 PMC 바로가기 [Article Type] Article