Toward Consensus on Correct Interpretation of Protein Binding in Plasma and Other Biological Matrices for COVID‐19 Therapeutic DevelopmentCOVID-19 치료제 개발을 위한 혈장 및 기타 생물학적 매트릭스의 단백질 결합에 대한 올바른 해석에 대한 합의를 향하여Review Published on 2020-11-212022-09-10 Journal: Clinical Pharmacology and Therapeutics [Category] SARS, 신약개발, 치료제, [키워드] antiviral drug antiviral drugs applied binding Biological clinical pharmacology Consensus Consequences COVID‐19 Critical development Drug development effort global public health groups hepatitis C hepatitis C virus HIV identify influence International Interpretation knowledge Other Pharmacodynamics plasma Protein Protein binding researcher respiratory SARS‐CoV‐2 seeking tissue protein viruses [DOI] 10.1002/cpt.2099 PMC 바로가기 [Article Type] Review
Population-based meta-analysis of chloroquine: informing chloroquine pharmacokinetics in COVID-19 patients클로로퀸의 인구 기반 메타 분석: COVID-19 환자의 클로로퀸 약동학 정보 제공Meta-Analysis Published on 2020-11-132022-08-31 Journal: European Journal of Clinical Pharmacology [Category] MERS, SARS, 신약개발, [키워드] Absorption approach approval best Chloroquine clearance Combination Concentration conducted coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient COVID-19 patients described develop distribution dosing regimen Efficacy FIVE Meta-analysis Open-label patients with COVID-19 Pharmacodynamics pharmacokinetics phosphate PK data PK parameter PK parameters Population pharmacokinetics receiving regimen Result Safe safety margin Side-effects single-center study supplementary material treat understanding Volume volume of distribution [DOI] 10.1007/s00228-020-03032-6 PMC 바로가기 [Article Type] Meta-Analysis
Potential drug-drug interactions associated with drugs currently proposed for COVID-19 treatment in patients receiving other treatmentsReview Published on 2020-10-012023-07-07 Journal: Fundamental & clinical pharmacology [Category] SARS, [키워드] adverse events Hydroxychloroquine Lopinavir Pharmacodynamics pharmacokinetics Therapeutic Drug Monitoring [DOI] 10.1111/fcp.12586 PMC 바로가기 [Article Type] Review
Concerns about pharmacokinetic (PK) and pharmacokinetic-pharmacodynamic (PK-PD) studies in the new therapeutic area of COVID-19 infectionReview article Published on 2020-09-012022-10-05 Journal: Antiviral Research [Category] SARS, 신약개발, [키워드] addressed affecting candidate concern consortia covariate COVID COVID-19 COVID-19 infection COVID-19 pandemic COVID-19 patient dose drug effective therapy highlight HIV identify implementation in vitro in vivo limitation malaria non-ICU patients organ support other disease Pharmacodynamics pharmacokinetic pharmacokinetics PK-PD promote Research severe patients therapeutic translation Treatment while [DOI] 10.1016/j.antiviral.2020.104866 [Article Type] Review article
Concentration-dependent mortality of chloroquine in overdose과다복용 시 클로로퀸의 농도 의존적 사망률Research Article Published on 2020-07-082022-10-31 Journal: eLife [Category] COVID-19, 말라리아, [키워드] analysed Bayesian benefit Blood Brazil bypassing calculate calculated cause changes in Chloroquine Clinical efficacy Clinical practice clinical trial clinical trials Concentration conditions correlated COVID-19 COVID-19 infections Critical determine died dosage dose drug electrical estimate Evidence France French greater healthy volunteer High dose highest Human Hydroxychloroquine indicated Laboratory test lack malaria mathematical metabolised Mortality outcome overdose overdoses Patient Pharmacodynamics pharmacokinetics potential benefits predict predicted Predictive problem prolongation prospectively studied randomised recovery regimen Regression model resulting rheumatological risk of death Safe shown Side effect Side effects single doses Stage statistical model suffered survival tested threshold threshold concentration Toxicity treating COVID-19 Treatment treatment for COVID-19 Trial trials unlikely ventricular virus [DOI] 10.7554/eLife.58631 PMC 바로가기 [Article Type] Research Article
Antimicrobial therapeutic drug monitoring in critically ill adult patients: a Position Paper #article Published on 2020-05-072024-09-02 Journal: Intensive care medicine [Category] 대상포진, [키워드] antibacterials antifungals antivirals Pharmacodynamics pharmacokinetics Sepsis [DOI] 10.1007/s00134-020-06050-1 PMC 바로가기 [Article Type] article
Accumulation of Major Linezolid Metabolites in Patients with Renal Impairment신장 기능 장애 환자에서 주요 리네졸리드 대사물질의 축적Article Published on 2020-04-212024-08-24 Journal: Med Instrum [Category] 폐렴구균 감염증, [키워드] dialysis myelosuppression oxazolidinones Pharmacodynamics toxicology
Cefuroxime pharmacokinetics and pharmacodynamics for intravenous dosage regimens with 750 mg or 1500 mg doses in healthy young volunteersarticle Published on 2020-03-312024-09-01 Journal: British Journal of Pain [Category] 폐렴구균 감염증, [키워드] breakpoints cefuroxime healthy volunteers Pharmacodynamics pharmacokinetics population modelling [Article Type] article
Kinetic Driver of Antibacterial Drugs against Plasmodium falciparum and Implications for Clinical DosingArticle Published on 2019-10-222024-08-28 Journal: Med Instrum [Category] 말라리아, [키워드] Chemotherapy chloramphenicol ciprofloxacin Clindamycin doxycycline malaria Pharmacodynamics pharmacokinetics PK/PD Plasmodium falciparum Tetracycline
Epithelial Lining Fluid and Plasma Concentrations of Dalbavancin in Healthy Adults after a Single 1,500-Milligram Infusion건강한 성인에서 단일 1,500밀리그램 주입 후 다르바반신의 상피 내액 및 혈장 농도Article Published on 2019-09-092024-07-31 Journal: Med Instrum [Category] 폐렴구균 감염증, [키워드] dalbavancin lung epithelial lining fluid Pharmacodynamics pharmacokinetics Pneumonia [DOI] 10.1128/AAC.01024-19 PMC 바로가기