Ionizing irradiation-induced Fgr in senescent cells mediates fibrosisArticle Published on 2021-11-122022-10-04 Journal: Cell Death Discovery [Category] 바이오마커, [키워드] abrogated absence addition Ageing Analysis Biomarker Cell cellular senescence expression fibrosis inducer inhibition inhibitor knockdown lung Lung fibrosis Macrophage mechanism Mechanisms of disease Neutrophils positive potential therapeutic target pulmonary fibrosis Radiation RNA-Seq RNA-seq analysis scRNAseq senescent senescent cell stem cells target cell target cells Thoracic tyrosine upregulated upregulation [DOI] 10.1038/s41420-021-00741-4 PMC 바로가기 [Article Type] Article
Vasoactive Peptides: Role in COVID-19 Pathogenesis and Potential Use as Biomarkers and Therapeutic Targets혈관 활성 펩티드: COVID-19 발병의 역할 및 바이오마커 및 치료 표적으로서의 잠재적 사용Review Published on 2021-11-012022-09-11 Journal: Archives of medical research [Category] MERS, SARS, 바이오마커, 신약개발, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition Ang II angiotensin Angiotensin II Biomarker Biomarkers bradykinin calcitonin calcitonin gene-related peptide cause coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 pandemic COVID-19 patient develop Effect Endothelin Endothelin-1 ET-1 global health Health Healthcare system intestinal management observation outbreak pathological conditions Patient peptide peptides physiological Potential potential therapeutic target potential therapeutic targets prognostic indicator respiratory Respiratory complications role SARS-CoV-2 severe acute respiratory syndrome Coronavirus substance P target the disease therapeutic target therapeutic targets Vasoactive vasoactive intestinal peptide Vasoactive peptides. VIP [DOI] 10.1016/j.arcmed.2021.05.007 PMC 바로가기 [Article Type] Review
Genome-Wide Profiling Reveals Alternative Polyadenylation of Innate Immune-Related mRNA in Patients With COVID-19게놈 전체 프로파일링, COVID-19 환자에서 선천적 면역 관련 mRNA의 대체 폴리아데닐화 밝혀냄Immunology Published on 2021-10-272022-09-11 Journal: Frontiers in Immunology [Category] MERS, SARS, 유전자 메커니즘, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 alternative polyadenylation alternative splicing APA APA regulator Biomarker cascade category caused Clinical treatment coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient COVID-19 patients cytokine cytokine production dataset de novo death Diseases effective event highlight human gene human genes human peripheral blood mononuclear cell Immune escape Immunity Infection Infectious diseases Innate innate immune response Innate immunity Interferon-gamma MAPK mechanism mechanisms mononuclear cell mRNA neutrophil neutrophil activation Ontology pandemic patients PBMC performed Peripheral blood Polyadenylation potential therapeutic target Profiling Regulation reported respiratory RNA RNA-seq data SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome Coronavirus Variation Viral [DOI] 10.3389/fimmu.2021.756288 PMC 바로가기 [Article Type] Immunology
Molecular Hydrogen: A Promising Adjunctive Strategy for the Treatment of the COVID-19Medicine Published on 2021-10-222022-10-31 Journal: Frontiers in Medicine [Category] COVID-19, [키워드] acute respiratory disease acute respiratory syndrome caused China composed coronavirus Coronavirus disease 2019 COVID-19 Critical disease Cytokines disease effective excessive inflammatory response Factors feasibility infect Inflammation inflammatory cell inhibiting International mechanism Molecular hydrogen Occurrence organism oxygen pathophysiological potential therapeutic target SARS-CoV-2 Strategy the patient therapeutic effect therapy Treatment virus widespread [DOI] 10.3389/fmed.2021.671215 PMC 바로가기 [Article Type] Medicine
The SARS-CoV-2 main protease M pro causes microvascular brain pathology by cleaving NEMO in brain endothelial cellsArticle Published on 2021-10-212022-10-04 Journal: Nature Neuroscience [Category] Fulltext, SARS, 변종, 유전자 메커니즘, 진단, [키워드] acute respiratory syndrome animal models block blood-brain barrier Brain Capillaries cause cell death Central nervous system infections changes in cleavage cleave cleaving coronavirus Coronavirus disease 2019 COVID-19 death Deletion Endothelial cell Evidence Germany individual induce inhibitor Lubeck M pro membrane mice NEMO Neurological symptoms nuclear Occurrence pathology patients with COVID-19 pharmacological potential mechanism potential therapeutic target prevented protease Protein Regulated cell death representing SARS-CoV-2 SARS-CoV-2 main protease Signaling small vessel Symptoms treat undergo Vascular vessel [DOI] 10.1038/s41593-021-00926-1 PMC 바로가기 [Article Type] Article
Upregulation of Human Endogenous Retroviruses in Bronchoalveolar Lavage Fluid of COVID-19 PatientsCOVID-19 환자의 기관지폐포 세척액에서 인간 내인성 레트로바이러스의 상향 조절Research Article Published on 2021-10-062022-09-10 Journal: Microbiology Spectrum [Category] MERS, SARS, 유전자 메커니즘, 진단, 치료기술, 치료제, [키워드] activated addition age analyzed BALF bronchial cell bronchial cells bronchial epithelial cell Bronchoalveolar lavage fluid Cancer cellular senescence changes in characterized China conditions controls Course COVID-19 COVID-19 patient COVID-19 patients COVID-19 pneumonia COVID-19 severity Disease progression disease severity dysregulated dysregulation element endogenous endogenous retroviruses epithelial cells examined explain exploration expression Families global pandemic groups HBEC HBECs healthy control healthy controls HERV HERVs Human human bronchial epithelial cells human endogenous retrovirus human endogenous retroviruses identify immune senescence increase in increasing age Infection Inflammation Inflammatory inflammatory pathway Inflammatory response Inflammatory responses Intensive lavage Local lung Lungs mechanism monocyte Monocytes Mortality Older age oncogene outcomes pathophysiological Patient PBMC PBMCs Peripheral blood peripheral blood monocytes Pneumonia populations Potential biomarker potential biomarkers potential therapeutic target provide recognize retroviral retrovirus risk factor SARS-CoV-2 senescent severe COVID-19 Severe COVID-19 pneumonia shown Transcriptome transcriptomes upregulated upregulation [DOI] 10.1128/Spectrum.01260-21 PMC 바로가기 [Article Type] Research Article
Targeting cathepsins: A potential link between COVID-19 and associated neurological manifestationsResearch article Published on 2021-09-292022-10-05 Journal: Heliyon [Category] 신약개발, [키워드] age Analysis binding binding ability Brain cathepsin Cathepsins complexes COVID-19 COVID-19 infection CTSL cyclosporine disorder disorders drug Drug repurposing expression Health host cells Hypothesis identify involved lysosomal cathepsins mitigate molecular molecular docking Neurological disorders neurological manifestation neurological manifestations performed potential therapeutic target Proteases required SARS-CoV-2 SARS-CoV-2 entry shown stability targeting virus entry [DOI] 10.1016/j.heliyon.2021.e08089 [Article Type] Research article
A CRISPR/Cas9 genetically engineered organoid biobank reveals essential host factors for coronavirusesArticle Published on 2021-09-172022-10-04 Journal: Nature Communications [Category] SARS, 변종, 치료제, [키워드] ACE2 B.1.1.7 cathepsin Cell cell line coronavirus coronavirus biology Coronaviruses CRISPR-Cas9 genome editing DPP4 entry receptor Factor generate Genetic genetic engineering genetic screen Host host gene human disease identify implicated in vivo increasingly intestinal organoid Intestinal stem cells MERS-CoV mutant Organoid Other performed potential therapeutic target protease TMPRSS2 Proteases Rapid Research reveal SARS-CoV SARS-CoV-2 SARS-CoV-2 replication Stem-cell biotechnology target cell therapeutic interventions therapeutic target therapeutic targets TMPRSS TMPRSS2 translated variant virus replication [DOI] 10.1038/s41467-021-25729-7 PMC 바로가기 [Article Type] Article
A possible pathogenic correlation between neutrophil elastase (NE) enzyme and inflammation in the pathogenesis of coronavirus disease 2019 (COVID-19)Article Published on 2021-09-142022-11-01 Journal: International immunopharmacology [Category] COVID-19, MERS, SARS, [키워드] acute respiratory syndrome Admission Analysis changes in Concentration coronavirus coronavirus disease correlation COVID-19 COVID-19 severity Critical CRP Deceased demonstrated Disease activity Diseases enzyme Evidence gradually increased healthy subject ICU ICU patient IL-10 IL-4 IL-6 IL-8 indicate Inflammation involved mortality rate Neutrophil elastase non-ICU patient Pathogenesis pathogenesis of COVID-19 pathogenic Patient patients with COVID-19 potential therapeutic target Protein recovered patient reduced ROC Curve SARS-CoV-2 serum Serum level significantly higher Support vitamin D level [DOI] 10.1016/j.intimp.2021.108137 PMC 바로가기 [Article Type] Article
Characterization of the NiRAN domain from RNA-dependent RNA polymerase provides insights into a potential therapeutic target against SARS-CoV-2Research Article Published on 2021-09-132022-10-28 Journal: PLoS Computational Biology [Category] COVID-19, SARS, [키워드] 3D structure acute respiratory syndrome affecting anti-SARS-CoV-2 approved bind binding biochemical bioinformatics canonical caused cell lines Characteristics characterization characterized Combination Compound coronavirus disease Coronavirus-2 COVID-19 COVID-19 pandemic COVID-19 therapeutics death domain domains drug drug target exhibit exhibited FDA FIVE functional Health in silico inhibiting inhibitor Kinase inhibitor molecular docking Nidovirale pandemic potential therapeutic target predict predicted provide provided RdRP reduce reported resulting RNA RNA polymerase RNA-dependent RNA polymerase SARS-CoV-2 SARS-CoV-2 infected cells significantly significantly higher small molecule inhibitor strain the SARS-CoV-2 thumb urgency viral life cycle Viral load [DOI] 10.1371/journal.pcbi.1009384 PMC 바로가기 [Article Type] Research Article