Integrated autolysis, DNA hydrolysis and precipitation enables an improved bioprocess for Q-Griffithsin, a broad-spectrum antiviral and clinical-stage anti-COVID-19 candidateResearch article Published on 2022-04-012022-10-05 Journal: Biochemical Engineering Journal [Category] 임상, 치료제, [키워드] anticipated Antiviral autolysis Biologics manufacturing Broad spectrum antiviral cellular clinical trial Complete contaminant COVID-19 COVID-19 pandemic DNA downstream Downstream recovery E. coli Efficiency endotoxin equipment feature fixed flexible griffithsin host cell hydrolysis IMPROVE membrane Modification nucleic acids pandemic performed produced Protein purified reducing Variation vessel [DOI] 10.1016/j.bej.2022.108403 [Article Type] Research article
Hybridization chain reaction circuit-based electrochemiluminescent biosensor for SARS-cov-2 RdRp gene assaySARS-cov-2 RdRp 유전자 분석을 위한 혼성화 연쇄 반응 회로 기반 전기화학발광 바이오센서Article Published on 2022-04-012022-09-11 Journal: Talanta [Category] COVID19(2023년), SARS, 치료기술, 치료제, [키워드] activated amplification applied Au-g-C(3)N(4) Base pairing Chain Reaction complementary complex decrease detect Detection limit DNA ECL gradually increased HCR hybridization Luminescence nucleic acids probe quantified RdRP RdRp gene SARS-CoV-2 nucleic acid SARS-CoV-2 RdRp SARS-CoV-2 RdRp gene signal target gene the SARS-CoV-2 this system Y-DNA. [DOI] 10.1016/j.talanta.2022.123207 PMC 바로가기 [Article Type] Article
Rapid and High-Throughput SARS-CoV-2 RNA Detection without RNA Extraction and Amplification by Using a Microfluidic BiochipArticle Published on 2022-03-282023-06-19 Journal: Chemistry (Weinheim an Der Bergstrasse, Germany) [Category] MERS, SARS, [키워드] amplification-free methods biosensors nucleic acids RNA purification-free methods [DOI] 10.1002/chem.202104054 PMC 바로가기
Development of colorimetric sensors based on gold nanoparticles for SARS-CoV-2 RdRp, E and S genes detectionArticle Published on 2022-03-162023-06-16 Journal: Talanta [Category] COVID19(2023년), MERS, SARS, [키워드] detection Gold nanoparticles nucleic acids PCR SARS-CoV-2 [DOI] 10.1016/j.talanta.2022.123393 PMC 바로가기 [Article Type] Article
Applying Machine Learning with Localized Surface Plasmon Resonance Sensors to Detect SARS-CoV-2 ParticlesSARS-CoV-2 입자를 감지하기 위해 국부적 표면 플라즈몬 공명 센서로 기계 학습 적용Article Published on 2022-03-132022-09-11 Journal: Biosensors [Category] SARS, 치료기술, [키워드] Accuracy antigens Applying approach artificial intelligence caused Chain Reaction chemiluminescence immunoassay Concentration COVID-19 deaths demonstrated detect Diagnostic method diagnostic methods early infection effective enzyme enzyme-linked immunosorbent enzyme-linked immunosorbent assay global pandemic greater Infection limit of detection Localized LSPR sensor machine learning microscopic imaging. nucleic acids optical outbreak Particle Patient PCR Plasmon polymerase chain polymerase chain reaction positive R 2 resonance SARS-CoV-2 SARS-CoV-2 virus SARS-CoV-2 virus particles sensor surface surface plasmon surface plasmon resonance the SARS-CoV-2 the SARS-CoV-2 virus viral nucleic acid viral nucleic acids virus [DOI] 10.3390/bios12030173 PMC 바로가기 [Article Type] Article
Effectiveness of Disinfectants Suitable for Inactivating SARS-CoV-2 at Cold-Chain Temperature저온 유통 온도에서 SARS-CoV-2 비활성화에 적합한 소독제의 효과Article Published on 2022-03-012022-09-11 Journal: Food and Environmental Virology [Category] SARS, 치료기술, [키워드] Ammonium carrier China chlorine Cold cold chain concentrations Cryogenic disinfectants Ct values disinfectant Disinfection Inactivate nucleic acid nucleic acids peracetic acid performed positive Prevent qRT-PCR SARS-CoV-2 SARS-CoV-2 RNA Spread tested treated viral nucleic acid viral nucleic acids Viral nucleic acids. virus virus RNA was used [DOI] 10.1007/s12560-022-09509-0 PMC 바로가기 [Article Type] Article
Structure- and Interaction-Based Design of Anti-SARS-CoV-2 AptamersAnti-SARS-CoV-2 앱타머의 구조 및 상호 작용 기반 설계Article Published on 2022-02-242022-09-11 Journal: Chemistry (Weinheim an Der Bergstrasse, Germany) [Category] COVID19(2023년), SARS, 변종, [키워드] approach aptamer Aptamers binding binding affinity blueprint complexes computational method Computational methods Cytometry develop Directed mutagenesis DNA docking drug design ENhance fragment molecular orbitals method functional IMPROVE in silico Infection Interaction iterative methodology molecular molecular docking molecular dynamics molecules Mutagenesis nucleic acids offer pathogen probes Protein protein structure Receptor-binding domain SARS-CoV-2 SARS-CoV-2 spike protein SAXS scratch speed Spike protein Structure synergy target target protein tertiary structure the receptor-binding domain the SARS-CoV-2 time-consuming variants X-ray scattering [DOI] 10.1002/chem.202104481 PMC 바로가기 [Article Type] Article
Centrifugal Microfluidic Method for Enrichment and Enzymatic Extraction of Severe Acute Respiratory Syndrome Coronavirus 2 RNA중증 급성 호흡기 증후군 코로나바이러스 2 RNA의 농축 및 효소 추출을 위한 원심 미세 유체 방법Article Published on 2022-02-222022-09-11 Journal: Analytical Chemistry [Category] COVID19(2023년), SARS, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 amplification analyst analyzed applicability buffer capsid Centrifugal Chain Reaction comparable complex controls coronavirus coronavirus 2 demonstrated development Diagnosis diagnostics downstream effective ENhance enrichment exposure to extraction imperative in viral inhibit Intervention Isolation lysed nasopharyngeal Nasopharyngeal swab nucleic acid nucleic acids Particle pathogen detection pathogenic Pathogens platform polymerase chain polymerase chain reaction positive purification real-time reverse transcriptase real-time RT-PCR removal respiratory reverse transcriptase Reverse transcriptase polymerase chain reaction RNA RNA extraction robust RT-PCR Saliva Sample SARS-CoV-2 SARS-CoV-2 detection SARS-CoV-2 RNA SARS-CoV-2 virion severe acute respiratory syndrome Coronavirus Surveillance Transmission Transport media Treatment tube Viral RNA viral transport media virus [DOI] 10.1021/acs.analchem.1c05215 PMC 바로가기 [Article Type] Article
Enzymatic Beacons for Specific Sensing of Dilute Nucleic AcidArticle Published on 2022-02-162023-07-07 Journal: Chembiochem [Category] COVID19(2023년), [키워드] beacons biosensors hedgehog nucleic acids SARS-CoV-2 [DOI] 10.1002/cbic.202100594 PMC 바로가기
The Extended Hadamard Transform: Sensitivity-Enhanced NMR Experiments Among Labile and Non-Labile 1 Hs of SARS-CoV-2-derived RNAsArticle Published on 2022-02-162023-07-07 Journal: Chemphyschem : a European journal of chemical physics and physical [Category] COVID19(2023년), [키워드] Hadamard encoding NMR spectroscopy NOESY nucleic acids SARS-CoV-2 genome [DOI] 10.1002/cphc.202100704 PMC 바로가기