Proposed mechanism for rare thrombotic events after use of some Covid-19 vaccinesResearch article Published on 2022-02-012022-10-05 Journal: Medical Hypotheses [Category] 변종, [키워드] Adenoviridae Adenovirus affected antibody binding caused Coagulation complex COVID-19 vaccines described DNA Factor X healthcare immune response Immunity Impaired impairment individuals mechanism Mutation offer option Platelet platelet activation PROTECT Protein stimulate thrombocytopenia thromboembolic complication Thromboembolic event thrombotic event Vaccine Vaccines Venous thrombosis virus [DOI] 10.1016/j.mehy.2021.110756 [Article Type] Research article
Multi-factorial Mechanism Behind COVID-19 Related ThrombosisCOVID-19 관련 혈전증 이면의 다인자 메커니즘Review Published on 2022-02-012022-09-12 Journal: Medical archives (Sarajevo, Bosnia and Herzegovina [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] antibodies antibody antiphospholipid antibodies association Coagulation concerning Coronavirus disease-19 COVID-19 COVID-19 patient COVID-19 patients disease severity endothelial cells endothelial damage Factor hypercoagulability Hyperviscosity induce Inflammation Leiden mechanism morbidity and mortality multifactorial Mutation mutations pathogenic patients with COVID-19 platelet activation promote provoke Research SARS-CoV-2 thought Thrombophilia thrombosis thrombotic viral infections with COVID-19 [DOI] 10.5455/medarh.2022.76.62-65 PMC 바로가기 [Article Type] Review
Role of SARS-CoV-2 -induced cytokines and growth factors in coagulopathy and thromboembolismReview Published on 2022-02-012023-07-07 Journal: Cytokine & growth factor reviews [Category] COVID19(2023년), [키워드] Coagulopathy COVID-19 Cytokines Growth factors Inflammation platelet activation Thromboembolism [DOI] 10.1016/j.cytogfr.2021.10.007 PMC 바로가기 [Article Type] Review
Production of anti-PF4 antibodies in antiphospholipid antibody-positive patients is not affected by COVID-19 vaccination항인지질항체 양성 환자의 항PF4 항체 생산은 코로나19 예방접종에 영향을 받지 않는다Article Published on 2022-02-012022-09-12 Journal: RMD Open [Category] MERS, 진단, [키워드] absence activate administration Affect aggregation antibodies antibody Antiphospholipid association Asymptomatic carriers cationic chemokine clinical manifestation clinical manifestations Control control groups COVID-19 COVID-19 vaccination COVID-19 vaccine COVID-19 vaccines described ELISA heparin heparin-induced thrombocytopenia Immunoglobulin in vitro infections mRNA-based not affect not affected Patient patients patients with COVID-19 Platelet platelet activation positive Production serum subject syndrome systemic lupus erythematosus tested thrombosis titre Treatment vaccination [DOI] 10.1136/rmdopen-2021-001902 PMC 바로가기 [Article Type] Article
Role of CD39 in COVID-19 Severity: Dysregulation of Purinergic Signaling and ThromboinflammationCOVID-19 중증도에서 CD39의 역할: 퓨린성 신호 전달 및 혈소판 염증의 조절 장애Immunology Published on 2022-01-312022-09-11 Journal: Frontiers in Immunology [Category] 바이오마커, [키워드] 95%CI adenosine adjusted odds ratio Admission ADP association ATP Biomarker blocked caused CD39 clinical parameter Cohort contribute COVID-19 COVID-19 patient COVID-19 patients COVID-19 pneumonia COVID-19 severity disorder dysregulation expression Extracellular healthy control homeostasis Hospital stay Hypoxemia hypoxia ICU admission Immune cell indicate Inflammatory Influenza influenza A inhibitor intensive care intensive care unit admission maintain nucleotide nucleotides overexpressed overexpression pathophysiology pathway Patient patients hospitalized plasma platelet activation Pneumonia prospective cohort Purinergic purinergic dysregulation receptor resulting role selected Severe COVID-19 pneumonia severity Signaling subset suggested systemic inflammation Thromboinflammation ticagrelor was related [DOI] 10.3389/fimmu.2022.847894 PMC 바로가기 [Article Type] Immunology
Antibodies against Platelet Factor 4 and Their Associated Pathologies: From HIT/HITT to Spontaneous HIT-Like Syndrome, to COVID-19, to VITT/TTSReview Published on 2022-01-212022-10-27 Journal: Antibodies [Category] COVID-19, [키워드] activated adenovirus-based aggregation antibodies antibody Anticoagulant arise bind complexes conditions COVID-19 develop disorder Factor heparin-induced thrombocytopenia high affinity HIT pathological thrombosis pathophysiological conditions pathophysiology Patient patients patients with COVID-19 PF4 Platelet platelet activation platelet factor 4 Platelets proportion Protein recipient released Spontaneous subsequent susceptible patients syndrome thrombotic thrombotic thrombocytopenia syndrome treated TTS vaccinated against COVID-19 vaccine-induced [immune] thrombotic thrombocytopenia Vaccines vessel VITT [DOI] 10.3390/antib11010007 PMC 바로가기 [Article Type] Review
Therapeutic potential of colchicine in cardiovascular medicine: a pharmacological review Reviews Published on 2022-01-192022-10-05 Journal: Acta pharmacologica Sinica [Category] 신약개발, [키워드] Activation administration Anti-inflammatory anti-inflammatory action anti-inflammatory agent anti-inflammatory effect Atherosclerosis cardiovascular complication cardiovascular disease cardiovascular diseases cardiovascular event cell proliferation cellular chemotaxis clinical trial Colchicine Colchicum Coronary artery disease COVID-19 curative dysfunction Efficacy Endothelial cell Gout heart failure incidence inhibit inhibiting Macrophage mechanism Mediterranean fever Migration molecular Myocardial infarction NF-κB signaling NLRP3 inflammasome Patient pharmacological platelet activation Proinflammatory cytokine reduce reducing shown therapeutic efficacy therapy treat unique Vascular [DOI] 10.1038/s41401-021-00835-w [Article Type] Reviews
Inflammation-Induced Coagulopathy Substantially Differs Between COVID-19 and Septic Shock: A Prospective Observational StudyMedicine Published on 2022-01-172022-10-31 Journal: Frontiers in Medicine [Category] COVID-19, [키워드] Activation age Biomarkers biomarkers of inflammation CD40L characterized Clinical characteristics co-morbidity Coagulation Coagulopathy controls COVID-19 COVID-19 patient Critical critical COVID-19 patients dysregulated endothelial Endothelium evaluated exhibited fibrinogen Gender help ICU IL-6 IL-7 IL-8 Improving incidence increase in Inflammation less myeloid NETosis Organ failure outcomes pathophysiology Patient Platelet platelet activation Platelets Prospective Respiratory failure sepsis-induced coagulopathy septic Septic shock systemic inflammatory T lymphocyte therapeutic target thrombosis tissue Treatment were used [DOI] 10.3389/fmed.2021.780750 PMC 바로가기 [Article Type] Medicine
Prothrombotic Phenotype in COVID-19: Focus on PlateletsReview Published on 2021-12-202022-10-29 Journal: International Journal of Molecular Sciences [Category] COVID-19, SARS, [키워드] abnormality activated activation of platelet acute lung injury affecting alteration alveolar capillary Biomarker Blood Cell cell fragment chemokine Coagulation Coagulopathy contribute COVID-19 COVID-19 infection COVID-19 patient COVID-19 patients COVID-19 progression critically ill patients cytokine Cytokine storm D-dimer described elevated endothelial Endothelial cell endothelial injury Evidence fatality fibrinogen focus functions Hemostasis immune response immunothrombosis Infectious disease Inflammation Inflammatory intrinsically involved late stage membrane microthrombi Multi-organ damage NET neutrophil observation P-selectin Pathogenesis phenotype Platelet platelet activation promote prothrombotic SARS-CoV-2 severity sites of inflammation thrombosis vascular permeability von Willebrand factor [DOI] 10.3390/ijms222413638 PMC 바로가기 [Article Type] Review
Adverse Outcome in COVID-19 Is Associated With an Aggravating Hypo-Responsive Platelet PhenotypeCardiovascular Medicine Published on 2021-12-102022-10-31 Journal: Frontiers in Cardiovascular Medicine [Category] COVID-19, [키워드] abrogated Adverse aggravate aggregate aggregation association Complication component Coronavirus disease 2019 COVID-19 COVID-19 patient degranulation disease Disease progression dysregulation healthy donor Hospitalization immune response immunoregulation increase in Infection Inflammation less outcome Patient phenotype plasma Plasma marker Platelet platelet activation platelet activation and reactivity platelet dysfunction platelet-leukocyte interaction reactivity response responses responsible while [DOI] 10.3389/fcvm.2021.795624 PMC 바로가기 [Article Type] Cardiovascular Medicine