A stability indicating RP-HPLC method for determination of the COVID-19 drug molnupiravir applied using nanoformulations in permeability studies투과성 연구에서 나노제형을 사용하여 적용된 COVID-19 약물 몰누피라비르의 측정을 위한 안정성을 나타내는 RP-HPLC 방법Article Published on 2022-05-302022-09-11 Journal: Journal of pharmaceutical and biomedical analysis [Category] COVID19(2023년), SARS, 치료기술, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 antiviral drugs applied Caco-2 calculated candidate cell line column conditions Coronavirus-2 Council COVID-19 demonstrated drug drug candidate drug delivery system flow rate homogeneity ICH in vitro Infection linear molnupiravir N4-hydroxycytidine nucleoside optimization oxidative stress pandemic peak permeability prodrug quantitation robust RP-HPLC SARS-CoV-2 SARS-CoV-2 treatment selective Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus specificity stability validation was performed was used water [DOI] 10.1016/j.jpba.2022.114693 PMC 바로가기 [Article Type] Article
Discovery of S-217622, a Noncovalent Oral SARS-CoV-2 3CL Protease Inhibitor Clinical Candidate for Treating COVID-19COVID-19 치료를 위한 비공유 경구 SARS-CoV-2 3CL 프로테아제 억제제 임상 후보인 S-217622 발견Article Published on 2022-05-122022-09-11 Journal: Journal of medicinal chemistry [Category] COVID19(2023년), SARS, 변종, 치료제, [키워드] 3CL acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 antiviral activity antiviral drug antiviral drugs candidate caused clinical coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 vaccines death drug design effective exhibited followed by house in vitro in vivo inhibited inhibitor intrapulmonary mice optimization oral oral dosing pandemic pharmacokinetic profile Protease inhibitor public health replication of SARS-CoV-2 SARS-CoV-2 SARS-CoV-2 variant severe acute respiratory syndrome Coronavirus spread of COVID-19 treating treating COVID-19 Vaccines Virtual screening [DOI] 10.1021/acs.jmedchem.2c00117 PMC 바로가기 [Article Type] Article
Comparative analysis of COVID-19 vaccine responses and third booster dose-induced neutralizing antibodies against Delta and Omicron variantsDelta 및 Omicron 변이체에 대한 COVID-19 백신 반응 및 3차 추가접종량 유도 중화항체의 비교 분석Article Published on 2022-05-052022-09-11 Journal: Nature Communications [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료기술, [키워드] Adenovirus adenovirus vector vaccine anti-SARS-CoV-2 antibody antibody levels BNT162b2 booster ChAdOx1 Combination Comparative analysis COVID-19 COVID-19 vaccine cross-protective Delta delta variant dose Dosing Europe fold Health care Health care worker health care workers increase indicate induce janssen mRNA mRNA vaccine mRNA vaccines mRNA-1273 mRNA-1273 booster Neutralizing antibodies neutralizing antibody of BNT162b2 omicron optimization regime response second dose variant variants [DOI] 10.1038/s41467-022-30162-5 PMC 바로가기 [Article Type] Article
Relationships Between Job Satisfaction of Operating Room Nurses and Hospital’s Compliance With Protective Guidelines During the Covid-19 Pandemic: A Cross-Sectional Study, IranResearch article Published on 2022-05-012022-10-05 Journal: Journal of perianesthesia nursing : official journal of the American [Category] 변종, [키워드] Affect age analyzed Clustering collected data Compliance conducted Contact contribute COVID-19 pandemic cross-sectional Efficiency finding Guidance guideline Health health system hospital hospital's compliance increase Infection Iran job Job satisfaction management measure Nurse Nurses Operating room operating room nursing optimization P-value pandemic participant patients Perspective Protective protective guidelines questionnaire relationship reported researcher resource room Satisfaction SPSS software surgical the mean WhatsApp [DOI] 10.1016/j.jopan.2022.03.007 [Article Type] Research article
Metaheuristics based COVID-19 detection using medical images: A review의료 영상을 활용한 메타휴리스틱 기반 코로나19 탐지: 리뷰Review Published on 2022-05-012022-09-11 Journal: Computers in biology and medicine [Category] COVID19(2023년), SARS, 변종, 치료기술, [키워드] Algorithm architecture automated Chest complex country COVID-19 CT-scan deep deep learning deep learning-based method deep learning-based methods Diagnosis Extensive Feature selection Healthcare systems Image image classification machine learning models Metaheuristics motivation Nature-inspired algorithm. optimization over patients popularity pressure problem reduce Research researcher simplicity spread of COVID-19 X-ray [DOI] 10.1016/j.compbiomed.2022.105344 PMC 바로가기 [Article Type] Review
Impact of SARS-CoV-2 Variants on the Analytical Sensitivity of rRT-PCR AssaysrRT-PCR 분석의 분석 감도에 대한 SARS-CoV-2 변이체의 영향Article Published on 2022-04-202022-09-11 Journal: Journal of Clinical Microbiology [Category] COVID19(2023년), SARS, 변종, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 affected Alpha analytical sensitivity assays Beta Chinese coronavirus country Critical Delta delta variant diagnostic E gene Efficacy Efficiency evaluate Evolution Gamma had no highlight Immune escape Impact Liferiver management MS2 Mutation N gene no significant effect omicron optimization ORF1ab gene pandemic pathogenicity PCR amplification Prevention and control regions reverse transcriptase reverse transcriptase PCR rRT-PCR SARS-CoV-2 SARS-CoV-2 detection SARS-CoV-2 variant SARS-CoV-2 variants sensitivity severe acute respiratory syndrome Coronavirus significant effect strategic management Transmissibility variant viral mutation Viral mutations virus Virus-like particle virus-like particles were used [DOI] 10.1128/jcm.02374-21 PMC 바로가기 [Article Type] Article
Development and validation of cost-effective one-step multiplex RT-PCR assay for detecting the SARS-CoV-2 infection using SYBR Green melting curve analysisSYBR Green Melting Curve 분석을 이용한 SARS-CoV-2 감염 검출을 위한 비용 효율적인 1단계 다중 RT-PCR 분석법 개발 및 검증Article Published on 2022-04-202022-09-11 Journal: Scientific Reports [Category] COVID19(2023년), SARS, 변종, 진단, 치료기술, 치료제, [키워드] combinations COVID-19 diagnosis detect development Diagnostic method E gene extracted RNA Host house Inc. Infection initial initial stage Internal control melting curve analysis multiplex Multiplex assay optimization PCR PCR reaction primer provided purification randomly selected sample ranged RdRP RdRp gene RdRp genes RNA extraction RT-PCR RT-PCR assay SARS-COV-2 infection SARS-CoV-2 infections SARS-CoV-2 virus sensitivity specificity subset SYBR Green TaqMan TaqMan probe the SARS-CoV-2 the SARS-CoV-2 virus Validity Variation Viral RNA were used β-actin [DOI] 10.1038/s41598-022-10413-7 PMC 바로가기 [Article Type] Article
Rational Design of CRISPR/Cas12a-RPA Based One-Pot COVID-19 Detection with Design of Experiments실험 계획을 통한 CRISPR/Cas12a-RPA 기반 One-Pot COVID-19 탐지의 합리적 설계Article Published on 2022-04-152022-09-11 Journal: ACS synthetic biology [Category] COVID19(2023년), SARS, 진단, 치료기술, [키워드] accelerate addition amplification applied approach benefit buffer complex component components condition COVID-19 COVID-19 pandemic CRISPR CRISPR/Cas12a critical impact definitive screening design demonstrated design of experiments detection Detection sensitivity diagnostic Diagnostic method diagnostics DNA DNA sequence DoE Effect effective experiment Factor full-length SARS-CoV-2 Genome highlight isothermal molecular Molecular diagnosis N gene one-pot COVID-19 testing optimization polymerase reaction reaction optimization Reactions recombinase polymerase amplification recombinase polymerase amplification (RPA). reverse transcription RNA RNase RNase inhibitor robust RPA RT-qPCR sensitivity significant effect significantly simple statistical variables [DOI] 10.1021/acssynbio.1c00617 PMC 바로가기 [Article Type] Article
Optimization of a new adaptive intervention using the SMART Design to increase COVID-19 testing among people at high risk in an urban communitySMART 디자인을 사용한 새로운 적응형 개입 최적화Randomized Controlled Trial Published on 2022-04-142022-09-11 Journal: Trials [Category] 변종, 임상, [키워드] adaptive adhere affected Analysis baseline booster Brief counseling cascade CDC center co-morbidities Community Complete completion Contact tracing continuum Control counseling COVID-19 COVID-19 testing COVID-19 treatment cascade COVID-19 vaccination Critical Critical dialog deaths determinant effective exposure to Factor Families Follow-up Health help herd immunity high risk high-risk population HIV HIV prevention Hospitalization identify Immunity impacted incarceration individual Intervention media morbidities Multiple Navigation services New optimization participant poverty predictor prevention protocol public health quarantine Randomized receive recommendation recommendations recruited reduce Sequential Multiple Assignment Randomized Trials (SMART). SmaRT social determinants social distancing social media state Stigmatization Treatment USA vaccination Vaccine variants variety while with COVID-19 [DOI] 10.1186/s13063-022-06216-w PMC 바로가기 [Article Type] Randomized Controlled Trial
Machine learning model from a Spanish cohort for prediction of SARS-COV-2 mortality risk and critical patientsSARS-COV-2 사망 위험 및 중환자 예측을 위한 스페인 코호트의 기계 학습 모델Article Published on 2022-04-062022-09-11 Journal: Scientific Reports [Category] COVID19(2023년), SARS, 치료기술, [키워드] Accuracy addition advance affected age Analysis approach Area AUC can be used Chinese classification clinical Cohort Comorbidities Comorbidity Critical Curve death detect determine develop Diagnosis diagnostic Evolution evolution of patient Factor Healthcare system Healthcare systems help high risk hospital hospitals ICD ICU IMPROVE Inclusion Infection intensive care unit International machine machine learning medical record medical records mortality risk Ninth optimization overcome pandemic Patient patients Population populations predict presenting Prevent Probability problem problems professional resource resources revision robust SARS-COV-2 infection SARS-CoV-2 patients sensitivity severity Sex Spanish Spanish patient stratified the disease the patient transformations Treatment [DOI] 10.1038/s41598-022-09613-y PMC 바로가기 [Article Type] Article